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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1995-4484-2014-423-429</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-1965</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРОГРАММА НЕПРЕРЫВНОГО ПОСЛЕДИПЛОМНОГО ОБРАЗОВАНИЯ ВРАЧЕЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>POSTGRADUATE PROGRAM OF CONTINUING MEDICAL EDUCATION</subject></subj-group></article-categories><title-group><article-title>Глюкокортикоидный остеопороз: диагностика, профилактика и лечение</article-title><trans-title-group xml:lang="en"><trans-title>GLUCOCORTICOID-INDUCED OSTEOPOROSIS: DIAGNOSIS, PREVENTION, AND TREATMENT</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Торопцова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Toroptsova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>заведующая лабораторией остеопороза отдела метаболических заболеваний костей и суставов с центром профилактики остеопороза Минздрава РоссииФГБНУ НИИР им. В.А. Насоновой, докт. мед. наук</p></bio><email xlink:type="simple">epid@irramn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>02</day><month>09</month><year>2014</year></pub-date><volume>52</volume><issue>4</issue><fpage>423</fpage><lpage>429</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Торопцова Н.В., 2014</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="ru">Торопцова Н.В.</copyright-holder><copyright-holder xml:lang="en">Toroptsova N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/1965">https://rsp.mediar-press.net/rsp/article/view/1965</self-uri><abstract><p>В лекции приведены сведения об эпидемиологии и патогенезе глюкокортикоидного остеопороза (ГК-ОП). Представлены последние критерии диагностики, модифицированный алгоритм FRAX  оценка 10-летней вероятности остеопоретического перелома) в зависимости от принимаемой дозы глюкокортикоидов (ГК), данные последних клинических рекомендаций по лечению и профилактике ГК-ОП, особенностям ведения больных в зависимости от возраста пациента.</p></abstract><trans-abstract xml:lang="en"><p>The lecture gives information on the epidemiology and pathogenesis of glucocorticoid-induced osteoporosis (GCOP). It presents the latest diagnostic criteria, a modified FRAX algorithm (assessment of 10-year osteoporotic fracture risk) in relation to the taken dose of glucocorticoids, the data of recent clinical guidelines for the treatment and prevention of GCOP, and the specific features in relation to patient age.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>глюкокортикоидный остеопороз</kwd><kwd>остеопоретические переломы</kwd><kwd>бисфосфонаты</kwd><kwd>алгоритм FRAX</kwd><kwd>клинические рекомендации</kwd></kwd-group><kwd-group xml:lang="en"><kwd>glucocorticoid-induced osteoporosis</kwd><kwd>osteoporotic fractures</kwd><kwd>bisphosphonates</kwd><kwd>FRAX algorithm</kwd><kwd>clinical guidelines</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Cushing H. The basophilic adenomas of the pituitary body and their clinical manifestations (pituitary asophilism). Bull Johns Hopkins Hosp. 1932;(1):137–92.</mixed-citation><mixed-citation xml:lang="en">Cushing H. The basophilic adenomas of the pituitary body and their clinical manifestations (pituitary asophilism). Bull Johns Hopkins Hosp. 1932;(1):137–92.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Kanis JA, Johansson H, Oden A, et al. A meta-analysis of prior corticosteroid use and fracture risk. J Bone Miner Res. 2004;19(6):893–9. Epub 2004 Jan 27. DOI:http://dx.doi.org/10.1359/JBMR.040134.</mixed-citation><mixed-citation xml:lang="en">Kanis JA, Johansson H, Oden A, et al. A meta-analysis of prior corticosteroid use and fracture risk. J Bone Miner Res. 2004;19(6):893–9. Epub 2004 Jan 27. DOI:http://dx.doi.org/10.1359/JBMR.040134.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Diez-Perez A, Hooven FH, Adachi JD, et al. Regional differences in treatment for osteoporosis. The Global Longitudinal Study of Osteoporosis in Women (GLOW). Bone. 2011;49(3):493–8. DOI: 10.1016/j.bone.2011.05.007. Epub 2011 May 14.</mixed-citation><mixed-citation xml:lang="en">Diez-Perez A, Hooven FH, Adachi JD, et al. Regional differences in treatment for osteoporosis. The Global Longitudinal Study of Osteoporosis in Women (GLOW). Bone. 2011;49(3):493–8. DOI: 10.1016/j.bone.2011.05.007. Epub 2011 May 14.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Angeli A, Guglielmi G, Dovio A, et al. High prevalence of asymptomatic vertebral fractures in post-menopausal women receiving chronic glucocorticoid therapy: a cross-sectional outpatient study. Bone. 2006;39(2):253–9. Epub 2006 Mar 30. DOI: http://dx.doi.org/10.1016/j.bone.2006.02.005.</mixed-citation><mixed-citation xml:lang="en">Angeli A, Guglielmi G, Dovio A, et al. High prevalence of asymptomatic vertebral fractures in post-menopausal women receiving chronic glucocorticoid therapy: a cross-sectional outpatient study. Bone. 2006;39(2):253–9. Epub 2006 Mar 30. DOI: http://dx.doi.org/10.1016/j.bone.2006.02.005.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Van Staa TP, Leufkens HG, Abenhaim L, et al. Oral corticosteroids and fracture risk: relationship to daily and cumulative doses. Rheumatology (Oxford). 2000;39(12):1383–9. DOI: http://dx.doi.org/10.1093/rheumatology/39.12.1383.</mixed-citation><mixed-citation xml:lang="en">Van Staa TP, Leufkens HG, Abenhaim L, et al. Oral corticosteroids and fracture risk: relationship to daily and cumulative doses. Rheumatology (Oxford). 2000;39(12):1383–9. DOI: http://dx.doi.org/10.1093/rheumatology/39.12.1383.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Steinbuch M, Youket TE, Cohen S. Oral glucocorticoid use is associated with an increased risk of fracture. Osteoporos Int. 2004;15(4):323–8. DOI: http://dx.doi.org/10.1007/s00198-003- 1548-3. Epub 2004 Feb 5.</mixed-citation><mixed-citation xml:lang="en">Steinbuch M, Youket TE, Cohen S. Oral glucocorticoid use is associated with an increased risk of fracture. Osteoporos Int. 2004;15(4):323–8. DOI: http://dx.doi.org/10.1007/s00198-003- 1548-3. Epub 2004 Feb 5.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Van Staa TP, Laan RF, Barton IP, et al. Bone density threshold and ther predictors of vertebral fracture in patients receiving oral glucocorticoid therapy. Arthritis Rheum. 2003 Nov;48(11):3224–9. DOI: http://dx.doi.org/10.1002/art.11283.</mixed-citation><mixed-citation xml:lang="en">Van Staa TP, Laan RF, Barton IP, et al. Bone density threshold and ther predictors of vertebral fracture in patients receiving oral glucocorticoid therapy. Arthritis Rheum. 2003 Nov;48(11):3224–9. DOI: http://dx.doi.org/10.1002/art.11283.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Hofbauer LC, Gori F, Riggs BL, et al. Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoids-induced osteoporosis. Endocrinology. 1999;140(10):4382–9.</mixed-citation><mixed-citation xml:lang="en">Hofbauer LC, Gori F, Riggs BL, et al. Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoids-induced osteoporosis. Endocrinology. 1999;140(10):4382–9.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Gulko PS, Mulloy AL. Glucocorticoid-induced osteoporosis: pathogenesis, prevention and treatment. Clin Exp Rheumatol. 1996;14(2):199–206.</mixed-citation><mixed-citation xml:lang="en">Gulko PS, Mulloy AL. Glucocorticoid-induced osteoporosis: pathogenesis, prevention and treatment. Clin Exp Rheumatol. 1996;14(2):199–206.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Лесняк ОМ, Баранова ИА, Торопцова НВ. Клинические рекомендации: диагностика, профилактика и лечение глюкокортикоидного остеопороза у мужчин и женщин 18 лет и старше. Ярославль: Литера; 2013. 48 с. [Lesnyak OM, Baranova IA, Toroptsova NV. Klinicheskie rekomendatsii: iagnostika, profilaktika i lechenie glyukokortikoidnogo osteoporoza u muzhchin i zhenshchin 18 let i starshe [Clinical recommendations: diagnostics, prevention and treatment of glucocorticoid osteoporosis at men and women of 18 years also is more senior]. Yaroslavl': Litera; 2013. 48 p.]</mixed-citation><mixed-citation xml:lang="en">Лесняк ОМ, Баранова ИА, Торопцова НВ. Клинические рекомендации: диагностика, профилактика и лечение глюкокортикоидного остеопороза у мужчин и женщин 18 лет и старше. Ярославль: Литера; 2013. 48 с. [Lesnyak OM, Baranova IA, Toroptsova NV. Klinicheskie rekomendatsii: iagnostika, profilaktika i lechenie glyukokortikoidnogo osteoporoza u muzhchin i zhenshchin 18 let i starshe [Clinical recommendations: diagnostics, prevention and treatment of glucocorticoid osteoporosis at men and women of 18 years also is more senior]. Yaroslavl': Litera; 2013. 48 p.]</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kanis JA, Johansson H, Oden A, McCloskey E. Guidance for the adjustment of FRAX according to the dose of glucocorticoids. Osteoporos Int. 2011;22(3):809–16. DOI: 10.1007/s00198-010-1524-7. Epub 2011 Jan 13.</mixed-citation><mixed-citation xml:lang="en">Kanis JA, Johansson H, Oden A, McCloskey E. Guidance for the adjustment of FRAX according to the dose of glucocorticoids. Osteoporos Int. 2011;22(3):809–16. DOI: 10.1007/s00198-010-1524-7. Epub 2011 Jan 13.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Adachi JD, Saag KG, Delmas PD, et al. Two-year effects of alendronate on bone mineral density and vertebral fracture in patients receiving glucocorticoids: a randomized, double-blind, lacebocontrolled extension trial. Arthritis Rheum. 2001;44(1):202–11. DOI: http://dx.doi.org/10.1002/1529-0131(200101)44:1%3C202::AID-ANR27%3E3.0.CO;2-W.</mixed-citation><mixed-citation xml:lang="en">Adachi JD, Saag KG, Delmas PD, et al. Two-year effects of alendronate on bone mineral density and vertebral fracture in patients receiving glucocorticoids: a randomized, double-blind, lacebocontrolled extension trial. Arthritis Rheum. 2001;44(1):202–11. DOI: http://dx.doi.org/10.1002/1529-0131(200101)44:1%3C202::AID-ANR27%3E3.0.CO;2-W.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">De Nijs RN, Jacobs JW, Lems WF, et al.; STOP Investigators. Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis. N Engl J Med. 2006;355(7):675–84. DOI: http://dx.doi.org/10.1056/NEJMoa053569.</mixed-citation><mixed-citation xml:lang="en">De Nijs RN, Jacobs JW, Lems WF, et al.; STOP Investigators. Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis. N Engl J Med. 2006;355(7):675–84. DOI: http://dx.doi.org/10.1056/NEJMoa053569.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Reid DM, Hughes RA, Laan RF, et al. Efficacy and safety of daily risedronate in the treatment of corticosteroidinduced osteoporosis in men and women: a randomized trial. European Corticosteroid- Induced Osteoporosis Treatment Study. J Bone Miner Res. 2000;15(6):1006–13. DOI: http://dx.doi.org/10.1359/jbmr.2000.15.6.1006.</mixed-citation><mixed-citation xml:lang="en">Reid DM, Hughes RA, Laan RF, et al. Efficacy and safety of daily risedronate in the treatment of corticosteroidinduced osteoporosis in men and women: a randomized trial. European Corticosteroid- Induced Osteoporosis Treatment Study. J Bone Miner Res. 2000;15(6):1006–13. DOI: http://dx.doi.org/10.1359/jbmr.2000.15.6.1006.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Wallach S, Cohen S, Reid DM, et al. Effects of risedronate treatment on bone density and vertebral fracture in patients on corticosteroid therapy. Calcif Tissue Int. 2000;67(4):277–85. DOI: http://dx.doi.org/10.1007/s002230001146.</mixed-citation><mixed-citation xml:lang="en">Wallach S, Cohen S, Reid DM, et al. Effects of risedronate treatment on bone density and vertebral fracture in patients on corticosteroid therapy. Calcif Tissue Int. 2000;67(4):277–85. DOI: http://dx.doi.org/10.1007/s002230001146.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Reid DM, Devogelaer JP, Saag K, et al.; HORIZON investigators. Zoledronic acid and risedronate in the prevention and treatment of glucocorticoidinduced osteoporosis (HORIZON): a multicentre, double-blind, double-dummy, randomised controlled trial. Lancet. 2009;373(9671):1253–63. DOI: 10.1016/S0140-6736(09)60250-6.</mixed-citation><mixed-citation xml:lang="en">Reid DM, Devogelaer JP, Saag K, et al.; HORIZON investigators. Zoledronic acid and risedronate in the prevention and treatment of glucocorticoidinduced osteoporosis (HORIZON): a multicentre, double-blind, double-dummy, randomised controlled trial. Lancet. 2009;373(9671):1253–63. DOI: 10.1016/S0140-6736(09)60250-6.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Saag KG, Shane E, Boonen S,et al. Teriparatide or alendronate in glucocorticoid-induced osteoporosis. N Engl J Med. 2007;357(20):2028–39. DOI: http://dx.doi.org/10.1056/NEJMoa071408.</mixed-citation><mixed-citation xml:lang="en">Saag KG, Shane E, Boonen S,et al. Teriparatide or alendronate in glucocorticoid-induced osteoporosis. N Engl J Med. 2007;357(20):2028–39. DOI: http://dx.doi.org/10.1056/NEJMoa071408.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Saag KG, Zanchetta JR, Devogelaer JP, et al. Effects of teriparatide versus alendronate for treating glucocorticoid-induced osteoporosis: thirty-six-month results of a randomized, doubleblind, controlled trial. Arthritis Rheum. 2009;60(11):3346–55. DOI: 10.1002/art.24879.</mixed-citation><mixed-citation xml:lang="en">Saag KG, Zanchetta JR, Devogelaer JP, et al. Effects of teriparatide versus alendronate for treating glucocorticoid-induced osteoporosis: thirty-six-month results of a randomized, doubleblind, controlled trial. Arthritis Rheum. 2009;60(11):3346–55. DOI: 10.1002/art.24879.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Compston J, Reid DM, Boisdron J, et al.; Group for the Respect of Ethics and Excellence in Science. Recommendations for the registration of agents for prevention and treatment of lucocorticoid- induced osteoporosis: an update from the Group for the Respect of Ethics and Excellence in Science. Osteoporos Int. 2008;19(9):1247–50. DOI: 10.1007/s00198-008-0670-7. Epub 2008 Jul 5.</mixed-citation><mixed-citation xml:lang="en">Compston J, Reid DM, Boisdron J, et al.; Group for the Respect of Ethics and Excellence in Science. Recommendations for the registration of agents for prevention and treatment of lucocorticoid- induced osteoporosis: an update from the Group for the Respect of Ethics and Excellence in Science. Osteoporos Int. 2008;19(9):1247–50. DOI: 10.1007/s00198-008-0670-7. Epub 2008 Jul 5.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">De Nijs RN, Jacobs JW, Lems WF, et al.; Investigators STOP. Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis. N Engl J Med. 2006;355(20):675–84. DOI: http://dx.doi.org/10.1056/NEJMoa053569.</mixed-citation><mixed-citation xml:lang="en">De Nijs RN, Jacobs JW, Lems WF, et al.; Investigators STOP. Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis. N Engl J Med. 2006;355(20):675–84. DOI: http://dx.doi.org/10.1056/NEJMoa053569.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">De Nijs RN, Jacobs JW, Algra A, et al. Prevention and treatment of glucocorticoid-induced osteoporosis with active vitamin D3 analogues: a review with metaanalysis of randomized controlled trials including organ transplantation studies. Osteoporos Int. 2004 Aug;15(8):589–602. DOI: http://dx.doi.org/10.1007/s00198-004-1614-5.</mixed-citation><mixed-citation xml:lang="en">De Nijs RN, Jacobs JW, Algra A, et al. Prevention and treatment of glucocorticoid-induced osteoporosis with active vitamin D3 analogues: a review with metaanalysis of randomized controlled trials including organ transplantation studies. Osteoporos Int. 2004 Aug;15(8):589–602. DOI: http://dx.doi.org/10.1007/s00198-004-1614-5.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Roux C, Reid DM, Devogelaer JP, et al. Post hoc analysis of a single IV infusion of zoledronic acid versus daily oral risedronate on lumbar spine bone mineral density in different subgroups with glucocorticoid-induced osteoporosis. Osteoporos Int. 2011;23(3):1083–90. DOI: 10.1007/s00198-00011-01800-00191.</mixed-citation><mixed-citation xml:lang="en">Roux C, Reid DM, Devogelaer JP, et al. Post hoc analysis of a single IV infusion of zoledronic acid versus daily oral risedronate on lumbar spine bone mineral density in different subgroups with glucocorticoid-induced osteoporosis. Osteoporos Int. 2011;23(3):1083–90. DOI: 10.1007/s00198-00011-01800-00191.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Langdahl BL, Marin F, Shane E, et al. Teriparatide versus alendronate for treating glucocorticoid-induced osteoporosis: an analysis by gender and menopausal status. Osteoporos Int. 2009;20(12):2095–104. DOI: 10.1007/s00198-009-0917-y. Epub 2009 Apr 7.</mixed-citation><mixed-citation xml:lang="en">Langdahl BL, Marin F, Shane E, et al. Teriparatide versus alendronate for treating glucocorticoid-induced osteoporosis: an analysis by gender and menopausal status. Osteoporos Int. 2009;20(12):2095–104. DOI: 10.1007/s00198-009-0917-y. Epub 2009 Apr 7.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Yeap SS, Fauzi AR, Kong NC, et al. A comparison of calcium, calcitriol, and alendronate in corticosteroid-treated premenopausal patients with systemic lupus erythematosus. J Rheumatol. 2008;35(12):2344–7. DOI: 10.3899/jrheum.080634. Epub 2008 Nov 1.</mixed-citation><mixed-citation xml:lang="en">Yeap SS, Fauzi AR, Kong NC, et al. A comparison of calcium, calcitriol, and alendronate in corticosteroid-treated premenopausal patients with systemic lupus erythematosus. J Rheumatol. 2008;35(12):2344–7. DOI: 10.3899/jrheum.080634. Epub 2008 Nov 1.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
