rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2018-531-534rsp-2602Research ArticleДИСКУССИИDISCUSSIONКакие неблагоприятные реакции на генно-инженерные биологические препараты относят к парадоксальным?WHAT ADVERSE REACTIONS TO BIOLOGICAL AGENTS ARE PARADOXICAL?МуравьевЮ. В.MuravyevYu. V.murawyu@mail.ruФГБНУ «Научноисследовательский институт ревматологии им. В.А. Насоновой», МоскваРоссияV.A. Nasonova Research Institute of Rheumatology, MoscowRussian Federation201808092018564531534Copyright © Муравьев Ю.В., 20182018Муравьев Ю.В.Muravyev Y.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2602

В статье обсуждается появление необычных – парадоксальных – неблагоприятных реакций, возникающих в результате лечения ревматических болезней генно-инженерными биологическими препаратами.

The paper discusses the appearance of unusual – paradoxical – adverse reactions that occur as a result of treatment of rheumatic diseases with biological agents.

 

ревматические болезнигенно-инженерные биологические препаратыингибиторы фактора некроза опухоли αпарадоксальные неблагоприятные реакцииrheumatic diseasesbiological agentstumor necrosis factor-α inhibitorsparadoxical adverse reactionsReferencesToussirot E, Aubin F. Paradoxical reactions under TNF-blocking agents and other biological agents given for chronic immune-mediated diseases: an analytical and comprehensive overview. RMD Open. 2016;2(2):e000239. doi: 10.1136/rmdopen-2015-000239Toussirot E, Aubin F. Paradoxical reactions under TNF-blocking agents and other biological agents given for chronic immune-mediated diseases: an analytical and comprehensive overview. RMD Open. 2016;2(2):e000239. doi: 10.1136/rmdopen-2015-000239Viguier M, Richette P, Bachelez H, et al. Paradoxical adverse effects of anti-TNF-alpha treatment: onset or exacerbation of cutaneous disorders. Expert Rev Clin Immunol. 2009;5:421-31. doi: 10.1586/eci.09.18Viguier M, Richette P, Bachelez H, et al. 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The authors declare that there are no conflicts of interest present.