rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2002-1211rsp-1121Research ArticleСтатьиArticlesПРОФИЛЬ НЕВРОЛОГИЧЕСКИХ ПРОЯВЛЕНИЙ ПРИ ПЕРВИЧНОМ СИНДРОМЕ ШЕГРЕНАPROFILE OF NEUROLOGICAL MANIFESTATIONS IN PRIMARY SJOGREN’S SYNDROMEPanchovskaM SPanchovskaM S-SlieilanovJ ISlieilanovJ I-SloilovR MSloilovR M-200215062002403№3 (2002)2122Copyright © Panchovska M.S., Slieilanov J.I., Sloilov R.M., 20022002Panchovska M.S., Slieilanov J.I., Sloilov R.M.Panchovska M.S., Slieilanov J.I., Sloilov R.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/1121

Цель. Установить частоту и вид неврологических проявлений у больных с первичным синдромом Шегрена среди болгарской популяции. Материал и методы. В течение 5 лет наблюдали за 65 больными, удовлетворяющими Европейским классификационным критериям первичного синдрома Шегрена. Оценены общий и неврологический статус пациентов. Проведены электромиография, компьютерная томография, аудиометрическое исследование (при наличии показаний). Результаты. Неврологические проявления и отклонения в диагностических тестах зарегисгрированы у 28 больных -43.06%. Некоторые симптомы имели рецидивирующий характер (невропатия n. trigeminus), другие привели к частичной инвалидности (множественный мононеврит). Заключение. У значительной части больных с первичным синдромом Шегрена наблюдается поражение нервной системы. Прогноз неврологических проявлений зависит от своевременной постановки диагноза и от проведенного лечения.

Objective. To establish the frequency and the type of the neurologic manifestations in pts with primary Sjogren’s syndrome in Bulgarian population. Material and methods. For the period of five years 65 pts with primary Sjogren’s syndrome fulfilling the European clasification criteria for diagnosis were observed. There were evaluated the neurological and the internal status. Electromyography, computer tomography, audiometric investigations were realised. Results. In 28 patients (43,06%) neurological manifestations and diversious in the diagnostic tests were found. Some of the manifestations showed a relapsing character (neuropathy of the n. trigemini), some of them showed a partial disability (mononeuritis multiplex). Conclusion. The engagement of the nervous system occurs in a great number of patients with primary Sjogren’s syndrome. The prognosis of the neurologic manifestations depends on Lhe accurate diagnosis and treatment.

первичный синдром Шегренаневрологические проявленияprimary Sjogren’s syndromeneurological manifestationsReferences<div><p>Насонова В.А, Бунчук Н.В. Клиническая ревматология. Медицина, М., 1997, 196.</p><p>Alexander E.L. Neurologic disease in Sjogren’s syndrome, mononuclear inl’ammatory vasculopathy affecting central/ peripheral nervous system and muscle. A clinical review and update of immunopathogenesis. Rheum. Dis. Clin. North. Am. 1993, 19 (4) , 869 - 908.</p><p>Bombardieri S., Moutsopoulos H., Vitali S. The European community study group on diagnostic criteria for SjOgren’s syndrome. Ann. Rheum. Dis. 1994, 53. 637 - 647,</p><p>Guell I., Pral J., Caspar O. et al. Isolated neuropathy of the trigeminal nerve as the first manifestation of primary Sj6gren's syndrome. Neurologia, 1993, 8(9), 320 - 321.</p><p>Jscnbcrg D.A, Horsfall A.C. Focus on Sjogren’s syndrome, BIOS, Oxford, 1994, 17-18.</p><p>Kancko Y„ Suwa A. Nakajima A. etal. A case of primary Sjogren’s syndrome accompanied by transverse myelitis. Ryumachi., 1998,38 (4), 600 - 604.</p><p>Li J.Y., Lai P.H., Lam H.C. et al. Hypertrophic cranial pachymeningitis and lymphocytic hypophysilis in Sjogren’s syndrome. Neurology ,1999, 15, 52 (2), 420-423.</p><p>Menage P. de Toflol B„ Degenne D. et al. Gougerot - SjOgren’s syndrome. Central neurological involvement with recurrent development. Rev. Neurol., 1993, 149 (10), 554- 556.</p><p>Moutsopoulos H.M., Vlachoyiannopoulos P.G. What would I do if I had SjOgren’s syndrome? Rheumatol. Rev., 1993,2, 17 - 23.</p><p>Rosier DH, Conway M.D., Anaya J.M. et al. Ischemic optic neuropathy and high-level anticardiolipin antibodies in primary Sjogren's syndrome. Lupus, 1995,4(2), 155- 157.</p><p>Talal N. Moutsopoulos H., Kassan S. Sjogren’s syndrome, Springer - Vcrlag, Berlin, 1987, 68-71.</p><p>Van Dijk G.W., Wokkc J.H. The diversity of peripheral nervous system disorders in Sjogren’s syndrome. Neth. J. Med., 1998, 53 (5) , 193-195.</p></div><br /><div><p>Насонова В.А, Бунчук Н.В. Клиническая ревматология. Медицина, М., 1997, 196.</p><p>Alexander E.L. Neurologic disease in Sjogren’s syndrome, mononuclear inl’ammatory vasculopathy affecting central/ peripheral nervous system and muscle. A clinical review and update of immunopathogenesis. Rheum. Dis. Clin. North. Am. 1993, 19 (4) , 869 - 908.</p><p>Bombardieri S., Moutsopoulos H., Vitali S. The European community study group on diagnostic criteria for SjOgren’s syndrome. Ann. Rheum. Dis. 1994, 53. 637 - 647,</p><p>Guell I., Pral J., Caspar O. et al. Isolated neuropathy of the trigeminal nerve as the first manifestation of primary Sj6gren's syndrome. Neurologia, 1993, 8(9), 320 - 321.</p><p>Jscnbcrg D.A, Horsfall A.C. Focus on Sjogren’s syndrome, BIOS, Oxford, 1994, 17-18.</p><p>Kancko Y„ Suwa A. Nakajima A. etal. A case of primary Sjogren’s syndrome accompanied by transverse myelitis. Ryumachi., 1998,38 (4), 600 - 604.</p><p>Li J.Y., Lai P.H., Lam H.C. et al. Hypertrophic cranial pachymeningitis and lymphocytic hypophysilis in Sjogren’s syndrome. Neurology ,1999, 15, 52 (2), 420-423.</p><p>Menage P. de Toflol B„ Degenne D. et al. Gougerot - SjOgren’s syndrome. Central neurological involvement with recurrent development. Rev. Neurol., 1993, 149 (10), 554- 556.</p><p>Moutsopoulos H.M., Vlachoyiannopoulos P.G. What would I do if I had SjOgren’s syndrome? Rheumatol. Rev., 1993,2, 17 - 23.</p><p>Rosier DH, Conway M.D., Anaya J.M. et al. Ischemic optic neuropathy and high-level anticardiolipin antibodies in primary Sjogren's syndrome. Lupus, 1995,4(2), 155- 157.</p><p>Talal N. Moutsopoulos H., Kassan S. Sjogren’s syndrome, Springer - Vcrlag, Berlin, 1987, 68-71.</p><p>Van Dijk G.W., Wokkc J.H. The diversity of peripheral nervous system disorders in Sjogren’s syndrome. Neth. J. Med., 1998, 53 (5) , 193-195.</p></div><br />

The authors declare that there are no conflicts of interest present.