rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2015-84-93rsp-2043Research ArticleПЕДИАТРИЧЕСКАЯ РЕВМАТОЛОГИЯPEDIATRIC RHEUMATOLOGYСовременная фармакотерапия системного ювенильного артритаCURRENT PHARMACOTHERAPY FOR SYSTEMIC JUVENILE ARTHRITISНикишинаИ. П.NikishinaI. P.irpetnik@yandex.ruКаледаМ. И.KaledaM. I.ФГБНУ Научно- исследовательский институт ревматологии им. В.А. Насоновой, Москва, Россия 115522 Москва, Каширское шоссе, 34АРоссияV.A. Nasonova Research Institute of Rheumatology, Moscow, Russia 34A, Kashirskoe Shosse, Moscow 115522Russian Federation2015120320155318493Copyright © Никишина И.П., Каледа М.И., 20152015Никишина И.П., Каледа М.И.Nikishina I.P., Kaleda M.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2043

Системный вариант ювенильного артрита (сЮА) входит в число самых тяжелых соматических заболеваний детского возраста. Актуальность проблемы сЮА определяется трудностью ранней диагностики, быстрым развитием инвалидности, неблагоприятным прогнозом с высоким риском развития жизнеугрожающих состояний. Она сохраняется, несмотря на значительные успехи фармакотерапии, позволившие существенно изменить прогноз сЮА. Использование базисных противовоспалительных препаратов (БПВП), а затем и появление генно-инженерных биологических препаратов (ГИБП) принципиально изменили лекарственную модель, применяемую для лечения сЮА. В статье рассмотрены аспекты применения при сЮА различных БПВП и ГИБП с позиций доказательной медицины на основе анализа литературных данных. 

Systemic juvenile arthritis (sJA) is one of the severest childhood somatic diseases. The relevance of the problem associated with sJA is determined by difficulties in early diagnosis, by the rapid development of disability, and by poor prognosis with a high risk for life-threatening conditions. It still persists despite the fact that a notable advance has been made in pharmacotherapy, which could substantially change the prognosis of sJA. The use of disease-modifying anti-rheumatic drugs (DMARDs) and then the advent of biological agents (BAs) have fundamentally changed the drug regimen for the treatment of sJA. The paper considers the aspects of using different DMARDs and BAs in sJA in the context of evidence-based medicine, by analyzing the data available in the literature. 

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The authors declare that there are no conflicts of interest present.