rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2010-1171rsp-1085Research ArticleСтатьиArticlesСИНДРОМ ГОРХЭМА-СТОУТА: ОПИСАНИЕ СЛУЧАЯGORHAM-STOUT SYNDROME: DESCRIPTION OF A CASEOttevaElvira NikolayevnaOttevaElvira Nikolayevnaelvott@mail.ruKocherovaT YuKocherovaT Yu-ShepichevE VShepichevE V-201015082010484№4 (2010)8386Copyright © Otteva E.N., Kocherova T.Y., Shepichev E.V., 20102010Otteva E.N., Kocherova T.Y., Shepichev E.V.Otteva E.N., Kocherova T.Y., Shepichev E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/1085

В статье дано описание случая одного из редких заболеваний - синдрома Горхэма-Стоута, который сопровождается массив- ным остеолизисом различных участков костной ткани. Приведен литературный обзор. Сочетание идиопатического остеолизиса с хилотораксом отличается неблагоприятным прогнозом. Лечение возможно только кальцитонинами или бисфосфонатами.

The paper describes a case of Gorham-Stout syndrome, a rare condition, which is accompanied by massive osteolysis of different portions of bone tissue. It reviews the data available in the literature on this problem. Idiopathic osteolysis concurrent with chylothorax has a poor prognosis. The syndrome can be treated only with calcitonins or bisphosphonates.

сидром Горхэма-Стоутаостеолизисостеокластыкостная резорбцияGorham-Stout syndromeosteolysisosteoclastsbone resorptionReferences<div><p>Jackson J.B.S. A boneless arm. Boston Med Surg J 1838;18:368-9.</p><p>Jackson J.B.S. Absorption of the humerus after fracture. Boston Med Surg J 1872;10:245-7.</p><p>Gorham L.W., Stout A.P. Massive osteolysis (acute spontaneous absorption of bone, phantom bone, disappearing bone): its relation to hemangiomatosis. J Bone Joint Surg (Am) 1955;37-A:985-1004.</p><p>Gowin W., Rahmanzadeh R. Radiologic diagnosis of massive idiopathic osteolysis (Gorham-Stout Syndrome). Rontgenpraxis 1985;38:128-34</p><p>Horst M., Zsernaviczky J., Delling G. A rare case of so-called idiopathic osteolysis associated with a lymphangioma of the fibula. Z Orthop 1979;117:88-95.</p><p>Flц rchinger A., Bottger E., Claass-Bottger F. et al. Gorham Stout syndrome of the spine: case report and review o literature. Rofo- Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 1998;168:68-76.</p><p>Tilling G., Skobowytsh B. Disappearing bone disease, Morbus Gorham: report of a case. Acta Orthop Scand 1968;39:398-406.</p><p>Johnson P.M., McClure J.G. Observations of massive osteolysis: a review of the literature and report of a case. Radiology 1958;71:28-42.</p><p>Thompson J.S., Schurman D.J. Massive osteolysis: case report and review of the literature. Clin Orthop 1974;103:206-11.</p><p>Gorham L.W., Wright A.W., Schultz H.H., Maxon F.C. Disappearing bones: a rare form of massive osteolysis: report of 2 cases, autopsy findings. Am J Med 1954;17:674-82.</p><p>Knoch H.-G. Die Gorhamsche Krankheit aus klinischer Sicht. Zentralbl Chir 1963;18:674-83.</p><p>Young J.W., Galbraith M., Cunningham J. et al. Progressive vertebral collapse in diffuse angiomatosis. Metab Bone Dis Relat Res 1983;5:53-60.</p><p>Heyden G., Kindblom L.-G., Nielsen J.M. Disappearing bone disease: a clinical and histological study. J Bone Joint Surg (Am) 1977;59-A:57-61.</p><p>Spieth M.E., Greenspan A., Forrester D.M. et al. Gorham's disease of the radius: radiographic, scintigraphic, and MRI findings with pathologic correlation: a case report and review of the literature. Skeletal Radiol 1997;26:659-63.</p><p>Kery L., Wouters H.W. Massive osteolysis: report of two cases. J Bone Joint Surg (Br) 1970;52-B:452-9.</p><p>Burkhard O., Beyer J., Schrezenmeir J. et al. A case of idiopathic multicentric osteolysis. Med Klin 1989;84:364-8.</p><p>Milner S.M., Baker S.L. Disappearing bones. J Bone Joint Surg (Br) 1958;40- B:502-13.</p><p>Chambers T.J. The cellular basis of bone resorption. Clin Orthop 1980;151:283-93.</p><p>Handl-Zeller L., Hohenberg G. Radiotherapy of Morbus Gorham-Stout: the biological value of low irradiation dose. Br J Radiol 1990;63:206-8.</p><p>Dunbar S.F., Rosenberg A., Mankin H. et al. Gorham's massive osteolysis: the role of radiation therapy and a review of the literature. Int J Radiat Oncol Biol Phys 1993;26:491-7.</p><p>Stц ve J., Reichelt A. Massive osteolysis of the pelvis, femur and sacral bone with a Gorham-Stout syndrome. Arch Orthop Trauma Surg 1995;114:207-10.</p><p>Hardegger F., Simpson L.A., Segmueller G. The syndrome of idiopathic osteolysis: classification, review and case report. J Bone Joint Surg (Br), 1985;67-B:89-93.</p></div><br /><div><p>Jackson J.B.S. A boneless arm. Boston Med Surg J 1838;18:368-9.</p><p>Jackson J.B.S. Absorption of the humerus after fracture. Boston Med Surg J 1872;10:245-7.</p><p>Gorham L.W., Stout A.P. Massive osteolysis (acute spontaneous absorption of bone, phantom bone, disappearing bone): its relation to hemangiomatosis. J Bone Joint Surg (Am) 1955;37-A:985-1004.</p><p>Gowin W., Rahmanzadeh R. Radiologic diagnosis of massive idiopathic osteolysis (Gorham-Stout Syndrome). Rontgenpraxis 1985;38:128-34</p><p>Horst M., Zsernaviczky J., Delling G. A rare case of so-called idiopathic osteolysis associated with a lymphangioma of the fibula. Z Orthop 1979;117:88-95.</p><p>Flц rchinger A., Bottger E., Claass-Bottger F. et al. Gorham Stout syndrome of the spine: case report and review o literature. Rofo- Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 1998;168:68-76.</p><p>Tilling G., Skobowytsh B. Disappearing bone disease, Morbus Gorham: report of a case. Acta Orthop Scand 1968;39:398-406.</p><p>Johnson P.M., McClure J.G. Observations of massive osteolysis: a review of the literature and report of a case. Radiology 1958;71:28-42.</p><p>Thompson J.S., Schurman D.J. Massive osteolysis: case report and review of the literature. Clin Orthop 1974;103:206-11.</p><p>Gorham L.W., Wright A.W., Schultz H.H., Maxon F.C. Disappearing bones: a rare form of massive osteolysis: report of 2 cases, autopsy findings. Am J Med 1954;17:674-82.</p><p>Knoch H.-G. Die Gorhamsche Krankheit aus klinischer Sicht. Zentralbl Chir 1963;18:674-83.</p><p>Young J.W., Galbraith M., Cunningham J. et al. Progressive vertebral collapse in diffuse angiomatosis. Metab Bone Dis Relat Res 1983;5:53-60.</p><p>Heyden G., Kindblom L.-G., Nielsen J.M. Disappearing bone disease: a clinical and histological study. J Bone Joint Surg (Am) 1977;59-A:57-61.</p><p>Spieth M.E., Greenspan A., Forrester D.M. et al. Gorham's disease of the radius: radiographic, scintigraphic, and MRI findings with pathologic correlation: a case report and review of the literature. Skeletal Radiol 1997;26:659-63.</p><p>Kery L., Wouters H.W. Massive osteolysis: report of two cases. J Bone Joint Surg (Br) 1970;52-B:452-9.</p><p>Burkhard O., Beyer J., Schrezenmeir J. et al. A case of idiopathic multicentric osteolysis. Med Klin 1989;84:364-8.</p><p>Milner S.M., Baker S.L. Disappearing bones. J Bone Joint Surg (Br) 1958;40- B:502-13.</p><p>Chambers T.J. The cellular basis of bone resorption. Clin Orthop 1980;151:283-93.</p><p>Handl-Zeller L., Hohenberg G. Radiotherapy of Morbus Gorham-Stout: the biological value of low irradiation dose. Br J Radiol 1990;63:206-8.</p><p>Dunbar S.F., Rosenberg A., Mankin H. et al. Gorham's massive osteolysis: the role of radiation therapy and a review of the literature. Int J Radiat Oncol Biol Phys 1993;26:491-7.</p><p>Stц ve J., Reichelt A. Massive osteolysis of the pelvis, femur and sacral bone with a Gorham-Stout syndrome. Arch Orthop Trauma Surg 1995;114:207-10.</p><p>Hardegger F., Simpson L.A., Segmueller G. The syndrome of idiopathic osteolysis: classification, review and case report. J Bone Joint Surg (Br), 1985;67-B:89-93.</p></div><br />

The authors declare that there are no conflicts of interest present.