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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1995-4484-2018-671-674</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-2634</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДИСКУССИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DISCUSSION</subject></subj-group></article-categories><title-group><article-title>Дискуссионные проблемы потенциального вреда применения ингибиторов протонного насоса</article-title><trans-title-group xml:lang="en"><trans-title>POTENTIAL HARMS OF THE USE OF PROTON PUMP INHIBITORS: DEBATABLE PROBLEMS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Муравьев</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Muravyev</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><email xlink:type="simple">murawyu@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бобкова</surname><given-names>О. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Bobkova</surname><given-names>O. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>115522, Москва, Каширское шоссе, 34А</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»<country>Россия</country></aff><aff xml:lang="en">V.A. Nasonova Research Institute of Rheumatology<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>09</day><month>11</month><year>2018</year></pub-date><volume>56</volume><issue>5</issue><fpage>671</fpage><lpage>674</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Муравьев Ю.В., Бобкова О.Р., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Муравьев Ю.В., Бобкова О.Р.</copyright-holder><copyright-holder xml:lang="en">Muravyev Y.V., Bobkova O.R.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/2634">https://rsp.mediar-press.net/rsp/article/view/2634</self-uri><abstract><p>В статье обсуждаются данные о высокой частоте назначения ингибиторов протонного насоса без показаний и о проявлениях потенциального вреда их применения.</p></abstract><trans-abstract xml:lang="en"><p>The paper discusses data on the high frequency of non-indicated use of proton pump inhibitors and on the manifestations of potential harms of their use.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ингибиторы протонного насоса</kwd><kwd>вред</kwd><kwd>ревматоидный артрит</kwd><kwd>гиперчувствительные реакции</kwd></kwd-group><kwd-group xml:lang="en"><kwd>proton pump inhibitors</kwd><kwd>harm</kwd><kwd>rheumatoid arthritis</kwd><kwd>hypersensitivity reactions</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Федеральное руководство по использованию лекарственных средств (формулярная система). 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