References

rsp

Научно-практическая ревматология

Rheumatology Science and Practice

1995-44841995-4492

IMA-PRESS, LLC

10.14412/1995-4484-2019-318-327

rsp-2733

Research Article

ПРОГРЕСС В РЕВМАТОЛОГИИ В XXI ВЕКЕ

PROGRESS IN RHEUMATOLOGY IN THE XXI CENTURY

Интерлейкин 6 как патогенетический фактор, опосредующий формирование клинических проявлений, и мишень для терапии ревматических заболеваний и депрессивных расстройств

Interleukin 6 as a pathogenic factor mediating clinical manifestations and a therapeutic target for rheumatic diseases and depressive disorders

Лисицына

Т. А.

Lisitsyna

T. A.

115522, Москва, Каширское шоссе, 34А.

34A, Kashirskoe Shosse, Moscow 115522.

talisitsyna@rambler.ru

Вельтищев

Д. Ю.

Veltishchev

D. Yu.

107076, Москва, ул. Потешная, 3, к. 10.

117997, Москва, ул. Островитянова, 1.

3, Poteshnaya St., Build. 10, Moscow 107076.

1, Ostrovityanov St., Moscow 117997.

Лила

А. М.

Lila

A. M.

115522, Москва, Каширское шоссе, 34А.

34A, Kashirskoe Shosse, Moscow 115522.

Насонов

Е. Л.

Nasonov

E. L.

115522, Москва, Каширское шоссе, 34А.

119991, Москва, ул. Трубецкая, 8, стр. 2.

34A, Kashirskoe Shosse, Moscow 115522.

8, Trubetskaya Str., Build. 2, Moscow, 119991.

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation

Московский научно-исследовательский институт психиатрии – филиал ФГБУ «Национальный медицинский исследовательский центр психиатрии и наркологии им. В.П. Сербского» Минздрава России; ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияMoscow Research Institute of Psychiatry, Branch, V.P. Serbsky National Medical Research Center of Psychiatry and Narcology, Ministry of Health of Russia; N.I. Pirogov Russian National Research Medical University, Ministry of Health of RussiaRussian Federation

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияV.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)Russian Federation

2019

11072019

573318327

2019

Лисицына Т.А., Вельтищев Д.Ю., Лила А.М., Насонов Е.Л.

Lisitsyna T.A., Veltishchev D.Y., Lila A.M., Nasonov E.L.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://rsp.mediar-press.net/rsp/article/view/2733

В обзоре обобщены современные представления о ключевой роли интерлейкина 6 (ИЛ6) в патогенезе ревматических заболеваний (РЗ) и депрессивных расстройств. Подробно рассмотрены механизмы участия ИЛ6 в формировании клинико-лабораторных проявлений РЗ и депрессии; влияние провоцирующих и предрасполагающих стрессовых факторов, включая психические травмы в детском возрасте, повышающих риск раз- вития РЗ и депрессии, на выработку ИЛ6. Особое внимание уделено рассмотрению перспектив использования ингибиторов ИЛ6 в терапии депрессии.

The review summarizes current idea on the key role of interleukin 6 (IL-6) in the pathogenesis of rheumatic diseases (RDs) and depressive disorders. It considers in detail the mechanisms by which IL6 induces the clinical and laboratory manifestations of RDs and depression; the influence of precipitating and predisposing stress factors, including childhood mental traumas, which increase the risk of RDs and depression, on IL-6 production. Particular attention is paid to the consideration of prospects for using IL-6 inhibitors in the therapy of depression.

интерлейкин 6воспалениеревматические заболеванияревматоидный артритпсихические расстройствадепрессияантидепрессантыингибиторы интерлейкина 6

interleukin 6inflammationrheumatic diseasesrheumatoid arthritismental disordersdepressionantidepressantsinterleukin 6 inhibitors

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The authors declare that there are no conflicts of interest present.