rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2018-5-18rsp-2685Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHРазвитие учения об аутовоспалительных заболеваниях в XXI в.Development of the doctrine of auto-inflammatory diseases in the XXI centuryФёдоровЕ. С.FedorovE. S.

Москва, 115522 Москва, Каширское шоссе, 34А

134A, Kashirskoe Shosse, Moscow 115522

СалугинаС. О.SaluginaS. O.

Москва, 115522 Москва, Каширское шоссе, 34А

134A, Kashirskoe Shosse, Moscow 115522

pafon1@yandex.ruКузьминаН. Н.KuzminaN. N.

Москва, 115522 Москва, Каширское шоссе, 34А

134A, Kashirskoe Shosse, Moscow 115522

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation201803042019560приложение 4518Copyright © Фёдоров Е.С., Салугина С.О., Кузьмина Н.Н., 20192019Фёдоров Е.С., Салугина С.О., Кузьмина Н.Н.Fedorov E.S., Salugina S.O., Kuzmina N.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2685

В статье представлено развитие учения об аутовоспалительных заболеваниях (АВЗ) в последнее десятилетие. Изложены сведения об интерлейкине 1, инфламмасомах и их роли в развитии АВЗ, а также об интерферонопатиях и, в частности, протеасомных болезнях как новом классе аутовоспалительной патологии. Показано многообразие вариантов АВЗ, включая нозологии с доминированием поражения одной системы (кожа, кишечник, кости). Обсуждаются достижения в диагностике и оценке течения АВЗ. Показана взаимосвязь АВЗ с проблемами фундаментальной и клинической ревматологии.

The article presents the development of the doctrine of autoinflammatory diseases (AID) in the last decade. Data on interleukin 1, inflammasomes and their role in the development of AID are presented. The paper also contains the data about interferonopathies and, in particular, proteasomal illnesses as a new class of hereditary autoinflammatory diseases. Variety of AID variants, including diseases with the dominance of one system damage (skin, intestines, bones) is shown. Advances in the AID diagnosis and course assessment of are discussed. Relationship of the AID with the problems of fundamental and clinical rheumatology is demonstrated.

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The authors declare that there are no conflicts of interest present.