rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2016-361-366rsp-2234Research ArticleДИСКУССИИDISCUSSIONНесвоевременные мысли о применении генно-инженерных биологических препаратов при ревматических болезняхTARDY IDEAS ON THE USE OF BIOLOGICAL AGENTS IN RHEUMATIC DISEASESМуравьевЮ. В.MuravyevYu. V.

115522 Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

murawyu@mail.ruМуравьеваЛ. А.MuravyevaL. A.

141400 Московская область, Химки, ул. Чкалова, 2/21

ФГБНУ Научно-исследовательский институт ревматологии им. В.А. НасоновойРоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationЦентральное поликлиническое отделение МБУЗ «Химкинская центральная клиническая больница»РоссияCentral Outpatient Department, Khimki Central Clinical HospitalRussian Federation201620072016543361366Copyright © Муравьев Ю.В., Муравьева Л.А., 20162016Муравьев Ю.В., Муравьева Л.А.Muravyev Y.V., Muravyeva L.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2234

В течение последних двух десятилетий разработан целый ряд инновационных генно-инженерных биологических препаратов, внедрение которых в клиническую практику позволило существенно улучшить результаты лечения ревматических болезней. В то же время отмечается нарастание числа сообщений о связанных с их применением неблагоприятных реакциях, нередко парадоксальных (показанное при многих аутоиммунных процессах назначение этих препаратов может вызвать аналогичные аутоиммунные процессы ).

The past two decades have been marked by the design of a great variety of innovative biological agents, the clinical introduction of which could substantially improve the results of treatment for rheumatic diseases. At the same time, there are a larger number of reports on their administration-associated adverse events, often paradoxical ones (these drugs indicated in many autoimmune processes may induce similar autoimmune processes).

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The authors declare that there are no conflicts of interest present.