rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2016-1S-60-66rsp-2255Research ArticleПРОГРЕСС В РЕВМАТОЛОГИИ В XXI ВЕКЕPROGRESS IN RHEUMATOLOGY IN THE XXI CENTURYИНТЕРЛЕЙКИН 17А – НОВАЯ МИШЕНЬ АНТИЦИТОКИНОВОЙ ТЕРАПИИ АНКИЛОЗИРУЮЩЕГО СПОНДИЛИТАINTERLEUKIN-17A IS A NEW TARGET OF ANTICYTOKINE THERAPY FOR ANKYLOSING SPONDYLITISЭрдесШ. Ф.ErdesSh. F.

 

123456_57@mail.ruНаучноисследовательский институт ревматологии имени В.А. Насоновой, МоскваРоссияV.A. Nasonova Research Institute of Rheumatology, MoscowRussian Federation201615092016541Sприложение 16066Copyright © Эрдес Ш.Ф., 20162016Эрдес Ш.Ф.Erdes S.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2255

Терапия  анкилозирующего спондилита  (АС) – сложная  задача для врача, в первую очередь из-за малого числа альтернативных возможностей лечения.  В последние  годы обнаружена  новая перспективная мишень для терапевтического воздействия – интерлейкин 17 (ИЛ17). Появился и первый представитель  новой группы лекарственных средств – моноклональные антитела к ИЛ17А (секукинумаб), – позволяющий расширить  терапевтические возможности при данном заболевании. Результаты проведенных  исследований показали, что секукинумаб  эффективен для лечения АС, обладает низкой  иммуногенностью и его профиль  безопасности практически не отличается от такового плацебо.

Therapy for ankylosing spondylitis (AS) is a challenge for a physician, primarily because of a small number of therapeutic alternatives. Interleukin-17 (IL17), a novel promising therapeutic  target, has been recently disclosed. The first representative of the new group of drugs – anti-IL17A monoclonal  antibodies (secukinumab)  has emerged, which allows expanding therapeutic  opportunities  for this disease. Trials have shown that secukinumab is effective in treating AS, has low immunogenicity and its safety profile does not virtually differ from that of placebo.

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The authors declare that there are no conflicts of interest present.