rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2015-204-213rsp-2077Research ArticleПЕДИАТРИЧЕСКАЯ РЕВМАТОЛОГИЯPEDIATRIC RHEUMATOLOGYЭФФЕК ТИВНОСТЬ И БЕЗОПАСНОСТЬ ТОЦИЛИЗУМАБА У ДЕТЕЙ С СИСТЕМНЫМ ВАРИАНТОМ ЮВЕНИЛЬНОГО АРТРИТА В КЛИНИЧЕСКОЙ ПРАКТИКЕEFFICACY AND SAFETY OF TOCILIZUMAB IN CHILDREN WITH SYSTEMIC JUVENILE ARTHRITIS IN CLINICAL PRACTICEКаледаМ. И.KaledaM. I.

Контакты: Мария Игоревна Каледа; kaleda-mi@yandex.ru

Contact: Maria Kaleda; kaleda-mi@yandex.ru

kaleda-mi@yandex.ruНикишинаИ. П.NikishinaI. P.kaleda-mi@yandex.ruНаучно- исследовательский институт ревматологии им. В.А. Насоновой, МоскваРоссияV.A. Nasonova Research Institute of Rheumatology, MoscowRussian Federation201529042015532204213Copyright © Каледа М.И., Никишина И.П., 20152015Каледа М.И., Никишина И.П.Kaleda M.I., Nikishina I.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2077

Представлены результаты проспективного исследования эффективности и безопасности терапии тоцилизумабом (ТЦЗ) системного  ювенильного артрита. Проанализировано влияние  на эффективность терапии таких факторов, как возраст дебюта заболевания, длительность заболевания на момент начала терапии ТЦЗ, число системных проявлений и активность  суставного синдрома, предшествующий опыт применения других генноинженерных биологических препаратов. Кроме того, проведен анализ безопасности длительного  применения ТЦЗ, причин отмены и возможности возобновления терапии,  путей повышения эффективности лечения. 

The paper presents the results of a prospective trial of the efficiency and safety of tocilizumab (TCZ) therapy for sys- temic juvenile arthritis. It analyzes the impact of factors, such as age at onset of the disease, its duration at the time of TCZ therapy initiation,  the number of systemic manifestations, activity of arthritis, and previous experience in using other biological agents, on the efficiency of the therapy. Moreover, the safety of long-term  TCZ usage, reasons for dis- continuation of the therapy, its resumption  possibilities, and ways of enhancing  therapeutic  effectiveness are analyzed.

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The authors declare that there are no conflicts of interest present.