References

rsp

Научно-практическая ревматология

Rheumatology Science and Practice

1995-44841995-4492

IMA-PRESS, LLC

10.14412/1995-4484-2014-669-677

rsp-2013

Research Article

ОБЗОР

REVIEW

Влияние терапии генно-инженерными биологическими препаратами на костную ткань больных ревматоидным артритом

IMPACT OF BIOLOGICAL THERAPY ON BONE IN PATIENTS WITH RHEUMATOID ARTHRITIS

Дыдыкина

П. С.

Dydykina

P. S.

polina_dydykina@mail.ru

Дыдыкина

И. С.

Dydykina

I. S.

Насонов

Е. Л.

Nasonov

E. L.

ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой, Москва, Россия 115522, Москва, Каширское шоссе, 34АРоссияV.A. Nasonova Research Institute of Rheumatology, Moscow, Russia 34A, Kashirskoe Shosse, Moscow 115522Russian Federation

2014

17122014

526669677

2014

Дыдыкина П.С., Дыдыкина И.С., Насонов Е.Л.

Dydykina P.S., Dydykina I.S., Nasonov E.L.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://rsp.mediar-press.net/rsp/article/view/2013

Представлены современные данные литературы о влиянии генно-инженерных биологических препаратов (ГИБП) на минеральную плотность кости, костный обмен и ремоделирование костной ткани при ревматоидном артрите (РА). Благодаря высокой эффективности эти препараты широко используются при лечении больных РА. Поскольку заметную роль в патогенезе РА играет локальная и генерализованная резорбция и деструкция костной ткани, изучение вопроса о влиянии ГИБП на костную ткань может представлять существенный интерес. При взаимодействии иммунной и костной систем под влиянием различных провоспалительных цитокинов происходит активация остеокластогенеза. Установлено, что ингибирование провоспалительных цитокинов не только уменьшает воспаление суставов, но и препятствует развитию локального и генерализованного остеопороза. В настоящем обзоре обсуждаются результаты этих работ и вопросы будущих исследований.

The paper gives the data currently available in the literature on the impact of biological agents (BA) on bone mineral density, metabolism, and remodeling in rheumatoid arthritis (RA). These agents, by virtue of their high efficacy, are widely used to treat patients with RA. Since localized and generalized bone resorption and destruction play a prominent role in its pathogenesis, an investigation of the effect of BA on bone may be of essential interest. Activated osteoclastogenesis occurs because of an interaction between the immune and bone systems under the influence of different proinflammatory cytokines. The inhibition of the latter has been ascertained to not only reduce joint inflammation, but also to prevent localized and generalized osteoporosis. This review discusses the results of these trials and the issues of further investigations.

ревматоидный артритвторичный остеопорозминеральная плотность костипровоспалительные цитокиныгенно-инженерные биологические препараты

rheumatoid arthritissecondary osteoporosisbone mineral densityproinflammatory cytokinesbiological agents

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The authors declare that there are no conflicts of interest present.