<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1995-4484-2018-10-14</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-2493</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МЕЖДУНАРОДНЫЕ И РОССИЙСКИЕ РЕКОМЕНДАЦИИ ПО ЛЕЧЕНИЮ РЕВМАТИЧЕСКИХ ЗАБОЛЕВАНИЙ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INTERNATIONAL AND RUSSIAN GUIDELINES FOR THE TREATMENT OF RHEUMATIC DISEASES</subject></subj-group></article-categories><title-group><article-title>Ремиссия при аксиальных спондилоартритах – определение и инструменты оценки (рекомендации Экспертной группы по изучению спондилоартритов при Общероссийской общественной организации «Ассоциация ревматологов России»)</article-title><trans-title-group xml:lang="en"><trans-title>REMISSION IN AXIAL SPONDYLOARTHRITIS: DEFINITION AND EVALUATION TOOLS (RECOMMENDATIONS OF THE SPONDYLOARTHRITIS STUDY GROUP OF EXPERTS, ALL-RUSSIAN PUBLIC ORGANIZATION «THE ASSOCIATION OF RHEUMATOLOGY OF RUSSIA»)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гайдукова</surname><given-names>И. З.</given-names></name><name name-style="western" xml:lang="en"><surname>Gaidukova</surname><given-names>I. Z.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Санкт-Петербург.</p></bio><bio xml:lang="en"><p>Saint Petersburg/</p></bio><email xlink:type="simple">ubp1976@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ребров</surname><given-names>А. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Rebrov</surname><given-names>A. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Саратов.</p></bio><bio xml:lang="en"><p>Saratov.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коротаева</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Korotaeva</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дубинина</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dubinina</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Оттева</surname><given-names>Э. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Otteva</surname><given-names>E. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хабаровск.</p></bio><bio xml:lang="en"><p>Khabarovsk.</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бадокин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Badokin</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бочкова</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Bochkova</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Егорьевск.</p></bio><bio xml:lang="en"><p>Egoryevsk.</p></bio><xref ref-type="aff" rid="aff-6"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бугрова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bugrova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Оренбург.</p></bio><bio xml:lang="en"/><xref ref-type="aff" rid="aff-7"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Годзенко</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Godzenko</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дубиков</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Dubikov</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Владивосток.</p></bio><bio xml:lang="en"><p>Vladivostok.</p></bio><xref ref-type="aff" rid="aff-8"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванова</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanova</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Воронеж.</p></bio><bio xml:lang="en"><p>Voronezh.</p></bio><xref ref-type="aff" rid="aff-9"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лапшина</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lapshina</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Казань.</p></bio><bio xml:lang="en"><p>Kazan.</p></bio><xref ref-type="aff" rid="aff-10"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Несмеянова</surname><given-names>О. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Nesmeyanova</surname><given-names>O. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Челябинск.</p></bio><bio xml:lang="en"><p>Chelyabinsk.</p></bio><xref ref-type="aff" rid="aff-11"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никишина</surname><given-names>И. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikishina</surname><given-names>I. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Раскина</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Raskina</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кемерово.</p></bio><bio xml:lang="en"><p>Kemerovo.</p></bio><xref ref-type="aff" rid="aff-12"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Румянцева</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rumyantseva</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-13"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смирнов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Smirnov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-13"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ситало</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sitalo</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-14"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эрдес</surname><given-names>Ш. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Erdes</surname><given-names>Sh. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-15"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Северо-Западный медицинский университет им. И.И.Мечникова» Минздрава России.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.I. Mechnikov North-Western Medical University, Ministry of Health of Russia/</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ВО «Саратовский государственный медицинский университет им. В.И.Разумовского» Минздрава России.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.I. Razumovsky Saratov State Medical University, Ministry of Health of Russia.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБНУ «Научноисследовательский институт ревматологии им. В.А.Насоновой».</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>КГБОУ ДПО «Институт повышения квалификации специалистов здравоохранения» Минздрава Хабаровского края.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Institute for Postgraduate Training of Health Professionals, Ministry of Health of the Khabarovsk Territory.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-6"><aff xml:lang="ru"><institution>Медицинский центр «Агат».</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Agat Medical Center.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-7"><aff xml:lang="ru"><institution>7ФГБОУ ВО «Оренбургский государственный медицинский университет» Минздрава России.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Orenburg State Medical University, Ministry of Health of Russia.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-8"><aff xml:lang="ru"><institution>Медицинский центр «САНАС».</institution><country>Россия</country></aff><aff xml:lang="en"><institution>SANAS Medical Center.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-9"><aff xml:lang="ru"><institution>БУЗ ВО «Воронежская областная клиническая больница №1».</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Voronezh Regional Clinical Hospital One.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-10"><aff xml:lang="ru"><institution>ФГБОУ ВО «Казанский государственный медицинский университет» Минздрава России.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kazan State Medical University, Ministry of Health of Russia.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-11"><aff xml:lang="ru"><institution>ГБУЗ «Челябинская областная клиническая больница».</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Chelyabinsk Regional Clinical Hospital.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-12"><aff xml:lang="ru"><institution>ФГБОУ ВО «Кемеровская государственная медицинская академия».</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kemerovo State Medical Academy.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-13"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А.Насоновой».</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-14"><aff xml:lang="ru"><institution>МРОБОИ «Общество взаимопомощи при болезни Бехтерева».</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Mutual Aid Society of Bechterew's Disease.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-15"><aff xml:lang="ru"><institution>ФГБНУ «Научноисследовательский институт ревматологии им. В.А.Насоновой».</institution><country>Россия</country></aff><aff xml:lang="en"><institution>3V.A. Nasonova Research Institute of Rheumatology.</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>02</day><month>03</month><year>2018</year></pub-date><volume>56</volume><issue>1</issue><fpage>10</fpage><lpage>14</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гайдукова И.З., Ребров А.П., Коротаева Т.В., Дубинина Т.В., Оттева Э.Н., Бадокин В.В., Бочкова А.Г., Бугрова О.В., Годзенко А.А., Дубиков А.И., Иванова О.Н., Лапшина С.А., Несмеянова О.Б., Никишина И.П., Раскина Т.А., Румянцева О.А., Смирнов А.В., Ситало А.В., Эрдес Ш.Ф., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Гайдукова И.З., Ребров А.П., Коротаева Т.В., Дубинина Т.В., Оттева Э.Н., Бадокин В.В., Бочкова А.Г., Бугрова О.В., Годзенко А.А., Дубиков А.И., Иванова О.Н., Лапшина С.А., Несмеянова О.Б., Никишина И.П., Раскина Т.А., Румянцева О.А., Смирнов А.В., Ситало А.В., Эрдес Ш.Ф.</copyright-holder><copyright-holder xml:lang="en">Gaidukova I.Z., Rebrov A.P., Korotaeva T.V., Dubinina T.V., Otteva E.N., Badokin V.V., Bochkova A.G., Bugrova O.V., Godzenko A.A., Dubikov A.I., Ivanova O.N., Lapshina S.A., Nesmeyanova O.B., Nikishina I.P., Raskina T.A., Rumyantseva O.A., Smirnov A.V., Sitalo A.V., Erdes S.F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/2493">https://rsp.mediar-press.net/rsp/article/view/2493</self-uri><abstract><p>В статье представлено определение ремиссии при аксиальных спондилоартритах (аксСпА), разработанное Экспертной группой по изучению спондилоартритов (ЭкСпА). В работе был использован принцип Дельфийского консенсуса. На первом этапе эксперты на основании данных анализа литературы и собственного клинического опыта предложили варианты определения ремиссии и способы ее оценки у больных аксСпА. На втором этапе путем анонимного голосования были отобраны варианты, получившие не менее 80% голосов, которые были приняты без дополнительного обсуждения. Варианты, получившие равное количество голосов, были пересмотрены, дополнительно обсуждены, после чего проведено повторное голосование с выбором окончательного их варианта. В итоге обсуждения были сформулированы определения клинико-лабораторной и определяемой по результатам магитно-резонансной томографии (МРТ) ремиссии. Предложено выделять следующие варианты ремиссии при аксСпА: лекарственную и безлекарственную, клинико-лабораторную и МРТ-ремиссию, а также ремиссию с наличием и отсутствием структурных изменений опорно-двигательного аппарата по данным визуализирующих методов исследования. Были разработаны критерии клинико-лабораторной ремиссии и основные инструменты ее оценки, которые можно использовать в реальной клинической практике и в научных исследованиях.</p></abstract><trans-abstract xml:lang="en"><p>The paper gives the definition of remission in axial spondyloarthritides (axSpA), which has been developed by the Spondyloarthritis Study Group of Experts. The work used the Delphi technique. At stage 1, based on the analysis of the data available in the literature and on their own clinical experiences, the experts proposed some variants of the definition of remission and ways of its evaluation in patients with axSpA. At Stage 2, the definitions that had received at least 80% of the votes via anonymous voting were selected and adopted without further discussion. Those that had received an equal number of votes were reconsidered and additionally discussed; then there was repeat voting, by choosing the final definition. As a result of their discussion, the experts formulated the definitions of clinical laboratory and magnetic resonance imaging (MRI) remissions. They proposed the following remissions in axSpA: drug and drug-free, clinical laboratory, and MRI remissions, as well as a remission in the presence and absence of structural changes in the locomotor system, as evidenced by imaging techniques. Criteria for clinical laboratory remission and basic tools for its evaluation that can be used in real clinical practice and researches have been elaborated.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>аксиальный спондилоартрит</kwd><kwd>анкилозирующий спондилит</kwd><kwd>ремиссия</kwd><kwd>клинически значимое улучшение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>axial spondyloarthritis</kwd><kwd>ankylosing spondylitis</kwd><kwd>remission</kwd><kwd>clinically significant improvement</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Эрдес ШФ, Бадокин ВВ, Бочкова АГ и др. О терминологии спондилоартритов. Научно-практическая ревматология. 2015;53(6):657-60 [Erdes ShF, Badokin VV, Bochkova AG, et al. On the terminology of spondyloarthritis. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2015;53(6):657-60 (In Russ.)]. doi: 10.14412/1995-4484-2015657-660</mixed-citation><mixed-citation xml:lang="en">Эрдес ШФ, Бадокин ВВ, Бочкова АГ и др. О терминологии спондилоартритов. Научно-практическая ревматология. 2015;53(6):657-60 [Erdes ShF, Badokin VV, Bochkova AG, et al. On the terminology of spondyloarthritis. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2015;53(6):657-60 (In Russ.)]. doi: 10.14412/1995-4484-2015657-660</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Schoels MM, Braun J, Dougados M, et al. Treating axial and peripheral spondyloarthritis, including psoriatic arthritis, to target: results of a systematic literature search to support an international treat-to-target recommendation in spondyloarthritis. Ann Rheum Dis. 2014;73(1):238-42. doi: 10.1136/annrheumdis-2013203860</mixed-citation><mixed-citation xml:lang="en">Schoels MM, Braun J, Dougados M, et al. Treating axial and peripheral spondyloarthritis, including psoriatic arthritis, to target: results of a systematic literature search to support an international treat-to-target recommendation in spondyloarthritis. Ann Rheum Dis. 2014;73(1):238-42. doi: 10.1136/annrheumdis-2013203860</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Gonzalez-Alvaro I, Martinez-Fernandez C, Dorantes-Calderon B, et al; Spanish Rheumatology Society and Hospital Pharmacy Society Consensus on recommendations for biologics optimization in patients with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis. Rheumatology (Oxford). 2015 Jul;54(7):1200-9. doi: 10.1093/rheumatology/keu461</mixed-citation><mixed-citation xml:lang="en">Gonzalez-Alvaro I, Martinez-Fernandez C, Dorantes-Calderon B, et al; Spanish Rheumatology Society and Hospital Pharmacy Society Consensus on recommendations for biologics optimization in patients with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis. Rheumatology (Oxford). 2015 Jul;54(7):1200-9. doi: 10.1093/rheumatology/keu461</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Ward MM. Update on the American College of Rheumatology/Spondyloarthritis Research and Treatment Network/Spondylitis Association of America axial spondyloarhtritis treatment guidelines project. Clin Rheumatol. 2014;33(6):73940. doi: 10.1007/s10067-014-2660-9</mixed-citation><mixed-citation xml:lang="en">Ward MM. Update on the American College of Rheumatology/Spondyloarthritis Research and Treatment Network/Spondylitis Association of America axial spondyloarhtritis treatment guidelines project. Clin Rheumatol. 2014;33(6):73940. doi: 10.1007/s10067-014-2660-9</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Wendling D, Lukas C, Paccou J, et al; French Society for Rheumatology (SFR). Recommendations of the French Society for Rheumatology (SFR) on the everyday management of patients with spondyloarthritis. Joint Bone Spine. 2014;81(1):6-14. doi: 10.1016/j.jbspin.2013.12.002</mixed-citation><mixed-citation xml:lang="en">Wendling D, Lukas C, Paccou J, et al; French Society for Rheumatology (SFR). Recommendations of the French Society for Rheumatology (SFR) on the everyday management of patients with spondyloarthritis. Joint Bone Spine. 2014;81(1):6-14. doi: 10.1016/j.jbspin.2013.12.002</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Van der Heijde D, Sieper J, Maksymowych WP, et al; Assessment of SpondyloArthritis international Society. 2010 Update of the international ASAS recommendations for the use of anti-TNF agents in patients with axial spondyloarthritis. Ann Rheum Dis. 2011;70(6):905-8. doi: 10.1136/ard.2011.151563</mixed-citation><mixed-citation xml:lang="en">Van der Heijde D, Sieper J, Maksymowych WP, et al; Assessment of SpondyloArthritis international Society. 2010 Update of the international ASAS recommendations for the use of anti-TNF agents in patients with axial spondyloarthritis. Ann Rheum Dis. 2011;70(6):905-8. doi: 10.1136/ard.2011.151563</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Van der Heijde D, Ramiro S, Landewe R, et al. 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis. Ann Rheum Dis. 2017. doi: 10.1136/annrheumdis-2016210770</mixed-citation><mixed-citation xml:lang="en">Van der Heijde D, Ramiro S, Landewe R, et al. 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis. Ann Rheum Dis. 2017. doi: 10.1136/annrheumdis-2016210770</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Coates L, Moverley A, McParland L, et al. Effect of tight control of inflammation in early psoriatic arthritis (TICOPA): a UK multicentre, open-label, randomised controlled study. Lancet. 2015;386:2489-98.</mixed-citation><mixed-citation xml:lang="en">Coates L, Moverley A, McParland L, et al. Effect of tight control of inflammation in early psoriatic arthritis (TICOPA): a UK multicentre, open-label, randomised controlled study. Lancet. 2015;386:2489-98.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Коротаева ТВ, Логинова ЕЮ, Каратеев ДЕ и др. Стратегия «Лечение до достижения цели» при раннем псориатическом артрите (предварительные результаты исследования РЕМАРКА). Научно-практическая ревматология. 2014;52(4):376-80 [Korotaeva TV, Loginova EYu, Karateev DE, et al. Treat-to-target strategy for early psoriatic arthritis (Preliminary results of the REMARCA study). NauchnoPrakticheskaya Revmatologiya = Rheumatology Science and Practice. 2014;52(4):376-80 (In Russ.)]. doi: 10.14412/19954484-2014-376-380</mixed-citation><mixed-citation xml:lang="en">Коротаева ТВ, Логинова ЕЮ, Каратеев ДЕ и др. Стратегия «Лечение до достижения цели» при раннем псориатическом артрите (предварительные результаты исследования РЕМАРКА). Научно-практическая ревматология. 2014;52(4):376-80 [Korotaeva TV, Loginova EYu, Karateev DE, et al. Treat-to-target strategy for early psoriatic arthritis (Preliminary results of the REMARCA study). NauchnoPrakticheskaya Revmatologiya = Rheumatology Science and Practice. 2014;52(4):376-80 (In Russ.)]. doi: 10.14412/19954484-2014-376-380</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Gossec L, Smolen J, Ramiro S, et al. European League Against Rheumatism (EULAR) recommendations for the management of psoriatic arthritis with pharmacological therapies: 2015 update. Ann Rheum Dis 2015;0:1-12. doi: 10.1136/annrheumdis-2015208337</mixed-citation><mixed-citation xml:lang="en">Gossec L, Smolen J, Ramiro S, et al. European League Against Rheumatism (EULAR) recommendations for the management of psoriatic arthritis with pharmacological therapies: 2015 update. Ann Rheum Dis 2015;0:1-12. doi: 10.1136/annrheumdis-2015208337</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Гайдукова ИЗ, Ребров АП, Шувалова АА. Ремиссия при анкилозирующем спондилите и аксиальных спондилоартритах: современное понимание проблемы. Современная ревматология. 2016;10(1):48-51 [Gaydukova IZ, Rebrov AP, Shuvalova AA. Remission in ankylosing spondylitis and axial spondyloarthritis: A modern understanding of the problem. Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2016;10(1):48-51 (In Russ.)]. doi: 10.14412/1996-70122016-1-48-51</mixed-citation><mixed-citation xml:lang="en">Гайдукова ИЗ, Ребров АП, Шувалова АА. Ремиссия при анкилозирующем спондилите и аксиальных спондилоартритах: современное понимание проблемы. Современная ревматология. 2016;10(1):48-51 [Gaydukova IZ, Rebrov AP, Shuvalova AA. Remission in ankylosing spondylitis and axial spondyloarthritis: A modern understanding of the problem. Sovremennaya Revmatologiya = Modern Rheumatology Journal. 2016;10(1):48-51 (In Russ.)]. doi: 10.14412/1996-70122016-1-48-51</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Poddubnyy D, Gensler LS. Spontaneous, drug-induced, and drugfree remission in peripheral and axial spondyloarthritis. Best Pract Res Clin Rheumatol. 2014;28(5):807-18. doi: 10.1016/j.berh.2014.10.005</mixed-citation><mixed-citation xml:lang="en">Poddubnyy D, Gensler LS. Spontaneous, drug-induced, and drugfree remission in peripheral and axial spondyloarthritis. Best Pract Res Clin Rheumatol. 2014;28(5):807-18. doi: 10.1016/j.berh.2014.10.005</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Sieper J. How to define remission in ankylosing spondylitis? Ann Rheum Dis. 2012;71 Suppl 2:i93-5. doi: 10.1136/annrheumdis2011-200798</mixed-citation><mixed-citation xml:lang="en">Sieper J. How to define remission in ankylosing spondylitis? Ann Rheum Dis. 2012;71 Suppl 2:i93-5. doi: 10.1136/annrheumdis2011-200798</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Braun J, Kiltz U, Sarholz M, et al. Monitoring ankylosing spondylitis: clinically useful markers and prediction of clinical outcomes. Expert Rev Clin Immunol. 2015:11(8):935-46. doi: 10.1586/1744666X.2015.1052795</mixed-citation><mixed-citation xml:lang="en">Braun J, Kiltz U, Sarholz M, et al. Monitoring ankylosing spondylitis: clinically useful markers and prediction of clinical outcomes. Expert Rev Clin Immunol. 2015:11(8):935-46. doi: 10.1586/1744666X.2015.1052795</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Poddubnyy D, Rudwaleit M, Haibel H, et al. Rates and predictors of radiographic sacroiliitis progression over 2 years in patients with axial spondyloarthritis. Ann Rheum Dis. 2011 Aug;70(8):1369-74. doi: 10.1136/ard.2010.145995</mixed-citation><mixed-citation xml:lang="en">Poddubnyy D, Rudwaleit M, Haibel H, et al. Rates and predictors of radiographic sacroiliitis progression over 2 years in patients with axial spondyloarthritis. Ann Rheum Dis. 2011 Aug;70(8):1369-74. doi: 10.1136/ard.2010.145995</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Poddubnyy D, Sieper J. Radiographic progression in ankylosing spondylitis/axial spondyloarthritis: how fast and how clinically meaningful? Curr Opin Rheumatol. 2012 Jul;24(4):363-9. doi: 10.1097/BOR.0b013e328352b7bd</mixed-citation><mixed-citation xml:lang="en">Poddubnyy D, Sieper J. Radiographic progression in ankylosing spondylitis/axial spondyloarthritis: how fast and how clinically meaningful? Curr Opin Rheumatol. 2012 Jul;24(4):363-9. doi: 10.1097/BOR.0b013e328352b7bd</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Bennett N, McGonagle D, O'Connor P, et al. Severity of Baseline Magnetic Resonance Imaging-Evident Sacroiliitis and HLA-B27 Status in Early Inflammatory Back Pain Predict Radiographically Evident Ankylosing Spondylitis at Eight Years. Arthritis Rheum. 2008 Nov;58(11):3413-8. doi: 10.1002/art.24024</mixed-citation><mixed-citation xml:lang="en">Bennett N, McGonagle D, O'Connor P, et al. Severity of Baseline Magnetic Resonance Imaging-Evident Sacroiliitis and HLA-B27 Status in Early Inflammatory Back Pain Predict Radiographically Evident Ankylosing Spondylitis at Eight Years. Arthritis Rheum. 2008 Nov;58(11):3413-8. doi: 10.1002/art.24024</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Lukas C, Landewe R, Sieper J, et al; Assessment of SpondyloArthritis international Society. Development of an ASAS-endorsed disease activity score (ASDAS) in patients with ankylosing spondylitis. Ann Rheum Dis. 2009 Jan;68(1):18-24. doi: 10.1136/ard.2008.094870</mixed-citation><mixed-citation xml:lang="en">Lukas C, Landewe R, Sieper J, et al; Assessment of SpondyloArthritis international Society. Development of an ASAS-endorsed disease activity score (ASDAS) in patients with ankylosing spondylitis. Ann Rheum Dis. 2009 Jan;68(1):18-24. doi: 10.1136/ard.2008.094870</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Garrett S, Jenkinson T, Kennedy LG, et al. A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol. 1994 Dec;21(12):2286-91.</mixed-citation><mixed-citation xml:lang="en">Garrett S, Jenkinson T, Kennedy LG, et al. A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol. 1994 Dec;21(12):2286-91.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Lambert RG, Bakker PA, van der Heijde D, et al. Defining active sacroiliitis on MRI for classification of axial spondy loarthritis: update by the ASAS MRI working group. Ann Rheum Dis. 2016 Nov;75(11):1958-63. doi: 10.1136/annrheumdis-2015208642</mixed-citation><mixed-citation xml:lang="en">Lambert RG, Bakker PA, van der Heijde D, et al. Defining active sacroiliitis on MRI for classification of axial spondy loarthritis: update by the ASAS MRI working group. Ann Rheum Dis. 2016 Nov;75(11):1958-63. doi: 10.1136/annrheumdis-2015208642</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Danve A, Deodhar A. Treat to Target in Axial Spondyloarthritis: What Are the Issues? Curr Rheumatol Rep. 2017 May;19(5):22. doi: 10.1007/s11926-017-0648-6</mixed-citation><mixed-citation xml:lang="en">Danve A, Deodhar A. Treat to Target in Axial Spondyloarthritis: What Are the Issues? Curr Rheumatol Rep. 2017 May;19(5):22. doi: 10.1007/s11926-017-0648-6</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Deodhar A, Kumthekar A, Dubreuil M. Minimal disease activity in axial spondyloarthritis: the need of the hour and a proposal for development. Curr Opin Rheumatol. 2017 Apr 3. doi: 10.1097/BOR.0000000000000387</mixed-citation><mixed-citation xml:lang="en">Deodhar A, Kumthekar A, Dubreuil M. Minimal disease activity in axial spondyloarthritis: the need of the hour and a proposal for development. Curr Opin Rheumatol. 2017 Apr 3. doi: 10.1097/BOR.0000000000000387</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Гайдукова ИЗ, Ребров АП. Особенности клинических исследований при спондилоартритах (обзор литературы). Доктор.Ру. 2014;4(92):51-5 [Gaidukova IZ, Rebrov AP. Specific Features of Clinical Trials in Patients with Spondyloarthritis: Review of Literature. Doctor.ru. 2014;4(92):51-5 (In Russ.)].</mixed-citation><mixed-citation xml:lang="en">Гайдукова ИЗ, Ребров АП. Особенности клинических исследований при спондилоартритах (обзор литературы). Доктор.Ру. 2014;4(92):51-5 [Gaidukova IZ, Rebrov AP. Specific Features of Clinical Trials in Patients with Spondyloarthritis: Review of Literature. Doctor.ru. 2014;4(92):51-5 (In Russ.)].</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Edwards CJ, Fautrel B, Schulze-Koops H, et al. Dosing down with biologic therapies: a systematic review and clinicians' perspective. Rheumatology (Oxford). 2017 Feb 16. doi: 10.1093/rheumatology/kew464</mixed-citation><mixed-citation xml:lang="en">Edwards CJ, Fautrel B, Schulze-Koops H, et al. Dosing down with biologic therapies: a systematic review and clinicians' perspective. Rheumatology (Oxford). 2017 Feb 16. doi: 10.1093/rheumatology/kew464</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Carron P, Varkas G, Cypers H, et al; CRESPA investigator group. Anti-TNF-induced remission in very early peripheral spondyloarthritis: the CRESPA study. Ann Rheum Dis. 2017 Feb 17. pii: annrheumdis-2016-210775. doi: 10.1136/annrheumdis-2016-210775</mixed-citation><mixed-citation xml:lang="en">Carron P, Varkas G, Cypers H, et al; CRESPA investigator group. Anti-TNF-induced remission in very early peripheral spondyloarthritis: the CRESPA study. Ann Rheum Dis. 2017 Feb 17. pii: annrheumdis-2016-210775. doi: 10.1136/annrheumdis-2016-210775</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Гайдукова ИЗ, Ребров АП, Оттева ЭН и др. Применение нестероидных противовоспалительных препаратов для лечения аксиальных спондилоартритов, включая анкилозирующий спондилит, мониторинг эффективности и безопасности (проект рекомендаций группы экспертов по диагностике и лечению спондилоартритов). Научнопрактическая ревматология. 2016;54(Прил. 1):67-74 [Gaidukova IZ, Rebrov AP, Otteva EN, et al. Use of nonsteroidal anti-inflammatory drugs for the treatment of axial spondyloarthritis, including ankylosing spondylitis, monitoring their efficacy and safety (draft guidelines of the Expert Spondyloarthritis Diagnosis and Treatment Group). Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2016;54(Suppl. 1):67-74 (In Russ.)]. doi: 10.14412/1995-44842016-1S-67-74</mixed-citation><mixed-citation xml:lang="en">Гайдукова ИЗ, Ребров АП, Оттева ЭН и др. Применение нестероидных противовоспалительных препаратов для лечения аксиальных спондилоартритов, включая анкилозирующий спондилит, мониторинг эффективности и безопасности (проект рекомендаций группы экспертов по диагностике и лечению спондилоартритов). Научнопрактическая ревматология. 2016;54(Прил. 1):67-74 [Gaidukova IZ, Rebrov AP, Otteva EN, et al. Use of nonsteroidal anti-inflammatory drugs for the treatment of axial spondyloarthritis, including ankylosing spondylitis, monitoring their efficacy and safety (draft guidelines of the Expert Spondyloarthritis Diagnosis and Treatment Group). Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2016;54(Suppl. 1):67-74 (In Russ.)]. doi: 10.14412/1995-44842016-1S-67-74</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Лапшина СА, Дубинина ТВ, Бадокин ВВ и др. Ингибиторы фактора некроза опухоли α в лечении аксиальных спондилоартритов (включая анкилозирующий спондилит). Научно-практическая ревматология. 2016;54(Прил. 1):75-9 [Lapshina SA, Dubinina TV, Badokin VV, et al. Tumor necrosis factor-α inhibitors in the treatment of axial spondyloarthritis, including ankylosing spondylitis. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2016;54(Suppl. 1):75-9 (In Russ.)]. doi: 10.14412/1995-44842016-1S-75-79</mixed-citation><mixed-citation xml:lang="en">Лапшина СА, Дубинина ТВ, Бадокин ВВ и др. Ингибиторы фактора некроза опухоли α в лечении аксиальных спондилоартритов (включая анкилозирующий спондилит). Научно-практическая ревматология. 2016;54(Прил. 1):75-9 [Lapshina SA, Dubinina TV, Badokin VV, et al. Tumor necrosis factor-α inhibitors in the treatment of axial spondyloarthritis, including ankylosing spondylitis. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2016;54(Suppl. 1):75-9 (In Russ.)]. doi: 10.14412/1995-44842016-1S-75-79</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
