rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2009-1317rsp-1199Research ArticleСтатьиArticlesНовые методы хирургического лечения дефектов гиалинового хряща коленного сустава у больных гонартрозомNew methods of surgical treatment of knee joints hyaline cartilage defects in patients with knee osteoarthritisStadnikovA AStadnikovA A-KavalerskyG M-ArhipovS VArhipovS V-ПавловВ. П.PavlovV P-МакаровС. А.MakarovS A-МакаровМ. А.MakarovM A-РоскидайлоА. А.RoskidailoA A-200915062009473№3 (2009)9093Copyright © Stadnikov A.A., Kavalersky Г.М., Arhipov S.V., Павлов В.П., Макаров С.А., Макаров М.А., Роскидайло А.А., 20092009Stadnikov A.A., Kavalersky Г.М., Arhipov S.V., Павлов В.П., Макаров С.А., Макаров М.А., Роскидайло А.А.Stadnikov A.A., Kavalersky G.M., Arhipov S.V., Pavlov V.P., Makarov S.A., Makarov M.A., Roskidailo A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/1199

Лечение дефектов гиалинового хряща у больных с гонартрозом является сложной ортопедической проблемой. Использование мезенхимальных стволовых клеток (МСК), обладающих способностью дифференцироваться в клетки с хондрогенной направленностью, и генно-инженерных технологий перспективно для восстановления суставного хряща. МСК могут быть выделены из различных тканей и размножены без потери способности к хондрогенной дифференцировке [8,17,27]. В данной статье рассматриваются новейшие технологии лечения дефектов суставного хряща коленного сустава при гонартрозе, основанные на применении МСК и прицельной генной терапии.

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Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis—structure, chaos and senescence. Nat. Clin. Pract. Rheumatol., 2007,3, 391–9</p><p>Bae D K, Yoon K H, Song S J et al. Cartilage healing after microfracture in osteoarthritic knees. Arthroscopy, 2006, 22, 4, 267-74</p><p>Barry F P Biology and clinical applications of mesenchymal stem cells. Birth Defects Res. C. Embryo Today, 2003, 69, 250–6</p><p>Bartlett W, Skinner J A, Gooding C R et al. Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised study. J Bone Joint Surg. Br., 2007, 87: 640–5</p><p>Bentley G, Biant L C, Carrington R W et al. A prospective, randomised comparison of autologous chondrocyte implantation versus mosaicplasty for osteochondral defects in the knee. J. Bone Joint. Surg. Br., 2003, 85, 223–30</p><p>Bert J M, Gasser S I. Approach to the osteoarthritic knee in the aging athlete: debridement to osteotomy. Arthroscopy, 2002, 18, 107–10</p><p>Buckwalter J. A., Martin J A, Brown T D. Perspectives on chondrocyte mechanobiology and osteoarthritis. Biorheology, 2006, 43, 603–9</p><p>Chen F H, Rousche K T, Tuan R S. Technology insight: adult stem cells in cartilage regeneration and tissue engineering. Nat. Clin. Pract. Rheumatol., 2006, 2, 373–82</p><p>Elders M J. The increasing impact of arthritis on public health. J. Rheumatol. Suppl., 2000, 60, 6–8</p><p>Hangody L, Fules P. Autologous osteochondral mosaicplasty for the treatment of full-thickness defects of weight-bearing joints: ten years of experimental and clinical experience. J. Bone Joint Surg. Am., 2003, 85A, 2, 25–32</p><p>Haupt J, Frisbie D D, McIlwraith C W et al. Dual transduction of insulin-like growth factor-I and inter- leukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model. J. Orthop. Res., 2005, 23,118–26</p><p>Henderson I, Francisco R, Oakes B et al. Autologous chondrocyte implantation for treatment of focal chondral defects of the knee — a clinical, arthroscopic, MRI and histologic evaluation at 2 years. Knee, 2005, 12, 209–16</p><p>Johnson L L. Arthroscopic abrasion arthroplasty historical and pathologic perspective: Present status. Arthroscopy, 1986, 2, 54-69</p><p>Kafienah W, Mistry S, Dickinson S C et al. Three-dimensional cartilage tissue engineering using adult stem cells from osteoarthritis patients. Arthritis Rheum., 2007, 56, 177–87</p><p>Kan I, Melamed E, Offen D. Autotransplantation of bone marrow-derived stem cells as a therapy for neurodegenerative diseases. Handb. Exp. Pharmacol., 2007, 180, 219–42</p><p>Knutsen G. Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial. J. Bone Joint Surg. Am., 2004, 86A, 455–64</p><p>Kolf C M, Cho E, Tuan R S. Mesenchymal stromal cells. Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation. Arthritis Res. Ther., 2007, 9, 204</p><p>Lee K B, Hui J H, Song I C et al. Injectable mesenchymal stem cell therapy for large cartilage defects – a porcine model. Stem Cells, 2007, 25, 2964–71</p><p>Leskelä H V, Risteli J, Niskanen Set al. Osteoblast recruitment from stem cells does not decrease by age at late adulthood. Biochem. Biophys. Res. Commun., 2003, 311, 1008–13</p><p>Martin J A. Chondrocyte senescence, joint loading and osteoarthritis. Clin. Orthop. Relat. Res., 2004, 427, 96–103</p><p>Moseley J B, O’Malley K, Petersen N J et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N. Engl. J. Med., 347, 81–8</p><p>Murphy J M, Dixon K, Beck S et al. Reduced chondrogenic and adipogenic activity of mesenchymal stem cells from patients with advanced osteoarthritis. Arthritis Rheum., 2002, 46, 704–13</p><p>Murphy J M, Fink D J, Hunziker E B et al. Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum., 2003, 48, 3464–74</p><p>Muschler G F, Nitto H, Boehm C A et al. Age- and gender-related changes in the cellularity of human bone marrow and the prevalence of osteoblastic pro- genitors. J. Orthop. Res., 2001, 19, 117–25</p><p>Nixon A J, Haupt J L, Frisbie D D et al. Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-I/interleukin-1 receptor antagonist therapy. Gene Ther., 2005, 12, 177–86</p><p>Peterson L. Treatment of osteochondritis dissecans of the knee with autologous chondrocyte transplantation: results at two to ten years. J. Bone Joint Surg. Am., 2003, 85A, 17–24</p><p>Pittenger M F, Mackay A M, Beck S C et al. Multilineage potential of adult human mesenchymal stem cells. Science, 1999, 284, 143–47</p><p>Quarto R, Thomas D, Liang C T et al. Bone progenitor cell deficits and the age-associated decline in bone repair capacity. Calcif. Tissue Int., 1995, 56, 123–9</p><p>Scharstuhl A, Schewe B, Benz K et al. Chondrogenic potential of human adult mesenchymal stem cells is independent of age or osteoarthritis etiology. Stem Cells, 2007, 25, 3244–51</p><p>Steinert A F, Ghivizzani S C, Rethwilm A et al. Major biological obstacles for persistent cell-based regenera- tion of articular cartilage. Arthritis Res. Ther., 2007, 9, 213 93</p><p>Trippel S B, Ghivizzani S C, Nixon A J et al. Gene-based approaches for the repair of articular cartilage. Gene Ther., 2004, 11, 351–9</p><p>Nöth U, Steinert A F, Tuan R S. Technology Insight: adult mesenchymal stem cells for osteoarthritis therapy. Nat. Clin. Pract. Rheumatology, 2008, 4, 371- 80</p><p>Wakitani S, Mitsuoka T, Nakamura N et al. Autologous bone marrow stromal cell transplantation for repair of full-thickness articular cartilage defects in human patellae: two case reports. Cell Transplant., 2004, 13, 595–600</p></div><br />

The authors declare that there are no conflicts of interest present.