rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2018-753-759rsp-2653Research ArticleПРОГРЕСС В РЕВМАТОЛОГИИ В XXI ВЕКЕPROGRESS IN RHEUMATOLOGY IN THE XXI CENTURYАнгиотензины и ревматоидный артритAngiotensins and rheumatoid arthritisСавушкинаН. М.SavushkinaN. M.

младший научный сотрудник лаборатории ранних артритов.

115522 Москва, Каширское шоссе, 34А.

34A, Kashirskoe Shosse, Moscow, 115522.

savushkinanm@mail.ruГалушкоE. А.GalushkoE. A.

ведущий научный сотрудник лаборатории ранних артритов.

115522 Москва, Каширское шоссе, 34А.

34A, Kashirskoe Shosse, Moscow, 115522.

ДемидоваН. В.DemidovaN. V.

научный сотрудник лаборатории ранних артритов.

115522 Москва, Каширское шоссе, 34А.

34A, Kashirskoe Shosse, Moscow, 115522.

ГордеевА. В.GordeevA. V.

профессор, зав. лабораторией ранних артритов.

115522 Москва, Каширское шоссе, 34А.

34A, Kashirskoe Shosse, Moscow, 115522.

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой».РоссияV.A. Nasonova Research Institute of Rheumatology.Russian Federation201821012019566753759Copyright © Савушкина Н.М., Галушко E.А., Демидова Н.В., Гордеев А.В., 20192019Савушкина Н.М., Галушко E.А., Демидова Н.В., Гордеев А.В.Savushkina N.M., Galushko E.A., Demidova N.V., Gordeev A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2653

В настоящее время хорошо изучена роль ренин-ангиотензиновой системы (РАС) в регуляции деятельности сердечно-сосудистой системы и поддержании водно-электролитного гомеостаза. Однако за последние десятилетия были идентифицированы новые компоненты РАС, позволяющие предполагать более широкий спектр ее потенциального воздействия на организм. Принципиально важной для ревматологов является возможность воздействовать на воспаление, в том числе и ревматоидное, посредством блокады образования ангиотензина (АТ) II с помощью эффектов АТ 1–7 и ингибиторов ангиотензинпревращающего фермента, а также подавления процессов ангиогенеза, в первую очередь, за счет снижения выработки эндотелиального фактора роста. Органопротективный и противовоспалительный потенциал лекарственных препаратов, уменьшающих выработку АТ, доказанный в экспериментах in vitro и in vivo, позволяет рассматривать их как ангиотропные средства первого ряда у пациентов с ревматоидным артритом, особенно при наличии сопутствующей артериальной гипертензии и/или нефропатии.

At present, the role of the renin-angiotensin system (RAS) in regulating the cardiovascular system and maintaining water and electrolyte homeostasis has been well studied. However, over the past decades, new components of the RAS have been identified, suggesting a wider range of its potential effects on the body. It is of fundamentally importance for rheumatologists to affect inflammation, including rheumatoid inflammation, through blockade of angiotensin (AT) II formation via the effects of AT 1–7 and angiotensin-converting enzyme inhibitors, as well as through suppression of angiogenesis, primarily by reducing the production of endothelial growth factor. The organ-protective and antiinflammatory potential of drugs that reduce the production of AT, which has been proven in in vitro and in vivo experiments, allows us to consider them as first-line angiotropic agents in patients with rheumatoid arthritis, especially in the presence of concomitant hypertension and/or nephropathy.

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The authors declare that there are no conflicts of interest present.