References

rsp

Научно-практическая ревматология

Rheumatology Science and Practice

1995-44841995-4492

IMA-PRESS, LLC

10.14412/1995-4484-2019-564-57

rsp-2780

Research Article

ПРОГРЕСС В РЕВМАТОЛОГИИ В XXI ВЕКЕ

PROGRESS IN RHEUMATOLOGY IN THE XXI CENTURY

Эффективность и безопасность сарилумаба (полностью человеческие моноклональные антитела к рецептору интерлейкина 6) при ревматоидном артрите: новые данные

The efficacy and safety of sarilumab, fully human monoclonal antibodies against interleukin 6 receptor, in rheumatoid arthritis: new evidence

Насонов

Е. Л.

Nasonov

E. L.

Насонов Евгений Львович - научный руководитель ФГБНУ НИИР им. В.А. Насоновой, академик РАН, профессор, доктор медицинских наук.

115522, Москва, Каширское шоссе, 34А; 119991 Москва, ул. Трубецкая, 8, стр. 2.

34A, Kashirskoe Shosse, Moscow 115522; 8, Trubetskaya St., Build. 2, Moscow 119991.

nasonov@irramn.ru

Лила

А. М.

Lila

A. M.

115522, Москва, Каширское шоссе, 34А; 125993, Москва, ул. Баррикадная, 2/1.

34A, Kashirskoe Shosse, Moscow 115522; 2/1, Barrikadnaya St., Build. 1, Moscow 125993.

Научно-исследовательский институт ревматологии им. В.А. Насоновой; Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России (Сеченовский Университет)РоссияV.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian Federation

Научно-исследовательский институт ревматологии им. В.А. Насоновой; Российская медицинская академия непрерывного профессионального образования Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuing Professional Education, Ministry of Health of RussiaRussian Federation

2019

14112019

575564577

2019

Насонов Е.Л., Лила А.М.

Nasonov E.L., Lila A.M.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://rsp.mediar-press.net/rsp/article/view/2780

Ревматоидныйартрит (РА) – иммуновоспалительное (аутоиммунное) ревматическое заболевание неизвестной этиологии, характеризующееся хроническим эрозивным артритом (синовитом) и системным поражением внутренних органов, приводящее к ранней инвалидности и сокращению продолжительности жизни пациентов. В спектре «провоспалительных» цитокинов, принимающих участие в патогенезе РА, большое внимание уделяется изучению роли интерлейкина 6 (ИЛ6). Внедрение в клиническую практику моноклональных антител к ИЛ6-рецепторам тоцилизумаба и сарилумаба, ингибирующих активность этого цитокина, является важным шагом на пути совершенствования терапии РА. В обзоре рассмотрены данные основных рандомизированных контролируемых исследований, касающихся эффективности и безопасности сарилумаба при РА, и обсуждены перспективы применения сарилумаба в терапии этого заболевания.

Rheumatoid arthritis (RA) is an immune-mediated inflammatory (autoimmune) rheumatic disease of unknown etiology, which is characterized by chronic erosive arthritis (synovitis) and systemic damage of internal organs and leads to early disability and shorter life expectancy in patients. Much attention is paid to studying the role of interleukin 6 (IL6) in the spectrum of proinflammatory cytokines involved in the pathogenesis of RA. The clinical introduction of anti-IL receptor monoclonal antibodies, such as tocilizumab and sarilumab, that inhibit the activity of this cytokine, is an important step in the improvement of RA treatment. The review considers the data from the main randomized controlled trials of the efficacy and safety of sarilumab in RA and discusses the prospects for using the drug to treat this disease.

ревматоидный артритинтерлейкин 6сарилумаб

rheumatoid arthritisinterleukin 6sarilumab

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The authors declare that there are no conflicts of interest present.