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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1995-4484-2018-70-81</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-2502</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРОГРЕСС В РЕВМАТОЛОГИИ В XXI ВЕКЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PROGRESS IN RHEUMATOLOGY IN THE XXI CENTURY</subject></subj-group></article-categories><title-group><article-title>Остеоартрит: современная клиническая концепция и некоторые перспективные терапевтические подходы</article-title><trans-title-group xml:lang="en"><trans-title>OSTEOARTHRITIS: CURRENT CLINICAL CONCEPT AND SOME PROMISING THERAPEUTIC APPROACHES</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каратеев</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Karateev</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>заведующий лабораторией патофизиологии боли и клинического полиморфизма скелетно-мышечных заболеваний, доктор медицинских наук.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><email xlink:type="simple">aekarat@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лила</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lila</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>профессор, врио директора, доктор медицинских наук.</p><p>Москва.</p></bio><bio xml:lang="en"><p>Moscow.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научноисследовательский институт ревматологии им. В.А.Насоновой».</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A.Nasonova Research Institute of Rheumatology.</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>03</day><month>03</month><year>2018</year></pub-date><volume>56</volume><issue>1</issue><fpage>70</fpage><lpage>81</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Каратеев А.Е., Лила А.М., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Каратеев А.Е., Лила А.М.</copyright-holder><copyright-holder xml:lang="en">Karateev A.E., Lila A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/2502">https://rsp.mediar-press.net/rsp/article/view/2502</self-uri><abstract><p>В последние годы наметилась тенденция к изменению клинической концепции остеоартрита (ОА). Очень долго это заболевание рассматривалось как «возрастная патология» и исход длительно текущего патологического процесса. Однако сейчас многие эксперты склоняются к необходимости выделения ранней, дорентгенологической стадии ОА, когда адекватная терапия может не только остановить прогрессирование, но и добиться обратного развития структурных изменений сустава. В настоящем обзоре рассмотрены ряд патогенетических и клинических аспектов ранней стадии ОА, важных для своевременной диагностики и выбора патогенетической терапии. Рассмотрены некоторые терапевтические подходы, как «классические», так и активно обсуждаемые в последнее время методики применения обогащенной тромбоцитами плазмы и аутологичной трансплантации хондроцитов.</p></abstract><trans-abstract xml:lang="en"><p>In recent years, there has been a trend toward changing the clinical concept of osteoarthritis (OA). This disease has been considered as an age-related disease and the long-term result of a current pathological process for a very long time. However, many experts are now inclined to consider it necessary to identify the early, pre-X-ray stage of OA, when adequate treatment may not only halt the progression, but also achieve the regression of joint structural changes. This review deals with a number of pathogenetic and clinical aspects of the early stages of OA, which are important for timely diagnosis and pathogenetic therapy choice. It also considers some therapeutic approaches, both a "classic" and recently actively discussed methods for using platelet-rich plasma and autologous chondrocyte transplantation.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>остеоартрит</kwd><kwd>ранний остеоартрит</kwd><kwd>патогенез</kwd><kwd>лечение</kwd><kwd>обогащенная тромбоцитами плазма</kwd><kwd>аутологичная трансплантация хондроцитов</kwd></kwd-group><kwd-group xml:lang="en"><kwd>osteoarthritis</kwd><kwd>early osteoarthritis</kwd><kwd>pathogenesis</kwd><kwd>treatment</kwd><kwd>platelet-rich plasma</kwd><kwd>autologous chondrocyte transplantation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева ЛИ, Шарапова ЕП, Кашеварова НГ, Пьяных СЕ. Новые возможности в терапии остеоартроза. Справочник поликлинического врача. 2015;(6-8):4-7 [Alekseeva LI, Sharapova EP, Kashevarova NG, P'yanykh SE. 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