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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1995-4484-2016-339-345</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-2230</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФОРУМ МОЛОДЫХ УЧЕНЫХ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>YOUNG SCIENTISTS FORUM</subject></subj-group></article-categories><title-group><article-title>Влияние коморбидных психических расстройств на эффективность терапии у больных ревматоидным артритом</article-title><trans-title-group xml:lang="en"><trans-title>IMPACT OF COMORBID MENTAL DISORDERS ON THE EFFICIENCY OF THERAPY IN PATIENTS WITH RHEUMATOID ARTHRITIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абрамкин</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Abramkin</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант, лаборатория системных ревматических заболеваний с группой гемореологических нарушений (научный руководитель – д.м.н. Т.А. Лисицына)</p><p>115522 Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><email xlink:type="simple">79096237832@ya.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>20</day><month>07</month><year>2016</year></pub-date><volume>54</volume><issue>3</issue><fpage>339</fpage><lpage>345</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Абрамкин А.А., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Абрамкин А.А.</copyright-holder><copyright-holder xml:lang="en">Abramkin A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/2230">https://rsp.mediar-press.net/rsp/article/view/2230</self-uri><abstract><p>В обзоре отечественной и зарубежной литературы приводится подробный анализ актуальных вопросов, связанных с влиянием коморбидных тревожно-депрессивных и когнитивных расстройств на эффективность противовоспалительной и болезнь-модифицирующей терапии больных ревматоидным артритом.</p></abstract><trans-abstract xml:lang="en"><p>The review of Russian and foreign literature provides a detailed analysis of topical issues associated with the impact of comorbid anxiety and depressive disorders and cognitive impairments on the efficiency of anti-inflammatory and disease-modifying therapy in patients with rheumatoid arthritis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ревматоидный артрит</kwd><kwd>депрессия</kwd><kwd>когнитивные нарушения</kwd><kwd>приверженность терапии</kwd><kwd>эффективность терапии</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rheumatoid arthritis</kwd><kwd>depression</kwd><kwd>cognitive impairments</kwd><kwd>therapy adherence</kwd><kwd>efficiency of therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Nasonov EL, Karateev DE. Does Russia need a treat-to-target initiative? Rheumatology. 2015;54(3):381-2. doi:10.1093/rheumatology/keu156</mixed-citation><mixed-citation xml:lang="en">Nasonov EL, Karateev DE. Does Russia need a treat-to-target initiative? Rheumatology. 2015;54(3):381-2. doi:10.1093/rheumatology/keu156</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Sokka T, Kautiainen H, Pincus T, et al. Work disability remains a major problem in rheumatoid arthritis in the 2000s: data from 32 countries in the QUEST-RA Study. Arthritis Res Ther. 2010;12(2):R42. doi: 10.1186/ar2951</mixed-citation><mixed-citation xml:lang="en">Sokka T, Kautiainen H, Pincus T, et al. Work disability remains a major problem in rheumatoid arthritis in the 2000s: data from 32 countries in the QUEST-RA Study. Arthritis Res Ther. 2010;12(2):R42. doi: 10.1186/ar2951</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Gabriel S, Michaud K. Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases. Arthritis Res Ther. 2009;11(3):229. doi: 10.1186/ar2669</mixed-citation><mixed-citation xml:lang="en">Gabriel S, Michaud K. Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases. Arthritis Res Ther. 2009;11(3):229. doi: 10.1186/ar2669</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Комиссинская ИГ, Степченко АА, Ворона ИС. Фармакоэкономические аспекты лечения ревматоидного артрита. Курский научно-практический вестник «Человек и его здоровье». 2008;(3):123-9 [Komissinskaya IG, Stepchenko AA, Vorona IS. Pharmacoeconomic aspects of treating rheumatoid arthritis. Kurskiy Nauchno-Prakticheskiy Vestnik "Chelovek I Ego Zdorov’e". 2008;(3):123-9 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Комиссинская ИГ, Степченко АА, Ворона ИС. Фармакоэкономические аспекты лечения ревматоидного артрита. Курский научно-практический вестник «Человек и его здоровье». 2008;(3):123-9 [Komissinskaya IG, Stepchenko AA, Vorona IS. Pharmacoeconomic aspects of treating rheumatoid arthritis. Kurskiy Nauchno-Prakticheskiy Vestnik "Chelovek I Ego Zdorov’e". 2008;(3):123-9 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Dougados M, Soubrier M, Antunez A, et al. Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA). Ann Rheum Dis. 2014;73(1):62-8. doi: 10.1136/annrheumdis-2013-204223</mixed-citation><mixed-citation xml:lang="en">Dougados M, Soubrier M, Antunez A, et al. Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA). Ann Rheum Dis. 2014;73(1):62-8. doi: 10.1136/annrheumdis-2013-204223</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Kekow J, Moots R, Khandker R, et al. Improvements in patient reported outcomes, symptoms of depression and anxiety, and their association with clinical remission among patients with moderateto-severe active early rheumatoid arthritis. Rheumatology. 2011;50:401-9. doi: 10.1093/rheumatology/keq327</mixed-citation><mixed-citation xml:lang="en">Kekow J, Moots R, Khandker R, et al. Improvements in patient reported outcomes, symptoms of depression and anxiety, and their association with clinical remission among patients with moderateto-severe active early rheumatoid arthritis. Rheumatology. 2011;50:401-9. doi: 10.1093/rheumatology/keq327</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Raftery G, He J, Pearce R, et al. Disease activity and cognition in rheumatoid arthritis: an open label pilot study. Arthritis Res Ther. 2012;14:R263. doi:10.1186/ar4108</mixed-citation><mixed-citation xml:lang="en">Raftery G, He J, Pearce R, et al. Disease activity and cognition in rheumatoid arthritis: an open label pilot study. Arthritis Res Ther. 2012;14:R263. doi:10.1186/ar4108</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Лисицына ТА, Вельтищев ДЮ, Краснов ВН, Насонов ЕЛ. Клинико-патогенетические взаимосвязи иммуновоспалительных ревматических заболеваний и психических расстройств. Клиническая медицина. 2014;(1):12-21 [Lisitsyna TA, Vel’tishchev DYu, Krasnov VN, Nasonov EL. Clinical and pathogenetic associations between immuno- inflammatory rheumatic diseases and mental disorders. Klinicheskaya Meditsina. 2014;(1):12-21 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Лисицына ТА, Вельтищев ДЮ, Краснов ВН, Насонов ЕЛ. Клинико-патогенетические взаимосвязи иммуновоспалительных ревматических заболеваний и психических расстройств. Клиническая медицина. 2014;(1):12-21 [Lisitsyna TA, Vel’tishchev DYu, Krasnov VN, Nasonov EL. Clinical and pathogenetic associations between immuno- inflammatory rheumatic diseases and mental disorders. Klinicheskaya Meditsina. 2014;(1):12-21 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Löwe B, Willand L, Fiehn Ch, et al. Psychiatric comorbidity and work disability in patients with inflammatory rheumatic diseases. Psychosomatic Medicine. 2004;66(3):395-402.</mixed-citation><mixed-citation xml:lang="en">Löwe B, Willand L, Fiehn Ch, et al. Psychiatric comorbidity and work disability in patients with inflammatory rheumatic diseases. Psychosomatic Medicine. 2004;66(3):395-402.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Joyce AT, Smith P, Khandker R, et al. Hidden cost of rheumatoid arthritis, estimating cost of comorbid cardiovascular disease and depression among patients with RA. J Rheumatol. 2009;36(4):743-52. doi: 10.3899/jrheum.080670</mixed-citation><mixed-citation xml:lang="en">Joyce AT, Smith P, Khandker R, et al. Hidden cost of rheumatoid arthritis, estimating cost of comorbid cardiovascular disease and depression among patients with RA. J Rheumatol. 2009;36(4):743-52. doi: 10.3899/jrheum.080670</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ang DC, Choi H, Kroenke K, Wolfe F. Comorbid depression is an independent risk factor for mortality in patients with rheumatoid arthritis. J Rheumatol. 2005;32:1013-9.</mixed-citation><mixed-citation xml:lang="en">Ang DC, Choi H, Kroenke K, Wolfe F. Comorbid depression is an independent risk factor for mortality in patients with rheumatoid arthritis. J Rheumatol. 2005;32:1013-9.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Margaretten M, Julian L, Katz P, Yelin E. Depression in patients with rheumatoid arthritis: description, causes and mechanisms. Int J Clin Rheum. 2011;6(6):617-23. doi: 10.2217/IJR.11.6</mixed-citation><mixed-citation xml:lang="en">Margaretten M, Julian L, Katz P, Yelin E. Depression in patients with rheumatoid arthritis: description, causes and mechanisms. Int J Clin Rheum. 2011;6(6):617-23. doi: 10.2217/IJR.11.6</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Abbott R, Whear R, Nikolaou V, et al. Tumour necrosis factor-α inhibitor therapy in chronic physical illness: A systematic review and metaanalysis of the effect on depression and anxiety. J Psychosom Res. 2015 Sep;79(3):175-84. doi: 10.1016/j.jpsychores.2015.04.008</mixed-citation><mixed-citation xml:lang="en">Abbott R, Whear R, Nikolaou V, et al. Tumour necrosis factor-α inhibitor therapy in chronic physical illness: A systematic review and metaanalysis of the effect on depression and anxiety. J Psychosom Res. 2015 Sep;79(3):175-84. doi: 10.1016/j.jpsychores.2015.04.008</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Rathbun AM, Reed GW, Harrold LR. The temporal relationship between depression and rheumatoid arthritis disease activity, treatment persistence and response: a systematic review. Rheumatology. 2013;52(10):1785-94. doi: 10.1093/rheumatology/kes356</mixed-citation><mixed-citation xml:lang="en">Rathbun AM, Reed GW, Harrold LR. The temporal relationship between depression and rheumatoid arthritis disease activity, treatment persistence and response: a systematic review. Rheumatology. 2013;52(10):1785-94. doi: 10.1093/rheumatology/kes356</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sheehy C, Murphy E, Barry M. Depression in rheumatoid arthritis – underscoring the problem. Rheumatology. 2006;45(11):1325-7. doi: 10.1093/rheumatology/kel231</mixed-citation><mixed-citation xml:lang="en">Sheehy C, Murphy E, Barry M. Depression in rheumatoid arthritis – underscoring the problem. Rheumatology. 2006;45(11):1325-7. doi: 10.1093/rheumatology/kel231</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Couzin-Frankel J. Inflammation bares a dark side. Science. 2010;330(6011):1621-31. doi: 10.1126/science.330.6011.162</mixed-citation><mixed-citation xml:lang="en">Couzin-Frankel J. Inflammation bares a dark side. Science. 2010;330(6011):1621-31. doi: 10.1126/science.330.6011.162</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Strain JJ, Blumenfield M. Challenges for consultation-liaison psychiatry in the 21st Century. Psychosomatics. 2008;49:2. doi: 10.1176/appi.psy.49.2.93</mixed-citation><mixed-citation xml:lang="en">Strain JJ, Blumenfield M. Challenges for consultation-liaison psychiatry in the 21st Century. Psychosomatics. 2008;49:2. doi: 10.1176/appi.psy.49.2.93</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Howren MB, Lamkin DM, Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med. 2009;71:171-86. doi: 10.1097/PSY.0b013e3181907c1b</mixed-citation><mixed-citation xml:lang="en">Howren MB, Lamkin DM, Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med. 2009;71:171-86. doi: 10.1097/PSY.0b013e3181907c1b</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Schmidt FM, Lichtblau N, Minkwitz J, et al. Cytokine levels in depressed and non-depressed subjects, and masking effects of obesity. J Psychiatr Res. 2014;55:29-34. doi: 10.1016/j.jpsychires.2014.04.021</mixed-citation><mixed-citation xml:lang="en">Schmidt FM, Lichtblau N, Minkwitz J, et al. Cytokine levels in depressed and non-depressed subjects, and masking effects of obesity. J Psychiatr Res. 2014;55:29-34. doi: 10.1016/j.jpsychires.2014.04.021</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Gimeno D, Kivimaki M, Brunner EJ, et al. Associations of Creactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study. Psychol Med. 2009;39(3):413-23. doi: 10.1017/S0033291708003723</mixed-citation><mixed-citation xml:lang="en">Gimeno D, Kivimaki M, Brunner EJ, et al. Associations of Creactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study. Psychol Med. 2009;39(3):413-23. doi: 10.1017/S0033291708003723</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Raison CL, Rutherford RE, Woolwine BJ, et al. A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry. 2013;70:31-41. doi: 10.1001/2013.jamapsychiatry.4</mixed-citation><mixed-citation xml:lang="en">Raison CL, Rutherford RE, Woolwine BJ, et al. A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers. JAMA Psychiatry. 2013;70:31-41. doi: 10.1001/2013.jamapsychiatry.4</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Beratis S, Katrivanou A, Georgiou S, et al. Major depression and risk of depressive symptomatology associated with short-term and low-dose interferon-alpha treatment. J Psychosom Res. 2005;58:15-8. doi: 10.1016/j.jpsychores.2004.03.010</mixed-citation><mixed-citation xml:lang="en">Beratis S, Katrivanou A, Georgiou S, et al. Major depression and risk of depressive symptomatology associated with short-term and low-dose interferon-alpha treatment. J Psychosom Res. 2005;58:15-8. doi: 10.1016/j.jpsychores.2004.03.010</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Musselman DL, Lawson DH, Gumnick JF, et al. Paroxetine for the prevention of depression induced by high-dose interferon alfa. N Engl J Med. 2001;344:961-6. doi: 10.1056/NEJM200103293441303</mixed-citation><mixed-citation xml:lang="en">Musselman DL, Lawson DH, Gumnick JF, et al. Paroxetine for the prevention of depression induced by high-dose interferon alfa. N Engl J Med. 2001;344:961-6. doi: 10.1056/NEJM200103293441303</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Mattey DL, Dawes PT, Hassell AB, et al. Effect of psychological distress on continuation of anti-tumor necrosis factor therapy in patients with rheumatoid arthritis. J Rheumatol. 2010;37(10):2021-4. doi: 10.3899/jrheum.100050</mixed-citation><mixed-citation xml:lang="en">Mattey DL, Dawes PT, Hassell AB, et al. Effect of psychological distress on continuation of anti-tumor necrosis factor therapy in patients with rheumatoid arthritis. J Rheumatol. 2010;37(10):2021-4. doi: 10.3899/jrheum.100050</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Hider SL, Tanveer W, Brownfield A, et al. Depression in RA patients treated with anti-TNF is common and under-recognized in the rheumatology clinic. Rheumatology. 2009;48(9):1152-4. doi: 10.1093/rheumatology/kep170</mixed-citation><mixed-citation xml:lang="en">Hider SL, Tanveer W, Brownfield A, et al. Depression in RA patients treated with anti-TNF is common and under-recognized in the rheumatology clinic. Rheumatology. 2009;48(9):1152-4. doi: 10.1093/rheumatology/kep170</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Zautra AJ, Smith BW. Depression and reactivity to stress in older women with rheumatoid arthritis and osteoarthritis. Psychosom Med. 2001;63:687-96. doi: 10.1097/00006842-200107000-00022</mixed-citation><mixed-citation xml:lang="en">Zautra AJ, Smith BW. Depression and reactivity to stress in older women with rheumatoid arthritis and osteoarthritis. Psychosom Med. 2001;63:687-96. doi: 10.1097/00006842-200107000-00022</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Zautra AJ, Yocum DC, Villanueva I, et al. Immune activation and depression in women with rheumatoid arthritis. J Rheumatol. 2004;31:457-63.</mixed-citation><mixed-citation xml:lang="en">Zautra AJ, Yocum DC, Villanueva I, et al. Immune activation and depression in women with rheumatoid arthritis. J Rheumatol. 2004;31:457-63.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Schieir O, Thombs BD, Hudson M, et al. Symptoms of depression predict the trajectory of pain among patients with early inflammatory arthritis: a path analysis approach to assessing change. J Rheumatol. 2009;36(2):231-9. doi: 10.3899/jrheum.080147</mixed-citation><mixed-citation xml:lang="en">Schieir O, Thombs BD, Hudson M, et al. Symptoms of depression predict the trajectory of pain among patients with early inflammatory arthritis: a path analysis approach to assessing change. J Rheumatol. 2009;36(2):231-9. doi: 10.3899/jrheum.080147</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Cabrera-Marroquin R, Contreras-Yanez I, Alcocer-Castillejos N, Pascual-Ramos V. Major depressive episodes are associated with poor concordance with therapy in rheumatoid arthritis patients: the impact on disease outcomes. Clin Exp Rheumatol. 2014;32(6):904-13.</mixed-citation><mixed-citation xml:lang="en">Cabrera-Marroquin R, Contreras-Yanez I, Alcocer-Castillejos N, Pascual-Ramos V. Major depressive episodes are associated with poor concordance with therapy in rheumatoid arthritis patients: the impact on disease outcomes. Clin Exp Rheumatol. 2014;32(6):904-13.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Leblanc-Trudeau C, Dobkin PL, Carrier N, et al. Depressive symptoms predict future simple disease activity index scores and simple disease activity index remission in a prospective cohort of patients with early inflammatory polyarthritis. Rheumatology (Oxford). 2015;54(12):2205-14. doi: 10.1093/rheumatology/kev272</mixed-citation><mixed-citation xml:lang="en">Leblanc-Trudeau C, Dobkin PL, Carrier N, et al. Depressive symptoms predict future simple disease activity index scores and simple disease activity index remission in a prospective cohort of patients with early inflammatory polyarthritis. Rheumatology (Oxford). 2015;54(12):2205-14. doi: 10.1093/rheumatology/kev272</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Wong M, Mulherin D. The influence of medication beliefs and other psychosocial factors on early discontinuation of diseasemodifying anti-rheumatic drugs. Musculoskel Care. 2007;5(3):148-59. doi: 10.1002/msc.107</mixed-citation><mixed-citation xml:lang="en">Wong M, Mulherin D. The influence of medication beliefs and other psychosocial factors on early discontinuation of diseasemodifying anti-rheumatic drugs. Musculoskel Care. 2007;5(3):148-59. doi: 10.1002/msc.107</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Насонов ЕЛ, Насонова ВА, редакторы. Ревматология: Национальное руководство. Москва: ГЭОТАР-Медиа; 2008. 720 с. [Nasonov EL, Nasonova VA, editors. Revmatologiya: Natsional’noe rukovodstvo [Rheumatology: National guidelines]. Moscow: GEOTAR-Media; 2008. 720 p. (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Насонов ЕЛ, Насонова ВА, редакторы. Ревматология: Национальное руководство. Москва: ГЭОТАР-Медиа; 2008. 720 с. [Nasonov EL, Nasonova VA, editors. Revmatologiya: Natsional’noe rukovodstvo [Rheumatology: National guidelines]. Moscow: GEOTAR-Media; 2008. 720 p. (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Aletaha D, Landewe R, Karonitsch T, et al. Reporting disease activity in clinical trials of patients with rheumatoid arthritis: EULAR/ACR collaborative recommendations. Ann Rheum Dis. 2008;67(10):1360-4. doi: 10.1136/ard.2008.091454</mixed-citation><mixed-citation xml:lang="en">Aletaha D, Landewe R, Karonitsch T, et al. Reporting disease activity in clinical trials of patients with rheumatoid arthritis: EULAR/ACR collaborative recommendations. Ann Rheum Dis. 2008;67(10):1360-4. doi: 10.1136/ard.2008.091454</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Kojioma M, Kojioma T, Suzuki S, et al. Depression, inflammation and pain in patients with rheumatoid arthritis. Arthritis Rheum. 2009;61(8):1018-24. doi: 10.1002/art.24647</mixed-citation><mixed-citation xml:lang="en">Kojioma M, Kojioma T, Suzuki S, et al. Depression, inflammation and pain in patients with rheumatoid arthritis. Arthritis Rheum. 2009;61(8):1018-24. doi: 10.1002/art.24647</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Ramsey-Goldman R, Rothrock N. Fatigue in systemic lupus erythematosus and rheumatoid arthritis. Amer Acad Phys Med Rehabil. 2010;2(5):384-92. doi: 10.1016/j.pmrj.2010.03.026</mixed-citation><mixed-citation xml:lang="en">Ramsey-Goldman R, Rothrock N. Fatigue in systemic lupus erythematosus and rheumatoid arthritis. Amer Acad Phys Med Rehabil. 2010;2(5):384-92. doi: 10.1016/j.pmrj.2010.03.026</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Inanc N, Yilmaz-Oner S, Can M, et al. The role of depression, anxiety, fatigue, and fibromyalgia on the evaluation of the remission status in patients with rheumatoid arthritis. J Rheumatol. 2014;41(9):1755-60. doi: 10.3899/jrheum.131171</mixed-citation><mixed-citation xml:lang="en">Inanc N, Yilmaz-Oner S, Can M, et al. The role of depression, anxiety, fatigue, and fibromyalgia on the evaluation of the remission status in patients with rheumatoid arthritis. J Rheumatol. 2014;41(9):1755-60. doi: 10.3899/jrheum.131171</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Ranzolin A, Tavares Brenol JC, Bredemeier M. Association of concomitant fibromyalgia with worse disease activity score in 28 joints, health assessment questionnaire, and short form 36 scores in patients with rheumatoid arthritis. Arthritis Rheum. 2009;61(6):794-800. DOI: 10.1002/art.24430</mixed-citation><mixed-citation xml:lang="en">Ranzolin A, Tavares Brenol JC, Bredemeier M. Association of concomitant fibromyalgia with worse disease activity score in 28 joints, health assessment questionnaire, and short form 36 scores in patients with rheumatoid arthritis. Arthritis Rheum. 2009;61(6):794-800. DOI: 10.1002/art.24430</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Boomershine ChS. Effective rheumatoid arthritis treatment requires comprehensive management strategies. Arthr Res Ther. 2009;11:138. doi: 10.1186/ar2872</mixed-citation><mixed-citation xml:lang="en">Boomershine ChS. Effective rheumatoid arthritis treatment requires comprehensive management strategies. Arthr Res Ther. 2009;11:138. doi: 10.1186/ar2872</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Cordingley L, Prajapati R, Plant D. The Biologics In Rheumatoid Arthritis Genetics And Genomics Study Syndicate (Braggss), Barton A. Impact of Psychological Factors on Subjective Disease Activity Assessments in Patients With Severe Rheumatoid Arthritis. Arthr Care Res. 2014;66(6):861-8. doi: 10.1002/acr.22249</mixed-citation><mixed-citation xml:lang="en">Cordingley L, Prajapati R, Plant D. The Biologics In Rheumatoid Arthritis Genetics And Genomics Study Syndicate (Braggss), Barton A. Impact of Psychological Factors on Subjective Disease Activity Assessments in Patients With Severe Rheumatoid Arthritis. Arthr Care Res. 2014;66(6):861-8. doi: 10.1002/acr.22249</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Roubille C, Richer V, Starnino T. Evidence-based Recommendations for the Management of Comorbidities in Rheumatoid Arthritis, Psoriasis, and Psoriatic Arthritis: Expert Opinion of the Canadian Dermatology-Rheumatology Comorbidity Initiative. J Rheumatol. 2015;42(10):1767-80. doi: 10.3899/jrheum.141112</mixed-citation><mixed-citation xml:lang="en">Roubille C, Richer V, Starnino T. Evidence-based Recommendations for the Management of Comorbidities in Rheumatoid Arthritis, Psoriasis, and Psoriatic Arthritis: Expert Opinion of the Canadian Dermatology-Rheumatology Comorbidity Initiative. J Rheumatol. 2015;42(10):1767-80. doi: 10.3899/jrheum.141112</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Uguz F, Akman C, Kucuksarac S, Tufekci O. Anti-tumor necrosis factor-alpha therapy is associated with less frequent mood and anxiety disorders in patients with rheumatoid arthritis. Psychiatry Clin Neurosci. 2009;63(1):50-5. doi: 10.1111/j.1440-1819.2008.01905.x</mixed-citation><mixed-citation xml:lang="en">Uguz F, Akman C, Kucuksarac S, Tufekci O. Anti-tumor necrosis factor-alpha therapy is associated with less frequent mood and anxiety disorders in patients with rheumatoid arthritis. Psychiatry Clin Neurosci. 2009;63(1):50-5. doi: 10.1111/j.1440-1819.2008.01905.x</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Hoving JL, Bartelds GM, Sluiter JK, et al. Perceived work ability, quality of life and fatigue in patients with rheumatoid arthritis after a 6-month course of TNF inhibitors: prospective intervention study and partial economic evaluation. Scand J Rheumatol. 2009;38:246-50. doi: 10.1080/03009740902748264</mixed-citation><mixed-citation xml:lang="en">Hoving JL, Bartelds GM, Sluiter JK, et al. Perceived work ability, quality of life and fatigue in patients with rheumatoid arthritis after a 6-month course of TNF inhibitors: prospective intervention study and partial economic evaluation. Scand J Rheumatol. 2009;38:246-50. doi: 10.1080/03009740902748264</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Moreland LW, Genovese MC, Sato R, Singh A. Effect of Etanercept on fatigue in patients with recent or established rheumatoid arthritis. Arthr Care Res. 2006;55(2):287-93. doi: 10.1002/art.21838</mixed-citation><mixed-citation xml:lang="en">Moreland LW, Genovese MC, Sato R, Singh A. Effect of Etanercept on fatigue in patients with recent or established rheumatoid arthritis. Arthr Care Res. 2006;55(2):287-93. doi: 10.1002/art.21838</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Wolf F, Michaud K. Fatigue, rheumatoid arthritis and anti-tumor necrosis factor therapy: an investigation in 24831 patients. J Rheumatol. 2004;31(11):2115-20.</mixed-citation><mixed-citation xml:lang="en">Wolf F, Michaud K. Fatigue, rheumatoid arthritis and anti-tumor necrosis factor therapy: an investigation in 24831 patients. J Rheumatol. 2004;31(11):2115-20.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Chauffier K, Salliot C, Berenbaum F, Sellam J. Effect of biotherapies on fatigue in rheumatoid arthritis: a systematic review of the literature and meta-analysis. Rheumatology (Oxford). 2012;51(1):60-8. doi: 10.1093/rheumatology/ker162</mixed-citation><mixed-citation xml:lang="en">Chauffier K, Salliot C, Berenbaum F, Sellam J. Effect of biotherapies on fatigue in rheumatoid arthritis: a systematic review of the literature and meta-analysis. Rheumatology (Oxford). 2012;51(1):60-8. doi: 10.1093/rheumatology/ker162</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Van Hoogmoed D, Fransen J, Bleijenberg G, van Riel P. Physical and psychosocial correlates of severe fatigue in rheumatoid arthritis. Rheumatology. 2010;49(7):1294-302. doi: 10.1093/rheumatology/keq043</mixed-citation><mixed-citation xml:lang="en">Van Hoogmoed D, Fransen J, Bleijenberg G, van Riel P. Physical and psychosocial correlates of severe fatigue in rheumatoid arthritis. Rheumatology. 2010;49(7):1294-302. doi: 10.1093/rheumatology/keq043</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor-Gjevre RM, Gjevre JA, Nair BV, et al. Improved sleep efficiency after anti-tumor necrosis factor a therapy in rheumatoid arthritis patients. Ther Adv Musculoskel Dis. 2011;3(5):227-33. doi: 10.1177/1759720X11416862</mixed-citation><mixed-citation xml:lang="en">Taylor-Gjevre RM, Gjevre JA, Nair BV, et al. Improved sleep efficiency after anti-tumor necrosis factor a therapy in rheumatoid arthritis patients. Ther Adv Musculoskel Dis. 2011;3(5):227-33. doi: 10.1177/1759720X11416862</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Лисицына ТА, Зелтынь АЕ, Вельтищев ДЮ и др. Расстройства тревожно-депрессивного спектра и когнитивные нарушения у больных ревматоидным артритом. Журнал неврологии и психиатрии им. С.С. Корсакова. 2012;11(2):96-103 [Lisitsyna TA, Zeltyn’ AE, Vel’tishchev DYu, et al. Anxiety disorders and depressive disorders in rheumatoid arthritis patients. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2012;11(2):96-103 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Лисицына ТА, Зелтынь АЕ, Вельтищев ДЮ и др. Расстройства тревожно-депрессивного спектра и когнитивные нарушения у больных ревматоидным артритом. Журнал неврологии и психиатрии им. С.С. Корсакова. 2012;11(2):96-103 [Lisitsyna TA, Zeltyn’ AE, Vel’tishchev DYu, et al. Anxiety disorders and depressive disorders in rheumatoid arthritis patients. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2012;11(2):96-103 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Tarkowski E, Andreasen N, Tarkowski A, Blennow K. Intrathecal inflammation precedes development of Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2003;74(9):1200-5. doi: 10.1136/jnnp.74.9.1200</mixed-citation><mixed-citation xml:lang="en">Tarkowski E, Andreasen N, Tarkowski A, Blennow K. Intrathecal inflammation precedes development of Alzheimer's disease. J Neurol Neurosurg Psychiatry. 2003;74(9):1200-5. doi: 10.1136/jnnp.74.9.1200</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Лисицына ТА, Вельтищев ДЮ, Серавина ОФ и др. Провоспалительные цитокины и депрессия при ревматоидном артрите. Научно-практическая ревматология. 2013;51(3):261-6 [Lisitsyna TA, Vel'tishchev DYu, Seravina OF, et al. Anti-inflammatory cytokines and depression in rheumatoid arthritis patients. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2013;51(3):261-6 (In Russ.)]. doi: 10.14412/1995-4484-2013-1498</mixed-citation><mixed-citation xml:lang="en">Лисицына ТА, Вельтищев ДЮ, Серавина ОФ и др. Провоспалительные цитокины и депрессия при ревматоидном артрите. Научно-практическая ревматология. 2013;51(3):261-6 [Lisitsyna TA, Vel'tishchev DYu, Seravina OF, et al. Anti-inflammatory cytokines and depression in rheumatoid arthritis patients. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2013;51(3):261-6 (In Russ.)]. doi: 10.14412/1995-4484-2013-1498</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Mü ller N, Schwarz MJ. COX-2 inhibition in schizophrenia and major depression. Curr Pharm Des. 2008;14(14):1452-65. doi: 10.2174/138161208784480243</mixed-citation><mixed-citation xml:lang="en">Mü ller N, Schwarz MJ. COX-2 inhibition in schizophrenia and major depression. Curr Pharm Des. 2008;14(14):1452-65. doi: 10.2174/138161208784480243</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Hayden KM, Zandi PP, Khachaturian AS, et al. Does NSAID use modify cognitive trajectories in the elderly? The Cache Country study. Neurology. 2007;69(3):275-82. doi: 10.1212/01.wnl.0000265223.25679.2a</mixed-citation><mixed-citation xml:lang="en">Hayden KM, Zandi PP, Khachaturian AS, et al. Does NSAID use modify cognitive trajectories in the elderly? The Cache Country study. Neurology. 2007;69(3):275-82. doi: 10.1212/01.wnl.0000265223.25679.2a</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Tobinick EL, Gross H. Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration. J Neuroinflammat. 2008;5(1):2. doi: 10.1186/1742-2094-5-2</mixed-citation><mixed-citation xml:lang="en">Tobinick EL, Gross H. Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration. J Neuroinflammat. 2008;5(1):2. doi: 10.1186/1742-2094-5-2</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Janssen DGA, Caniato RN, Verster JC, Baune BT. A psychoneuroimmunological review on cytokines involved in antidepressant treatment response. Hum Psychopharmacol Clin Exp. 2010;25(3):201-15. doi: 10.1002/hup.1103</mixed-citation><mixed-citation xml:lang="en">Janssen DGA, Caniato RN, Verster JC, Baune BT. A psychoneuroimmunological review on cytokines involved in antidepressant treatment response. Hum Psychopharmacol Clin Exp. 2010;25(3):201-15. doi: 10.1002/hup.1103</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Slaughter JR, Parker JC, Martens MP, et al. Clinical outcomes following a trial of sertraline in rheumatoid arthritis. Psychosom. 2002;43(1):36-41. doi: 10.1176/appi.psy.43.1.36</mixed-citation><mixed-citation xml:lang="en">Slaughter JR, Parker JC, Martens MP, et al. Clinical outcomes following a trial of sertraline in rheumatoid arthritis. Psychosom. 2002;43(1):36-41. doi: 10.1176/appi.psy.43.1.36</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Richards BL, Whittle SL, van der Heijde DM, Buchbinder R. The efficacy and safety of antidepressants in inflammatory arthritis: a Cochrane systematic review. J Rheumatol Suppl. 2012 Sep;90:21-7. doi: 10.3899/jrheum.120338</mixed-citation><mixed-citation xml:lang="en">Richards BL, Whittle SL, van der Heijde DM, Buchbinder R. The efficacy and safety of antidepressants in inflammatory arthritis: a Cochrane systematic review. J Rheumatol Suppl. 2012 Sep;90:21-7. doi: 10.3899/jrheum.120338</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Miller AH, Maletic V, Raison ChL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry. 2009;65(9):732-41. doi: 10.1016/j.biopsych.2008.11.029</mixed-citation><mixed-citation xml:lang="en">Miller AH, Maletic V, Raison ChL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry. 2009;65(9):732-41. doi: 10.1016/j.biopsych.2008.11.029</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Castanon N, Leonard BE, Neveu PJ, Yirmiya R. Effects of antidepressants on cytokine production and actions. Brain Behav Immun. 2002;16(5):569-74. doi: 10.1016/S0889-1591(02)00008-9</mixed-citation><mixed-citation xml:lang="en">Castanon N, Leonard BE, Neveu PJ, Yirmiya R. Effects of antidepressants on cytokine production and actions. Brain Behav Immun. 2002;16(5):569-74. doi: 10.1016/S0889-1591(02)00008-9</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Kato M, Serretti A. Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder. Mol Psychiatr. 2010;15(5):473-500. doi: 10.1038/mp.2008.116</mixed-citation><mixed-citation xml:lang="en">Kato M, Serretti A. Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder. Mol Psychiatr. 2010;15(5):473-500. doi: 10.1038/mp.2008.116</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Bian-Sheng JI, He JI, Guo-Ging LIU. Doxepine protects cultured neurons against oxidative stress-induced injury. Acta Pharmacol Sin. 2004;25(3):297-300.</mixed-citation><mixed-citation xml:lang="en">Bian-Sheng JI, He JI, Guo-Ging LIU. Doxepine protects cultured neurons against oxidative stress-induced injury. Acta Pharmacol Sin. 2004;25(3):297-300.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Ash G, Dickens CM, Creed FH, et al. The effects of dothiepin on subjects with rheumatoid arthritis and depression. Rheumatology. 1999;38:959-67. doi: 10.1093/rheumatology/38.10.959</mixed-citation><mixed-citation xml:lang="en">Ash G, Dickens CM, Creed FH, et al. The effects of dothiepin on subjects with rheumatoid arthritis and depression. Rheumatology. 1999;38:959-67. doi: 10.1093/rheumatology/38.10.959</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Huber AM, Tomlinson GA, Koren G, Feldman BM. Amitriptyline to relieve pain in Juvenile Idiopathic Arthritis: a pilot study using Bayesian metaanalysis of multiple N-of-1 Clinical Trials. J Rheumatol. 2007;34:1125-32. doi: 10.1186/ISRCTN95255919</mixed-citation><mixed-citation xml:lang="en">Huber AM, Tomlinson GA, Koren G, Feldman BM. Amitriptyline to relieve pain in Juvenile Idiopathic Arthritis: a pilot study using Bayesian metaanalysis of multiple N-of-1 Clinical Trials. J Rheumatol. 2007;34:1125-32. doi: 10.1186/ISRCTN95255919</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Fishbain DA, Cutler RB, Lewis J, et al. Do second-generation «atypical neuroleptics» have analgesic properties: a structured evidence-based review. Pain Med. 2004;5(4):359-65. doi: 10.1111/j.1526-4637.2004.04054.x</mixed-citation><mixed-citation xml:lang="en">Fishbain DA, Cutler RB, Lewis J, et al. Do second-generation «atypical neuroleptics» have analgesic properties: a structured evidence-based review. Pain Med. 2004;5(4):359-65. doi: 10.1111/j.1526-4637.2004.04054.x</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
