rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2018-667-670rsp-2633Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL OBSERVATIONSУспешное применение ингибитора интерлейкина 17 (секукинумаба) в лечении изолированного деструктивного энтезита при псориатическом артритеSUCCESSFUL USE OF AN INTERLEUKIN 17 INHIBITOR (SECUKINUMAB) IN THE TREATMENT OF ISOLATED DESTRUCTIVE ENTHESITIS IN PSORIATIC ARTHRITISГубарьЕ. Е.GubarE. E.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

gubarelena@yandex.ruЛогиноваЕ. Ю.LoginovaE. Yu.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

КоротаеваТ. В.KorotaevaT. V.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation201809112018565667670Copyright © Губарь Е.Е., Логинова Е.Ю., Коротаева Т.В., 20182018Губарь Е.Е., Логинова Е.Ю., Коротаева Т.В.Gubar E.E., Loginova E.Y., Korotaeva T.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2633

Энтезит – это воспаление в месте прикрепления к кости сухожилия, связки или суставной капсулы, типичный симптом псориатического артрита (ПсА). Наибольшее клиническое значение имеет энтезит пяточной области. Решающая роль в развитии энтезита отводится активации оси интерлейкин 23 / интерлейкин 17 (ИЛ23/ИЛ17). Наличие у пациента энтезита может серьезно ограничивать функцию опорно-двигательного аппарата и тяжело поддается терапии. При недостаточной эффективности нестероидных противовоспалительных препаратов рекомендуется немедленное назначение генно-инженерного биологического препарата. Применение синтетических базисных противовоспалительных препаратов для лечения энтезита не рекомендуется в связи с их неэффективностью. Несмотря на успехи, достигнутые при использовании ингибиторов фактора некроза опухоли α в лечении энтезитов при ПсА, сохраняется потребность в применении новых лекарственных препаратов.Приведено описание клинического наблюдения, демонстрирующее успешное лечение изолированного деструктивного энтезита пяточной области у пациента с ПсА ингибитором ИЛ17А секукинумабом (Козентикс).

Enthesitis is inflammation at the site of attachment of tendon, ligament, or joint capsule to bone, a typical symptom of psoriatic arthritis (PsA). Heel enthesitis is of the greatest clinical significance. The activation of the interleukin 23/interleukin 17 (IL-23/IL-17) axis plays a pivotal role in the development of enthesitis. The latter can seriously limit the function of the musculoskeletal system and is incurable. If nonsteroidal anti-inflammatory drugs are ineffective, a biological agent should be immediately prescribed. The use of synthetic disease-modifying antirheumatic drugs for the treatment for enthesitis is not recommended due to their inefficacy. Despite the progress in the treatment of enteritis in PsA with tumor necrosis factor-α inhibitors, there is a need for the use of new drugs.The paper describes the clinical case of a patient with PsA who has been successfully treated for isolated destructive enthesitis of the heel with the IL-17А inhibitor secukinumab (Cosentyx).

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The authors declare that there are no conflicts of interest present.