References

rsp

Научно-практическая ревматология

Rheumatology Science and Practice

1995-44841995-4492

IMA-PRESS, LLC

10.14412/1995-4484-2019-83-90

rsp-2678

Research Article

ПРОГРЕСС В РЕВМАТОЛОГИИ В XXI ВЕКЕ

PROGRESS IN RHEUMATOLOGY IN THE XXI CENTURY

Психологический стресс и ревматоидный артрит – интерференция патогенетических механизмов

Psychological stress and rheumatoid arthritis – interference of pathogenetic mechanisms

Туаева

Н. О.

Tuaeva

N. O.

научный сотрудник ЦНИЛ Казанской государственной академии, химик-эксперт центра биоаналитических исследований и молекулярного дизайна (ЦБИиМД) Первого МГМУ им. И.М. Сеченова, канд. биол. наук;

420012, Казань, ул. Муштари, 11;

119991, Москва, ул. Трубецкая, 8, стр. 2

11, Moushtary St., Kazan 420012;

8, Trubetskaya St., Build. 2, Moscow 119991

Natalya.Tuaeva@gmail.com

Носырев

А. Е.

Nosyrev

A. E.

руководитель, канд. техн. наук;

119991, Москва, ул. Трубецкая, 8, стр. 2

8, Trubetskaya St., Build. 2, Moscow 119991

Ренадино

И.

Renaudineau

профессор, старший научный сотрудник ЦНИЛ КГМА, заведующий лабораторией иммунологии и иммунотерапии Университета Бреста;

420012, Казань, ул. Муштари, 11;

2 Avenue Foch, CHRU Morvan, 29609 Brest, France

11, Moushtary St., Kazan 420012;

2 Avenue Foch, CHRU Morvan, 29609 Brest, France

Арлеевская

М. И.

Arleevskaya

M. I.

старший научный сотрудник, канд. мед. наук;

420012, Казань, ул. Муштари, 11

11, Moushtary St., Kazan 420012

Казанская государственная академия – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияKazan State Medical Academy – Branch Campus of Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)Russian Federation

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)Russian Federation

Казанская государственная академия – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России; Laboratory of Immunology and Immunotherapy, INSERM U1227, Hospital Morvan, Centre Hospitalier Regional Universitaire (CHU) de BrestРоссияKazan State Medical Academy – Branch Campus of Russian Medical Academy of Postgraduate Education, Ministry of Health of Russia; Laboratory of Immunology and Immunotherapy, INSERM U1227, Hospital Morvan, Centre Hospitalier Regional Universitaire (CHU) de BrestRussian Federation

Казанская государственная академия – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияKazan State Medical Academy – Branch Campus of Russian Medical Academy of Postgraduate Education, Ministry of Health of RussiaRussian Federation

2019

20032019

5718390

2019

Туаева Н.О., Носырев А.Е., Ренадино И., Арлеевская М.И.

Tuaeva N.O., Nosyrev A.E., Renaudineau Y., Arleevskaya M.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://rsp.mediar-press.net/rsp/article/view/2678

Проанализированы молекулярные механизмы развития нормального и патологического нейроэндокринного и иммунного адаптивного ответа на психологический (ментальный) стресс с точки зрения его возможной провоцирующей роли в развитии ревматоидного артрита (РА). При детальном анализе выявляется синергизм механизмов, провоцирующих развитие патологического антистрессового адаптивного ответа и РА. Возможно, у лиц группы риска развития РА минимальные и малозаметные для индивидуума стрессовые ситуации, периодически провоцирующие продолжительную продукцию провоспалительных цитокинов, могут, в конце концов, привести к развитию ревматического заболевания.

Molecular mechanisms of development of normal and pathological neuroendocrine and immune adaptive response to psychological (mental) stress are analyzed considering its possible provoking role in the development of rheumatoid arthritis (RA). A detailed analysis reveals the synergism of mechanisms that provoke the development of pathological anti-stress adaptive response and RA. It is possible that in persons at risk of developing RA minimal and unobtrusive for the individual stressful situations, periodically provoking prolonged production of pro-inflammatory cytokines, can, finally, lead to the development of rheumatic disease.

ревматоидный артритпсихологический стрессаллостазэустрессдистресс

rheumatoid arthritispsychological stressallostasiseustressdistress

грант Российского научного фонда (№. 17-15-01099)

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The authors declare that there are no conflicts of interest present.