rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2016-469-477rsp-2278Research ArticleОБЗОРЫКоморбидные инфекции у больных системной красной волчанкой: современное состояние проблемыComorbid infections in patients with systemic lupus erythematosus: State-of-the-artБеловБ. С.BelovB. S.

115522 Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

belovbor@yandex.ruСоловьевС. К.SolovyevS. K.

115522 Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

КлюквинаН. Г.KlyukvinaN. G.

кафедра ревматологии Института профессионального образования

119991 Москва, ул. Трубецкая, 8, стр. 2 

Department of Rheumatology, Institute of Professional Education

8, Trubetskaya St., Build. 2, Moscow 119991 

ТарасоваГ. М.TarasovaG. M.

34A, Kashirskoe Shosse, Moscow 115522

ПолянскаяМ. В.Polyanskaya M.V.M. V.

115522 Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

ФГБНУ Научно- исследовательский институт ревматологии им. В.А. Насоновой, МоскваРоссияV.A. Nasonova Research Institute of Rheumatology, MoscowRussian FederationФГБОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России, МоскваРоссияI.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, MoscowRussian Federation201620102016544469477Copyright © Белов Б.С., Соловьев С.К., Клюквина Н.Г., Тарасова Г.М., Полянская М.В., 20162016Белов Б.С., Соловьев С.К., Клюквина Н.Г., Тарасова Г.М., Полянская М.В.Belov B.S., Solovyev S.K., Klyukvina N.G., Tarasova G.M., Polyanskaya M.V. M.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2278

В современной ревматологии коморбидные инфекции (КИ) оказывают значительное влияние на морбидность и летальность у больных системной красной волчанкой (СКВ). Повышенная восприимчивость больных СКВ к инфекциям связана с разнообразными расстройствами иммунной системы. Выделен ряд факторов риска развития КИ при СКВ, имеющих отношение как к самому заболеванию, так и к его лечению. Однако, несмотря на достаточное количество этих факторов, вклад каждого из них весьма разнится в зависимости от когорты наблюдаемых больных СКВ. Рассмотрены эпидемиологические и клинико-лабораторные характеристики некоторых бактериальных и вирусных КИ у больных СКВ в современной клинической практике. Подчеркивается значимость иммунизации, в первую очередь противогриппозной и пневмококковой вакцинами, больных СКВ, поскольку среди них риск летальных исходов от инфекций нижних дыхательных путей достаточно высок. Намечены пути дальнейших исследований в рамках рассматриваемой проблемы. 

In modern rheumatology, comorbid infections (CIs) have a significant impact on morbidity and mortality of patients with systemic lupus erythematosus (SLE). The increased susceptibility of SLE patients to infections is associated with various immune disorders. A number of risk factors for CIs in SLE, which are related to the disease and its treatment, have been identified. However, despite the fact that there are a sufficient number of these factors, the contribution of each of them varies considerably with the cohort of examined SLE patients. The paper considers the epidemiological, clinical, and laboratory characteristics of some bacterial and viral CIs in patients with SLE in current clinical practice. It underlines the importance of primarily influenza and pneumococcal vaccination in patients with SLE since among them the risk of deaths from lower respiratory tract infections is quite high. The ways of further investigations in the framework of the problem under consideration are outlined.

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[Pis’mo Federal’noi sluzhby po nadzoru v sfere zdravookhraneniya ot 7 fevralya 2014 g. №02I-110/14 «O novykh dannykh po bezopasnosti lekarstvennogo preparata Benlista» [The letter of Federal service on supervision in sphere of public health from February 7, 2014 №02I-110/14, "On the new drug for safety data Benlista"]. Available from: http://www.garant.ru/products/ipo/prime/doc/70485650/#ixzz3 OWJlGxDT. Treatment Date January 10, 2015].Письмо Федеральной службы по надзору в сфере здравоохранения от 7 февраля 2014 г. №02И-110/14 «О новых данных по безопасности лекарственного препарата Бенлиста». Доступно по ссылке: http://www.garant.ru/products/ipo/prime/doc/70485650/#ixzz3 OWJlGxDT. Дата обращения 10 января 2015 г. 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The authors declare that there are no conflicts of interest present.