rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2019-440-444rsp-2757Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHСравнительный анализ основных клинических проявлений у мужчин и женщин с ранним аксиальным спондилоартритомCOMPARATIVE ANALYSIS OF MAIN CLINICAL MANIFESTATIONS IN MALES AND FEMALES WITH EARLY AXIAL SPONDYLOARTHRITISРумянцеваД. Г.RumyantsevaD. G.

Москва, Россия 115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

rumiantceva01@gmail.comДубининаТ. В.DubininaT. V.

Москва, Россия 115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

ДеминаА. Б.DeminaA. B.

Москва, Россия 115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

СмирновА. В.SmirnovA. V.

Москва, Россия 115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

ЭрдесШ.ErdesSh.

Москва, Россия 115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation201916092019574440444Copyright © Румянцева Д.Г., Дубинина Т.В., Демина А.Б., Смирнов А.В., Эрдес Ш., 20192019Румянцева Д.Г., Дубинина Т.В., Демина А.Б., Смирнов А.В., Эрдес Ш.Rumyantseva D.G., Dubinina T.V., Demina A.B., Smirnov A.V., Erdes S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2757

В настоящее время имеется небольшое количество работ, посвященных различиям между мужчинами и женщинами с аксиальным спондилоартритом (аксСпА), и нет исследований, оценивающих различие прогрессирования рентгенологического сакроилиита между полами при аксСпА.

Цель исследования – сравнить основные клинические проявления и рентгенологическое прогрессирование сакроилиита при аксСпА у мужчин и женщин в динамике за 2 года наблюдения. 

Материал и методы

Материал и методы. Исследование проведено на московской Когорте Раннего СпондилоАртрита (КоРСАр), в которую в настоящее время включено 175 пациентов. В анализ вошли 68 больных, наблюдавшихся ≥2 лет. Их средний возраст на момент включения в когорту составил 28,5±5,8 года, средняя длительность болезни – 24,1±15,4 мес. Позитивными по HLA-B27 были 92,6% больных.

Результаты и обсуждение

Результаты и обсуждение. Из 68 пациентов, наблюдавшихся в течение 2 лет, мужчин было 33 (48,5%), женщин – 35 (51,5%). Исходно женщины были старше мужчин (р<0,01), при этом длительность заболевания была одинаковой и составила в среднем около 2 лет. Среди мужчин было больше больных с анкилозирующим спондилитом (АС), чем среди женщин (75,5 и 42,8% соответственно; р<0,05), и они имели больший суммарный счет рентгенологического сакроилиита (ссрСИ), чем женщины. Уровень С-реактивного белка (СРБ) также был выше у мужчин, чем у женщин (12,8 и 4,3 мг/л соответственно; р<0,05). Спустя 2 года среди мужчин АС имели 90,9%, а среди женщин – 60,0% (р<0,05).

Заключение

Заключение. Женщины заболевают аксСпА позже мужчин, а у последних чаще встречается HLA-B27, выше ссрСИ и уровень СРБ. У мужчин чаще отмечалось прогрессирование нерентгенологического аксСпА в АС.

Currently, there have been a small number of works on differences between males and females with axial spondyloarthritis (axSpA) and there have been no studies estimating a gender difference in radiographic sacroiliitis progression in axSpA.Objective: to compare the main clinical manifestations of sacroiliitis and its radiological progression in axSpA in men and women over time during a 2-year follow-up period.Subjects and methods. The investigation was conducted using the Moscow cohort from the early SpondyloArthritis (CoRSAr) study, which currently consisted of 175 patients. The analysis included 68 patients followed up for ≥2 years. Their mean age at the time of inclusion in the cohort was 28.5±5.8 years; the mean disease duration was 24.1±15.4 months. 92.6% of patients were HLA-B27-positive.Results and discussion. Among the 68 patients followed up over 2 years, there were 33 (48.5%) men and 35 (51.5%) women. At baseline, the females were older than the males (p<0.01), while the disease duration was the same and averaged about 2 years. Among the males, there were more patients with ankylosing spondylitis (AS) than those among the females (75.5 and 42.8%, respectively; p<0.05), and the men had a higher total score of radiological sacroiliitis (tsrSI) than the women. The level of C-reactive protein (CRP) was also higher in the men than in the women (12.8 and 4.3 mg/l, respectively; p<0.05). Two years later, AS was present in 90.9% of the males and in 60.0% of the females (p<0.05).Conclusion. Women fall ill with axSpA later than men, and the latter are more frequently observed to have HLA-B27, higher tsrSI and elevated CRP levels. Progression from non-radiological axSpa to AS was more common in men.

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Arthritis Res Ther. 2017;19(1):240. doi: 10.1186/s13075-017-1453-3Poddubnyy D, Haibel H, Listing J, et al. Baseline radiographic damage, elevated acute-phase reactant levels, and cigarette smoking status predict spinal radiographic progression in early axial spondylarthritis. Arthritis Rheum. 2012;64(5):1388-98. doi: 10.1002/art.33465Poddubnyy D, Haibel H, Listing J, et al. Baseline radiographic damage, elevated acute-phase reactant levels, and cigarette smoking status predict spinal radiographic progression in early axial spondylarthritis. Arthritis Rheum. 2012;64(5):1388-98. doi: 10.1002/art.33465Poddubnyy D, Haibel H, Listing J, et al. Baseline radiographic damage, elevated acute-phase reactant levels, and cigarette smoking status predict spinal radiographic progression in early axial spondylarthritis. Arthritis Rheum. 2012;64(5):1388-98. doi: 10.1002/art.33465Poddubnyy D, Haibel H, Listing J, et al. Baseline radiographic damage, elevated acute-phase reactant levels, and cigarette smoking status predict spinal radiographic progression in early axial spondylarthritis. Arthritis Rheum. 2012;64(5):1388-98. doi: 10.1002/art.33465Poddubnyy D, Haibel H, Listing J, et al. Baseline radiographic damage, elevated acute-phase reactant levels, and cigarette smoking status predict spinal radiographic progression in early axial spondylarthritis. Arthritis Rheum. 2012;64(5):1388-98. doi: 10.1002/art.33465Poddubnyy D, Haibel H, Listing J, et al. Baseline radiographic damage, elevated acute-phase reactant levels, and cigarette smoking status predict spinal radiographic progression in early axial spondylarthritis. Arthritis Rheum. 2012;64(5):1388-98. doi: 10.1002/art.33465

The authors declare that there are no conflicts of interest present.