rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.14412/1995-4484-2020-304-316rsp-2898Research ArticleПРОГРЕСС В РЕВМАТОЛОГИИ В XXI ВЕКЕPROGRESS IN RHEUMATOLOGY IN THE XXI CENTURYБарицитиниб: новые возможности фармакотерапии ревматоидного артрита и других иммуновоспалительных ревматических заболеванийBARICITINIB: NEW PHARMACOTHERAPY OPTIONS FOR RHEUMATOID ARTHRITIS AND OTHER IMMUNE-MEDIATED INFLAMMATORY RHEUMATIC DISEASEShttps://orcid.org/0000-0002-1598-8360НасоновЕ. Л.NasonovE. L.

Евгений Львович Насонов 

115522, Москва, Каширское шоссе, 34А 119991, Москва, ул. Трубецкая, 8, стр. 2

Evgeny Nasonov

34A, Kashirskoe Shosse, Moscow 115522 

8, Trubetskaya St., Build. 2, Moscow 119991

nasonov@irramn.ruhttps://orcid.org/0000-0002-6068-3080ЛилаА. М.LilaA. M.

34A, Kashirskoe Shosse, Moscow 115522

2/1, Barrikadnaya St., Build. 1, Moscow 125993

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияV.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of RussiaRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuing Professional Education, Ministry of Health of RussiaRussian Federation202024062020583304316Copyright © Насонов Е.Л., Лила А.М., 20202020Насонов Е.Л., Лила А.М.Nasonov E.L., Lila A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2898

Расшифровка механизмов патогенеза иммуновоспалительных ревматических заболеваний (ИВРЗ) в сочетании с разработкой широкого спектра генно-инженерных биологических препаратов относится к числу крупных достижений медицины XXI в. Новое перспективное направление фармакотерапии ИВРЗ связано с созданием так называемых «таргетных» пероральных лекарственных препаратов, к которым в первую очередь относятся ингибиторы Янус-киназ (JAK). В обзоре представлены новые данные, касающиеся эффективности и безопасности нового ингибитора JAK – барицитиниба – при ревматоидном артрите и других ИВРЗ.

Deciphering the mechanisms of the pathogenesis of immune-mediated inflammatory rheumatic diseases (IMIRDs) in conjunction with designing a wide range of biological agents is one of the major medical advances in the 21st century. A new promising area of pharmacotherapy for IMIRDs is associated with the design of the so-called targeted oral medications that primarily include Janus kinase (JAK) inhibitors. The review presents new data on the efficacy and safety of the new JAK inhibitor baricitinib in treating rheumatoid arthritis and other IMIRDs.

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The authors declare that there are no conflicts of interest present.