rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2010-1402rsp-1241Research ArticleСтатьиArticlesСТРОНЦИЯ РАНЕЛАТ В ЛЕЧЕНИИ ОСТЕОПОРОЗА: ДОКАЗАТЕЛЬСТВА ЭФФЕКТИВНОСТИStrontium ranelate in the treatment of osteoporosis: evidence for its efficacyТоропцоваН. В.ToroptsovaN Vepid@irramn.ru <mailto:epid@irramn.ru>КоротковаТ. А.KorotkovaT A-ТоропцоваН. В.ToroptsovaN V-КоротковаТ. А.KorotkovaT A-201015022010481№1 (2010)1923Copyright © Торопцова Н.В., Короткова Т.А., Торопцова Н.В., Короткова Т.А., 20102010Торопцова Н.В., Короткова Т.А., Торопцова Н.В., Короткова Т.А.Toroptsova N.V., Korotkova T.A., Toroptsova N.V., Korotkova T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/1241References<div><p>Hamdy N.A.T. Strontium ranelate: the logical answer for a living tissue. Osteoporos Int 2007;18(1):177-8.</p><p>Reginster J.-Y., Felsenberg D., Boonen S. Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis results of a five-year, randomized, placebo-controlled trial. Arthritis & Rheum 2008;58(6):1687-95.</p><p>Roux C., Fechtenbaum J., Kolta S. et al. Strontium ranelate reduces the risk of vertebral fracture in young postmenopausal women with severe osteoporosis. Ann Rheum Dis 2008;67:1736-8.</p><p>Reginster J.Y., Bruyere O., Sawicki A. et al. Long-term treatment of postmenopausal osteoporosis with strontium ranelate: Results at 8 years. Bone 2009 (PMD:13679207).</p><p>Blake G.M., Foglman I. Long-Term Effect of Strontium Ranelate treatment on BMD. J Bone Mineral Res 2005;20:1901-4.</p><p>Meunier P.J., Slosman D.O., Delmas P.D. et al. Strontium ranelate: Dosedependent effects in established postmenopausal vertebral osteoporosis - a 2-year randomized placebo controlled trial. J Clin Endocrinol Metab 2002;87:2060-6.</p><p>Bruyere O., Roux C., Detilleux J. et al. Relationship between Bone mineral density changes and fracture risk reduction in patients treated with strontium ranelate. J Clin Endocrinol Metab 2007;92:3076-81.</p><p>Ortolani S., Diaz-Curiel M. Strontium ranelate: changes in BMD and bone markers one year after treatment discontinuation. Osteoporos Int 2007;18(1):25.</p><p>Collette J., Reginster J.-Y., Bruyere O. et al. Dissociation between bone formation and bone resorption evidenced by changes in biochemical markers of bone turnover in patients treated with strontium ranelate. Osteoporos Int 2007;18(1):125.</p><p>Choudhary S., Halbout P., Alander C. et al. Strontium ranelate effects on osteoblastic differentiation are associated with PGE2-dependent growth factor production. Osteoporos Int 2007;18(1):167.</p><p>Brennan T.C., Rybchyn M.S., Conigrave A.D., Mason R.S. Strontium ranelate effects on bone formation and bone resorption: an in vitro in human osteoblasts. Osteoporos Int 2007;18(1):166-7.</p><p>Bonnelye E., Chabadel A., Saltel F., Jurdic P. Dual effect of strontium ranelate: Stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone 2008;42:129-38.</p><p>Ammann P., Shen V., Robin B. et al. Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats. J Bone Miner Res 2004;19:2012-20.</p><p>Arlot M. E., Jiang Y., Genant H. K. et al. Histomorphometric and CT analysis of bone biopsies from postmenopausal osteoporotic women treated with strontium ranelate. J Bone Miner Res 2008;23(2):215-22.</p><p>Meunier P.J., Roux C., Seeman E. et al. The effects of strontium ranelate on the risk of vertebral fracture in women with post-menopausal osteoporosis. N Engl J Med 2004;350:459-68.</p><p>Reginster J.Y., Seeman E., De Vernejoul M.C. et al. Strontium ranelate reduces the risk of nonvertebral fractures in post-menopausal women with osteoporosis: treatment of peripheral Osteoporosis (TROPOS) study. J Clin Endocrinol Metab 2005;90:2816-22.</p><p>Boivin G., Khebbab M.T., Jaurand X. et al. Localization of strontium, by X-ray microanalysis cartography, in bone biopsies of postmenopausal osteoporotic women treated for 3 years with strontium ranelate. Osteoporos Int 2007;18(1):165-6.</p><p>Marquis P., Roux C., de la Loge C. et al. Strontium ranelate prevents quality of life impairment in post-menopausal women with established vertebral osteoporosis. Osteoporos Int 2008;19:503-10.</p></div><br /><div><p>Hamdy N.A.T. Strontium ranelate: the logical answer for a living tissue. Osteoporos Int 2007;18(1):177-8.</p><p>Reginster J.-Y., Felsenberg D., Boonen S. Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis results of a five-year, randomized, placebo-controlled trial. Arthritis & Rheum 2008;58(6):1687-95.</p><p>Roux C., Fechtenbaum J., Kolta S. et al. Strontium ranelate reduces the risk of vertebral fracture in young postmenopausal women with severe osteoporosis. Ann Rheum Dis 2008;67:1736-8.</p><p>Reginster J.Y., Bruyere O., Sawicki A. et al. Long-term treatment of postmenopausal osteoporosis with strontium ranelate: Results at 8 years. Bone 2009 (PMD:13679207).</p><p>Blake G.M., Foglman I. Long-Term Effect of Strontium Ranelate treatment on BMD. J Bone Mineral Res 2005;20:1901-4.</p><p>Meunier P.J., Slosman D.O., Delmas P.D. et al. Strontium ranelate: Dosedependent effects in established postmenopausal vertebral osteoporosis - a 2-year randomized placebo controlled trial. J Clin Endocrinol Metab 2002;87:2060-6.</p><p>Bruyere O., Roux C., Detilleux J. et al. Relationship between Bone mineral density changes and fracture risk reduction in patients treated with strontium ranelate. J Clin Endocrinol Metab 2007;92:3076-81.</p><p>Ortolani S., Diaz-Curiel M. Strontium ranelate: changes in BMD and bone markers one year after treatment discontinuation. Osteoporos Int 2007;18(1):25.</p><p>Collette J., Reginster J.-Y., Bruyere O. et al. Dissociation between bone formation and bone resorption evidenced by changes in biochemical markers of bone turnover in patients treated with strontium ranelate. Osteoporos Int 2007;18(1):125.</p><p>Choudhary S., Halbout P., Alander C. et al. Strontium ranelate effects on osteoblastic differentiation are associated with PGE2-dependent growth factor production. Osteoporos Int 2007;18(1):167.</p><p>Brennan T.C., Rybchyn M.S., Conigrave A.D., Mason R.S. Strontium ranelate effects on bone formation and bone resorption: an in vitro in human osteoblasts. Osteoporos Int 2007;18(1):166-7.</p><p>Bonnelye E., Chabadel A., Saltel F., Jurdic P. Dual effect of strontium ranelate: Stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. Bone 2008;42:129-38.</p><p>Ammann P., Shen V., Robin B. et al. Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats. J Bone Miner Res 2004;19:2012-20.</p><p>Arlot M. E., Jiang Y., Genant H. K. et al. Histomorphometric and CT analysis of bone biopsies from postmenopausal osteoporotic women treated with strontium ranelate. J Bone Miner Res 2008;23(2):215-22.</p><p>Meunier P.J., Roux C., Seeman E. et al. The effects of strontium ranelate on the risk of vertebral fracture in women with post-menopausal osteoporosis. N Engl J Med 2004;350:459-68.</p><p>Reginster J.Y., Seeman E., De Vernejoul M.C. et al. Strontium ranelate reduces the risk of nonvertebral fractures in post-menopausal women with osteoporosis: treatment of peripheral Osteoporosis (TROPOS) study. J Clin Endocrinol Metab 2005;90:2816-22.</p><p>Boivin G., Khebbab M.T., Jaurand X. et al. Localization of strontium, by X-ray microanalysis cartography, in bone biopsies of postmenopausal osteoporotic women treated for 3 years with strontium ranelate. Osteoporos Int 2007;18(1):165-6.</p><p>Marquis P., Roux C., de la Loge C. et al. Strontium ranelate prevents quality of life impairment in post-menopausal women with established vertebral osteoporosis. Osteoporos Int 2008;19:503-10.</p></div><br />
The authors declare that there are no conflicts of interest present.