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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1995-4484-2003-1333</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-1211</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Эффективность антибиотикотерапии при урогенном реактивном артрите и периферическом варианте анкилозирующего спондилоартрита</article-title><trans-title-group xml:lang="en"><trans-title>Efficacy of antibiotic therapy in urogenous reactive arthritis and peripheral variant of ankylosing spondyloarthritis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Urumova</surname><given-names>M M</given-names></name><name name-style="western" xml:lang="en"><surname>Urumova</surname><given-names>M M</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Agababova</surname><given-names>E R</given-names></name><name name-style="western" xml:lang="en"><surname>Agababova</surname><given-names>E R</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Soldatova</surname><given-names>S. I.</given-names></name><name name-style="western" xml:lang="en"><surname>Soldatova</surname><given-names>S. I.</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шубин</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shubin</surname><given-names>S V</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib></contrib-group><pub-date pub-type="collection"><year>2003</year></pub-date><pub-date pub-type="epub"><day>15</day><month>08</month><year>2003</year></pub-date><volume>41</volume><issue>4</issue><issue-title>№4 (2003)</issue-title><fpage>49</fpage><lpage>52</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Urumova M.M., Agababova E.R., Soldatova S.I., Шубин С.В., 2003</copyright-statement><copyright-year>2003</copyright-year><copyright-holder xml:lang="ru">Urumova M.M., Agababova E.R., Soldatova S.I., Шубин С.В.</copyright-holder><copyright-holder xml:lang="en">Urumova M.M., Agababova E.R., Soldatova S.I., Shubin S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/1211">https://rsp.mediar-press.net/rsp/article/view/1211</self-uri><abstract><p>Цель. Оценить эффективность антибиотиков двух различных групп - азитромицина/сумаме- да(макролид) и ломефлоксацина/максаквина(фторхинолон) - при урогенном реактивном артри- те(УрРеА) и при периферической форме анкилозирующего спондилоартрита (АС) с признаками урогенитального хламидийного воспаления. Материал н методы. Исследованы 86 пациентов: 51 - с УрРеА (включая болезнь Рейтера - БР) и 35 больных АС с поражением периферических суставов. Диагнозы УрРеА, БР и АС были достоверны во всех случаях. 43 пациента получали сумамед в курсовой дозе 15 г,43 пациента- максаквин - 24 г/курс. Эффективность терапии оценивалась по измененению клинико-лабораторных показателей сразу по окончании, а также через 1 и 3 мес после проведения антибиотикотерапии. Результаты. У больных УрРеА и АС одинаково часто отмечено достоверное снижение числа воспаленных и болезненных суставов, средних значений лабораторных показателей воспаления, что сочеталось с исчезновением признаков урогенитального воспаления и эрадикацией хламидий. Заключение. Антибиотикотерапия урогенитального хламидиоза показана во всех случаях комплексного лечения не только при УрРеА, но и при периферическом варианте АС с признаками хламидийного воспаления в урогенитальной сфере.</p></abstract><trans-abstract xml:lang="en"><p>Objective. To study efficacy of antibiotics from two different groups - asitromycin/sumamed (macrolid) and lomefloxacine/maxaquine (ftorquinolone) in urogenous rheactive arthritis (URA) and peripheral variant of ankylosing spondyloarthritis (PVAS) with signs of urogenital Chlamidia inflammation. Material and methods. 86 pts were examined: 51 with URA (including Reiter’s disease - RD) and 35 with PVAS. Diagnoses of URA, RD and PVAS were definite in all pts. 43 pts received sumamed in total dose of I5g, 43 - maxaquinum - 24g total. Treatment efficacy was assessed according to clinical and laboratory indices changes immediately after the end of treatment and then in 1 and 3 months. Results. Similar significant decrease of swollen and tender joint counf as well as laboratory activity indices accompanied by disappearance of urogenital inflammation signs was seen in URA and PVAS. Conclusion. Antibiotics administration for chlamidiosis is indicated in all cases of URA and PVAS with urogenital inflammation signs.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>урогенный реактивный артрит</kwd><kwd>анкшюзирующий спондшюартрит</kwd><kwd>антибиотикотерапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>urogenital rheactive arthritis</kwd><kwd>ankylosing spondyloarthritis</kwd><kwd>antibiotic therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">&lt;div&gt;&lt;p&gt;Киселева Н.М., Шубин С.В.О дифференциальной диагностике хронического урогенного артрита. Тер. арх., 2000, 5, 52-55.&lt;/p&gt;&lt;p&gt;Сидельникова С.М. Клинико-генетические аспекты реактивных артритов при некоторых кишечных и урогенитальных заболеваниях. Дис. д.м.н. 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М.,1991, 187, 203.&lt;/p&gt;&lt;p&gt;Amor В., Dougados М., Listrat V.Les criteres de spondiloarthropties.Criteres de classification et/on d aide an diagnostic? Rev. Rheumatol., 1995, 61,1, 11-16.&lt;/p&gt;&lt;p&gt;Braun J., Kingsley G., Sieper J. On the difficulties of establishing a consensus on the definition of and diagnostic investigations for reactive arthritis. J. Rheumatol., 2000, 27,9,2185-2192.&lt;/p&gt;&lt;p&gt;Leirisalo-Repo Y. When should reactive arthritis be treated DMARD. Scand. J. Rheum., 2002, 117,3l,abstr. 19.&lt;/p&gt;&lt;p&gt;Li F., Bulbul R., Shumacher H.R. Molecular detection of bacterial DNA in veneral-associated arthritis. Arthr. Rheum., 1996, 39,6. 950-958.&lt;/p&gt;&lt;p&gt;Nanagara R., Li F., Beutler A. et al. Alteration of Chlamydia trachomatis biologic behavior in synovial membranes. Suppression of surface antigen production in reactive arthritis and Reiter's syndrome. Arthr. Rheum., 1995,38, 10, 1410-1417.&lt;/p&gt;&lt;p&gt;Sieper L., Braun J. 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