rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2019-612-617rsp-2795Research ArticleПЕРЕДОВАЯLEADING ARTICLEФункциональная магнитно-резонансная томография при хронической боли у пациентов с ревматическими заболеваниямиFunctional magnetic resonance imaging for chronic pain in patients with rheumatic diseasesФилатоваЕ. С.FilatovaE. S.

Екатерина Сергеевна Филатова;

115522, Москва, Каширское шоссе, 34А

Ekaterina Filatova

34A, Kashirskoe Shosse, Moscow 115522

Es-Filatova@mail.ruКаратеевА. Е.KarateevA. E.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

ЛилаА. М.LilaA. M.

115522, Москва, Каширское шоссе, 34А; 125993, Москва, ул. Баррикадная, 2/1, стр. 1

2/1, Barrikadnaya St., Build. 1, Moscow 125993; 34A, Kashirskoe Shosse, Moscow 115522

НасоновЕ. Л.NasonovE. L.

1115522, Москва, Каширское шоссе, 34А; 119991, Москва, ул. Трубецкая, 8, стр. 2

34A, Kashirskoe Shosse, Moscow 115522; 8, Trubetskaya St., Build. 2, Moscow 119991

ФГБНУ Научно-исследовательский институт ревматологии им. В.А. НасоновойРоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuing Professional Education, Ministry of Health of RussiRussian FederationФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой; ФГБОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияV.A. Nasonova Research Institute of Rheumatology; .M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian Federation201918122019576612617Copyright © Филатова Е.С., Каратеев А.Е., Лила А.М., Насонов Е.Л., 20192019Филатова Е.С., Каратеев А.Е., Лила А.М., Насонов Е.Л.Filatova E.S., Karateev A.E., Lila A.M., Nasonov E.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2795

В патогенезе хронической боли при ревматических заболеваниях (РЗ) наряду с повреждением ткани, воспалением и дегенеративными процессами важную роль играет центральная сенситизация — гиперактивность спинальных и супраспинальных нейронов, возникающая в результате постоянной ноцицептивной стимуляции. Применение функциональной магнитно-резонансной томографии (фМРТ) позволяет визуализировать отделы центральной нервной системы (ЦНС), участвующие в формировании ноцицептивного восприятия, диагностировать развитие центральной сенситизации и связанных с ней эмоциональных и когнитивных аспектов переживания боли. Так, использование фМРТ при ревматоидном артрите выявило активацию преимущественно медиальной системы боли, включающей переднюю поясную извилину, префронтальную кору, островок (инсулу) — структуры ЦНС, которые не участвуют в первичной сенсорно-дискриминационной оценке боли, а определяют ее эмоциональную оценку и формирование болевого поведения. Метод фМРТ позволяет лучше понять центральные механизмы хронической боли при РЗ и дает возможность более точно подбирать медикаментозные и немедикаментозные методы лечения, а также контролировать их эффективность.

Along with tissue damage, inflammation, and degenerative processes, central sensitization (spinal and supraspinal neuronal hyperactivity resulting from continuous nociceptive stimulation) plays an important role in the pathogenesis of chronic pain in rheumatic diseases (RDs). Functional magnetic resonance imaging (fMRI) makes it possible to visualize the central nervous system (CNS) parts involved in nociception and to diagnose central sensitization and its associated emotional and cognitive aspects of the experience of pain. Thus, fMRI for rheumatoid arthritis has revealed activation predominantly in the medial pain system, including the anterior cingulate gyrus, prefrontal cortex, and insula — the CNS structures that do not participate in the primary sensory discrimination assessment of pain, but determine its emotional assessment and the formation of pain behavior. The fMRI technique makes it possible to better understand the central mechanisms of chronic pain in RDs, to more accurately select drug and non-drug treatments, and to monitor their efficiency.

ревматические заболеванияревматоидный артритфибромиалгияхроническая больцентральная сенситизацияфункциональная магнитно-резонансная томографияrheumatic diseasesrheumatoid arthritisfibromyalgiachronic paincentral sensitizationfunctional magnetic resonance imagingReferencesНасонов ЕЛ, редактор. Российские клинические рекомендации. Ревматология. Москва: ГЭОТАР-Медиа; 2017. 464 с.ISBN 978-5-9704-4261-6Nasonov EL, editor. Rossiyskie klinicheskie rekomendatsii. Revmatologiya [Russian clinical recommendations. Rheumatology]. Moscow: GEOTAR-Media; 2017. 464 p. (In Russ.). ISBN 978-5-9704-4261-6Пирадов МА, Танашян ММ, Кротенкова МВ и др. Передовые технологии нейровизуализации. Клиническая неврология. 2015;9(4):11-8Piradov MA, Tanashyan MM, Krotenkova MV, et al. Advanced neuroimaging technologies. KlinicheskayaNevrologiya. 2015;9(4):11-8 (In Russ.)].Штарк МБ, Коростышевская АМ, Резакова МВ и др. Функциональная магнитно-резонансная томография и нейронауки. Успехи физиологических наук. 2012;43(1):3-29Shtark MB, Korostyshevskaya AM, Rezakova MV, et al. Functional magnetic resonance imaging and neuroscience. UspekhiFiziologicheskikh Nauk. 2012;43(1):3-29 (In Russ.).Ogawa S, Lee TM. Magnetic resonance imaging of blood vessels at high fields: In vivo and in vitro measurements and image simulation. Magn Reson Med. 1990;16(1):9-18. doi:10.1002/mrm.1910160103Ogawa S, Lee TM. Magnetic resonance imaging of blood vessels at high fields: In vivo and in vitro measurements and image simulation. Magn Reson Med. 1990;16(1):9-18. doi:10.1002/mrm.1910160103Glover GH, Lai S. Self-navigated spiral fMRI: Interleaved versus single-shot. Magn Reson Med. 1998;39:361-8. doi: 10.1002/mrm.1910390305Glover GH, Lai S. Self-navigated spiral fMRI: Interleaved versus single-shot. Magn Reson Med. 1998;39:361-8. doi: 10.1002/mrm.1910390305Treede RD, Kenshalo DR, Gracely RH, et al. The cortical representation of pain. Pain. 1999;79:105-11. doi: 10.1016/S0304-3959(98)00184-5Treede RD, Kenshalo DR, Gracely RH, et al. The cortical representation of pain. Pain. 1999;79:105-11. doi: 10.1016/S0304-3959(98)00184-5Melzack R. From the gate to the neuromatrix. Pain. 1999;6:121-6. doi: 10.1016/S0304-3959(99)00145-1Melzack R. From the gate to the neuromatrix. Pain. 1999;6:121-6. doi: 10.1016/S0304-3959(99)00145-1Bowsher D. Termination of the central pain pathway in man: the conscious appreciation of pain. Brain. 1957;80(4):606-22. doi: 10.1093/brain/80.4.606Bowsher D. Termination of the central pain pathway in man: the conscious appreciation of pain. Brain. 1957;80(4):606-22. doi: 10.1093/brain/80.4.606Kulkarni B, Bentley DE, Elliott R, et al. Attention to pain localization and unpleasantness discriminates the functions of themedi-al and lateral pain systems. Eur JNeurosci. 2005;21:3133-42. doi: 10.1111/j.1460-9568.2005.04098.xKulkarni B, Bentley DE, Elliott R, et al. Attention to pain localization and unpleasantness discriminates the functions of themedi-al and lateral pain systems. Eur JNeurosci. 2005;21:3133-42. doi: 10.1111/j.1460-9568.2005.04098.xPorro CA, Cettolo V, Francescato MP, et al. Temporal and intensity coding of pain in human cortex. J Neurophysiol. 1998;80(6):3312-20. doi: 10.1152/jn.1998.80.6.3312Porro CA, Cettolo V, Francescato MP, et al. Temporal and intensity coding of pain in human cortex. J Neurophysiol. 1998;80(6):3312-20. doi: 10.1152/jn.1998.80.6.3312Apkarian AV, Bushnell MC, Treede R-D, et al. Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain. 2005;9(4):463-84. doi: 10.1016/j.ejpain.2004.11.001Apkarian AV, Bushnell MC, Treede R-D, et al. Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain. 2005;9(4):463-84. doi: 10.1016/j.ejpain.2004.11.001Seifert F, Maihafner C. Central mechanisms of experimental and chronic neuropathic pain: Findings from functional imaging studies. Cell Mol Life Sci. 2009;66:375-90. doi: 10.1007/s00018-008-8428-0Seifert F, Maihafner C. Central mechanisms of experimental and chronic neuropathic pain: Findings from functional imaging studies. Cell Mol Life Sci. 2009;66:375-90. doi: 10.1007/s00018-008-8428-0Baron R, Baron Y, Disbrow E, et al. Brain processing of capsaicin-induced secondary hyperalgesia: a functional MRI study. Neurology. 1999;53:548-57. doi: 10.1212/WNL.53.3.548Baron R, Baron Y, Disbrow E, et al. Brain processing of capsaicin-induced secondary hyperalgesia: a functional MRI study. Neurology. 1999;53:548-57. doi: 10.1212/WNL.53.3.548Maihofner C, Schmelz M, Forster C, et al. Neural activation during experimental allodynia: a functional magnetic resonance imaging study. Eur J Neurosci. 2004;19:3211-8. doi: 10.1111/j.1460-9568.2004.03437.xMaihofner C, Schmelz M, Forster C, et al. Neural activation during experimental allodynia: a functional magnetic resonance imaging study. Eur J Neurosci. 2004;19:3211-8. doi: 10.1111/j.1460-9568.2004.03437.xMaihofner C, Handwerker HO. Differential coding of hyperalgesia in the human brain: a functional MRI study. Neuroimage. 2005;28:996-1006. doi: 10.1016/j.neuroimage.2005.06.049Maihofner C, Handwerker HO. Differential coding of hyperalgesia in the human brain: a functional MRI study. Neuroimage. 2005;28:996-1006. doi: 10.1016/j.neuroimage.2005.06.049Zambreanu L, Wise RG, Brooks JC, et al. A role for the brainstem in central sensitisation in humans. Evidence from functional magnetic resonance imaging. Pain. 2005;114:397-407. doi: 10.1016/j.pain.2005.01.005Zambreanu L, Wise RG, Brooks JC, et al. A role for the brainstem in central sensitisation in humans. Evidence from functional magnetic resonance imaging. Pain. 2005;114:397-407. doi: 10.1016/j.pain.2005.01.005Baliki MN, Geha PY, Apkarian AV, et al. Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics. JNeurosci. 2008;28:1398-403. doi: 10.1523/JNEU-ROSCI.4123-07.2008Baliki MN, Geha PY, Apkarian AV, et al. Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics. JNeurosci. 2008;28:1398-403. doi: 10.1523/JNEU-ROSCI.4123-07.2008Каратеев АЕ, Насонов ЕЛ. Хроническая боль и центральная сенситизация при иммуновоспалительных ревматических заболеваниях: патогенез, клинические проявления, возможность применения таргетных базисных противовоспалительных препаратов. Научно-практическая ревматология. 2019;57(2):197-209 doi: 10.14412/1995-4484-2019-197-209Karateev AE, Nasonov EL. Chronic pain and central sensitization in immuno-inflammatory rheumatic diseases: pathogenesis, clinical manifestations, the possibility of using targeted disease modifying antirheumatic drugs. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2019;57(2):197-209 (In Russ.). doi: 10.14412/1995-4484-2019-197-209Kidd BL. Osteoarthritis and joint pain. Pain. 2006 Jul;123(1-2):6-9. doi: 10.1016/j.pain.2006.04.009Kidd BL. Osteoarthritis and joint pain. Pain. 2006 Jul;123(1-2):6-9. doi: 10.1016/j.pain.2006.04.009Jones AK, Friston K, Frackowiak RS. Localization of responses to pain in human cerebral cortex. Science. 1992;255:215-6. doi: 10.1126/science.1553549Jones AK, Friston K, Frackowiak RS. Localization of responses to pain in human cerebral cortex. Science. 1992;255:215-6. doi: 10.1126/science.1553549Jones AK, Brown WD, Friston KJ, et al. Cortical and subcortical localization of response to pain in man using positron emission tomography. Proc R Soc Lond B Biol Sci. 1991;244:39-44. doi: 10.1098/rspb.1991.0048Jones AK, Brown WD, Friston KJ, et al. Cortical and subcortical localization of response to pain in man using positron emission tomography. Proc R Soc Lond B Biol Sci. 1991;244:39-44. doi: 10.1098/rspb.1991.0048Kennedy DP, Courchesne E. Functional abnormalities of the default network during self- and other-reflection in autism. Soc Cogn Affect Neurosci. 2008;3:177-90. doi: 10.1093/scan/nsn011Kennedy DP, Courchesne E. Functional abnormalities of the default network during self- and other-reflection in autism. Soc Cogn Affect Neurosci. 2008;3:177-90. doi: 10.1093/scan/nsn011Kalk NJ, Schweinhardt P, et al. Functional magnetic resonance imaging of central processing of clinical and experimental pain in rheumatoid arthritis. Abstracts 11th World Congress on Pain. August 21-26. Sydney: N.S.W.; 2005. P. 108.Kalk NJ, Schweinhardt P, et al. Functional magnetic resonance imaging of central processing of clinical and experimental pain in rheumatoid arthritis. Abstracts 11th World Congress on Pain. August 21-26. Sydney: N.S.W.; 2005. P. 108.Seifert F, Jungfer I, Schmelz M, et al. Representation of UV-B-induced thermal and mechanical hyperalgesia in the human brain: A functional MRI study. Hum Brain Mapp. 2008;29(12):1327-42. doi: 10.1002/hbm.20470Seifert F, Jungfer I, Schmelz M, et al. Representation of UV-B-induced thermal and mechanical hyperalgesia in the human brain: A functional MRI study. Hum Brain Mapp. 2008;29(12):1327-42. doi: 10.1002/hbm.20470Bickel A, Dorfs S, Schmelz M, et al. Effects of antihyperalgesic drugs on experimentally induced hyperalgesia in man. Pain. 1998;76:317-25. doi: 10.1016/S0304-3959(98)00062-1Bickel A, Dorfs S, Schmelz M, et al. Effects of antihyperalgesic drugs on experimentally induced hyperalgesia in man. Pain. 1998;76:317-25. doi: 10.1016/S0304-3959(98)00062-1Wasner G, Schattschneider J, Binder A, et al. Topical menthol — a human model for cold pain by activation and sensitization of C nociceptors. Brain. 2004;127:1159-71. doi: 10.1093/brain/awh134Wasner G, Schattschneider J, Binder A, et al. Topical menthol — a human model for cold pain by activation and sensitization of C nociceptors. Brain. 2004;127:1159-71. doi: 10.1093/brain/awh134Seifert F, Maihofner C. Representation of cold allodynia in the human brain — a functional MRI study. Neuroimage. 2007;35:1168-80. doi: 10.1016/j.neuroimage.2007.01.021Seifert F, Maihofner C. Representation of cold allodynia in the human brain — a functional MRI study. Neuroimage. 2007;35:1168-80. doi: 10.1016/j.neuroimage.2007.01.021Jones AKP, Derbyshire SWG. Reduced cortical responses to noxious heat in patients with rheumatoid arthritis. Ann Rheum Dis. 1997;56:601-7. doi: 10.1136/ard.56.10.601Jones AKP, Derbyshire SWG. Reduced cortical responses to noxious heat in patients with rheumatoid arthritis. Ann Rheum Dis. 1997;56:601-7. doi: 10.1136/ard.56.10.601Keefe FJ, Caldwell DS, Martinez S, et al. Analyzing pain in rheumatoid arthritis patients. Pain coping strategies in patients who have had knee replacement surgery. Pain. 1991;46(2):153-60. doi: 10.1016/0304-3959(91)90070-EKeefe FJ, Caldwell DS, Martinez S, et al. Analyzing pain in rheumatoid arthritis patients. Pain coping strategies in patients who have had knee replacement surgery. Pain. 1991;46(2):153-60. doi: 10.1016/0304-3959(91)90070-EНасонов ЕЛ, Олюнин ЮА, Лила АМ. Ревматоидный артрит: проблемы ремиссии и резистентности к терапии. Научно-практическая ревматология. 2018;56(3):263-71 doi: 10.14412/1995-4484-2018-263-271[Nasonov EL, Olyunin YuA, Lila AM. Rheumatoid arthritis: the problems of remission and therapy resistance. Nauchno-Prakticheskaya Revmatologiya = Rheumatology Science and Practice. 2018;56(3):263-71 (In Russ.)]. doi: 10.14412/1995-4484-2018-263-271Schweinhardt P, Kalk N, Wartolowska K, et al. Investigation into the neural correlates of emotional augmentation of clinical pain. Neuroimage. 2008;40(2):759-66. doi: 10.1016/j.neuroim-age.2007.12.016Schweinhardt P, Kalk N, Wartolowska K, et al. Investigation into the neural correlates of emotional augmentation of clinical pain. Neuroimage. 2008;40(2):759-66. doi: 10.1016/j.neuroim-age.2007.12.016Nahit ES, Pritchard CM, Cherry NM, et al. The influence of work related psychosocial factors and psychological distress on regional musculoskeletal pain: a study of newly employed workers. J Rheumatol. 2001;28(6):1378-84.Nahit ES, Pritchard CM, Cherry NM, et al. The influence of work related psychosocial factors and psychological distress on regional musculoskeletal pain: a study of newly employed workers. J Rheumatol. 2001;28(6):1378-84.Flodin P, Martinsen S, Altawil R, et al. Intrinsic Brain Connectivity in Chronic Pain: A resting-state fMRI Study in patients with rheumatoid arthritis. Front Hum Neurosci. 2016;10:107. doi: 10.3389/fnhum.2016.00107Flodin P, Martinsen S, Altawil R, et al. Intrinsic Brain Connectivity in Chronic Pain: A resting-state fMRI Study in patients with rheumatoid arthritis. Front Hum Neurosci. 2016;10:107. doi: 10.3389/fnhum.2016.00107Boettger MK, Hensellek S, Richter F, et al. Antinociceptive effects of tumor necrosis factor alpha neutralization in a rat model of antigen-induced arthritis: evidence of a neuronal target. Arthritis Rheum. 2008;58:2368-78. doi: 10.1002/art.23608Boettger MK, Hensellek S, Richter F, et al. Antinociceptive effects of tumor necrosis factor alpha neutralization in a rat model of antigen-induced arthritis: evidence of a neuronal target. Arthritis Rheum. 2008;58:2368-78. doi: 10.1002/art.23608Hess A, Axmannb R, Rechb J, et al. Blockade of TNF-a rapidly inhibits pain responses in the central nervous system. Proc Natl Acad Sci. 2011;108(9):3731-6. doi: 10.1073/pnas.1011774108Hess A, Axmannb R, Rechb J, et al. Blockade of TNF-a rapidly inhibits pain responses in the central nervous system. Proc Natl Acad Sci. 2011;108(9):3731-6. doi: 10.1073/pnas.1011774108Rech J, Hess A, Finzel S, et al. Association of brain functional magnetic resonance activity with response to tumor necrosis factor inhibition in rheumatoid arthritis. Arthritis Rheum. 2013;65(2):325-33. doi: 10.1002/art.37761Rech J, Hess A, Finzel S, et al. Association of brain functional magnetic resonance activity with response to tumor necrosis factor inhibition in rheumatoid arthritis. Arthritis Rheum. 2013;65(2):325-33. doi: 10.1002/art.37761Basu N, Kaplan CM, Ichesco E, et al. Neurobiologic features of fibromyalgia are also present among rheumatoid arthritis patients. Arthritis Rheum. 2018;70:1000-7. doi: 10.1002/art.40451Basu N, Kaplan CM, Ichesco E, et al. Neurobiologic features of fibromyalgia are also present among rheumatoid arthritis patients. Arthritis Rheum. 2018;70:1000-7. doi: 10.1002/art.40451Kaplan CM, Schrepf A, Ichesco E, et al. Inflammation is associated with pro-nociceptive brain connections in rheumatoid arthritis patients with concomitant fibromyalgia. Arthritis Rheum. 2019 Aug 5. doi: 10.1002/art.41069Kaplan CM, Schrepf A, Ichesco E, et al. Inflammation is associated with pro-nociceptive brain connections in rheumatoid arthritis patients with concomitant fibromyalgia. Arthritis Rheum. 2019 Aug 5. doi: 10.1002/art.41069Basu N, Kaplan CM, Ichesco E, et al. Functional and structural magnetic resonance imaging correlates of fatigue in patients with rheumatoid arthritis. Rheumatology (Oxford). 2019 Oct 1;58(10):1822-30. doi: 10.1093/rheumatology/kez132Basu N, Kaplan CM, Ichesco E, et al. Functional and structural magnetic resonance imaging correlates of fatigue in patients with rheumatoid arthritis. Rheumatology (Oxford). 2019 Oct 1;58(10):1822-30. doi: 10.1093/rheumatology/kez132Schrepf A, Kaplan CM, Ichesco E, et al. A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis. Nat Commun. 2018 Jun 8;9(1):2243. doi: 10.1038/s41467-018-04648-0Schrepf A, Kaplan CM, Ichesco E, et al. A multi-modal MRI study of the central response to inflammation in rheumatoid arthritis. Nat Commun. 2018 Jun 8;9(1):2243. doi: 10.1038/s41467-018-04648-0Gibson S, Littlejohn G, Gorman M, et al. Altered heat pain thresholds and cerebral event-related potentials following painful CO2 laser stimulation in subjects with fibromyalgia syndrome. Pain. 1994;58(2):185-93. doi: 10.1016/0304-3959(94)90198-8Gibson S, Littlejohn G, Gorman M, et al. Altered heat pain thresholds and cerebral event-related potentials following painful CO2 laser stimulation in subjects with fibromyalgia syndrome. Pain. 1994;58(2):185-93. doi: 10.1016/0304-3959(94)90198-8Lorenz J, Grasedyck K, Bromm B. Middle and long latency somatosensory evoked potentials after painful laser stimulation in patients with fibromyalgia syndrome. Electroencephalogr Clin Neurophysiol. 1996;100(2):165-8. doi: 10.1016/0013-4694(95)00259-6Lorenz J, Grasedyck K, Bromm B. Middle and long latency somatosensory evoked potentials after painful laser stimulation in patients with fibromyalgia syndrome. Electroencephalogr Clin Neurophysiol. 1996;100(2):165-8. doi: 10.1016/0013-4694(95)00259-6Stevens A, Batra A, Ko tter I, et al. Both pain and EEG response to cold pressor stimulation occurs faster in fibromyalgia patients than in control subjects. Psychiatry Res. 2000;97(2-3):237-47. doi: 10.1016/S0165-1781(00)00223-7Stevens A, Batra A, Ko tter I, et al. Both pain and EEG response to cold pressor stimulation occurs faster in fibromyalgia patients than in control subjects. Psychiatry Res. 2000;97(2-3):237-47. doi: 10.1016/S0165-1781(00)00223-7Cook DB, Lange G, Ciccone DS, et al. Functional imaging of pain in patients with primary fibromyalgia. J Rheumatol. 2004;31(2):364-78.Cook DB, Lange G, Ciccone DS, et al. Functional imaging of pain in patients with primary fibromyalgia. J Rheumatol. 2004;31(2):364-78.Staud R, Smitherman ML. Peripheral and central sensitization in fibromyalgia: pathogenetic role. Curr Pain Headache Rep. 2002;6(4):259-66. doi: 10.1007/s11916-002-0046-1Staud R, Smitherman ML. Peripheral and central sensitization in fibromyalgia: pathogenetic role. Curr Pain Headache Rep. 2002;6(4):259-66. doi: 10.1007/s11916-002-0046-1Jones AKP, Huneke NTM, Lloyd DM, et al. Role of Functional Brain Imaging in Understanding Rheumatic Pain. Curr Rheumatol Rep. 2012;14:557. doi: 10.1007/s11926-012-0287-xJones AKP, Huneke NTM, Lloyd DM, et al. Role of Functional Brain Imaging in Understanding Rheumatic Pain. Curr Rheumatol Rep. 2012;14:557. doi: 10.1007/s11926-012-0287-xWik G, Fischer H, Finer B, et al. Retrospenial cortical deactivation during painful stimulation of fibromyalgia patients. Int J Neurosci. 2006;116(1):1-8. doi: 10.1080/00207450690962208Wik G, Fischer H, Finer B, et al. Retrospenial cortical deactivation during painful stimulation of fibromyalgia patients. Int J Neurosci. 2006;116(1):1-8. doi: 10.1080/00207450690962208Jensen KB, Kosek E, Petzke F, et al. Evidence of dysfunctional pain inhibition in fibromyalgia reflected in rACC during provoked pain. Pain. 2009;144(1-2):95-100. doi: 10.1016/j.pain.2009.03.018Jensen KB, Kosek E, Petzke F, et al. Evidence of dysfunctional pain inhibition in fibromyalgia reflected in rACC during provoked pain. Pain. 2009;144(1-2):95-100. doi: 10.1016/j.pain.2009.03.018Pujol J, Lopez-Sola M, Ortiz H, et al. Mapping brain response to pain in fibromyalgia patients using temporal analysis of FMRI. PLoSOne. 2009;4(4):5224. doi: 10.1371/journal.pone.0005224Pujol J, Lopez-Sola M, Ortiz H, et al. Mapping brain response to pain in fibromyalgia patients using temporal analysis of FMRI. PLoSOne. 2009;4(4):5224. doi: 10.1371/journal.pone.0005224Crombez G, Eccleston C, van den Broeck A, et al. Hypervigilance to pain in fibromyalgia: the mediating role of pain intensity and catastrophic thinking about pain. Clin J Pain. 2004;20:98-102. doi: 10.1097/00002508-200403000-00006Crombez G, Eccleston C, van den Broeck A, et al. Hypervigilance to pain in fibromyalgia: the mediating role of pain intensity and catastrophic thinking about pain. Clin J Pain. 2004;20:98-102. doi: 10.1097/00002508-200403000-00006Gracely RH, Geisser ME, Giesecke T, et al. Pain catastrophizing and neural responses to pain among persons with fibromyalgia. Brain. 2004;127(4):835-43. doi: 10.1093/brain/awh098Gracely RH, Geisser ME, Giesecke T, et al. Pain catastrophizing and neural responses to pain among persons with fibromyalgia. Brain. 2004;127(4):835-43. doi: 10.1093/brain/awh098Robinson ME, Craggs JG, Price DD, et al. Gray matter volumes of pain-related brain areas are decreased in fibromyalgia syndrome. J Pain. 2011;12(4):436-43. doi: 10.1016/j.jpain.2010.10.003Robinson ME, Craggs JG, Price DD, et al. Gray matter volumes of pain-related brain areas are decreased in fibromyalgia syndrome. J Pain. 2011;12(4):436-43. doi: 10.1016/j.jpain.2010.10.003

The authors declare that there are no conflicts of interest present.