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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1995-4484-2020-214-224</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-2880</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРОГРЕСС В РЕВМАТОЛОГИИ В XXI ВЕКЕ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PROGRESS IN RHEUMATOLOGY IN THE XXI CENTURY</subject></subj-group></article-categories><title-group><article-title>Эффективность и безопасность тофацитиниба при иммуновоспалительных ревматических заболеваниях (часть II)</article-title><trans-title-group xml:lang="en"><trans-title>EFFICACY AND SAFETY OF TOFACITINIB FOR IMMUNEMEDIATED INFLAMMATORY RHEUMATIC DISEASES (PART II)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1598-8360</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Насонов</surname><given-names>Е. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Nasonov</surname><given-names>E. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>научный руководитель, академик РАН, профессор, докт. мед. наук</p><p>115522, Москва, Каширское шоссе, 34А</p><p>119991, Москва, ул. Трубецкая, 8, стр. 2 </p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p><p>8, Trubetskaya St., Build. 2, Moscow 119991</p><p> </p></bio><email xlink:type="simple">nasonov@irramn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3057-9175</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Авдеева</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Avdeeva</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>научный сотрудник лаборатории стандартизации терапии ревматических заболеваний, канд. мед. наук</p><p>115522, Москва, Каширское шоссе, 34А</p><p> </p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6068-3080</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лила</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lila</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>директор, профессор, докт. мед. наук</p><p>115522, Москва, Каширское шоссе, 34А</p><p>125993, Москва, ул. Баррикадная, 2/1, стр.1 </p><p> </p></bio><bio xml:lang="en"><p>34A, Kashirskoe Shosse, Moscow 115522</p><p>2/1, Barrikadnaya St., Build. 1, Moscow 125993 </p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»;&#13;
ФГБОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский  Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of  Rheumatology;&#13;
I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of  Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»;&#13;
ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of  Rheumatology;&#13;
Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>26</day><month>04</month><year>2020</year></pub-date><volume>58</volume><issue>2</issue><fpage>214</fpage><lpage>224</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Насонов Е.Л., Авдеева А.С., Лила А.М., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Насонов Е.Л., Авдеева А.С., Лила А.М.</copyright-holder><copyright-holder xml:lang="en">Nasonov E.L., Avdeeva A.S., Lila A.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/2880">https://rsp.mediar-press.net/rsp/article/view/2880</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>ингибиторы Янус-киназ</kwd><kwd>тофацитиниб</kwd><kwd>иммуновоспалительные ревматические заболевания</kwd></kwd-group><kwd-group xml:lang="en"><kwd>JAK inhibitors</kwd><kwd>tofacitinib</kwd><kwd>immune-mediated inflammatory rheumatic diseases</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Schwartz DM, Kanno Y, Villarino A, et al. 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