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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1995-4484-2016-191-198</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-2216</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРОГРАММА НЕПРЕРЫВНОГО ПОСЛЕДИПЛОМНОГО ОБРАЗОВАНИЯ ВРАЧЕЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>POSTGRADUATE PROGRAM OF CONTINUING MEDICAL EDUCATION</subject></subj-group></article-categories><title-group><article-title>Полимиозит/дерматомиозит: дифференциальная диагностика</article-title><trans-title-group xml:lang="en"><trans-title>POLYMYOSITIS/DERMATOMIOSITIS: DIFFERENTIAL DIAGNOSIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Антелава</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Antelava</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Институт профессионального образования</p><p>кафедра ревматологии </p><p>канд. мед. наук</p></bio><bio xml:lang="en"><p>Institute of Professional Education</p><p>Department of Rheumatology</p><p>8, Trubetskaya St., Build. 2, Moscow 119991</p></bio><email xlink:type="simple">antelavao@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>19</day><month>07</month><year>2016</year></pub-date><volume>54</volume><issue>2</issue><fpage>191</fpage><lpage>198</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Антелава О.А., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Антелава О.А.</copyright-holder><copyright-holder xml:lang="en">Antelava O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/2216">https://rsp.mediar-press.net/rsp/article/view/2216</self-uri><abstract><p>В лекции рассматривается проблема редких системных заболеваний соединительной ткани – идиопатических воспалительных миопатий (ИВМ). Подчеркивается клинико-иммунологическая неоднородность их подтипов, определяющая терапевтическую тактику и прогноз. Представлены диагностические критерии ИВМ. Предлагается алгоритм дифференциальной диагностики, который базируется на исключении фенотипически сходных форм миопатий различного генеза. </p></abstract><trans-abstract xml:lang="en"><p>The lecture considers the problem of rare systemic connective tissue diseases, such as idiopathic inflammatory myopathies (IIMs). It underlines the clinical and immunological heterogeneity of their subtypes, which defines therapeutic tactics and prognosis. The diagnostic criteria for IIMs are given. A differential diagnostic algorithm based on the exclusion of phenotypically similar forms of myopathies of different genesis is proposed. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>идиопатические воспалительные миопатии</kwd><kwd>полимиозит</kwd><kwd>дерматомиозит</kwd><kwd>антисинтетазный синдром</kwd><kwd>некротизирующая миопатия</kwd><kwd>миозит с включениями</kwd><kwd>дифференциальная диагностика миопатий</kwd></kwd-group><kwd-group xml:lang="en"><kwd>idiopathic inflammatory myopathies</kwd><kwd>polymyositis</kwd><kwd>dermatomyositis</kwd><kwd>antisynthetase syndrome</kwd><kwd>necrotizing myopathy</kwd><kwd>inclusion body myositis</kwd><kwd>differential diagnosis of myopathies</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Plotz PH, Dalakas M, Leff RL, et al. Current concepts in the idiopathic inflammatory myopathies: Polymyositis, dermatomyositis and related disorders. Ann Intern Med. 1989;111:143. doi: 10.7326/0003-4819-111-2-143</mixed-citation><mixed-citation xml:lang="en">Plotz PH, Dalakas M, Leff RL, et al. Current concepts in the idiopathic inflammatory myopathies: Polymyositis, dermatomyositis and related disorders. Ann Intern Med. 1989;111:143. doi: 10.7326/0003-4819-111-2-143</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Dalakas M. Mechanisms of disease:signaling pathways and immunobyology of inflammatory myopathies. Nat Clin Pract Rheumatol. 2006;2(4):219-27. doi: 10.1038/ncprheum0140</mixed-citation><mixed-citation xml:lang="en">Dalakas M. Mechanisms of disease:signaling pathways and immunobyology of inflammatory myopathies. Nat Clin Pract Rheumatol. 2006;2(4):219-27. doi: 10.1038/ncprheum0140</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Sarkar K, Miller FW. Autoantibodies as predictive and diagnostic markers of idiopathic inflammatory myopathies. Autoimmunity. 2004 Jun;37(4):291-4. doi: 10.1080/08916930410001710839</mixed-citation><mixed-citation xml:lang="en">Sarkar K, Miller FW. Autoantibodies as predictive and diagnostic markers of idiopathic inflammatory myopathies. Autoimmunity. 2004 Jun;37(4):291-4. doi: 10.1080/08916930410001710839</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Gazeley DJ, Cronin ME. Diagnosis and treatment of the idiopathic inflammatory myopathies. Ther Adv Musculoskel Dis. 2011;3:315-24. doi: 10.1177/1759720X11415306</mixed-citation><mixed-citation xml:lang="en">Gazeley DJ, Cronin ME. Diagnosis and treatment of the idiopathic inflammatory myopathies. Ther Adv Musculoskel Dis. 2011;3:315-24. doi: 10.1177/1759720X11415306</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Mastaglia FL. Inflammatory muscle diseases. Neurol India. 2008;56:263-70. doi: 10.4103/0028-3886.43444</mixed-citation><mixed-citation xml:lang="en">Mastaglia FL. Inflammatory muscle diseases. Neurol India. 2008;56:263-70. doi: 10.4103/0028-3886.43444</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Van der Kooi AJ, de Visser M. Idiopathic inflammatory myopathies. Handb Clin Neurol. 2014;119:495-512. doi: 10.1016/B978-0-7020-4086-3.00032-1</mixed-citation><mixed-citation xml:lang="en">Van der Kooi AJ, de Visser M. Idiopathic inflammatory myopathies. Handb Clin Neurol. 2014;119:495-512. doi: 10.1016/B978-0-7020-4086-3.00032-1</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Раденска-Лоповок СГ. Основные разновидности воспалительных миопатий: морфологическая дифференциальная диагностика. Нервно-мышечные болезни. 2011;(1):5-8 [Radenska-Lopovok SG. The main varieties of inflammatory myopathies: morphological differential diagnosis. Nervno-Myshechnye Bolezni. 2011;(1):5-8 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Раденска-Лоповок СГ. Основные разновидности воспалительных миопатий: морфологическая дифференциальная диагностика. Нервно-мышечные болезни. 2011;(1):5-8 [Radenska-Lopovok SG. The main varieties of inflammatory myopathies: morphological differential diagnosis. Nervno-Myshechnye Bolezni. 2011;(1):5-8 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Needham M, Fabian V, Knezevic W, et al. Progressive myopathy with upregulation of MHC-I associated with statin therapy. Neuromuscul Disord. 2007;17:194-200. doi: 10.1016/j.nmd.2006.10.007</mixed-citation><mixed-citation xml:lang="en">Needham M, Fabian V, Knezevic W, et al. Progressive myopathy with upregulation of MHC-I associated with statin therapy. Neuromuscul Disord. 2007;17:194-200. doi: 10.1016/j.nmd.2006.10.007</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Lunberg I, Ulfgren A-K, Nyberg P, et al. Cynokine production in muscle tissue of patients with idiopathic inflammatory myopathies. Arthritis Rheum. 1997;40:865-74. doi: 10.1002/art.1780400514</mixed-citation><mixed-citation xml:lang="en">Lunberg I, Ulfgren A-K, Nyberg P, et al. Cynokine production in muscle tissue of patients with idiopathic inflammatory myopathies. Arthritis Rheum. 1997;40:865-74. doi: 10.1002/art.1780400514</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Amato AA, Barohn RJ. Inclusion body myositis: old and new concepts. J Neurol Neurosurg. 2009;Psychiat 80:1186-93.</mixed-citation><mixed-citation xml:lang="en">Amato AA, Barohn RJ. Inclusion body myositis: old and new concepts. J Neurol Neurosurg. 2009;Psychiat 80:1186-93.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов ЕЛ, Штутман ВЗ, Саложин КВ и др. Клинико-иммунологическая гетерогенность идиопатических воспалительных миопатий. Клиническая медицина. 1995;(2):3-8 [Nasonov EL, Shtutman VZ, Salozhin KV, et al. Clinical and immunological heterogeneity of idiopathic inflammatory myopathies. Klinicheskaya Meditsina. 1995;(2):3-8 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Насонов ЕЛ, Штутман ВЗ, Саложин КВ и др. Клинико-иммунологическая гетерогенность идиопатических воспалительных миопатий. Клиническая медицина. 1995;(2):3-8 [Nasonov EL, Shtutman VZ, Salozhin KV, et al. Clinical and immunological heterogeneity of idiopathic inflammatory myopathies. Klinicheskaya Meditsina. 1995;(2):3-8 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Lega JC, Cottin V, Fabien N, et al. Interstitial lung disease associated with anti-PM/Scl or anti-aminoacyl-tRNA synthetase autoantibodies: a similar condition? J Rheumatol. 2010;37(5):1000-9. doi: 10.3899/jrheum.090652</mixed-citation><mixed-citation xml:lang="en">Lega JC, Cottin V, Fabien N, et al. Interstitial lung disease associated with anti-PM/Scl or anti-aminoacyl-tRNA synthetase autoantibodies: a similar condition? J Rheumatol. 2010;37(5):1000-9. doi: 10.3899/jrheum.090652</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ghirardello A, Zampieri S, Tarricone E, et al. Clinical implications of autoantibody screening in patients with autoimmune myositis. Autoimmunity. 2006;39:217-21. doi: 10.1080/08916930600622645</mixed-citation><mixed-citation xml:lang="en">Ghirardello A, Zampieri S, Tarricone E, et al. Clinical implications of autoantibody screening in patients with autoimmune myositis. Autoimmunity. 2006;39:217-21. doi: 10.1080/08916930600622645</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Ghirardello A, Zampieri S, Iaccarino L, et al. Anti-MI-2 antibodies. Autoimmunity. 2005;38:79-83 doi: 10.1080/08916930400022681</mixed-citation><mixed-citation xml:lang="en">Ghirardello A, Zampieri S, Iaccarino L, et al. Anti-MI-2 antibodies. Autoimmunity. 2005;38:79-83 doi: 10.1080/08916930400022681</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Zampieri S, Ghirardello A, Iaccarino L, et al. Anti-JO-1 antibodies. Autoimmunity. 2005;38:73-8. doi: 10.1080/08916930400022640</mixed-citation><mixed-citation xml:lang="en">Zampieri S, Ghirardello A, Iaccarino L, et al. Anti-JO-1 antibodies. Autoimmunity. 2005;38:73-8. doi: 10.1080/08916930400022640</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Mahler M, Raijmakers R, Dä hnrich C, et al. Clinical evaluation of autoantibodies to a novel PM/Scl peptide antigen. Arthritis Res Ther. 2005;7(3):R704-13. doi: 10.1186/ar1729</mixed-citation><mixed-citation xml:lang="en">Mahler M, Raijmakers R, Dä hnrich C, et al. Clinical evaluation of autoantibodies to a novel PM/Scl peptide antigen. Arthritis Res Ther. 2005;7(3):R704-13. doi: 10.1186/ar1729</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Euwer RL, Sontheimer RD. Amyopathic dermatomyositis (dermatomyositis sine myositis) Presentation of six new cases and review of the literature. J Am Acad Dermatol. 1991;24:959-66. doi: 10.1016/0190-9622(91)70153-S</mixed-citation><mixed-citation xml:lang="en">Euwer RL, Sontheimer RD. Amyopathic dermatomyositis (dermatomyositis sine myositis) Presentation of six new cases and review of the literature. J Am Acad Dermatol. 1991;24:959-66. doi: 10.1016/0190-9622(91)70153-S</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Sontheimer RD. A portable digital microphotography unit for rapid documentation of periungualnailfold capillary changes in autoimmune connective tissue diseases. J Rheumatol. 2004 Mar;31(3):539-44.</mixed-citation><mixed-citation xml:lang="en">Sontheimer RD. A portable digital microphotography unit for rapid documentation of periungualnailfold capillary changes in autoimmune connective tissue diseases. J Rheumatol. 2004 Mar;31(3):539-44.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Gono T, Sato S, Kawaguchi Y, et al. Anti-MDA5 antibody, ferritin and IL-18 are useful for the evaluation of response to treatment in interstitial lung diseasewith anti-MDA5 antibody-positive der￾matomyositis. Rheumatology (Oxford). 2012 May 15.</mixed-citation><mixed-citation xml:lang="en">Gono T, Sato S, Kawaguchi Y, et al. Anti-MDA5 antibody, ferritin and IL-18 are useful for the evaluation of response to treatment in interstitial lung diseasewith anti-MDA5 antibody-positive der￾matomyositis. Rheumatology (Oxford). 2012 May 15.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ghazi E, Sontheimer RD, Werth VP. The importance of including amyopathic dermatomyositis in the idiopathic inflammatory myositis spectrum. Clin Exp Rheumatol. 2013 Jan-Feb;31(1):128- 34. Epub 2012 Nov 22.</mixed-citation><mixed-citation xml:lang="en">Ghazi E, Sontheimer RD, Werth VP. The importance of including amyopathic dermatomyositis in the idiopathic inflammatory myositis spectrum. Clin Exp Rheumatol. 2013 Jan-Feb;31(1):128- 34. Epub 2012 Nov 22.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Антелава ОА. Паранеопластический миозит. Особенности дебюта, клинической картины, течения, стероид-респонсивности. Научно-практическая ревматология. 2013;51(2):181-5 [Antelava OA. The specific features of the onset, clinical picture, steroid responsiveness of paraneoplastic myositis. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2013;51(2):181-5 (In Russ.)]. doi: 10.14412/1995-4484-2013-647</mixed-citation><mixed-citation xml:lang="en">Антелава ОА. Паранеопластический миозит. Особенности дебюта, клинической картины, течения, стероид-респонсивности. Научно-практическая ревматология. 2013;51(2):181-5 [Antelava OA. The specific features of the onset, clinical picture, steroid responsiveness of paraneoplastic myositis. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2013;51(2):181-5 (In Russ.)]. doi: 10.14412/1995-4484-2013-647</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Christopher-Stine L, Casciola-Rosen LA, Hong,G, et al. A novel autoantibody recognizing 200-kd and100 kd proteins is associated with an immune mediated ecrotizing myopathy. Arthritis Rheum. 2010;62:2757-66. doi: 10.1002/art.27572</mixed-citation><mixed-citation xml:lang="en">Christopher-Stine L, Casciola-Rosen LA, Hong,G, et al. A novel autoantibody recognizing 200-kd and100 kd proteins is associated with an immune mediated ecrotizing myopathy. Arthritis Rheum. 2010;62:2757-66. doi: 10.1002/art.27572</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">So MW, Koo BS, Kim YGC, et al. Idiopathic inflammatory myopathy associated with malignancy: a retrospective cohort of 151 Korean patients with dermatomyositis and olymyositis. J Rheumatol. 2011;38(11):2432-5. doi: 10.3899/jrheum.110320</mixed-citation><mixed-citation xml:lang="en">So MW, Koo BS, Kim YGC, et al. Idiopathic inflammatory myopathy associated with malignancy: a retrospective cohort of 151 Korean patients with dermatomyositis and olymyositis. J Rheumatol. 2011;38(11):2432-5. doi: 10.3899/jrheum.110320</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Антелава ОА, Тарасова ГМ, Сажина ЕГ и др. Антисинтетазный синдром — наиболее тяжелый подтип полимиозита/дерматомиозита (описание случаев). Современная ревматология. 2009;3(4):54-8 [Antelava OA, Tarasova GM, Sazhina EG, et al. Antisynthetase syndrome is the most severe subtype of polymyositis/dermatomyositis: description of cases. Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2009;3(4):54-8 (In Russ.)]. doi: 10.14412/1996-7012-2009-574</mixed-citation><mixed-citation xml:lang="en">Антелава ОА, Тарасова ГМ, Сажина ЕГ и др. Антисинтетазный синдром — наиболее тяжелый подтип полимиозита/дерматомиозита (описание случаев). Современная ревматология. 2009;3(4):54-8 [Antelava OA, Tarasova GM, Sazhina EG, et al. Antisynthetase syndrome is the most severe subtype of polymyositis/dermatomyositis: description of cases. Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2009;3(4):54-8 (In Russ.)]. doi: 10.14412/1996-7012-2009-574</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Ананьева ЛП, Волков АВ, Смирнов АВ, Антелава ОА. Поражение органов дыхания при системных заболеваниях соеди- нительной ткани. В кн.: Чучалин АГ, редактор. Респираторная медицина: Руководство. Москва: ГЭОТАР-Медиа; 2007. Т. 2. С. 251-68 [Anan’eva LP, Volkov AV, Smirnov AV, Antelava OA. The defeat of the respiratory system in systemic diseases of con￾nective tissue. In: Chuchalin AG, editor. Respiratornaya meditsina: Rukovodstvo [Respiratory Medicine: A Guide]. Moscow: GEOTAR-Media; 2007. Vol. 2. P. 251-68].</mixed-citation><mixed-citation xml:lang="en">Ананьева ЛП, Волков АВ, Смирнов АВ, Антелава ОА. Поражение органов дыхания при системных заболеваниях соеди- нительной ткани. В кн.: Чучалин АГ, редактор. Респираторная медицина: Руководство. Москва: ГЭОТАР-Медиа; 2007. Т. 2. С. 251-68 [Anan’eva LP, Volkov AV, Smirnov AV, Antelava OA. The defeat of the respiratory system in systemic diseases of con￾nective tissue. In: Chuchalin AG, editor. Respiratornaya meditsina: Rukovodstvo [Respiratory Medicine: A Guide]. Moscow: GEOTAR-Media; 2007. Vol. 2. P. 251-68].</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Labirua A, Lundberg IE. Interstitial lung disease and idiopathic inflammatory myopathies: progress and pitfalls. Curr Opin Rheumatol. 2010;22:633-8. doi: 10.1097/BOR.0b013e32833f1970</mixed-citation><mixed-citation xml:lang="en">Labirua A, Lundberg IE. Interstitial lung disease and idiopathic inflammatory myopathies: progress and pitfalls. Curr Opin Rheumatol. 2010;22:633-8. doi: 10.1097/BOR.0b013e32833f1970</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Антелава ОА, Балабанова РМ, Сажина ЕГ и др. Особенности дебюта и течения антисинтетазного синдрома как наиболее тяжелого подтипа полимиозита/дерматомиозита. Русский медицинский журнал. 2009;21:1443 [Antelava OA, Balabanova RM, Sazhina EG, et al. Features debut and course antisintetaznogo syndrome as the most severe subtype of polymyositis/dermatomyositis. Russkii Meditsinskii Zhurnal. 2009;21:1443 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Антелава ОА, Балабанова РМ, Сажина ЕГ и др. Особенности дебюта и течения антисинтетазного синдрома как наиболее тяжелого подтипа полимиозита/дерматомиозита. Русский медицинский журнал. 2009;21:1443 [Antelava OA, Balabanova RM, Sazhina EG, et al. Features debut and course antisintetaznogo syndrome as the most severe subtype of polymyositis/dermatomyositis. Russkii Meditsinskii Zhurnal. 2009;21:1443 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Katzap E, Barilla-LaBarca ML, Marder G. Antisynthetase syndrome.Curr Rheumatol Rep. 2011;13:175-81. doi: 10.1007/s11926- 011-0176-8</mixed-citation><mixed-citation xml:lang="en">Katzap E, Barilla-LaBarca ML, Marder G. Antisynthetase syndrome.Curr Rheumatol Rep. 2011;13:175-81. doi: 10.1007/s11926- 011-0176-8</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Антелава ОА, Бондаренко ИБ, Хитров АН, Насонов ЕЛ. Поражение дыхательной системы при полимиозите/дерматоми- озите. Русский медицинский журнал. 2008;34(24):1633-7 [Antelava OA, Bondarenko IB, Khitrov AN, Nasonov EL. The defeat of the respiratory system with polymyositis/dermatomyositis. Russkii Meditsinskii Zhurnal. 2008;34(24):1633-7 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Антелава ОА, Бондаренко ИБ, Хитров АН, Насонов ЕЛ. Поражение дыхательной системы при полимиозите/дерматоми- озите. Русский медицинский журнал. 2008;34(24):1633-7 [Antelava OA, Bondarenko IB, Khitrov AN, Nasonov EL. The defeat of the respiratory system with polymyositis/dermatomyositis. Russkii Meditsinskii Zhurnal. 2008;34(24):1633-7 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Mileti LM, Strek ME, Niewold TB, et al. Clinical characteristics of patients with anti-Jo-1 antibodies: a single center experience. J Clin Rheumatol. 2009;15(5):254-5. doi: 10.1097/RHU.0b013e3181b0e910</mixed-citation><mixed-citation xml:lang="en">Mileti LM, Strek ME, Niewold TB, et al. Clinical characteristics of patients with anti-Jo-1 antibodies: a single center experience. J Clin Rheumatol. 2009;15(5):254-5. doi: 10.1097/RHU.0b013e3181b0e910</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Hervier B, Wallaert B, Hachulla E, et al. Clinical manifestations of antisynthetase syndrome positive for anti-alanyl-tRNA synthetase (anti-PL12) antibodies: a retrospective study of 17 cases. Rheumatology (Oxford). 2010;49(5):972-6. doi: 10.1093/rheumatology/kep455</mixed-citation><mixed-citation xml:lang="en">Hervier B, Wallaert B, Hachulla E, et al. Clinical manifestations of antisynthetase syndrome positive for anti-alanyl-tRNA synthetase (anti-PL12) antibodies: a retrospective study of 17 cases. Rheumatology (Oxford). 2010;49(5):972-6. doi: 10.1093/rheumatology/kep455</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Handa T, Nagai S, Kawabata D, et al. Long-term clinical course of a patient with anti PL-12 antibody accompanied by interstitial pneumonia and severe pulmonary hypertension. Intern Med. 2005;44(4):319-25. doi: 10.2169/internalmedicine.44.319</mixed-citation><mixed-citation xml:lang="en">Handa T, Nagai S, Kawabata D, et al. Long-term clinical course of a patient with anti PL-12 antibody accompanied by interstitial pneumonia and severe pulmonary hypertension. Intern Med. 2005;44(4):319-25. doi: 10.2169/internalmedicine.44.319</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Kalluri M, Sahn SA, Oddis CV, et al. Clinical profile of anti￾PL-12 autoantibody: cohort study and review of the literature. Chest. 2009;135(6):1550-6. doi: 10.1378/chest.08-2233</mixed-citation><mixed-citation xml:lang="en">Kalluri M, Sahn SA, Oddis CV, et al. Clinical profile of anti￾PL-12 autoantibody: cohort study and review of the literature. Chest. 2009;135(6):1550-6. doi: 10.1378/chest.08-2233</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Matsushita T, Hasegawa M, Fujimoto M, et al. Clinical evaluation of anti-aminoacyl tRNA synthetase antibodies in Japanese patients with dermatomyositis. J Rheumatol. 2007;34(5):1012-8.</mixed-citation><mixed-citation xml:lang="en">Matsushita T, Hasegawa M, Fujimoto M, et al. Clinical evaluation of anti-aminoacyl tRNA synthetase antibodies in Japanese patients with dermatomyositis. J Rheumatol. 2007;34(5):1012-8.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Arnett FC, Targoff IN, Mimori T, et al. Interrelationship of major histocompatibility complex class II alleles and autoantibodies in four ethnic groups with various forms of myositis. Arthritis Rheum. 1996;39:1507-18. doi: 10.1002/art.1780390910</mixed-citation><mixed-citation xml:lang="en">Arnett FC, Targoff IN, Mimori T, et al. Interrelationship of major histocompatibility complex class II alleles and autoantibodies in four ethnic groups with various forms of myositis. Arthritis Rheum. 1996;39:1507-18. doi: 10.1002/art.1780390910</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Hengstman GJD, Brouwer R, Vree Egberts WTM, et al. Clinical and serological characteristics of 125 Dutch myositis patients; myositis specific autoantibodies aid in the differential diagnosis of the idiopathic inflammatory myopathies. J Neurol. 2002;249:69- 75. doi: 10.1007/PL00007850</mixed-citation><mixed-citation xml:lang="en">Hengstman GJD, Brouwer R, Vree Egberts WTM, et al. Clinical and serological characteristics of 125 Dutch myositis patients; myositis specific autoantibodies aid in the differential diagnosis of the idiopathic inflammatory myopathies. J Neurol. 2002;249:69- 75. doi: 10.1007/PL00007850</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Hirakata M, Nakamura K, Fuji J, et al. Clinical and immunogenetic features of anti-SRP autoantibodies in Japanese patients. Arthritis Rheum. 1995;38:S321.</mixed-citation><mixed-citation xml:lang="en">Hirakata M, Nakamura K, Fuji J, et al. Clinical and immunogenetic features of anti-SRP autoantibodies in Japanese patients. Arthritis Rheum. 1995;38:S321.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Targoff IN, Johnson AE, Miller FW. Antibody to signal recogni￾tion particle. Arthritis Rheum. 1990;33:1361-70. doi: 10.1002/art.1780330908</mixed-citation><mixed-citation xml:lang="en">Targoff IN, Johnson AE, Miller FW. Antibody to signal recogni￾tion particle. Arthritis Rheum. 1990;33:1361-70. doi: 10.1002/art.1780330908</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Amato AA, Gronseth GS, Jackson CE, et al. Inclusion body myositis: clinical and pathological boundaries. Ann Neurol. 1996;40(4):581-6. doi: 10.1002/ana.410400407</mixed-citation><mixed-citation xml:lang="en">Amato AA, Gronseth GS, Jackson CE, et al. Inclusion body myositis: clinical and pathological boundaries. Ann Neurol. 1996;40(4):581-6. doi: 10.1002/ana.410400407</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Barohn RJ, Amato AA. Inclusion body myositis. Curr Treat Options Neurol. 2000;2(1):7-12. doi: 10.1007/s11940-000-0019-9</mixed-citation><mixed-citation xml:lang="en">Barohn RJ, Amato AA. Inclusion body myositis. Curr Treat Options Neurol. 2000;2(1):7-12. doi: 10.1007/s11940-000-0019-9</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Phillips BA, Cala LA, Thickbroom GW, et al. Patterns of muscle involvement in inclusion body myositis: clinical and magnetic resonance imaging study. Muscle Nerve. 2001;24:1526-34. doi: 10.1002/mus.1178</mixed-citation><mixed-citation xml:lang="en">Phillips BA, Cala LA, Thickbroom GW, et al. Patterns of muscle involvement in inclusion body myositis: clinical and magnetic resonance imaging study. Muscle Nerve. 2001;24:1526-34. doi: 10.1002/mus.1178</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Needham M, James I, Corbett A, et al. Sporadic inclusion body myositis: phenotypic variability and influence of HLA-DR3 in a cohort of 57 Australian cases. J Neurol Neurosurg Psychiatry. 2008;79(9):1056-60. doi: 10.1136/jnnp.2007.138891</mixed-citation><mixed-citation xml:lang="en">Needham M, James I, Corbett A, et al. Sporadic inclusion body myositis: phenotypic variability and influence of HLA-DR3 in a cohort of 57 Australian cases. J Neurol Neurosurg Psychiatry. 2008;79(9):1056-60. doi: 10.1136/jnnp.2007.138891</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Barohn RJ, Amato AA, Sahenk Z, et al. Inclusion body myositis: explanation for poor response to immunosuppressive therapy. Neurology. 1995;45(7):1302-4. doi: 10.1212/WNL.45.7.1302</mixed-citation><mixed-citation xml:lang="en">Barohn RJ, Amato AA, Sahenk Z, et al. Inclusion body myositis: explanation for poor response to immunosuppressive therapy. Neurology. 1995;45(7):1302-4. doi: 10.1212/WNL.45.7.1302</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Lotz BP, Engel AG, Nishino H, et al. Inclusion body myositis. Observations in 40 patients. Brain. 1989;112(Pt 3):727-47. doi: 10.1093/brain/112.3.727</mixed-citation><mixed-citation xml:lang="en">Lotz BP, Engel AG, Nishino H, et al. Inclusion body myositis. Observations in 40 patients. Brain. 1989;112(Pt 3):727-47. doi: 10.1093/brain/112.3.727</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Rodriguez Cruz PM, Needham M, Hollingsworth P, et al. Sleep dis￾ordered breathing and subclinical impairment of respiratory function are common in sporadic inclusion body myositis. Neuromuscul Disord. 2014;24:1036-41. doi: 10.1016/j.nmd.2014.08.003</mixed-citation><mixed-citation xml:lang="en">Rodriguez Cruz PM, Needham M, Hollingsworth P, et al. Sleep dis￾ordered breathing and subclinical impairment of respiratory function are common in sporadic inclusion body myositis. Neuromuscul Disord. 2014;24:1036-41. doi: 10.1016/j.nmd.2014.08.003</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Della Marca G, Sancricca C, Losurdo A, et al. Sleep disordered breathing in a cohort of patients with sporadic inclusion body myositis. Clin Neurophysiol. 2013;124:1615-21. doi: 10.1016/j.clinph.2013.03.002</mixed-citation><mixed-citation xml:lang="en">Della Marca G, Sancricca C, Losurdo A, et al. Sleep disordered breathing in a cohort of patients with sporadic inclusion body myositis. Clin Neurophysiol. 2013;124:1615-21. doi: 10.1016/j.clinph.2013.03.002</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Cox FM, Titulaer MJ, Sont JK, et al. A 12-year follow-up in sporadic inclusion body myositis: an end stage with major disabilities. Brain. 2011;134:3167-75. doi: 10.1093/brain/awr217</mixed-citation><mixed-citation xml:lang="en">Cox FM, Titulaer MJ, Sont JK, et al. A 12-year follow-up in sporadic inclusion body myositis: an end stage with major disabilities. Brain. 2011;134:3167-75. doi: 10.1093/brain/awr217</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Bohan A, Peter JB. Polymyositis and dermatomyositis (second of two parts). N Engl J Med. 1975;292:403-7. doi: 10.1056/NEJM197502202920807</mixed-citation><mixed-citation xml:lang="en">Bohan A, Peter JB. Polymyositis and dermatomyositis (second of two parts). N Engl J Med. 1975;292:403-7. doi: 10.1056/NEJM197502202920807</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Bohan A, Peter JB. Polymyositis and dermatomyositis (first of two parts). N Engl J Med. 1975;292:344-7. doi: 10.1056/NEJM197502132920706</mixed-citation><mixed-citation xml:lang="en">Bohan A, Peter JB. Polymyositis and dermatomyositis (first of two parts). N Engl J Med. 1975;292:344-7. doi: 10.1056/NEJM197502132920706</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Targoff IN, Miller FW, Medsger TA, et al. Classification criteria for the idiopathic inflammatory myopathies. Curr Opin Rheumatol. 1997;9:527-35. doi: 10.1097/00002281-199711000-00008</mixed-citation><mixed-citation xml:lang="en">Targoff IN, Miller FW, Medsger TA, et al. Classification criteria for the idiopathic inflammatory myopathies. Curr Opin Rheumatol. 1997;9:527-35. doi: 10.1097/00002281-199711000-00008</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Hoogendijk JE, Amato AA, Lecky BR, et al. 119th ENMC international workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10-12 October 2003, Naarden, The Netherlands. Neuromuscul Disord. 2004 May;14(5):337-45. doi: 10.1016/j.nmd.2004.02.006</mixed-citation><mixed-citation xml:lang="en">Hoogendijk JE, Amato AA, Lecky BR, et al. 119th ENMC international workshop: trial design in adult idiopathic inflammatory myopathies, with the exception of inclusion body myositis, 10-12 October 2003, Naarden, The Netherlands. Neuromuscul Disord. 2004 May;14(5):337-45. doi: 10.1016/j.nmd.2004.02.006</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Griggs RC, Askanas V, DiMauro S, et al. Inclusion body myositis and myopathies. Ann Neurol. 1995;38(5):705-13. doi: 10.1002/ana.410380504</mixed-citation><mixed-citation xml:lang="en">Griggs RC, Askanas V, DiMauro S, et al. Inclusion body myositis and myopathies. Ann Neurol. 1995;38(5):705-13. doi: 10.1002/ana.410380504</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Selva-O’Callaghan A, Fonollosa-Pla V, Trallero-Araguas E, et al. Nailfold capillary microscopy in adults withinflammatory myopathy. Sem Arthritis Rheum. 2010a;39:398-404. doi: 10.1016/j.semarthrit.2008.09.003</mixed-citation><mixed-citation xml:lang="en">Selva-O’Callaghan A, Fonollosa-Pla V, Trallero-Araguas E, et al. Nailfold capillary microscopy in adults withinflammatory myopathy. Sem Arthritis Rheum. 2010a;39:398-404. doi: 10.1016/j.semarthrit.2008.09.003</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Tillie-Leblond I, Wislez M, Valeyre D, et al. Interstitial lung disease and anti-Jo-1 antibodies: difference between acute and gradual onset. Thorax. 2008;63(1):53-9. doi: 10.1136/thx.2006.069237</mixed-citation><mixed-citation xml:lang="en">Tillie-Leblond I, Wislez M, Valeyre D, et al. Interstitial lung disease and anti-Jo-1 antibodies: difference between acute and gradual onset. Thorax. 2008;63(1):53-9. doi: 10.1136/thx.2006.069237</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Braun NM, Arora NS, Rochester DF. Respiratory muscle and pulmonary function in polymyositis and otherproximalmyopathies. Thorax. 1983;38(8):616-23. doi: 10.1136/thx.38.8.616</mixed-citation><mixed-citation xml:lang="en">Braun NM, Arora NS, Rochester DF. Respiratory muscle and pulmonary function in polymyositis and otherproximalmyopathies. Thorax. 1983;38(8):616-23. doi: 10.1136/thx.38.8.616</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Lundberg IE. The heart in dermatomyositis and polymyositis. Rheumatology (Oxford). 2006;45 Suppl 4: iv18-21. doi: 10.1093/rheumatology/kel311</mixed-citation><mixed-citation xml:lang="en">Lundberg IE. The heart in dermatomyositis and polymyositis. Rheumatology (Oxford). 2006;45 Suppl 4: iv18-21. doi: 10.1093/rheumatology/kel311</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Costa AF, Di Primio GA, Schweitzer ME. Magnetic resonance imaging of muscle disease: A pattern-based approach. Muscle Nerve. 2012;46:465-81. doi: 10.1002/mus.23370</mixed-citation><mixed-citation xml:lang="en">Costa AF, Di Primio GA, Schweitzer ME. Magnetic resonance imaging of muscle disease: A pattern-based approach. Muscle Nerve. 2012;46:465-81. doi: 10.1002/mus.23370</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Cox FM, Reijnierse M, van Rijswijk CS, et al. Magnetic resonance imaging of skeletal muscles in sporadic inclusion body myositis. Rheumatology (Oxford). 2011;50:1153-61. doi: 10.1093/rheumatology/ker001</mixed-citation><mixed-citation xml:lang="en">Cox FM, Reijnierse M, van Rijswijk CS, et al. Magnetic resonance imaging of skeletal muscles in sporadic inclusion body myositis. Rheumatology (Oxford). 2011;50:1153-61. doi: 10.1093/rheumatology/ker001</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Tasca G, Monforte M, De Fino C, et al. MRI pattern recognition in sporadic inclusion body myositis. Muscle Nerve. 2015;52(6):956-62. doi: 10.1002/mus.24661</mixed-citation><mixed-citation xml:lang="en">Tasca G, Monforte M, De Fino C, et al. MRI pattern recognition in sporadic inclusion body myositis. Muscle Nerve. 2015;52(6):956-62. doi: 10.1002/mus.24661</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Dion E, Cherin P, Payan C, et al. Magnetic resonance imaging criteria for distinguishing between inclusion body myositis and polymyositis. J Rheumatol. 2002;29:1897-906.</mixed-citation><mixed-citation xml:lang="en">Dion E, Cherin P, Payan C, et al. Magnetic resonance imaging criteria for distinguishing between inclusion body myositis and polymyositis. J Rheumatol. 2002;29:1897-906.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Антелава ОА, Насонов ЕЛ. Современные методы оценки активности и повреждения при идиопатических воспалительных миопатиях. Научно-практическая ревматология. 2007;45(1):59-62 [Antelava OA, Nasonov EL. Modern methods of evaluation activity and damage in idiopathic inflammatory myopathies. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2007;45(1):59-62 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Антелава ОА, Насонов ЕЛ. Современные методы оценки активности и повреждения при идиопатических воспалительных миопатиях. Научно-практическая ревматология. 2007;45(1):59-62 [Antelava OA, Nasonov EL. Modern methods of evaluation activity and damage in idiopathic inflammatory myopathies. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2007;45(1):59-62 (In Russ.)].</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
