References

rsp

Научно-практическая ревматология

Rheumatology Science and Practice

1995-44841995-4492

IMA-PRESS, LLC

10.14412/1995-4484-2017-685-689

rsp-2475

Research Article

ОБЗОРЫ

Патология периодонта и системные васкулиты: взгляд сквозь призму междисциплинарных исследований

PERIODONTAL DISEASES AND SYSTEMIC VASCULITIS: A VIEW THROUGH THE PRISM OF INTERDISCIPLINARY STUDIES

Бекетова

Т. В.

Beketova

T. V.

tvbek@rambler.ru

Селифанова

Е. И.

Selifanova

E. I.

tvbek@rambler.ru

ФГБНУ «Научно- исследовательский институт ревматологии им. В.А. Насоновой», МоскваРоссияV.A. Nasonova Research Institute of Rheumatology, MoscowRussian Federation

2017

05012018

556685689

2018

Бекетова Т.В., Селифанова Е.И.

Beketova T.V., Selifanova E.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://rsp.mediar-press.net/rsp/article/view/2475

Обзор посвящен исследованиям, направленным на изучение взаимосвязи патологии периодонта (ПП) и хронического аутоиммунного воспалительного ответа, к наиболее ярким моделям которого относят системные васкулиты (СВ). Заболевания периодонта ассоциируются с системным воспалением и сосудистой патологией, что характеризуется эндотелиальной дисфункцией и существенным риском кардиоваскулярных и цереброваскулярных заболеваний, сахарного диабета, аутоиммунных болезней. Обсуждается перспективность междисциплинарных исследований, направленных на изучение биологических эффектов ПП при СВ и других ревматических заболеваниях.

The review deals with investigations aimed to examine the relationship between periodontal diseases (PDs) and a chronic autoimmune inflammatory response, the most striking models of which include systemic vasculitis (SV). PDs are associated with systemic inflammation and vascular pathology, which is characterized by endothelial dysfunction and a considerable risk for cardiovascular and cerebrovascular diseases, diabetes mellitus, and autoimmune diseases. The paper also discusses the prospect of interdisciplinary studies focused on the examination of the biological effects of PDs in SV and other rheumatic diseases.

системный васкулитревматические заболеванияпериодонтпериодонтитантинейтрофильные цитоплазматические антитела

systemic vasculitisrheumatic diseasesperiodontiumperiodontal diseaseantineutrophil cytoplasmic antibodies

References1

De Pablo P, Chapple IL, Buckley CD, Dietrich T. Periodontitis in systemic rheumatic diseases. Nat Rev Rheumatol. 2009;5(4):218-24. doi: 10.1038/nrrheum.2009.28

Jennette JC, Falk RJ, Bacon PA, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65:1-11. doi: 10.1002/art.37715

Saffi MAL, Furtado MV, Polanczyk CA, et al. Relationship between vascular endothelium and periodontal disease in athero-sclerotic lesions: Review article. World J Cardiol. 2015;7(1):26-30. doi: 10.4330/wjc.v7.i1.26

Dietrich T, Jimenez M, Krall Kaye EA, et al. Age-dependent associations between chronic periodontitis/edentulism and risk of coronary heart disease. Circulation. 2008;117(13):1668-74.

doi: 10.1161/CIRCULATIONAHA.107.711507

Aarabi G, Eberhard J, Reissmann DR, et al. Interaction between periodontal disease and atherosclerotic vascular disease – Fact or fiction? Atherosclerosis. 2015;241(2):555-60. doi: 10.1016/j.atherosclerosis.2015.04.819

Nesse W, Dijkstra PU, Abbas F, et al. Increased prevalence of cardiovascular and autoimmune diseases in periodontitis patients: a cross-sectional study. J Periodontol. 2010;81(11):1622-8. doi: 10.1902/jop.2010.100058

Mercado FB, Marshall RI, Bartold PM. Inter-relationships between rheumatoid arthritis and periodontal disease. A review. J Clin Periodontol. 2003;30(9):761-72. doi: 10.1034/j.1600-051X.2003.00371.x

Brook I. Microbiology and management of periodontal infections. Gen Dent. 2003;51(5):424-8.

Nair S, Faizuddin M, Dharmapalan J. Role of autoimmune responses in periodontal disease. Autoimmun Dis. 2014;2014:596824. doi: 10.1155/2014/596824

Sharma CG, Pradeep AR. Anti-neutrophil cytoplasmic autoanti-bodies: a renewed paradigm in periodontal disease pathogenesis? J Periodontol. 2006;77(8):1304-13. doi: 10.1902/jop.2006.050308

Takeuchi Y, Yoshie H, Hara K. Expression of interleukin-2 receptor and HLA-DR on lymphocyte subsets of gingival crevicular fluid in patients with periodontitis. J Periodont Res. 1991;26(6):502-10. doi: 10.1111/j.1600-0765.1991.tb01802.x

Sugawara M, Yamashita K, Yoshie H, Hara K. Detection of, and anti-collagen antibody produced by, CD5-positive B cells in inflamed gingival tissues. J Periodont Res. 1992;27(5):489-98. doi: 10.1111/j.1600-0765.1992.tb01822.x

D'Aiuto F, Graziani F, Tete S, et al. Periodontitis: from local infection to systemic diseases. Int J Immunopathol Pharmacol. 2005;18(3 Suppl):1-11.

Arigbede AO, Babatope BO, Bamidele MK. Periodontitis and systemic diseases: A literature review. J Indian Soc Periodontol. 2012;16(4):487-91. doi: 10.4103/0972-124X.106878

Scannapieco FA, Bush RB, Paju S. Periodontal disease as a risk factor for adverse pregnancy outcome: A systematic review. Ann Periodontol. 2003;8:70-8. doi: 10.1902/annals.2003.8.1.70

Slade GD, Ghezzi EM, Heiss G, et al. Relationship between periodontal disease and C-reactive protein among adults in the Atherosclerosis Risk in Communities study. Arch Intern Med. 2003;163(10):1172-9. doi: 10.1001/archinte.163.10.1172

Loos BG. Systemic markers of inflammation in periodontitis. J Periodontol. 2005;76(11 Suppl):2106-15.

doi: 10.1902/jop.2005.76.11-S.2106

Chukkapalli SS, Rivera-Kweh MF, Velsko IM, et al. Chronic oral infection with major periodontal bacteria Tannerella forsythia modulates systemic atherosclerosis risk factors and inflammatory markers. Pathogen Dis. 2015;73(3). doi: 10.1093/femspd/ftv009

Haraszthy V, Zambon J, Trevisan M, et al. Identification of periodontal pathogens in atheromatous plaques. J Periodontol. 2000;71(10):1554-60. doi: 10.1902/jop.2000.71.10.1554

Willershausen B, Kasaj A, Willershausen I, et al. Association between chronic dental infection and acute myocardial infarction. J Endodont. 2009;35(5):626-30. doi: 10.1016/j.joen.2009.01.012

Mendall MA, Patel P, Ballan L, et al. C-reactive protein and its relation to cardiovascular risk factor: a population based cros-section study. Brit Med J. 1996;312:1061-5. doi: 10.1136/bmj.312.7038.1061

Banks M, Flint J, Bacon P, Kitas G. Rheumatoid arthritis is an independent risk factor for ischemic heart disease. Arthritis Rheum. 2000;43 Suppl:385.

Hollan I, Meroni PL, Ahearn JM, et al. Cardiovascular disease in autoimmune rheumatic diseases. Autoimmun Rev. 2013;12:1004-15. doi: 10.1016/j.autrev.2013.03.013

Ridker PM. Inflammation, infection, and cardiovascular risk: how good is the clinical evidence? Circulation. 1998;97(17):1671-4. doi: 10.1161/01.CIR.97.17.1671

Chiu B, Viira E, Tucker W, Fong IW. Chlamydia pneumoniae, cytomegalovirus, and herpes simplex virus in atherosclerosis of the carotid artery. Circulation. 1997;96(7):2144-8.

doi: 10.1161/01.CIR.96.7.2144

Wiedermann CJ, Kiechl S, Dunzendorfer S, et al. Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results for the Brunek study. J Am Coll Cardiol. 1999;34:1975-81. doi: 10.1016/S0735-1097(99)00448-9

Etemadifar R, Konarizadeh S, Zarei A, et al. Relationship between periodontal status and C-reactive protein and inter-leuckin-6 levels among atherosclerotic patients in Bandar Abbas, Iran in 2014. Electr Phys. 2015;7(1):1010-6.

Glurich I, Grossi S, Albini B, et al. Systemic inflammation in cardiovascular and periodontal disease: comparative study. Clin Diagn Lab Immunol. 2002;9(2):425-32. doi: 10.1128/CDLI.9.2.425-432.2002

Pradeep AR, Hadge P, Arjun Raju P, et al. Periodontitis as a risk factor for cerebrovascular accident: a case-control study in the Indian population. J Periodontal Res. 2010;45(2):223-8. doi: 10.1111/j.1600-0765.2009.01220.x

Janket SJ, Qvarnströ m M, Meurman JH, et al. Asymptotic dental score and prevalent coronary heart disease. Circulation. 2004;109(9):1095-100. doi: 10.1161/01.CIR.0000118497.44961.1E

Vettore MV, Leal M, Leao AT, et al. The Relationship between Periodontitis and Preterm Low Birth weight. J Dent Res. 2008;87:73-8. doi: 10.1177/154405910808700113

Goldenberg RL, Culhane JF. Preterm Birth and Periodontal Disease. N Engl J Med. 2006;355:1925-7. doi: 10.1056/NEJMe068210

Offenbacher S, Boggess KA, Murtha AP, et al. Progressive periodontal disease and risk of very preterm delivery. Obstet Gynecol. 2006;107:29-36. doi: 10.1097/01.AOG.0000190212.87012.96

Pitiphat W, Joshipura K, Gillman MW, et al. Maternal periodonti-tis and adverse pregnancy outcomes. Community Dent Oral Epidemiol. 2008;36:3-11.

Xiong X, Elkind-Hirsch KE, Vastardis S, et al. Periodontal disease is associated with gestational diabetes mellitus: a case-control study. J Periodontol. 2009;80(11):1742-9. doi: 10.1902/jop.2009.090250

Negrato CA, Tarzia O, Jovanovic L, Chinellato LE. Periodontal disease and diabetes mellitus. J Appl Oral Sci. 2013;21(1):1-12. doi: 10.1590/1678-7757201302106

Dunning T. Periodontal disease – the overlooked diabetes complication. Nephrol Nurs J. 2009;36(5):489-95.

Iacopino AM. Periodontitis and diabetes interrelationships: Role of inflammation. Ann Periodontol. 2001;6:125-37.

doi: 10.1902/annals.2001.6.1.125

Mealey BL, Rose LF. Diabetes mellitus and inflammatory periodontal diseases. Curr Opin Endocrinol Diabetes Obes. 2008;15:135-41. doi: 10.1097/MED.0b013e3282f824b7

Rosenquist K. Risk factors in oral and oropharyngeal squamous cell carcinoma: A population-based case-control study in southern Sweden. Swed Dent J. 2005;179:1-66.

Michaud DS, Liu Y, Meyer M, et al. Periodontal disease, tooth loss, and cancer risk in male health professionals: A prospective cohort study. Lancet Oncol. 2008;9:550-8. doi: 10.1016/S1470-2045(08)70106-2

Tezal M, Sullivian MA, Hyland A, et al. Chronic periodontitis and the incidence of head and neck squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2009;18:2409-12. doi: 10.1158/1055-9965.EPI-09-0334

Soory M. Periodontal diseases and rheumatoid arthritis: a coincident model for therapeutic intervention? Curr Drug Metab. 2007;8(8):750-7. doi: 10.2174/138920007782798162

Liao F, Li Z, Wang Y, et al. Porphyromonas gingivalis may play an important role in the pathogenesis of periodontitis-associated rheumatoid arthritis. Med Hypoth. 2009;72(6):732-5.

doi: 10.1016/j.mehy.2008.12.040

Arkema EV, Karlson EW, Costenbader KH. A prospective study of periodontal disease and risk of rheumatoid arthritis. J Rheumatol. 2010;37(9):1800-4. doi: 10.3899/jrheum.091398

Hitchon C, Chandad F, Ferucci E, et al. Antibodies to porphyromonas gingivalis are associated with anticitrullinated protein antibodies in patients with rheumatoid arthritis and their relatives. Rheumatology. 2010;37(6):1105-12. doi: 10.3899/jrheum.091323

Bartold P, Marino V, Cantley M, et al. Effect of Porphyromonas gingivalis-induced inflammation on the development of rheumatoid arthritis. J Clin Periodontol. 2010;37(5):405-11.

doi: 10.1111/j.1600-051X.2010.01552.x

Lundberg K, Wegner N, Yucel-Lindberg T, Venables PJ. Periodontitis in RA-the citrullinated enolase connection. Nat Rev Rheumatol. 2010;6(12):727-30. doi: 10.1038/nrrheum.2010.139

Katz J, Goultschin J, Benoliel R, Brautbar C. Human leukocyte antigen (HLA) DR4. Positive association with rapidly progressing periodontitis. J Periodontol. 1987;58:607-10. doi: 10.1902/jop.1987.58.9.607

Bonfil JJ, Dillier FL, Mercier P, et al. A «case control» study on the role of HLA DR4 in severe periodontitis and rapidly progressive periodontitis. Identification of types and subtypes using molecular biology (PcR.SSO). J Clin Periodontol. 1999;26:77-84. doi: 10.1034/j.1600-051X.1999.260203.x

Dingle JT, Leeming MRG, Martindale JJ. Effect of Tenidap on cartilage integrity in vitro. Ann Rheum Dis. 1993;52:292-9.

doi: 10.1136/ard.52.4.292

Weyand C, McCarthy T, Goronzy J. Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis. J Clin Invest. 1995;95:2120-6. doi: 10.1172/JCI117900

Marotte H, Farge P, Gaudin P, et al. The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA-DR shared epitope and severity of bone destruction. Ann Rheum Dis. 2006;65:905-9. doi: 10.1136/ard.2005.036913

Sorensen LK, Havemose-Poulsen A, Sonder SU, et al. Blood cell gene expression profiling in subjects with aggressive periodontitis and chronic arthritis. J Periodontol. 2008;79(3):477-85.

doi: 10.1902/jop.2008.070309

Graves D. Cytokines that promote periodontal tissue destruction. J Periodontol. 2008;79:1585-91. doi: 10.1902/jop.2008.080183

McInnes IB, Schett G. Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol. 2007;7(6):429-42. doi: 10.1038/nri2094

Sorsa T, Tjä derhane L, Konttinen YT, et al. Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation. Ann Med. 2006;38(5):306-21. doi: 10.1080/07853890600800103

Jeffcoat MK, Geurs NC, Lewis CE Osteoporosis and periodontal bone loss. Clin Calcium. 2003;13(5):577-81.

Mayer Y, Balbir-Gurman A, Machtei EE. Anti-tumor necrosis factor-alpha therapy and periodontal parameters in patients with rheumatoid arthritis. J Periodontol. 2009;80(9):1414-20.

doi: 10.1902/jop.2009.090015

Novo E, Garcia-MacGregor E, Viera N, et al. Periodontitis and anti-neutrophil cytoplasmic antibodies in systemic lupus erythematosus and rheumatoid arthritis: a comparative study. J Periodontol. 1999;70:185-8. doi: 10.1902/jop.1999.70.2.185

Rzeszutko W, Konopka T, Kopec W. Anti-neutrophil cytoplasmic antibodies and autoantibodies to human heat shock protein 60

in periodontitis patients. Adv Clin Exp Med. 2006;15(4):599-605.

Gomez-Puerta JA, Bosch X. Anti-neutrophil cytoplasmic antibody pathogenesis in small-vessel vasculitis: an update. Am J Pathol. 2009;175:1790-8. doi: 10.2353/ajpath.2009.090533

Kallenberg CG. Pathogenesis of ANCA-associated vasculitis, an update. Clin Rev Allerg Immunol. 2011;41(2):224-31. doi: 10.1007/s12016-011-8258-y

Rohini NV, Pradeep AR, Faizuddin M. Antineutrophil cytoplasmic antibodies and adult periodontitis. J Periodont Res. 2000;35(6):374-6. doi: 10.1034/j.1600-0765.2000.035006374.x

Stewart C, Cohen D, Bhattacharyya I, et al. Oral manifestations of Wegener's granulomatosis: a report of three cases and a literature review. J Am Dent Assoc. 2007;138(3):338-48. doi: 10.14219/jada.archive.2007.0166

Patten SF, Tomecki KJ. Wegener's granulomatosis: cutaneous and oral mucosal disease. J Am Acad Dermatol. 1993;28(5):710-8. doi: 10.1016/0190-9622(93)70098-E

Cohen RE, Cardoza TT, Drinnan AJ, et al. Gingival manifestations of Wegener's granulomatosis. J Periodontol. 1990;61(11):705-9. doi: 10.1902/jop.1990.61.11.705

Shiboski CH, Regezi JA, Sanchez HC, Silverman S Jr. Oral lesions as the first clinical sign of microscopic polyangiitis: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;94(6):707-11. doi: 10.1067/moe.2002.129178

Xing X, Zhang T, Wang X. Pediatric Wegener's granulomatosis with oral ulcers and progressive periodontitis: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;112(4):1-5. doi: 10.1016/j.tripleo.2011.05.030

Ruokonen H, Helve T, Arola J, et al. «Strawberry like» gingivitis being the first sign of Wegener's granulomatosis. Eur J Intern Med. 2009;20(6):651-3. doi: 10.1016/j.ejim.2009.04.007

Siar CH, Yeo KB, Nakano K, et al. Strawberry gingivitis as the first presenting sign of Wegener's granulomatosis: report of a case. Eur J Med Res. 2011;16(7):331-4. doi: 10.1186/2047-783X-16-7-331

Aravena V, Beltran V, Cantin M, Fuentes R. Gingival hyperplasia being the first sign of Wegener's granulomatosis. Intern J Clin Exper Med. 2014;7(8):2373-6.

Popa ER, Stegeman CA, Abdulahad WH, et al. Staphylococcal toxic-shock-syndrome-toxin-1 as a risk factor for disease relapse in Wegener's granulomatosis. Rheumatology (Oxford). 2007;46(6):1029-33. doi: 10.1093/rheumatology/kem022

Kitagawa K, Furuichi K, Sagara A, et al; Kanazawa Study Group for Renal Diseases and Hypertension. Risk factors associated with relapse or infectious complications in Japanese patients with microscopic polyangiitis. Clin Exp Nephrol. 2015 Nov 20. [Epub ahead of print]. PubMed PMID: 26590051.

Azarpazhooh A, Leake JL. Systematic review of the association between respiratory diseases and oral health. J Periodontol. 2006;77(9):1465-82. doi: 10.1902/jop.2006.060010

Scannapieco FA, Ho AW. Potential associations between chronic respiratory disease and periodontal disease: analysis of National Health and Nutrition Examination Survey III. J Periodontol. 2001;72(1):50-6. doi: 10.1902/jop.2001.72.1.50

Mojon P. Oral health and respiratory infection. J Can Dent Assoc. 2002;68(6):340-5.

Bosnjak A, Plancak D, Curilovic Z. Advances in the relationship between periodontitis and systemic diseases. Acta Stomatol Croat. 2001;35:267-71.

Inoue CN, Matsutani S, Ishidoya M, et al. Impact of periodontal treatment in combination with tonsillectomy plus methylprednisolone pulse therapy and angiotensin blockade for pediatric IgA nephropathy. Clin Nephrol. 2012;77(2):137-45. doi: 10.5414/CN106836

Akman A, Kacaroglu H, Donmez L, et al. Relationship between periodontal findings and Behcet's disease: a controlled study. J Clin Periodontol. 2007;34(6):485-91. doi: 10.1111/j.1600-051X.2007.01085.x

Karacayli U, Mumcu G, Simsek I, et al. The close association between dental and periodontal treatments and oral ulcer course in Behcet's disease: a prospective clinical study. J Oral Pathol Med. 2009;38(5):410-5. doi: 10.1111/j.1600-0714.2009.00765.x

Loo JA, Yan W, Ramachandran P, Wong DT. Comparative human salivary and plasma proteomes. J Dent Res. 2010;89(10):1016-23. doi: 10.1177/0022034510380414

Al Kawas S, Rahim ZH, Ferguson DB. Potential uses of human salivary protein and peptide analysis in the diagnosis of disease. Arch Oral Biol. 2012;57(1):1-9. doi: 10.1016/j.archoralbio.2011.06.013

Yoshizawa JM, Schafer CA, Schafer JJ, et al. Salivary biomarkers: toward future clinical and diagnostic utilities. Clin Microbiol Rev. 2013;26(4):781-91. doi: 10.1128/CMR.00021-13

Iwasaki K, Okawa-Takatsuji M, Aotsuka S, Ono T. Detection of anti-SS-A/Ro and anti-SS-B/La antibodies of IgA and IgG iso-types in saliva and sera of patients with Sjö gren's syndrome. Nihon Rinsho Meneki Gakkai Kaishi. 2003;26(6):346-54. doi: 10.2177/jsci.26.346

Aqrawi LA, Skarstein K, Oijordsbakken G, Brokstad KA. Ro52-and Ro60-specific B cell pattern in the salivary glands of patients with primary Sjö gren's syndrome. Clin Exp Immunol. 2013;172(2):228-37. doi: 10.1111/cei.12058

Janket S, Meurman JH, Baird AE, et al. Salivary immunoglobulins and prevalent coronary artery disease. J Dent Res. 2010;89(4):389-94. doi: 10.1177/0022034509359884

The authors declare that there are no conflicts of interest present.