<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1995-4484-2017-446-448</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-2419</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКОЕ НАБЛЮДЕНИЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group></article-categories><title-group><article-title>Индуцированный инфликсимабом волчаночно-подобный синдром у больной ревматоидным артритом (описание случая): случайность или закономерность?</article-title><trans-title-group xml:lang="en"><trans-title>INFLIXIMAB-INDUCED LUPUS-LIKE SYNDROME IN A FEMALE PATIENT WITH RHEUMATOID ARTHRITIS (A CASE REPORT): AN ACCIDENT OR REGULARITY?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Муравьев</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Muravyev</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><email xlink:type="simple">murawyu@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедева</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedeva</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аламанкина</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Alamankina</surname><given-names>S. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522 Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>29</day><month>09</month><year>2017</year></pub-date><volume>55</volume><issue>4</issue><fpage>446</fpage><lpage>448</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Муравьев Ю.В., Лебедева В.В., Аламанкина С.Ю., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Муравьев Ю.В., Лебедева В.В., Аламанкина С.Ю.</copyright-holder><copyright-holder xml:lang="en">Muravyev Y.V., Lebedeva V.V., Alamankina S.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/2419">https://rsp.mediar-press.net/rsp/article/view/2419</self-uri><abstract><p>В статье описывается случай развития волчаночно-подобного синдрома, индуцированного инфликсимабом, у больной ревматоидным артритом, с обсуждением возможных причин возникновения такой патологии.</p></abstract><trans-abstract xml:lang="en"><p>The paper describes a case of infliximab-induced lupus-like syndrome in a female patient with rheumatoid arthritis and discusses the possible causes of this pathology.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ревматоидный артрит</kwd><kwd>инфликсимаб</kwd><kwd>волчаночно-подобный синдром</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rheumatoid arthritis</kwd><kwd>infliximab</kwd><kwd>lupus-like syndrome</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Wetter DA, Davis MDP. Lupus-like syndrome attributable to antitumor necrosis factor alpha therapy in 14 patients during an 8-year period at Mayo Clinic. Mayo Clinic Proc. 2009 Nov;84(11):979-84.doi: 10.1016/S0025-6196(11)60668-X</mixed-citation><mixed-citation xml:lang="en">Wetter DA, Davis MDP. Lupus-like syndrome attributable to antitumor necrosis factor alpha therapy in 14 patients during an 8-year period at Mayo Clinic. Mayo Clinic Proc. 2009 Nov;84(11):979-84.doi: 10.1016/S0025-6196(11)60668-X</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Desai SB, Furst DE. Problems encountered during anti-tumour necrosis factor therapy. Best Pract Res Clin Rheumatol. 2006;20:757-90. doi: 10.1016/j.berh.2006.06.002</mixed-citation><mixed-citation xml:lang="en">Desai SB, Furst DE. Problems encountered during anti-tumour necrosis factor therapy. Best Pract Res Clin Rheumatol. 2006;20:757-90. doi: 10.1016/j.berh.2006.06.002</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Hoffman BJ. Sensitivity to sulfadiazine resembling acute disseminated lupus erythematosus. Arch Dermatol Syph. 1945;51:190-2. doi: 10.1001/archderm.1945.01510210032007</mixed-citation><mixed-citation xml:lang="en">Hoffman BJ. Sensitivity to sulfadiazine resembling acute disseminated lupus erythematosus. Arch Dermatol Syph. 1945;51:190-2. doi: 10.1001/archderm.1945.01510210032007</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Borchers AT, Keen CL, Gershwin ME. Drug-induced lupus. Ann N Y Acad Sci. 2007;1108:166-82. doi: 10.1196/annals.1422.019</mixed-citation><mixed-citation xml:lang="en">Borchers AT, Keen CL, Gershwin ME. Drug-induced lupus. Ann N Y Acad Sci. 2007;1108:166-82. doi: 10.1196/annals.1422.019</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Vasoo S. Drug-induced lupus: an update. Lupus. 2006;15:757-61. doi: 10.1177/0961203306070000</mixed-citation><mixed-citation xml:lang="en">Vasoo S. Drug-induced lupus: an update. Lupus. 2006;15:757-61. doi: 10.1177/0961203306070000</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982;25:1271-7. doi: 10.1002/art.1780251101</mixed-citation><mixed-citation xml:lang="en">Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982;25:1271-7. doi: 10.1002/art.1780251101</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997;40:1725. doi: 10.1002/art.1780400928</mixed-citation><mixed-citation xml:lang="en">Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1997;40:1725. doi: 10.1002/art.1780400928</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Williams EL, Gadola S, Edwards CJ. Anti-TNF-induced lupus. Rheumatology (Oxford). 2009;48:716-20. doi: 10.1093/rheumatology/kep080</mixed-citation><mixed-citation xml:lang="en">Williams EL, Gadola S, Edwards CJ. Anti-TNF-induced lupus. Rheumatology (Oxford). 2009;48:716-20. doi: 10.1093/rheumatology/kep080</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Charles PJ, Smeenk RJ, De Jong J, et al. Assessment of antibodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor alpha: findings in open-label and randomized placebo-controlled trials. Arthritis Rheum. 2000;43:2383-90. doi: 10.1002/15290131(200011)43:11&lt;2383::AID-ANR2&gt;3.0.CO;2-D</mixed-citation><mixed-citation xml:lang="en">Charles PJ, Smeenk RJ, De Jong J, et al. Assessment of antibodies to double-stranded DNA induced in rheumatoid arthritis patients following treatment with infliximab, a monoclonal antibody to tumor necrosis factor alpha: findings in open-label and randomized placebo-controlled trials. Arthritis Rheum. 2000;43:2383-90. doi: 10.1002/15290131(200011)43:11&lt;2383::AID-ANR2&gt;3.0.CO;2-D</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Favalli EG, Sinigaglia L, Varenna M, Arnoldi C. Drug-induced lupus following treatment with infliximab in rheumatoid arthritis. Lupus. 2002;11:753-5. doi: 10.1191/0961203302lu236cr</mixed-citation><mixed-citation xml:lang="en">Favalli EG, Sinigaglia L, Varenna M, Arnoldi C. Drug-induced lupus following treatment with infliximab in rheumatoid arthritis. Lupus. 2002;11:753-5. doi: 10.1191/0961203302lu236cr</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Costa MF, Said NR, Zimmermann B. Drug-induced lupus due to anti-tumor necrosis factor alpha agents. Semin Arthritis Rheum. 2008;37:381-7. doi: 10.1016/j.semarthrit.2007.08.003</mixed-citation><mixed-citation xml:lang="en">Costa MF, Said NR, Zimmermann B. Drug-induced lupus due to anti-tumor necrosis factor alpha agents. Semin Arthritis Rheum. 2008;37:381-7. doi: 10.1016/j.semarthrit.2007.08.003</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Klapman JB, Ene-Stroscu D, Becker MA, Hanauer SB. A lupuslike syndrome associated with infiximab therapy. Inflamm Bowel Dis. 2003;9:176-8. doi: 10.1097/00054725-00305000-00005</mixed-citation><mixed-citation xml:lang="en">Klapman JB, Ene-Stroscu D, Becker MA, Hanauer SB. A lupuslike syndrome associated with infiximab therapy. Inflamm Bowel Dis. 2003;9:176-8. doi: 10.1097/00054725-00305000-00005</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Sarzi-Puttini P, Ardizzone S, Manzionna G, et al. Infliximabinduced lupus in Crohn's disease: a case report. Dig Liver Dis. 2003;35:814-7. doi: 10.1016/S1590-8658(03)00448-1</mixed-citation><mixed-citation xml:lang="en">Sarzi-Puttini P, Ardizzone S, Manzionna G, et al. Infliximabinduced lupus in Crohn's disease: a case report. Dig Liver Dis. 2003;35:814-7. doi: 10.1016/S1590-8658(03)00448-1</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Bleumink GS, ter Borg EJ, Ramselaar CG, Strickler BH. Etanercept-induced subacute cutaneous lupus erythemaotosus. Rheumatology. 2001;40:1317-9. doi: 10.1093/rheumatology/40.11.1317</mixed-citation><mixed-citation xml:lang="en">Bleumink GS, ter Borg EJ, Ramselaar CG, Strickler BH. Etanercept-induced subacute cutaneous lupus erythemaotosus. Rheumatology. 2001;40:1317-9. doi: 10.1093/rheumatology/40.11.1317</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Shakoor N, Michalska M, Harris CA, Block JA. Drug-induced systemic lupus erythematosus associated with etanercept therapy. Lancet. 2002;359:579-80. doi: 10.1016/S0140-6736(02)07714-0</mixed-citation><mixed-citation xml:lang="en">Shakoor N, Michalska M, Harris CA, Block JA. Drug-induced systemic lupus erythematosus associated with etanercept therapy. Lancet. 2002;359:579-80. doi: 10.1016/S0140-6736(02)07714-0</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Carlson E, Rothfield N. Etanercept-induced lupus like syndrome in a patient with rheumatoid arthritis. Arthritis Rheum. 2003;48:1165-6. doi: 10.1002/art.11033</mixed-citation><mixed-citation xml:lang="en">Carlson E, Rothfield N. Etanercept-induced lupus like syndrome in a patient with rheumatoid arthritis. Arthritis Rheum. 2003;48:1165-6. doi: 10.1002/art.11033</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Cairns AP, Duncan MK, Hinder AE, Taggart AJ. New onset systemic lupus erythematosus in a patient receiving etanercept for rheumatoid arthritis. Ann Rheum Dis. 2002;61:1031-2. doi: 10.1136/ard.61.11.1031</mixed-citation><mixed-citation xml:lang="en">Cairns AP, Duncan MK, Hinder AE, Taggart AJ. New onset systemic lupus erythematosus in a patient receiving etanercept for rheumatoid arthritis. Ann Rheum Dis. 2002;61:1031-2. doi: 10.1136/ard.61.11.1031</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Swale VJ, Perrett CM, Denton CP, et al. Etanercept-induced systemic lupus erythematosus. Clin Exp Dermatol. 2003;28:604-7. doi: 10.1046/j.1365-2230.2003.01411.x</mixed-citation><mixed-citation xml:lang="en">Swale VJ, Perrett CM, Denton CP, et al. Etanercept-induced systemic lupus erythematosus. Clin Exp Dermatol. 2003;28:604-7. doi: 10.1046/j.1365-2230.2003.01411.x</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Kang M-J, Lee Y-H, Lee J. Etanercept-induced systemic lupus erythematosus in a patient with rheumatoid arthritis. J Korean Med Sci. 2006;21:946-9. doi: 10.3346/jkms.2006.21.5.946</mixed-citation><mixed-citation xml:lang="en">Kang M-J, Lee Y-H, Lee J. Etanercept-induced systemic lupus erythematosus in a patient with rheumatoid arthritis. J Korean Med Sci. 2006;21:946-9. doi: 10.3346/jkms.2006.21.5.946</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Haake H, Kä neke J, Amann K, et al. Development of systemic lupus erythematosus with focal proliferative lupus nephritis during anti-TNF-alpha therapy for psoriatic arthritis. Med Klin. 2007;102:852-7. doi: 10.1007/s00063-007-1104-6</mixed-citation><mixed-citation xml:lang="en">Haake H, Kä neke J, Amann K, et al. Development of systemic lupus erythematosus with focal proliferative lupus nephritis during anti-TNF-alpha therapy for psoriatic arthritis. Med Klin. 2007;102:852-7. doi: 10.1007/s00063-007-1104-6</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Van Rijthoven AWAM, Bijlsma JWJ, Canninga-Van Dijk M, et al. Onset of systemic lupus erythematosus after conversion of infliximab to adalimumab treatment in rheumatoid arthritis with a preexisting anti-dsDNA antibody level. Rheumatology. 2006;45:1317- 9. doi: 10.1093/rheumatology/kel227</mixed-citation><mixed-citation xml:lang="en">Van Rijthoven AWAM, Bijlsma JWJ, Canninga-Van Dijk M, et al. Onset of systemic lupus erythematosus after conversion of infliximab to adalimumab treatment in rheumatoid arthritis with a preexisting anti-dsDNA antibody level. Rheumatology. 2006;45:1317- 9. doi: 10.1093/rheumatology/kel227</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Schiff MH, Burmester GR, Kent JD, et al. Safety analyses of adalimumab (HUMIRA)in global clinical trials and US postmarketing surveillance of patients with rheumatoid arthritis. Ann Rheum Dis. 2006;65:889-94. doi: 10.1136/ard.2005.043166</mixed-citation><mixed-citation xml:lang="en">Schiff MH, Burmester GR, Kent JD, et al. Safety analyses of adalimumab (HUMIRA)in global clinical trials and US postmarketing surveillance of patients with rheumatoid arthritis. Ann Rheum Dis. 2006;65:889-94. doi: 10.1136/ard.2005.043166</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">De Bant M, Sibilia J, Le Loet X, et al. Systemic lupus erythematosus induced by anti- tumor necrosis factor alpha therapy: a French survey. Arthritis Res Ther. 2005;7(3):R545-51. doi: 10.1186/ar1715</mixed-citation><mixed-citation xml:lang="en">De Bant M, Sibilia J, Le Loet X, et al. Systemic lupus erythematosus induced by anti- tumor necrosis factor alpha therapy: a French survey. Arthritis Res Ther. 2005;7(3):R545-51. doi: 10.1186/ar1715</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Ramos-Casal M, Brito-Zeron P, Munoz S, et al. Autoimmune diseases induced by TNF- targeted therapies. Analysis of 233 cases. Medicine. 2007;86:242-51. doi: 10.1097/MD.0b013e3181441a68</mixed-citation><mixed-citation xml:lang="en">Ramos-Casal M, Brito-Zeron P, Munoz S, et al. Autoimmune diseases induced by TNF- targeted therapies. Analysis of 233 cases. Medicine. 2007;86:242-51. doi: 10.1097/MD.0b013e3181441a68</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Thornhill J, Watson KD, Lord PA, et al. Drug-induced lupus in patients with inflammatory arthritis treated with TNF blocking agents: results from the BSR Biologics Register. BSR Abstracts. 2008.</mixed-citation><mixed-citation xml:lang="en">Thornhill J, Watson KD, Lord PA, et al. Drug-induced lupus in patients with inflammatory arthritis treated with TNF blocking agents: results from the BSR Biologics Register. BSR Abstracts. 2008.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Jacob CO, McDevitt HO. Tumour necrosis factor-alpha in urine autoimmune 'lupus' nephritis. Nature. 1988;331:356-8. doi: 10.1038/331356a0</mixed-citation><mixed-citation xml:lang="en">Jacob CO, McDevitt HO. Tumour necrosis factor-alpha in urine autoimmune 'lupus' nephritis. Nature. 1988;331:356-8. doi: 10.1038/331356a0</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Kontoyiannis D, Kollias G. Accelerated autoimmunity and lupus nephritis in NZB mice with an engineered heterozygous deficiency in tumour necrosis factor. Eur J Immunol. 2000;30:2038-47. doi: 10.1002/1521-4141(200007)30:7&lt;2038::AIDIMMU2038&gt;3.0.CO;2-K</mixed-citation><mixed-citation xml:lang="en">Kontoyiannis D, Kollias G. Accelerated autoimmunity and lupus nephritis in NZB mice with an engineered heterozygous deficiency in tumour necrosis factor. Eur J Immunol. 2000;30:2038-47. doi: 10.1002/1521-4141(200007)30:7&lt;2038::AIDIMMU2038&gt;3.0.CO;2-K</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Gordon C, Ranges GE, Greenspan JS, Wofsy D. Chronic therapy with recombinant tumour necrosis factor-alpha in autoimmune NZB/NZW F1 mice. Clin Immunol Immunopathol. 1989;52:421- 34. doi: 10.1016/0090-1229(89)90157-8</mixed-citation><mixed-citation xml:lang="en">Gordon C, Ranges GE, Greenspan JS, Wofsy D. Chronic therapy with recombinant tumour necrosis factor-alpha in autoimmune NZB/NZW F1 mice. Clin Immunol Immunopathol. 1989;52:421- 34. doi: 10.1016/0090-1229(89)90157-8</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Singh VK, Mehrotra S, Agarwal SS. The paradigm of Th1 and Th2 cytokines: its relevance to autoimmunity and allergy. Immunol Res. 1999;20:147-61. doi: 10.1007/BF02786470</mixed-citation><mixed-citation xml:lang="en">Singh VK, Mehrotra S, Agarwal SS. The paradigm of Th1 and Th2 cytokines: its relevance to autoimmunity and allergy. Immunol Res. 1999;20:147-61. doi: 10.1007/BF02786470</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Romagnani S. Th1/Th2 cells. Inflamm Bowel Dis. 1999;5:285-94. doi: 10.1097/00054725-199911000-00009</mixed-citation><mixed-citation xml:lang="en">Romagnani S. Th1/Th2 cells. Inflamm Bowel Dis. 1999;5:285-94. doi: 10.1097/00054725-199911000-00009</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Bickerstaff MC, Botto M, Hutchinson WL, et al. Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity. Nat Med. 1999;5:694-7. doi: 10.1038/9544</mixed-citation><mixed-citation xml:lang="en">Bickerstaff MC, Botto M, Hutchinson WL, et al. Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity. Nat Med. 1999;5:694-7. doi: 10.1038/9544</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Lorenz HM, Herrmann M, Winkler T, et al. Role of apoptosis in autoimmunity. Apoptosis. 2000;5:443-9. doi: 10.1023/A:1009692902805</mixed-citation><mixed-citation xml:lang="en">Lorenz HM, Herrmann M, Winkler T, et al. Role of apoptosis in autoimmunity. Apoptosis. 2000;5:443-9. doi: 10.1023/A:1009692902805</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Erikkson C, Engstrand S, Sundqvist K-G, Rantapaat-Dahlqvist S. Autoantibody formationin patients with rheumatoid arthritis treated with anti-TNF. Ann Rheum Dis. 2005;64:403-7. doi: 10.1136/ard.2004.024182</mixed-citation><mixed-citation xml:lang="en">Erikkson C, Engstrand S, Sundqvist K-G, Rantapaat-Dahlqvist S. Autoantibody formationin patients with rheumatoid arthritis treated with anti-TNF. Ann Rheum Dis. 2005;64:403-7. doi: 10.1136/ard.2004.024182</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Zheng L, Fisher G, Miller R, et al. Induction of apoptosis in mature T cells by tumor necrosis factor. Nature. 1995;377:348-51. doi: 10.1038/377348a0</mixed-citation><mixed-citation xml:lang="en">Zheng L, Fisher G, Miller R, et al. Induction of apoptosis in mature T cells by tumor necrosis factor. Nature. 1995;377:348-51. doi: 10.1038/377348a0</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Sarzi-Puttini P, Atzeni F, Capsoni F, et al. Drug-induced lupus erythematosus. Autoimmunity. 2005;38:507-18. doi: 10.1080/08916930500285857</mixed-citation><mixed-citation xml:lang="en">Sarzi-Puttini P, Atzeni F, Capsoni F, et al. Drug-induced lupus erythematosus. Autoimmunity. 2005;38:507-18. doi: 10.1080/08916930500285857</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">D'Auria F, Rovere-Querini P, Giazzon M, et al. Accumulation of plasma nucleosomes upon treatment with anti-tumour necrosis factor-α antibodies. J Intern Med. 2004;255:409-18. doi: 10.1111/j.1365-2796.2003.01298.x</mixed-citation><mixed-citation xml:lang="en">D'Auria F, Rovere-Querini P, Giazzon M, et al. Accumulation of plasma nucleosomes upon treatment with anti-tumour necrosis factor-α antibodies. J Intern Med. 2004;255:409-18. doi: 10.1111/j.1365-2796.2003.01298.x</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Benucci M, Saviola G, Baiardi P, et al. Anti-nucleosome antibodies as prediction factor of development of autoantibodies during therapy with three different TNF blocking agents in rheumatoid arthritis. Clin Rheumatol. 2008;27:91-5. doi: 10.1007/s10067-007-0728-5</mixed-citation><mixed-citation xml:lang="en">Benucci M, Saviola G, Baiardi P, et al. Anti-nucleosome antibodies as prediction factor of development of autoantibodies during therapy with three different TNF blocking agents in rheumatoid arthritis. Clin Rheumatol. 2008;27:91-5. doi: 10.1007/s10067-007-0728-5</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
