rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2007-41-46rsp-2186Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHДИАГНОСТИЧЕСКОЕ ЗНАЧЕНИЕ АНТИТЕЛ К НУКЛЕОСОМАМ У БОЛЬНЫХ «РАННЕЙ» СИСТЕМНОЙ КРАСНОЙ ВОЛЧАНКОЙClinical significance of antinucleosome antibodies in patients with “early” systemic lupus erythematosusКотовскаяМ. А.KotovskayaM. A.

Адрес: 115522 Москва, Каширское шоссе, 34а, Тел/факс: 8-499-614-44-80

СоловьевС. К.SolovjovS. K.

Адрес: 115522 Москва, Каширское шоссе, 34а, Тел/факс: 8-499-614-44-80

НикишинаН. Ю.NikishinaN. Y.

Адрес: 115522 Москва, Каширское шоссе, 34а, Тел/факс: 8-499-614-44-80

НасоновЕ. Л.NasonovE. L.

Адрес: 115522 Москва, Каширское шоссе, 34а, Тел/факс: 8-499-614-44-80

ГУ Институт ревматологии РАМН, МоскваRussian Federation2007120520164544146Copyright © Котовская М.А., Соловьев С.К., Никишина Н.Ю., Насонов Е.Л., 20162016Котовская М.А., Соловьев С.К., Никишина Н.Ю., Насонов Е.Л.Kotovskaya M.A., Solovjov S.K., Nikishina N.Y., Nasonov E.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2186Цель

Цель. Изучить клиническое и диагностическое значение антител к нуклеосомам у больных «ранней» системной красной волчанкой (СКВ).

Материал и методы

Материал и методы. Обследованы 37 больных «ранней» СКВ (длительность забо

Objective

Objective. To assess clinical and diagnostic value of antibodies to nucleosom e in «early» systemic lupus erythematosus (SLE).

Material and methods

Material and methods. 37 pts with «early « SLE were included. The control groups consisted of 36 pts with rheumatoid arthritis (RA), 31 pts with primary Sjogren›s syndrom e (SS) and 45 healthy subjects. Concentration of antibodies to nucleosom e and to double stranded deoxyribonucleic acid (dsDNA) was measured with enzyme immunoassay (EIA).

Results

Results. The level of antinucleosom e antibodies in SLE pts (64,5 ± 53,7 U/ml) was significantly higher than in RA and SS pts (JO, 9 ±23,7 U/ml; p<0,05 и 15,7 ±11,5 U/ml respectively; p<0,05) or in donors (8,3 ± 5,2 U/ml; p<0,05). Correlation was found between level of antibodies to nucleosom e and antibodies to dsDNA (χ2 = 14,4; p<0,05). Sensitivity (87,5%) and specificity (95%) of antinucleosom e antibodies were similar to anti-dsDNA antibodies (85,2% и 93% respectively). Simultaneous evaluation of antibodies to nucleosom e and dsDNA provided 97 % specificity. There was a correlation between the level of antibodies to nucleosom e and disease activity in SLE (p<0,0001).

Conclusion

Conclusion. Evaluation of antinucleosom e antibodies with EIA is a sensitive and specific serological test for early SLE diagnosis. The antibodies to nucleosom e reflect activity of SLE

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The authors declare that there are no conflicts of interest present.