rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2019-468-473rsp-2761Research ArticleОБЗОРREVIEWЭтодолак: хорошо известен и активно используется в разных странах мира. Пора бы и нам?ETODOLAC, A WELL KNOWN AND ACTIVELY USED DRUG IN DIFFERENT COUNTRIES OF THE WORLD. WOULD IT BE TIME FOR US?КаратеевА. Е.KarateevA. E.

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aekarat@yandex.ruФГБНУ «Научно-исследовательский институт ревматологии им. В.А Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation201916092019574468473Copyright © Каратеев А.Е., 20192019Каратеев А.Е.Karateev A.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2761

Этодолак – нестероидный противовоспалительный препарат (НПВП), умеренно селективный ингибитор циклооксигеназы-2, который уже более 30 лет используется в клинической практике как универсальное обезболивающее и противовоспалительное средство. Этодолак хорошо зарекомендовал себя при купировании острой боли, связанной с травмами и хирургическими вмешательствами (в частности, в стоматологии). Однако основной «точкой приложения» этодолака является длительный контроль боли при хронических ревматических заболеваниях, таких как остеоартрит и ревматоидный артрит. По данным многочисленных клинических исследований, этодолак как минимум не уступает по лечебному действию многим другим популярным представителям группы НПВП или превосходит их. Основным достоинством этодолака является низкая частота осложнений со стороны желудочно-кишечного тракта. В настоящем обзоре представлены основные данные литературы об эффективности и безопасности этодолака.

Etodolac is a nonsteroidal anti-inflammatory drug (NSAID), a moderately selective cyclooxygenase-2 inhibitor, which has been already used in clinical practice for more than 30 years as a universal analgesic and anti-inflammatory agent. Etodolac has proven itself in relieving acute pain associated with injuries and surgical interventions (particularly in dentistry). However, the main point of application of etodolac is long-term pain control in chronic rheumatic diseases, such as osteoarthritis and rheumatoid arthritis. Numerous clinical trials have shown that etodolac is at least not inferior in its therapeutic effect to many other popular representatives of the NSAID group or exceeds them. The main advantage of etodolac is the low frequency of gastrointestinal complications. This review presents the basic data available in the literature on the efficacy and safety of etodolac.

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The authors declare that there are no conflicts of interest present.