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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14412/1995-4484-2020-233-237</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-2882</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group></article-categories><title-group><article-title>Тяжелое течение анкилозирующего спондилита с резистентностью к медикаментозной терапии</article-title><trans-title-group xml:lang="en"><trans-title>THE SEVERE COURSE OF DRUG THERAPY-RESISTANT ANKYLOSING SPONDYLITIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1684-1213</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Румянцева</surname><given-names>Д. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Rumyantseva</surname><given-names>D. G.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><email xlink:type="simple">rumiantceva01@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4190-4471</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Подряднова</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Podryadnova</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7569-4110</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Румянцева</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rumyantseva</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9755-5760</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Урумова</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Urumova</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3195-5187</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эрдес</surname><given-names>Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Erdes</surname><given-names>Sh.</given-names></name></name-alternatives><bio xml:lang="ru"/><bio xml:lang="en"/><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V.A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>27</day><month>04</month><year>2020</year></pub-date><volume>58</volume><issue>2</issue><fpage>232</fpage><lpage>237</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Румянцева Д.Г., Подряднова М.В., Румянцева О.А., Урумова М.М., Эрдес Ш., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Румянцева Д.Г., Подряднова М.В., Румянцева О.А., Урумова М.М., Эрдес Ш.</copyright-holder><copyright-holder xml:lang="en">Rumyantseva D.G., Podryadnova M.V., Rumyantseva O.A., Urumova M.M., Erdes S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/2882">https://rsp.mediar-press.net/rsp/article/view/2882</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>анкилозирующий спондилит</kwd><kwd>генно-инженерные биологические препараты</kwd><kwd>высокая активность</kwd><kwd>неэффективность генно-инженерных биологических препаратов</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ankylosing spondylitis</kwd><kwd>biological agents</kwd><kwd>high activity</kwd><kwd>inefficacy of biological agents</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Эрдес ШФ, Бадокин ВВ, Бочкова АГ и др. 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