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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1995-4484-2017-647-654</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-2470</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРОГРАММА НЕПРЕРЫВНОГО ПОСЛЕДИПЛОМНОГО ОБРАЗОВАНИЯ ВРАЧЕЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>POSTGRADUATE PROGRAM OF CONTINUING MEDICAL EDUCATION</subject></subj-group></article-categories><title-group><article-title>Ультразвуковое исследование опорно-двигательного аппарата в диагностике и мониторинге активности болезни при ювенильных артритах</article-title><trans-title-group xml:lang="en"><trans-title>ULTRASOUND EXAMINATION OF THE LOCOMOTOR SYSTEM IN THE DIAGNOSIS AND MONITORING OF DISEASE ACTIVITY IN JUVENILE ARTHRITIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеев</surname><given-names>Д. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Alekseev</surname><given-names>D. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>научный сотрудник лаборатории ревматических заболеваний детского возраста с реабилитационной группой</p></bio><email xlink:type="simple">aleks0148@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никишина</surname><given-names>И. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikishina</surname><given-names>I. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>заведующая лабораторией ревматических заболеваний детского возраста с реабилитационной группой ФГБНУ НИИР им. В.А. Насоновой, канд. мед. наук</p></bio><email xlink:type="simple">aleks0148@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно- исследовательский институт ревматологии им. В.А. Насоновой», Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>05</day><month>01</month><year>2018</year></pub-date><volume>55</volume><issue>6</issue><fpage>647</fpage><lpage>654</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Алексеев Д.Л., Никишина И.П., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Алексеев Д.Л., Никишина И.П.</copyright-holder><copyright-holder xml:lang="en">Alekseev D.L., Nikishina I.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/2470">https://rsp.mediar-press.net/rsp/article/view/2470</self-uri><abstract><p>Ювенильные артриты – наиболее часто встречающаяся группа ревматических заболеваний у детей, доминирующим проявлением которых является хроническое прогрессирующее воспалительное поражение суставов со значительной вариабельностью клинической картины и возможностью различных нозологических исходов. Диагностика и мониторирование активности болезни при ювенильных артритах, в отличие от воспалительных заболеваний суставов у взрослых, сопряжена с большими трудностями интерпретации клинических симптомов и данных лучевых методов исследования. Одной из наиболее востребованных современных технологий лучевой визуализации опорно-двигательного аппарата является ультразвуковое исследование, став- шее за последние годы неотъемлемым компонентом практики детского ревматолога. На основании данных литературы и собственного опыта многолетнего повседневного использования ультразвуковой диагностики авторами представлены современные подходы к использованию метода ультразвуковой диагностики у пациентов с ювенильными артритами с учетом особенностей детского возраста.</p><p> </p></abstract><trans-abstract xml:lang="en"><p>Juvenile arthritis is the most common group of childhood rheumatic diseases, the dominant manifestation of which is chronic progressive joint inflammation showing the considerable variability of clinical presentations and the possibility of different nosological outcomes. Diagnosis and monitoring of disease activity in juvenile arthritis, unlike inflammatory joint diseases in adults, are attended with great difficulties in the interpretation of clinical symptoms and radiological findings. One of the most popular current technologies of musculoskeletal visualization is ultrasonography that has become an integral part of a pediatric rheumatology practice. Based on the data available in the literature and their own experience of long-term daily use of ultrasound diagnosis, the authors present current approaches to using the ultrasound diagnostic technique in patients with juvenile arthritis, by taking into account the features of child development.</p><p> </p></trans-abstract><kwd-group xml:lang="ru"><kwd>ювенильные артриты</kwd><kwd>ювенильный хронический артрит</kwd><kwd>артрит</kwd><kwd>ультразвуковая диагностика артрита у детей</kwd><kwd>субклинический синовит</kwd></kwd-group><kwd-group xml:lang="en"><kwd>juvenile arthritis</kwd><kwd>juvenile chronic arthritis</kwd><kwd>arthritis</kwd><kwd>ultrasound diagnosis of childhood arthritis</kwd><kwd>subclinical synovitis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева ЕИ. Ювенильный идиопатический артрит: клиническая картина, диагностика, лечение. Вопросы современной педиатрии. 2015;14(1):78-94 [Alekseeva EI. Juvenile idiopathic arthritis: clinical picture, diagnosis, treatment. Voprosy Sovremennoi Pediatrii. 2015;14(1):78-94 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Алексеева ЕИ. Ювенильный идиопатический артрит: клиническая картина, диагностика, лечение. Вопросы современной педиатрии. 2015;14(1):78-94 [Alekseeva EI. Juvenile idiopathic arthritis: clinical picture, diagnosis, treatment. Voprosy Sovremennoi Pediatrii. 2015;14(1):78-94 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Баранов АА, Алексеева ЕИ, Валиева СИ и др. Биологическая терапия в педиатрической ревматологии. Вопросы современной педиатрии. 2011;10(1):5-16 [Baranov AA, Alekseeva EI, Valieva SI, et al. Biological therapy in pediatric rheumatology. Voprosy Sovremennoi Pediatrii. 2011;10(1):5-16</mixed-citation><mixed-citation xml:lang="en">Баранов АА, Алексеева ЕИ, Валиева СИ и др. Биологическая терапия в педиатрической ревматологии. Вопросы современной педиатрии. 2011;10(1):5-16 [Baranov AA, Alekseeva EI, Valieva SI, et al. Biological therapy in pediatric rheumatology. Voprosy Sovremennoi Pediatrii. 2011;10(1):5-16</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">(In Russ.)].</mixed-citation><mixed-citation xml:lang="en">(In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Никишина ИП. Ювенильный артрит. В кн.: Насонов ЕЛ, Насонова ВА, редакторы. Ревматология. Национальное руководство. Москва: ГЭОТАР-Медиа; 2008. С. 686-710 [Nikishina IP. Juvenile arthritis. In: Nasonov EL, Nasonova VA, editors. Revmatologiya. Natsional'noe rukovodstvo [Rheumatology. National guidelance]. Moscow: GEOTAR-Media; 2008. P. 686-710].</mixed-citation><mixed-citation xml:lang="en">Никишина ИП. Ювенильный артрит. В кн.: Насонов ЕЛ, Насонова ВА, редакторы. Ревматология. Национальное руководство. Москва: ГЭОТАР-Медиа; 2008. С. 686-710 [Nikishina IP. Juvenile arthritis. In: Nasonov EL, Nasonova VA, editors. Revmatologiya. Natsional'noe rukovodstvo [Rheumatology. National guidelance]. Moscow: GEOTAR-Media; 2008. P. 686-710].</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">МакНелли Ю. Ультразвуковые исследования костно-мышечной системы: Практическое руководство. Москва: Видар; 2007. 400 с. [MakNelli Yu. Ul'trazvukovye issledovaniya kostno-myshechnoi sistemy: Prakticheskoe rukovodstvo [Ultrasonic Studies of the Musculoskeletal System: A Practical Guide]. Moscow: Vidar; 2007. 400 p.].</mixed-citation><mixed-citation xml:lang="en">МакНелли Ю. Ультразвуковые исследования костно-мышечной системы: Практическое руководство. Москва: Видар; 2007. 400 с. [MakNelli Yu. Ul'trazvukovye issledovaniya kostno-myshechnoi sistemy: Prakticheskoe rukovodstvo [Ultrasonic Studies of the Musculoskeletal System: A Practical Guide]. Moscow: Vidar; 2007. 400 p.].</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Petty RE, Laxer RM, Lindsley CB, Wedderburn L, editors. Textbook of pediatric rheumatology, 7th ed. Philadelphia: Elsevier; 2016. 736 p.</mixed-citation><mixed-citation xml:lang="en">Petty RE, Laxer RM, Lindsley CB, Wedderburn L, editors. Textbook of pediatric rheumatology, 7th ed. Philadelphia: Elsevier; 2016. 736 p.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Damasio MB, Malattia C, Martini A, Toma P. Synovial and inflammatory diseases in childhood: role of new imaging modalities in the assessment of patients with juvenile idiopathic arthritis. Pediatr Radiol. 2010;40(6):985-98.</mixed-citation><mixed-citation xml:lang="en">Damasio MB, Malattia C, Martini A, Toma P. Synovial and inflammatory diseases in childhood: role of new imaging modalities in the assessment of patients with juvenile idiopathic arthritis. Pediatr Radiol. 2010;40(6):985-98.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">doi: 10.1007/s00247-010-1612-z</mixed-citation><mixed-citation xml:lang="en">doi: 10.1007/s00247-010-1612-z</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Oen K, Malleson PN, Cabral DA, et al. Early predictors of long term outcome in patients with juvenile rheumatoid arthritis: subset-specific correlations. J Rheumatol. 2003;30(3):585-93.</mixed-citation><mixed-citation xml:lang="en">Oen K, Malleson PN, Cabral DA, et al. Early predictors of long term outcome in patients with juvenile rheumatoid arthritis: subset-specific correlations. J Rheumatol. 2003;30(3):585-93.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Карпенко АК. Лучевая визуализация синовиальных изменений при различных формах ювенильного хронического артрита. Кремлевская медицина. Клинический вестник. 2013;(1):96-9 [Karpenko AK. Radial visualization of synovial changes in various forms of juvenile chronic arthritis. Kremlevskaya Meditsina. Klinicheskii Vestnik. 2013;(1):96-9 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Карпенко АК. Лучевая визуализация синовиальных изменений при различных формах ювенильного хронического артрита. Кремлевская медицина. Клинический вестник. 2013;(1):96-9 [Karpenko AK. Radial visualization of synovial changes in various forms of juvenile chronic arthritis. Kremlevskaya Meditsina. Klinicheskii Vestnik. 2013;(1):96-9 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Collado P, Jousse-Joulin S, Alcalde M, et al. Is ultrasound a validated imaging tool for the diagnosis and management of synovitis in juvenile idiopathic arthritis? A systematic literature review. Arthritis Care Res (Hoboken). 2012;64(7):1011-9. doi: 10.1002/acr.21644</mixed-citation><mixed-citation xml:lang="en">Collado P, Jousse-Joulin S, Alcalde M, et al. Is ultrasound a validated imaging tool for the diagnosis and management of synovitis in juvenile idiopathic arthritis? A systematic literature review. Arthritis Care Res (Hoboken). 2012;64(7):1011-9. doi: 10.1002/acr.21644</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Backhaus M, Burmester G, Gerber T, et al. Guidelines for musculoskeletal ultrasound in rheumatology. Ann Rheum Dis. 2001;60(7):641-9. doi: 10.1136/ard.60.7.641</mixed-citation><mixed-citation xml:lang="en">Backhaus M, Burmester G, Gerber T, et al. Guidelines for musculoskeletal ultrasound in rheumatology. Ann Rheum Dis. 2001;60(7):641-9. doi: 10.1136/ard.60.7.641</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Guzman J, Burgos-Vargas R, Duarte-Salazar C, Gomez-Mora PJ. Reliability of the articular examination in children with juvenile rheumatoid arthritis: interobserver agreement and sources of disagreement. J Rheumatol. 1995;22(12):2331-6.</mixed-citation><mixed-citation xml:lang="en">Guzman J, Burgos-Vargas R, Duarte-Salazar C, Gomez-Mora PJ. Reliability of the articular examination in children with juvenile rheumatoid arthritis: interobserver agreement and sources of disagreement. J Rheumatol. 1995;22(12):2331-6.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Colebatch-Bourn AN, Edwards CJ, Collado P, et al. EULAR-PReS points to consider for the use of imaging in the diagnosis and management of juvenile idiopathic arthritis in clinical practice. Ann Rheum Dis. 2015;74(11):1946-57.</mixed-citation><mixed-citation xml:lang="en">Colebatch-Bourn AN, Edwards CJ, Collado P, et al. EULAR-PReS points to consider for the use of imaging in the diagnosis and management of juvenile idiopathic arthritis in clinical practice. Ann Rheum Dis. 2015;74(11):1946-57.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">doi: 10.1136/annrheumdis-2015-207892</mixed-citation><mixed-citation xml:lang="en">doi: 10.1136/annrheumdis-2015-207892</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Graham TB. Imaging in juvenile arthritis. Curr Opin Rheumatol. 2005;17(5):574-8. doi: 10.1097/01.bor.0000169365.46196.b6</mixed-citation><mixed-citation xml:lang="en">Graham TB. Imaging in juvenile arthritis. Curr Opin Rheumatol. 2005;17(5):574-8. doi: 10.1097/01.bor.0000169365.46196.b6</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Wakefield RJ, Balint PV, Szkudlarek M, et al. Special Interest Group Musculoskeletal ultrasound including definitions for ultra-sonographic pathology. J Rheumatol. 2005;32(12):2485-7.</mixed-citation><mixed-citation xml:lang="en">Wakefield RJ, Balint PV, Szkudlarek M, et al. Special Interest Group Musculoskeletal ultrasound including definitions for ultra-sonographic pathology. J Rheumatol. 2005;32(12):2485-7.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Janow GL, Panghaal V, Trinh A, et al. Detection of active disease in juvenile idiopathic arthritis: sensitivity and specificity of the physical examination vs ultrasound. J Rheumatol. 2011;38(12):2671-4. doi: 10.3899/jrheum.110360</mixed-citation><mixed-citation xml:lang="en">Janow GL, Panghaal V, Trinh A, et al. Detection of active disease in juvenile idiopathic arthritis: sensitivity and specificity of the physical examination vs ultrasound. J Rheumatol. 2011;38(12):2671-4. doi: 10.3899/jrheum.110360</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Magni-Manzoni S, Epis O, Ravelli A, et al. Comparison of clinical versus ultrasound-determined synovitis in juvenile idiopathic arthritis. Arthritis Rheum. 2009;61(11):1497-504.</mixed-citation><mixed-citation xml:lang="en">Magni-Manzoni S, Epis O, Ravelli A, et al. Comparison of clinical versus ultrasound-determined synovitis in juvenile idiopathic arthritis. Arthritis Rheum. 2009;61(11):1497-504.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">doi: 10.1002/art.24823</mixed-citation><mixed-citation xml:lang="en">doi: 10.1002/art.24823</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Breton S, Jousse-Joulin S, Cangemi C, et al. Comparison of clinical and ultrasonographic evaluations for peripheral synovitis in juvenile idiopathic arthritis. Semin Arthritis Rheum. 2011;41(2):272-8. doi: 10.1016/j.semarthrit.2010.12.005</mixed-citation><mixed-citation xml:lang="en">Breton S, Jousse-Joulin S, Cangemi C, et al. Comparison of clinical and ultrasonographic evaluations for peripheral synovitis in juvenile idiopathic arthritis. Semin Arthritis Rheum. 2011;41(2):272-8. doi: 10.1016/j.semarthrit.2010.12.005</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Haslam KE, McCann LJ, Wyatt S, Wakefield RJ. The detection of subclinical synovitis by ultrasound in oligoarticular juvenile idiopathic arthritis: a pilot study. Rheumatology (Oxford). 2010;49(1):123-7. doi: 10.1093/rheumatology/kep339</mixed-citation><mixed-citation xml:lang="en">Haslam KE, McCann LJ, Wyatt S, Wakefield RJ. The detection of subclinical synovitis by ultrasound in oligoarticular juvenile idiopathic arthritis: a pilot study. Rheumatology (Oxford). 2010;49(1):123-7. doi: 10.1093/rheumatology/kep339</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Magni-Manzoni S, Scire CA, Ravelli A, et al. Ultrasound-detected synovial abnormalities are frequent in clinically inactive juvenile idiopathic arthritis, but do not predict a flare of synovitis. Ann Rheum Dis. 2013;72(2):223-8. doi: 10.1136/annrheumdis-2011-201264</mixed-citation><mixed-citation xml:lang="en">Magni-Manzoni S, Scire CA, Ravelli A, et al. Ultrasound-detected synovial abnormalities are frequent in clinically inactive juvenile idiopathic arthritis, but do not predict a flare of synovitis. Ann Rheum Dis. 2013;72(2):223-8. doi: 10.1136/annrheumdis-2011-201264</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Осипова НВ, Намазова-Баранова ЛС. Ультразвуковые признаки поражения коленных суставов при ювенильных артритах. Вопросы диагностики в педиатрии. 2009;(2):45-50 [Osipova NV, Namazova-Baranova LS. Ultrasonic signs of knee joint damage in juvenile arthritis. Voprosy Diagnostiki v Pediatrii. 2009;(2):45-50 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Осипова НВ, Намазова-Баранова ЛС. Ультразвуковые признаки поражения коленных суставов при ювенильных артритах. Вопросы диагностики в педиатрии. 2009;(2):45-50 [Osipova NV, Namazova-Baranova LS. Ultrasonic signs of knee joint damage in juvenile arthritis. Voprosy Diagnostiki v Pediatrii. 2009;(2):45-50 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Чебышева СН, Геппе НА, Мелешкина АВ и др. Ультразвуковая диагностика при псориатическом артрите</mixed-citation><mixed-citation xml:lang="en">Чебышева СН, Геппе НА, Мелешкина АВ и др. Ультразвуковая диагностика при псориатическом артрите</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">у детей. Педиатрия. Приложение к журналу Consilium Medicum. 2016;(1):84-6 [Chebysheva SN, Geppe NA, Meleshkina AV, et al. Ultrasound diagnosis in psoriatic arthritis in children. Pediatriya = Pediatrics. The appendix to the journal Consilium Medicum. 2016;(1):84-6 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">у детей. Педиатрия. Приложение к журналу Consilium Medicum. 2016;(1):84-6 [Chebysheva SN, Geppe NA, Meleshkina AV, et al. Ultrasound diagnosis in psoriatic arthritis in children. Pediatriya = Pediatrics. The appendix to the journal Consilium Medicum. 2016;(1):84-6 (In Russ.)].</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
