rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2020-140-146rsp-2868Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHКлиническая характеристика трех когорт раннего ревматоидного артрита с поздним началом (в возрасте 50 лет и старше). Обобщение 40-летнего опытаCLINICAL CHARACTERISTICS OF THREE COHORTS OF PATIENTS WITH EARLY- AND LATE-ONSET RHEUMATOID ARTHRITIS (AT 50 YEARS OR OLDER). GENERALIZATION OF 40 YEARS’ EXPERIENCEhttps://orcid.org/0000-0002-1508-0854СатыбалдыевА. М.SatybaldyevA. M.

34A, Kashirskoe Shosse, Moscow 115522

azamatsat@yandex.ruhttps://orcid.org/0000-0003-3065-4235ДемидоваН. В.DemidovaN. V.

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0002-0928-3911ГридневаГ. И.GridnevaG. I.

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0002-4160-7218НикишинаН. Ю.NikishinaN. Yu.

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0001-5815-561XГерасимоваЕ. В.GerasimovaE. V.

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0002-6175-2674ГукасянД. А.GukasianD. A.

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0002-6852-6741КасумоваК. А.KasumovaK. A.

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0002-6519-1106ЛучихинаЕ. Л.LuchikhinaE. L.

129110, Москва, ул. Щепкина, 61/2, корп. 1

https://orcid.org/0000-0002-5272-4735МисиюкА. С.MisiyukA. S.

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0003-0789-3609ОскилкоТ. Г.OskilkoT. G.

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0002-7569-4110РумянцеваО. А.RumyantsevaO. A.

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0001-8130-5081ЗлепкоЕ. А.ZlepkoE. A.

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0002-7816-8722ТюринаЛ. Н.TyurinaL. N.

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0003-2115-9611ФедоренкоЕ. В.FedorenkoE. V.

34A, Kashirskoe Shosse, Moscow 115522

ШорниковаН. В.ShornikovaN. V.

115522, Москва, Каширское шоссе, 34А

107140, Москва, ул. Нижняя Красносельская, 4

34A, Kashirskoe Shosse, Moscow 115522

4, Nizhnyaya Krasnoselskaya St., Moscow 107140

https://orcid.org/0000-0002-1598-8360НасоновЕ. Л.NasonovE. L.

115522, Москва, Каширское шоссе, 34А

119991, Москва, ул. Трубецкая, 8, стр. 2

34A, Kashirskoe Shosse, Moscow 115522

48, Trubetskaya St., Build. 2, Moscow 119991

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationГБУЗ МО «Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского»РоссияM.F. Vladimirsky Moscow Regional Research Clinical InstituteRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; «Центр лечения суставов и сердца»РоссияV.A. Nasonova Research Institute of Rheumatology; Joint and Heart Treatment CenterRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияV.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian Federation202024042020582140146Copyright © Сатыбалдыев А.М., Демидова Н.В., Гриднева Г.И., Никишина Н.Ю., Герасимова Е.В., Гукасян Д.А., Касумова К.А., Лучихина Е.Л., Мисиюк А.С., Оскилко Т.Г., Румянцева О.А., Злепко Е.А., Тюрина Л.Н., Федоренко Е.В., Шорникова Н.В., Насонов Е.Л., 20202020Сатыбалдыев А.М., Демидова Н.В., Гриднева Г.И., Никишина Н.Ю., Герасимова Е.В., Гукасян Д.А., Касумова К.А., Лучихина Е.Л., Мисиюк А.С., Оскилко Т.Г., Румянцева О.А., Злепко Е.А., Тюрина Л.Н., Федоренко Е.В., Шорникова Н.В., Насонов Е.Л.Satybaldyev A.M., Demidova N.V., Gridneva G.I., Nikishina N.Y., Gerasimova E.V., Gukasian D.A., Kasumova K.A., Luchikhina E.L., Misiyuk A.S., Oskilko T.G., Rumyantseva O.A., Zlepko E.A., Tyurina L.N., Fedorenko E.V., Shornikova N.V., Nasonov E.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2868ревматоидный артритстаршие возрастные периодыклассификационные критерии ревматоидного артритаревматоидный факторантитела к циклическому цитруллинированному пептидуDAS28функциональный классОбщероссийский регистр больных ревматоидным артритом (ОРЕЛ)rheumatoid arthritisolder age periodsclassification criteria for rheumatoid arthritisrheumatoid factoranticyclic citrullinated peptide antibodiesDAS28functional classOREL All-Russian register of rheumatoid arthritis patientsReferencesMcInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365:2205-19. doi: 10.1056/NEJMra1004965McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365:2205-19. doi: 10.1056/NEJMra1004965Pincus T, Callahan LF, Sale WG, et al. Severe functional declines, work disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over nine years. Arthritis Rheum. 1984;27:864-72. doi: 10.1002/art.1780270805Pincus T, Callahan LF, Sale WG, et al. Severe functional declines, work disability, and increased mortality in seventy-five rheumatoid arthritis patients studied over nine years. Arthritis Rheum. 1984;27:864-72. doi: 10.1002/art.1780270805Van der Heide A, Jacobs JW, Bijlsma JW, et al. The effectiveness of early treatment with «second-line» antirheumatic drugs: a randomized, controlled trial. Ann Intern Med. 1996;124:699-707. doi: 10.7326/0003-4819-124-8-199604150-00001Van der Heide A, Jacobs JW, Bijlsma JW, et al. The effectiveness of early treatment with «second-line» antirheumatic drugs: a randomized, controlled trial. Ann Intern Med. 1996;124:699-707. doi: 10.7326/0003-4819-124-8-199604150-00001Sokka T, Abelson B, Pincus T. Mortality in rheumatoid arthritis: 2008 update. Clin Exp Rheumatol. 2008;26:S35-S61.Sokka T, Abelson B, Pincus T. Mortality in rheumatoid arthritis: 2008 update. Clin Exp Rheumatol. 2008;26:S35-S61.Quartuccio L, Fabris M, Salvin S, et al. Rheumatoid factor positivity rather then ant-CCP positivity, a lower disability and a lower number anti-TNF agents failed are associated with response to Rituximab in rheumatoid arthritis. Rheumatology. 2009;48(5):1557-9. doi: 10.1093/rheumatology/kep314Quartuccio L, Fabris M, Salvin S, et al. Rheumatoid factor positivity rather then ant-CCP positivity, a lower disability and a lower number anti-TNF agents failed are associated with response to Rituximab in rheumatoid arthritis. Rheumatology. 2009;48(5):1557-9. doi: 10.1093/rheumatology/kep314Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet. 2010;376:1094-108. doi: 10.1016/S0140-6736(10)60826-4Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet. 2010;376:1094-108. doi: 10.1016/S0140-6736(10)60826-4Haraoui B, Pope J. Treatment of early rheumatoid arthritis: concepts in management. Semin Arthritis Rheum. 2011;40:371-88. doi: 10.1016/j.semarthrit.2010.10.004Haraoui B, Pope J. Treatment of early rheumatoid arthritis: concepts in management. Semin Arthritis Rheum. 2011;40:371-88. doi: 10.1016/j.semarthrit.2010.10.004Nishimura K, Sugiyama D, Kogata Y, et al. Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Intern Med. 2007;146:797-808. doi: 10.7326/0003-4819-146-11-200706050-Nishimura K, Sugiyama D, Kogata Y, et al. Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Intern Med. 2007;146:797-808. doi: 10.7326/0003-4819-146-11-200706050-00008Calvo-Alen J, Corrales A, Sanchez-Andrada S, et al. Outcome of late-onset rheumatoid arthritis. Clin Rheumatol. 2005;24:485-9. doi: 10.1007/s10067-004-1067-4.13Calvo-Alen J, Corrales A, Sanchez-Andrada S, et al. Outcome of late-onset rheumatoid arthritis. Clin Rheumatol. 2005;24:485-9. doi: 10.1007/s10067-004-1067-4.13Calvo-Alen J, Corrales A, Sanchez-Andrada S, et al. Outcome of late-onset rheumatoid arthritis. Clin Rheumatol. 2005;24:485-9. doi: 10.1007/s10067-004-1067-4.13Bukhari M, Lunt M, Barton A, et al. Increasing age at symptom onset is associated with worse radiological damage at presentation in patients with early inflammatory polyarthritis. Ann Rheum Dis. 2007;66:389-93. doi: 10.1136/ard.2006.055657Bukhari M, Lunt M, Barton A, et al. Increasing age at symptom onset is associated with worse radiological damage at presentation in patients with early inflammatory polyarthritis. Ann Rheum Dis. 2007;66:389-93. doi: 10.1136/ard.2006.055657Radovits BJ, Fransen J, Eijsbouts A, et al. Missed opportunities in the treatment of elderly patients with rheumatoid arthritis. Rheumatology (Oxford). 2009;48:906-10. doi: 10.1093/rheumatology/kep12Radovits BJ, Fransen J, Eijsbouts A, et al. Missed opportunities in the treatment of elderly patients with rheumatoid arthritis. Rheumatology (Oxford). 2009;48:906-10. doi: 10.1093/rheumatology/kep12Innala L, Berglin E, Mü ller B, et al. Age at onset determines severity and choice of treatment in early rheumatoid arthritis: a prospective study. Arthritis Res Ther. 2014;16:R94. doi: 10.1186/ar4540Innala L, Berglin E, Mü ller B, et al. Age at onset determines severity and choice of treatment in early rheumatoid arthritis: a prospective study. Arthritis Res Ther. 2014;16:R94. doi: 10.1186/ar4540Oka M, Kytila J. Rheumatoid arthritis with the onset in old age. Acta Rheumatol Scand. 1957;3:249-58. doi: 10.3109/rhe1.1957.3.issue-1-4.28Oka M, Kytila J. Rheumatoid arthritis with the onset in old age. Acta Rheumatol Scand. 1957;3:249-58. doi: 10.3109/rhe1.1957.3.issue-1-4.28Adler E. Rheumatoid arthritis in old age. Isr J Med Sci. 1966;2:607-13.Adler E. Rheumatoid arthritis in old age. Isr J Med Sci. 1966;2:607-13.Ehrlich GE, Katz WA, Cohen SH. Rheumatoid arthritis in the aged. Geriatrics. 1970;25:103-13.Ehrlich GE, Katz WA, Cohen SH. Rheumatoid arthritis in the aged. Geriatrics. 1970;25:103-13.Corrigan AB, Robinson RG, Terenty TR, et al Benign rheumatoid arthritis of the aged. Br Med J. 1974;1:444-6. doi: 10.1136/bmj.1.5905.444Corrigan AB, Robinson RG, Terenty TR, et al Benign rheumatoid arthritis of the aged. Br Med J. 1974;1:444-6. doi: 10.1136/bmj.1.5905.444MacGregor AJ. Classification criteria for rheumatoid arthritis. Baillieres Clin Rheumatol. 1995 May;9(2):287-304. doi: 10.1016/S0950-3579(05)80191-8MacGregor AJ. Classification criteria for rheumatoid arthritis. Baillieres Clin Rheumatol. 1995 May;9(2):287-304. doi: 10.1016/S0950-3579(05)80191-8Arnett FC, Edworthy SM, Bloch DA, et al The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315-24. doi: 10.1002/art.1780310302Arnett FC, Edworthy SM, Bloch DA, et al The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315-24. doi: 10.1002/art.1780310302Aletaha D, Neogi T, Silman AJ, et al. 2010 Rheumatoid arthritis classification criteria an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2010;69:1580-8. doi: 10.1136/ard.2010.138461Aletaha D, Neogi T, Silman AJ, et al. 2010 Rheumatoid arthritis classification criteria an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis. 2010;69:1580-8. doi: 10.1136/ard.2010.138461Ferraccioli GF, Cavalieri F, Mercadanti M, et al Clinical features, scintiscan characteristics and X-ray progression of late onset rheumatoid arthritis. Clin Exp Rheumatol. 1984;2:157-61.Ferraccioli GF, Cavalieri F, Mercadanti M, et al Clinical features, scintiscan characteristics and X-ray progression of late onset rheumatoid arthritis. Clin Exp Rheumatol. 1984;2:157-61.Pease CT, Bhakta BB, Devlin J, Emery P. Does the age of onset of rheumatoid arthritis influence phenotype? A prospective study of outcome and prognostic factors. Rheumatology (Oxford). 1999;38:228-34. doi: 10.1093/rheumatology/38.3.228Pease CT, Bhakta BB, Devlin J, Emery P. Does the age of onset of rheumatoid arthritis influence phenotype? A prospective study of outcome and prognostic factors. Rheumatology (Oxford). 1999;38:228-34. doi: 10.1093/rheumatology/38.3.228Van der Heijde DM, van Riel PL, van Leeuwen MA, et al. Older versus younger onset rheumatoid arthritis: results at onset and after 2 years of a prospective followup study of early rheumatoid arthritis. J Rheumatol. 1991;18:1285-9.Van der Heijde DM, van Riel PL, van Leeuwen MA, et al. Older versus younger onset rheumatoid arthritis: results at onset and after 2 years of a prospective followup study of early rheumatoid arthritis. J Rheumatol. 1991;18:1285-9.Satybaldyev AM. Clinico-immunologic characteristics of rheumatoid arthritis developed in old age. Voprosy Revmatizma. 1980;20(3):22-5 (In Russ.).Сатыбалдыев AM. Клинико-иммунологическая характеристика ревматоидного артрита, начавшегося в пожилом возрасте. Вопросы ревматизма. 1980;20(3):22-5.Alpizar-Rodriguez D, Pluchino N, Canny G, et al. The role of female hormonal factors in the development of rheumatoid arthritis. Rheumatology (Oxford). 2017 Aug;56(8):1254-63. doi: 10.1093/rheumatology/kew318Alpizar-Rodriguez D, Pluchino N, Canny G, et al. The role of female hormonal factors in the development of rheumatoid arthritis. Rheumatology (Oxford). 2017 Aug;56(8):1254-63. doi: 10.1093/rheumatology/kew318Satybaldiyev AM. Rheumatoid arthritis in the elderly. Consilium Medicum. 2007;12:85-92 (In Russ.).Сатыбалдыев АМ. Ревматоидный артрит у пожилых. Consilium Medicum. 2007;12:85-92.Arnold MB, Bykerk VP, Boire G, et al; on behalf of CATCH Investigators. Are there differences between young- and olderonset early inflammatory arthritis and do these impact outcomes? An analysis from the CATCH cohort. Rheumatology. 2014 Jun;53(6):1075-86. doi: 10.1093/rheumatology/ket 449Arnold MB, Bykerk VP, Boire G, et al; on behalf of CATCH Investigators. Are there differences between young- and olderonset early inflammatory arthritis and do these impact outcomes? An analysis from the CATCH cohort. Rheumatology. 2014 Jun;53(6):1075-86. doi: 10.1093/rheumatology/ket 449Arnold MB, Bykerk VP, Boire G, et al; on behalf of CATCH Investigators. Are there differences between young- and olderonset early inflammatory arthritis and do these impact outcomes? An analysis from the CATCH cohort. Rheumatology. 2014 Jun;53(6):1075-86. doi: 10.1093/rheumatology/ket 449

The authors declare that there are no conflicts of interest present.