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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1995-4484-2015-38-44</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-2036</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Обеспеченность витаминами и кальцием при ревматоидном артрите: оценка по потреблению и концентрации в плазме крови</article-title><trans-title-group xml:lang="en"><trans-title>PROVISION OF VITAMINS AND CALCIUM IN RHEUMATOID ARTHRITIS: ESTIMATION OF INTAKE AND PLASMA CONCENTRATIONS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ходырев</surname><given-names>В. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Khodyrev</surname><given-names>V. N.</given-names></name></name-alternatives><email xlink:type="simple">vitalykhodyrev@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мартинчик</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Martinchik</surname><given-names>A. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лесняк</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lesnyak</surname><given-names>O. M.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бекетова</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Beketova</surname><given-names>N. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коденцова</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kodentsova</surname><given-names>V. M.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кошелева</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosheleva</surname><given-names>O. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вржесинская</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vrzhesinskaya</surname><given-names>O. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Спиричев</surname><given-names>В. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Spirichev</surname><given-names>V. B.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО «Уральский государственный медицинский университет» Минздрава России; 620028 Екатеринбург, ул. Репина, 3;</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ural State Medical University; 3, Repin St., Yekaterinburg, 620028</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Научно- исследовательский институт питания»; 109240, Москва, Устьинский проезд, 2/14</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute of Nutrition; 2/14 Ustyinsky Proezd, Moscow, 109240</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>12</day><month>03</month><year>2015</year></pub-date><volume>53</volume><issue>1</issue><fpage>38</fpage><lpage>44</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ходырев В.Н., Мартинчик А.Н., Лесняк О.М., Бекетова Н.А., Коденцова В.М., Кошелева О.В., Вржесинская О.А., Спиричев В.Б., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Ходырев В.Н., Мартинчик А.Н., Лесняк О.М., Бекетова Н.А., Коденцова В.М., Кошелева О.В., Вржесинская О.А., Спиричев В.Б.</copyright-holder><copyright-holder xml:lang="en">Khodyrev V.N., Martinchik A.N., Lesnyak O.M., Beketova N.A., Kodentsova V.M., Kosheleva O.V., Vrzhesinskaya O.A., Spirichev V.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/2036">https://rsp.mediar-press.net/rsp/article/view/2036</self-uri><abstract><p>Целью исследования явилось изучение фактического потребления витаминов и кальция и обеспеченности ими при ревматоидном артрите (РА) на Среднем Урале. Материал и методы. Методом «случай–контроль» сформировано 150 пар больных РА в возрасте 55,31±11,3 года. Фактическое питание изучалось по частоте потребления пищевых продуктов в течение месяца с использованием анкеты. На основании полученных данных потребления пищи рассчитывали суточное потребление витаминов А, В2, С, Е, β-каротина и кальция. В 40% случайной выборки больных и у 68 (45%) человек в контроле определено содержание этих витаминов в плазме крови. В комплекс клинического обследования больных входили оценка общего состояния и суставного статуса, определение степени активности воспалительного процесса по DAS28, лабораторные исследования (общий анализ крови и мочи, определение уровней трансаминаз, креатинина, электролитов, С-реактивного белка и ревматоидного фактора) и инструментальное обследование, включая электрокардиографию и рентгенографию суставов. Результаты и обсуждение. Исследование показало, что фактическое питание больных РА по сравнению с контролем обеднено витаминами А, С, В2. При РА выявлена недостаточная обеспеченность по витамину С, β-каротину, рибофлавину и кальцию. Несоответствие между потреблением витаминов С, В2 и β-каротина и их уровнем в плазме крови позволило предположить повышенную потребность в этих нутриентах при РА. Полученные нами данные подлежат детальному изучению, прежде всего это касается сопоставления потребления нутриентов и обеспеченности ими с важнейшими клиническими характеристиками РА: длительностью, прогрессированием и активностью, рентгенологической стадией и наличием ревматоидного фактора. Знание этих вопросов позволило бы, по нашему мнению, улучшить результаты базисной терапии и прогноз при РА. </p></abstract><trans-abstract xml:lang="en"><p>Objective: to study the actual intake of vitamins and calcium and their provision in rheumatoid arthritis (RA) in the Middle Urals. Subjects and methods. The case-control method was used to form 150 pairs of RA patients aged 55.31±11.3 years. Their actual nutrition was studied from the frequency of food intake for a month, by applying a questionnaire. Based on the obtained food consumption data, the authors calculated the daily intake of vitamins A, B2, C, E, β-carotene, and calcium. The plasma levels of these factors were measured in 40% of the random patient sample and in 68 (45%) control persons. A complete clinical examination included the evaluation of patients' general health and articular status, inflammatory activity assessment with DAS28, laboratory tests (general blood and urine analyses, estimation of the levels of transaminases, creatinine, electrolytes, C-reactive protein, and rheumatoid factor), and instrumental examination, involving electrocardiography and joint X-ray. Results and discussion. The study demonstrated that actual nutrition was depleted of vitamins A, C, and B2 in the patients with RA as compared to the controls. Inadequate provision of vitamin C, β-carotene, riboflavin, and calcium was found in RA. The inconsistency between the consumption of vitamins C, B2, and β-carotene and their plasma levels could suggest increased demands for these nutrients in RA. The findings should undergo detailed studies; first of all, this concerns the comparison of intake of the nutrients and their provision with the most important clinical characteristics of RA, such as duration, progression, activity, X-ray stage, and the presence of rheumatoid factor. The knowledge of these matters could, in our opinion, improve the results of therapy and prognosis in RA.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ревматоидный артрит</kwd><kwd>витамины</kwd><kwd>потребление</kwd><kwd>обеспеченность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rheumatoid arthritis</kwd><kwd>vitamins</kwd><kwd>consumption</kwd><kwd>provision</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов ЕЛ, Каратеев ДЕ, Балабанова РМ. Ревматоидный артрит. В кн.: Ревматология. Национальное руководство. Под. ред. Е.Л. Насонова, В.А. Насоновой. Москва: ГЭОТАР-Медиа; 2008. С. 290–331. [Nasonov EL, Karateev DE, Balabanova RM. Rheumatoid arthritis. In: Revmatologiya. Natsional'noe rukovodstvo [Rheumatology. National Guide]. Nasonov EL, Nasonova VA, ediors. Moscow: GEOTAR-media; 2008. 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