rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2016-60-77rsp-2171Research ArticleПРОГРЕСС В РЕВМАТОЛОГИИ В XXI ВЕКЕPROGRESS IN RHEUMATOLOGY IN THE XXI CENTURYРоль интерлейкина 1 в развитии заболеваний человекаROLE OF INTERLEUKIN 1 IN THE DEVELOPMENT OF HUMAN DISEASESНасоновЕ. Л.NasonovE. L.

директор ФГБНУ НИИР им. В.А. Насоновой, академик РАН, докт. мед. наук, профессор,

115522 Москва, Каширское шоссе, 34А,

119991 Москва, ул. Трубецкая, 8, стр. 2

34A, Kashirskoe Shosse, Moscow 115522;

8, Trubetskaya St., Build. 2, Moscow 119991

sokrat@irramn.ruЕлисеевМ. С.EliseevM. S.

зав. лабораторией микрокристаллических артритов, канд. мед. наук,

115522 Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой; ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaRussian FederationФГБНУ Научно-исследовательский институт ревматологии им. В.А. НасоновойРоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation2016230320165416077Copyright © Насонов Е.Л., Елисеев М.С., 20162016Насонов Е.Л., Елисеев М.С.Nasonov E.L., Eliseev M.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2171

Иммуновоспалительные заболевания человека в зависимости от преобладающих механизмов активации иммунитета разделяются на две основные категории: аутоиммунные и аутовоспалительные. В то же время между аутоиммунными и аутовоспалительными заболеваниями много общего в отношении как спектра клинических проявлений, так и «триггерных» внешнесредовых, эпигенетических и генетических факторов, медиаторов воспаления, тканевого повреждения и подходов к фармакотерапии. Предполагается, что гиперпродукция «провоспалительного» цитокина – интерлейкина 1 (ИЛ1) – во многом определяет «перекрест» между аутоиммунитетом и аутовоспалением, характерный для многих иммуновоспалительных заболеваний. Изучение роли ИЛ1 в регуляции взаимодействия между врожденным (активация Toll-подобных рецепторов, инфламмасомы) и приобретенным (Th1- и Th17-типы иммунного ответа) иммунитетом и эффективности ингибиторов ИЛ1 может иметь важное значение в плане расшифровки патогенетических механизмов иммуно-воспалительных заболеваний человека и разработки новых подходов к персонифицированной терапии.

According to the predominant mechanisms of immunity activation, human inflammatory diseases are divided into two main categories: autoimmune and autoinflammatory ones. At the same time, the autoimmune and autoinflammatory diseases have much common in both the range of clinical manifestations and trigger environmental, epigenetic, and genetic factors, inflammatory mediators, tissue damage, and approaches to pharmacotherapy. The hyperproduction of the proinflammatory cytokine interleukin 1 (IL-1) is supposed to largely determine the cross between autoimmunity and autoinflammation, which is characteristic of many immunoinflammatory diseases. The study of a role of IL-1 in regulating an interaction between innate (Toll-like receptor activation, inflammasomes) and adaptive (Th1 and Th17 immune responses) immunities and efficiency of IL-1 inhibitors may be of great importance in interpreting the pathogenetic mechanisms of human immunoinflammatory diseases and elaborating novel approaches to personified therapy.

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The authors declare that there are no conflicts of interest present.