rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2018-48-54rsp-2499Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHКачество жизни пациентов, перенесших остеопоротический перелом позвонковQUALITY OF LIFE IN PATIENTS WITH PRIOR OSTEOPOROTIC VERTEBRAL FRACTUREСолодовниковА. Г.SolodovnikovA. G.

Екатеринбург.

Yekaterinburg.

dr.alexander.solodovnikov@gmail.comЛеснякО. М.LesnyakO. M.

Екатеринбург; Санкт-Петербург.

Yekaterinburg; Saint Petersburg.

ДобровольскаяО. В.DobrovolskayaO. V.

Москва.

Moscow.

БеловаК. Ю.BelovaK. Yu.

Ярославль.

Yaroslavl.

ВаравкоЮ. А.VaravkoYu. A.

Иркутск.

Irkuts.

ГолубевГ. Ш.GolubevG. Sh.

Ростов-на-Дону.

Rostov-on-Don.

ГребенщиковВ. А.GrebenshchikovV. A.

Ростов-на-Дону.

Rostov-on-Don.

ЕршоваО. Б.ErshovaO. B.

Ярославль.

Yaroslavl.

ЗоткинЕ. Г.ZotkinE. G.

Москва.

Moscow.

ИвановС. Н.IvanovS. N.

Санкт-Петербург.

Saint Petersburg.

КочишА. Ю.KochishA. Yu.

Санкт-Петербург.

Saint Petersburg.

МеньшиковаЛ. В.MenshikovaL. V.

Ярославль.

Yaroslavl.

УсенкоК. П.UsenkoK. P.

Екатеринбург.

Yekaterinburg.

ФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России.РоссияUral State Medical University, Ministry of Health of Russia.Russian FederationФГБОУ ВО «Уральский государственный медицинский университет» Минздрава России; ФГБОУ ВО «Северо-Западный государственный медицинский университет им. И.И.Мечникова» Минздрава России.РоссияUral State Medical University, Ministry of Health of Russia; I.I.Mechnikov NorthWestern State Medical University, Ministry of Health of Russia.Russian FederationФГБНУ «Научноисследовательский институт ревматологии им. В.А.Насоновой».РоссияV.A.Nasonova Research Institute of Rheumatology.Russian FederationФГБОУ ВО «Ярославский государственный медицинский университет» Минздрава России.РоссияYaroslavl State Medical University, Ministry of Health of Russia.Russian FederationГБОУ ДПО «Иркутская государственная медицинская академия последипломного образования» Минздрава России.Россия5Irkutsk State Medical Academy of Postgraduate Education, Ministry of Health of Russia.Russian FederationФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава России.РоссияRostov State Medical University, Ministry of Health of Russia.Russian FederationФГБУ «Российский научно-исследовательский институт травматологии и ортопедии им. Р.Р.Вредена» Минздрава России.РоссияR.R.Vreden Russian Research Institute of Traumatology and Orthopedics, Ministry of Health of Russia.Russian Federation2018030320185614854Copyright © Солодовников А.Г., Лесняк О.М., Добровольская О.В., Белова К.Ю., Варавко Ю.А., Голубев Г.Ш., Гребенщиков В.А., Ершова О.Б., Зоткин Е.Г., Иванов С.Н., Кочиш А.Ю., Меньшикова Л.В., Усенко К.П., 20182018Солодовников А.Г., Лесняк О.М., Добровольская О.В., Белова К.Ю., Варавко Ю.А., Голубев Г.Ш., Гребенщиков В.А., Ершова О.Б., Зоткин Е.Г., Иванов С.Н., Кочиш А.Ю., Меньшикова Л.В., Усенко К.П.Solodovnikov A.G., Lesnyak O.M., Dobrovolskaya O.V., Belova K.Y., Varavko Y.A., Golubev G.S., Grebenshchikov V.A., Ershova O.B., Zotkin E.G., Ivanov S.N., Kochish A.Y., Menshikova L.V., Usenko K.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2499

Цель данного исследования – проанализировать динамику качества жизни (КЖ) пациентов, перенесших остеопоротический компрессионный перелом позвонков, в течение 18 мес наблюдения.

Материал и методы

Материал и методы. В исследование включены 219 пациентов (средний возраст – 67,6 года) с переломом позвонка из семи центров Российской Федерации. Оценка КЖ проводилась четырежды с использованием опросников EQ-5D (EuroQoL-5D) и ТТО (Time Trade-Off) в течение 18 мес проспективного наблюдения. Работа выполнена в рамках международного многоцентрового исследования ICUROS (The International Costs and Utilities Related to Osteoporotic Fractures Study), организованного Международным фондом остеопороза (www.icuros.org).

Результаты и обсуждение

Результаты и обсуждение. У пациентов с компрессионным переломом позвонка наблюдалось статистически значимое снижение КЖ в течение всего периода наблюдения. Сразу после перелома регистрировалось резкое снижение общего счета EQ-5D, после чего наблюдался его постепенный рост. Однако наметившаяся тенденция к восстановлению КЖ оказалась нестойкой, и к концу 18-го месяца оно было достоверно ниже, чем до перелома. Напротив, КЖ по опроснику ТТО резко снижалось непосредственно после перелома, но к 4-му месяцу оно достигло уровня, который был до перелома, и оставалось стабильным до конца наблюдения.

Заключение

Заключение. Проведенное исследование позволило впервые получить данные о КЖ по EQ-5D (оценка КЖ с социальной точки зрения) и TTO (индивидуальная оценка КЖ) в популяции жителей Российской Федерации, мужчин и женщин в возрасте 50 лет и старше с остеопоротическим компрессионным переломом позвонка.

Objective

Objective: to analyze the dynamics of quality of life (QOL) in patients with prior osteoporotic vertebral compression fracture during an 18-month follow-up study.

Subjects and methods

Subjects and methods. The investigation enrolled 219 patients (mean age, 67.6 years) with vertebral fracture from seven centers of the Russian Federation. QOL was assessed four times using the EQ-5D (EuroQoL-5D) and TTO (Time Trade-Off) questionnaires during an 18-month prospective follow-up study. The work was done within the framework of the International Multicenter Study ICUROS (The International Costs and Utilities Related to Osteoporotic Fractures Study) organized by the International Osteoporosis Foundation (www.icuros.org).

Results and discussion

Results and discussion. The patients with vertebral compression fracture showed a statistically significant decrease in QOL throughout the follow-up period. Immediately after the fracture, there was a dramatic decrease in the total EQ-5D score, followed by its gradual increase. However, the emerging trend in QOL recovery proved to be unstable, and by the end of the 18th month, it was significantly lower than that before the fracture. On the contrary, the TTO questionnaire showed that QOL drastically decreased immediately after fracture, but at month 4 it reached the level that was before the fracture, and remained stable until the end of the follow-up period.

Conclusion

Conclusion. The performed investigation enabled us to obtain data on QOL using the EQ-5D (QOL assessment from the social point of view) and TTO (individual QOL assessment) in the population of residents of the Russian Federation, in men and women aged 50 years and older with osteoporotic vertebral compression fracture. 

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The authors declare that there are no conflicts of interest present.