rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2020-225-231rsp-2881Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL OBSERVATIONSАнтифосфолипидный синдром и системная красная волчанка: какое заболевание является причиной повреждения органов?ANTIPHOSPHOLIPID SYNDROME AND SYSTEMIC LUPUS ERYTHEMATOSUS: WHAT DISEASE IS A CAUSE OF ORGAN DAMAGES?https://orcid.org/0000-0001-5217-4932ЧельдиеваФ. А.CheldievaF. A.

115522, Москва, Каширское шоссе, 34А

125993, Москва, ул. Баррикадная, 2/1 

34A, Kashirskoe Shosse, Moscow 115522

22/1, Barrikadnaya St., Build. 1, Moscow, 125993 

https://orcid.org/0000-0003-3552-2522РешетнякТ. М.ReshetnyakT. M.

115522, Москва, Каширское шоссе, 34А

125993, Москва, ул. Баррикадная, 2/1 

34A, Kashirskoe Shosse, Moscow 115522

22/1, Barrikadnaya St., Build. 1, Moscow, 125993 

t_reshetnyak@yahoo.comhttps://orcid.org/0000-0002-4669-260XРаденска-ЛоповокС. Г.Radenska-LopovokS. G.

125993, Москва, ул. Баррикадная, 2/1 

119991, Москва, ул. Трубецкая, 8, стр. 2

22/1, Barrikadnaya St., Build. 1, Moscow, 125993 

38, Trubetskaya St., Build. 2, Moscow 119991

https://orcid.org/0000-0002-3052-7466КорсаковаЮ. О.KorsakovaYu. O.

115522, Москва, Каширское шоссе, 34А

34A, Kashirskoe Shosse, Moscow 115522

https://orcid.org/0000-0002-6068-3080ЛилаА. М.LilaA. M.

115522, Москва, Каширское шоссе, 34А

125993, Москва, ул. Баррикадная, 2/1

34A, Kashirskoe Shosse, Moscow 115522

22/1, Barrikadnaya St., Build. 1, Moscow, 125993

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuing Professional Education, Ministry of Health of RussiaRussian FederationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава РоссииРоссияRussian Medical Academy of Continuing Professional Education, Ministry of Health of Russia; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation202027042020582225231Copyright © Чельдиева Ф.А., Решетняк Т.М., Раденска-Лоповок С.Г., Корсакова Ю.О., Лила А.М., 20202020Чельдиева Ф.А., Решетняк Т.М., Раденска-Лоповок С.Г., Корсакова Ю.О., Лила А.М.Cheldieva F.A., Reshetnyak T.M., Radenska-Lopovok S.G., Korsakova Y.O., Lila A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2881антифосфолипидный синдромсистемная красная волчанкатромботическая микроангиопатияваскулопатиятромбофилияклинический случайantiphospholipid syndromesystemic lupus erythematosusthrombotic microangiopathyvasculopathythrombophiliaclinical caseИсследование выполнено в рамках темы ФГБНУ НИИР им. В.А. Насоновой «Разработка методов персонифицированной терапии ревматических заболеваний с коморбидной патологией» (АААА-А19-119021190151-3).The investigation was conducted as part of the topic of the V.A. Nasonova Research Institute of Rheumatology “The development of methods for personalized treatment of rheumatic diseases with comorbid pathology” (АААА-А19-119021190151-3).ReferencesMiyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006 Feb;4(2):295-306. doi: 10.1111/j.1538-7836.2006.01753.xMiyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006 Feb;4(2):295-306. doi: 10.1111/j.1538-7836.2006.01753.xНасонов ЕЛ. Антифосфолипидный синдром. Монография. Москва: Литтерра; 2004. С. 36.Nasonov EL. Antifosfolipidnyi sindrom. Monografiya [Antiphospholipid syndrome. Monograph]. Moscow: Litterra; 2004. P. 36 (In Russ.)Asherson RA, Pierangel SS, Cervera R. Is there a microangiopathic antiphospholipid syndrome? Ann Rheum Dis. 2007;66:429-33. doi: 10.1136/ard.2006.067033Asherson RA, Pierangel SS, Cervera R. Is there a microangiopathic antiphospholipid syndrome? Ann Rheum Dis. 2007;66:429-33. doi: 10.1136/ard.2006.067033Asherson RA, Cervera R. Microvascular and microangiopathic antiphospholipid-associated syndromes («MAPS»): semantic or antisemantic? Autoimmun Rev. 2008;7(3):164-7. doi: 10.1016/j.autrev.2007.11.009Asherson RA, Cervera R. Microvascular and microangiopathic antiphospholipid-associated syndromes («MAPS»): semantic or antisemantic? Autoimmun Rev. 2008;7(3):164-7. doi: 10.1016/j.autrev.2007.11.009Musa MO, Nounou R, Sahovic E, et al. Fulminant thrombotic thrombocytopenic purpura in two patients with systemic lupus erythematosus and phospholipid autoantibodies. Eur J Haematol. 2000;64:433-5. doi: 10.1034/j.1600-0609.2000.9l125.xMusa MO, Nounou R, Sahovic E, et al. Fulminant thrombotic thrombocytopenic purpura in two patients with systemic lupus erythematosus and phospholipid autoantibodies. Eur J Haematol. 2000;64:433-5. doi: 10.1034/j.1600-0609.2000.9l125.xCervera R, Piette JC, Font J, et al. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum. 2002 Apr;46(4):1019-27. doi: 10.1002/art.10187Cervera R, Piette JC, Font J, et al. Antiphospholipid syndrome: clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum. 2002 Apr;46(4):1019-27. doi: 10.1002/art.10187Ruggenenti P, Remuzzi G. Thrombotic thrombocytopenic purpura and related disorders. Hematol Oncol Clin North Am. 1990;4:219-41. doi: 10.1016/S0889-8588(18)30514-8Ruggenenti P, Remuzzi G. Thrombotic thrombocytopenic purpura and related disorders. Hematol Oncol Clin North Am. 1990;4:219-41. doi: 10.1016/S0889-8588(18)30514-8Saha M, McDaniel JK, Zhang L. Thrombotic thrombocytopenic purpura: pathogenesis, diagnosis and potential novel therapeutics. J Thromb Haemost. 2017;15:1889-900. doi: 10.1111/jth.13764Saha M, McDaniel JK, Zhang L. Thrombotic thrombocytopenic purpura: pathogenesis, diagnosis and potential novel therapeutics. J Thromb Haemost. 2017;15:1889-900. doi: 10.1111/jth.13764Camous L, Veyradier A, Darmon M, et al. Macrovascular thrombosis in critically ill patients with thrombotic microangiopathies. Intern Emerg Med. 2014 Apr;9(3):267-72. doi: 10.1007/s11739-012-0851-4. Epub 2012 Oct 7.Camous L, Veyradier A, Darmon M, et al. Macrovascular thrombosis in critically ill patients with thrombotic microangiopathies. Intern Emerg Med. 2014 Apr;9(3):267-72. doi: 10.1007/s11739-012-0851-4. Epub 2012 Oct 7.Symmers W. Thrombotic microangiopathic haemolitic anaemia (thrombotic microangiopathy). BMJ. 1952;ii:897-903. doi: 10.1136/bmj.2.4790.897Symmers W. Thrombotic microangiopathic haemolitic anaemia (thrombotic microangiopathy). BMJ. 1952;ii:897-903. doi: 10.1136/bmj.2.4790.897Макацария АД, Бренер Б, Бицадзе ВО, Акиньшина СВ. Тромботическая микроангиопатия. В кн.: Системный венозный и артериальный тромбоэмболизм в акушерско-гинекологической практике. Москва: Медицинское информационное агентство; 2016. С. 853-77.Makatsariya AD, Brener B, Bitsadze VO, Akin'shina SV. Thrombotic microangiopathy. In: Sistemnyi venoznyi i arterial'nyi tromboembolizm v akushersko-ginekologicheskoi praktike [Systemic venous and arterial thromboembolism in obstetric and gynecological practice]. Moscow: Meditsinskoe informatsionnoe agentstvo; 2016. P. 853-77 (In Russ.)Hess DC, Sethi K, Awad E. Thrombotic thrombocytopenic purpura in systemic lupus erythematosus and antiphospholipid antibodies: effective treatment with plasma exchange and immunosuppression. J Rheumatol. 1992 Sep;19(9):1474-8.Hess DC, Sethi K, Awad E. Thrombotic thrombocytopenic purpura in systemic lupus erythematosus and antiphospholipid antibodies: effective treatment with plasma exchange and immunosuppression. J Rheumatol. 1992 Sep;19(9):1474-8.Durand JM, Lefevre P, Kaplanski G, Soubeyrand J. Thrombotic microangiopathy and the antiphospholipid antibody syndrome. J Rheumatol. 1991;18:1916-8.Durand JM, Lefevre P, Kaplanski G, Soubeyrand J. Thrombotic microangiopathy and the antiphospholipid antibody syndrome. J Rheumatol. 1991;18:1916-8.Glueck HI, Kant KS, Weiss MA, et al. Thrombosis in systemic lupus erythematosus. Relation to the presence of circulating anticoagulants. Arch Intern Med. 1985 Aug;145(8):1389-95. doi: 10.1001/archinte.145.8.1389Glueck HI, Kant KS, Weiss MA, et al. Thrombosis in systemic lupus erythematosus. Relation to the presence of circulating anticoagulants. Arch Intern Med. 1985 Aug;145(8):1389-95. doi: 10.1001/archinte.145.8.1389Kant KS, Pollak VE, Weiss MA, et al. Glomerular thrombosis in systemic lupus erythematosus: prevalence and significance. Medicine (Baltimore). 1981 Mar;60(2):71-86. doi: 10.1097/00005792-198103000-00001Kant KS, Pollak VE, Weiss MA, et al. Glomerular thrombosis in systemic lupus erythematosus: prevalence and significance. Medicine (Baltimore). 1981 Mar;60(2):71-86. doi: 10.1097/00005792-198103000-00001Love PE, Santoro SA. Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders. Prevalence and clinical significance. Ann Intern Med. 1990 May;112(9):682-8. doi: 10.7326/0003-4819-112-9-682Love PE, Santoro SA. Antiphospholipid antibodies: anticardiolipin and the lupus anticoagulant in systemic lupus erythematosus (SLE) and in non-SLE disorders. Prevalence and clinical significance. Ann Intern Med. 1990 May;112(9):682-8. doi: 10.7326/0003-4819-112-9-682Farrugia E, Torres VE, Gastineau D, et al. Lupus anticoagulant in systemic lupus erythematosus: a clinical and renal pathological study. Am J Kidney Dis. 1992 Nov;20(5):463-71. doi: 10.1016/S0272-6386(12)70258-5Farrugia E, Torres VE, Gastineau D, et al. Lupus anticoagulant in systemic lupus erythematosus: a clinical and renal pathological study. Am J Kidney Dis. 1992 Nov;20(5):463-71. doi: 10.1016/S0272-6386(12)70258-5Frampton G, Hicks J, Cameron JS. Significance of anti-phospholipid antibodies in patients with lupus nephritis. Kidney Int. 1991 Jun;39(6):1225-31. doi: 10.1038/ki.1991.155Frampton G, Hicks J, Cameron JS. Significance of anti-phospholipid antibodies in patients with lupus nephritis. Kidney Int. 1991 Jun;39(6):1225-31. doi: 10.1038/ki.1991.155Tsai HM. Molecular mechanisms in thrombotic thrombocytopenic purpura. Semin Thromb Hemost. 2004 Oct;30(5):549-57. doi: 10.1055/s-2004-835675Tsai HM. Molecular mechanisms in thrombotic thrombocytopenic purpura. Semin Thromb Hemost. 2004 Oct;30(5):549-57. doi: 10.1055/s-2004-835675Babar F, Cohen SD. Thrombotic microangiopathies with rheumatologic involvement. Rheum Dis Clin North Am. 2018 Nov;44(4):635-49. doi: 10.1016/j.rdc.2018.06.010. Epub 2018 Sep 7.Babar F, Cohen SD. Thrombotic microangiopathies with rheumatologic involvement. Rheum Dis Clin North Am. 2018 Nov;44(4):635-49. doi: 10.1016/j.rdc.2018.06.010. Epub 2018 Sep 7.Copelovitch L, Kaplan BS. The thrombotic microangiopathies. Pediatr Nephrol. 2008 Oct;23(10):1761-7. doi: 10.1007/s00467-007-0616-xCopelovitch L, Kaplan BS. The thrombotic microangiopathies. Pediatr Nephrol. 2008 Oct;23(10):1761-7. doi: 10.1007/s00467-007-0616-xBarbour T, Johnson S, Cohney S, Hughes P. Thrombotic microangiopathy and associated renal disorders. Nephrol Dial Transplant. 2012 Jul;27(7):2673-85. doi: 10.1093/ndt/gfs279Barbour T, Johnson S, Cohney S, Hughes P. Thrombotic microangiopathy and associated renal disorders. Nephrol Dial Transplant. 2012 Jul;27(7):2673-85. doi: 10.1093/ndt/gfs279Nochy D, Daugas E, Droz D, et al. The intrarenal vascular lesions associated with primary antiphospholipid syndrome. Arthritis Rheum. 2002;46(4):1019-27.Nochy D, Daugas E, Droz D, et al. The intrarenal vascular lesions associated with primary antiphospholipid syndrome. Arthritis Rheum. 2002;46(4):1019-27.Arachchillage DRJ, Machin SJ, Mackie IJ, Cohen H. Diagnosis and management of non-criteria obstetric antiphospholipid syndrome. Thromb Haemost. 2014;113:13-9. doi: 10.1160/TH14-05-0416Arachchillage DRJ, Machin SJ, Mackie IJ, Cohen H. Diagnosis and management of non-criteria obstetric antiphospholipid syndrome. Thromb Haemost. 2014;113:13-9. doi: 10.1160/TH14-05-0416Silvarino R, Sant F, Espinosa G, et al. Nephropathy associated with antiphospholipid antibodies in patients with systemic lupus erythematosus. Lupus. 2011;20:721-9. doi: 10.1177/0961203310397410Silvarino R, Sant F, Espinosa G, et al. Nephropathy associated with antiphospholipid antibodies in patients with systemic lupus erythematosus. Lupus. 2011;20:721-9. doi: 10.1177/0961203310397410Amigo MC, Garcia-Torres R, Robles M, et al. Renal involvement in primary antiphospholipid syndrome. J Rheumatol. 1992;19:1181-5.Amigo MC, Garcia-Torres R, Robles M, et al. Renal involvement in primary antiphospholipid syndrome. J Rheumatol. 1992;19:1181-5.Turrent-Carriles A, Herrera-Felix JP, Amigo M-C. Renal involvement in antiphospholipid syndrome. Front Immunol. 2018;1(9):1008. doi: 10.3389/fimmu.2018.01008Turrent-Carriles A, Herrera-Felix JP, Amigo M-C. Renal involvement in antiphospholipid syndrome. Front Immunol. 2018;1(9):1008. doi: 10.3389/fimmu.2018.01008Praprotnik S, Ferluga D, Vizjak A. Microthrombotic/microangiopathic manifestations of the antiphospholipid syndrome. Clin Rev Allergy Immunol. 2009 Jun;36(2-3):109-25. doi: 10.1007/s12016-008-8104-zPraprotnik S, Ferluga D, Vizjak A. Microthrombotic/microangiopathic manifestations of the antiphospholipid syndrome. Clin Rev Allergy Immunol. 2009 Jun;36(2-3):109-25. doi: 10.1007/s12016-008-8104-zWeening JJ, D’Agati VD, Schwartz MM, et al. The classification of glomerulonephritis in systemic lupus erythematosus revisited. J Am Soc Nephrol. 2004;15:241-50. doi: 10.1097/01.ASN.0000108969.21691.5DWeening JJ, D’Agati VD, Schwartz MM, et al. The classification of glomerulonephritis in systemic lupus erythematosus revisited. J Am Soc Nephrol. 2004;15:241-50. doi: 10.1097/01.ASN.0000108969.21691.5DCuadrado MJ, Khamashta MA, Ballesteros A, et al. Can neurologic manifestations of Hughes (antiphospholipid) syndrome be distinguished from multiple sclerosis? Analysis of 27 patients and review of the literature. Medicine (Baltimore). 2000 Jan;79(1):57-68. doi: 10.1097/00005792-200001000-00006Cuadrado MJ, Khamashta MA, Ballesteros A, et al. Can neurologic manifestations of Hughes (antiphospholipid) syndrome be distinguished from multiple sclerosis? Analysis of 27 patients and review of the literature. Medicine (Baltimore). 2000 Jan;79(1):57-68. doi: 10.1097/00005792-200001000-00006Tektonidou MG, Varsou N, Kotoulas G, et al. Cognitive deficits in patients with antiphospholipid syndrome: association with clinical, laboratory, and brain magnetic resonance imaging findings. Arch Intern Med. 2006 Nov 13;166(20):2278-84. doi: 10.1001/archinte.166.20.2278Tektonidou MG, Varsou N, Kotoulas G, et al. Cognitive deficits in patients with antiphospholipid syndrome: association with clinical, laboratory, and brain magnetic resonance imaging findings. Arch Intern Med. 2006 Nov 13;166(20):2278-84. doi: 10.1001/archinte.166.20.2278Murphy J, Leach IH. Findings at necropsy in the heart of a patient with anticardiolipin syndrome. Br Heart J. 1989 Jul;62(1):61-4. doi: 10.1136/hrt.62.1.61Murphy J, Leach IH. Findings at necropsy in the heart of a patient with anticardiolipin syndrome. Br Heart J. 1989 Jul;62(1):61-4. doi: 10.1136/hrt.62.1.61Brown JH, Doherty CC, Allen DC, et al. Fatal cardiac failure due to myocardial microthrombi in systemic lupus erythematosus. Br Med J (Clin Res Ed). 1988 May 28;296(6635):1505. doi: 10.1136/bmj.296.6635.1505Brown JH, Doherty CC, Allen DC, et al. Fatal cardiac failure due to myocardial microthrombi in systemic lupus erythematosus. Br Med J (Clin Res Ed). 1988 May 28;296(6635):1505. doi: 10.1136/bmj.296.6635.1505Kaplan SD, Chartash EK, Pizzarello RA, et al. Cardiac manifestations of the antiphospholipid syndrome. Am Heart J. 1992 Nov;124(5):1331-8. doi: 10.1016/0002-8703(92)90420-zKaplan SD, Chartash EK, Pizzarello RA, et al. Cardiac manifestations of the antiphospholipid syndrome. Am Heart J. 1992 Nov;124(5):1331-8. doi: 10.1016/0002-8703(92)90420-zРешетняк ТМ. Лечение антифосфолипидного синдрома: современные стандарты. Тромбоз, гемостаз и реология. 2016;1(65):11-20. doi: 10,25555/THR/2017/3/0790Reshetnyak TM. Treatment of antiphospholipid syndrome: modern standards. Tromboz, Gemostaz i Reologiya. 2016;1(65):11-20. doi: 10,25555/THR/2017/3/0790 (In Russ.)

The authors declare that there are no conflicts of interest present.