rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2020-62-79rsp-2845Research ArticleПРОГРЕСС В РЕВМАТОЛОГИИ В XXI ВЕКЕPROGRESS IN RHEUMATOLOGY IN THE XXI CENTURYЭффективность и безопасность тофацитиниба при иммуновоспалительных ревматических заболеваниях (часть I)Efficacy and safety of tofacitinib for immune-mediated inflammatory rheumatic diseases (Part I)НасоновЕ. Л.NasonovE. L.

Евгений Львович Насонов - научный руководитель ФГБНУ«НИИР им. В.А. Насоновой», академик РАН, профессор, доктор медицинских наук.

115522, Москва, Каширское шоссе, 34А; 119991, Москва, ул. Трубецкая, 8, стр. 2

34A, Kashirskoe Shosse, Moscow 115522; 8, Trubetskaya St., Build. 2, Moscow 119991

nasonov@irramn.ruАвдееваА. С.AvdeevaA. S.

Научный сотрудник лаборатории стандартизации терапии ревматических заболеваний ФГБНУ «НИИР им. В.А. Насоновой», кандидат медицинских наук.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

ЛилаА. М.LilaA. M.

Директор ФГБНУ «НИИР им. В.А. Насоновой», профессор, доктор медицинских наук.

115522, Москва, Каширское шоссе, 34А; 125993, Москва, ул. Баррикадная, 2/1, стр.1

34A, Kashirskoe Shosse, Moscow 115522; 2/1, Barrikadnaya St., Build. 1, Moscow 125993

ФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой; ФГБОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияV.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian FederationФГБНУ Научно-исследовательский институт ревматологии им. В.А. НасоновойРоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationФГБНУ Научно-исследовательский институт ревматологии им. В.А. Насоновой; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuing Professional Education, Ministry of Health of RussiaRussian Federation2020200220205816279Copyright © Насонов Е.Л., Авдеева А.С., Лила А.М., 20202020Насонов Е.Л., Авдеева А.С., Лила А.М.Nasonov E.L., Avdeeva A.S., Lila A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2845

Расшифровка механизмов патогенеза иммуновоспалительных ревматических заболеваний (ИВРЗ) в сочетании с разработкой широкого спектра генно-инженерных биологических препаратов (ГИБП) относятся к числу крупных достижений медицины XXI в. Новое перспективное направление фармакотерапии ИВРЗ связано с созданием так называемых «таргетных» пероральных лекарственных препаратов, к которым в первую очередь относятся ингибиторы Янус-киназ (Januskinase — JAK), получившие название Якинибы (Jakinibs). Первым представителем класса ингибиторов JAK является тофацитиниб (ТОФА), который зарегистрирован для лечения ревматоидного артрита (РА), псориатического артрита и язвенного колита. В обзоре (часть I) представлены новые данные, касающиеся эффективности и безопасности ТОФА при РА, обсуждается место ТОФА в лечении РА в рамках стратегии «Лечение до достижения цели» и новых рекомендаций EULAR. В части II обзора будут представлены данные, касающиеся применения ТОФА при других ИВРЗ.

Deciphering the mechanisms of the pathogenesis of immune-mediated inflammatory rheumatic diseases (IIRDs) and designing a wide range of biological agents (BAs) are the major achievements of 21st century medicine. A new promising area of pharmacotherapy for IIRDs is associated with the design of so-called targeted oral medications that primarily include Janus kinase (JAK) inhibitors, called jakinibs. The first representative of the class of JAK inhibitors is tofacitinib (TOFA), which has been registered for the treatment of rheumatoid arthritis (RA), psoriatic arthritis, and ulcerative colitis. The review (Part I) presents new data on the efficacy and safety of TOFA in RA and discusses the role of TOFA in the treatment of RA as part of the treat-to-target strategy and new EULAR recommendations. Part II of the review will provide data on the use of TOFA in other IIRDs.

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The authors declare that there are no conflicts of interest present.