rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2015-336-341rsp-2099Research ArticleНАБЛЮДЕНИЯ ИЗ ПРАКТИКИCLINICAL NOTESОпыт клинического применения устекинумаба в лечении раннего псориатического артрита в рамках стратегии лечения до достижения целиCLINICAL EXPERIENCE WITH USTEKINUMAB IN THE TREATMENT OF EARLY PSORIATIC ARTHRITIS USING TREAT-TO-TARGET STRATEGYЛогиноваЕ. Ю.LoginovaE. Yu.eyloginova@mail.ruКоротаеваТ. В.KorotaevaT. V.КаратеевД. Е.KarateevD. E.НасоновЕ. Л.NasonovE. L.ФГБНУ Научно- исследовательский институт ревматологии им. В.А. Насоновой, Москва, Россия 115522 Москва, Каширское шоссе, 34АРоссияV.A. Nasonova Research Institute of Rheumatology, Moscow, Russia 34A, Kashirskoe Shosse, Moscow 115522Russian Federation201510092015533336341Copyright © Логинова Е.Ю., Коротаева Т.В., Каратеев Д.Е., Насонов Е.Л., 20152015Логинова Е.Ю., Коротаева Т.В., Каратеев Д.Е., Насонов Е.Л.Loginova E.Y., Korotaeva T.V., Karateev D.E., Nasonov E.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2099

Новая стратегия в терапии раннего псориатического артрита (ПсА) – лечение до достижения цели (Treat to Target – Т2Т) – направлена на достижение ремиссии или низкой активности болезни. В настоящее время для лечения псориаза и ПсА применяется новый генно-инженерный биологический препарат устекинумаб (УСТ) – моноклональные антитела к интерлейкину (ИЛ) 12/23. В статье представлены клинические наблюдения эффективности УСТ при раннем ПсА в рамках стратегии Т2Т. Представленные клинические случаи демонстрируют, что при раннем ПсА с умеренной и высокой активностью применение УСТ в дозе 45 мг способствует уменьшению проявлений периферического артрита, псориаза как в режиме монотерапии, так и в комбинации с метотрексатом, способствуя быстрому достижению ремиссии или минимальной активности болезни. В целом УСТ хорошо переносится больными.

The new Treat-to-Target (T2T) strategy in the treatment of early psoriatic arthritis (PsA) is aimed at achieving remission or low disease activity. As of now, the new biological agent ustekinumb (UST), anti-interleukin (IL) 12/23 monoclonal antibodies, was used to treat psoriasis and PsA. The paper presents clinical observations of the efficacy of UST in early PsA treated according T2T strategy. The described clinical cases demonstrate that use of UST 45 mg both alone and in combination with methotrexate for early PsA with moderate and high activity reduced manifestations of peripheral arthritis and psoriasis, promoting rapid achievement of remission or minimal disease activity. Overall, UST is well tolerated by the patients.

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The authors declare that there are no conflicts of interest present.