rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2021-56-61rsp-2990Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHРаспространенность и риск переломов костей у пациентов с хроническим панкреатитом: метаанализPrevalence and risk of bone fractures in patients with chronic pancreatitis: meta-analysishttps://orcid.org/0000-0002-4007-7112АндреевД. Н.AndreevD. N.

Андреев Дмитрий Николаевич

127473, Москва, ул. Делегатская, 20, стр. 1

 

Dmitriy Andreev

127473, Moscow, Delegatskaya str., 20, building 1

dna-mit8@mail.ruhttps://orcid.org/0000-0001-6114-564XМаевИ. В.MaevI. V.

127473, Москва, ул. Делегатская, 20, стр. 1

Igor V. Maev

127473, Moscow, Delegatskaya str., 20, building 1

 

https://orcid.org/0000-0001-7760-2091КучерявыйЮ. А.KucheryavyyYu. A.

127473, Москва, ул. Делегатская, 20, стр. 1

Yuri A. Kucheryavyy

127473, Moscow, Delegatskaya str., 20, building 1

ФГБОУ ВО «Московский государственный медико-стоматологический университет имени А.И. Евдокимова»РоссияA.I. Yevdokimov Moscow State University of Medicine and DentistryRussian Federation2021020320215915661Copyright © Андреев Д.Н., Маев И.В., Кучерявый Ю.А., 20212021Андреев Д.Н., Маев И.В., Кучерявый Ю.А.Andreev D.N., Maev I.V., Kucheryavyy Y.A.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/2990

Цель исследования – систематизация данных о частоте и риске переломов костей у пациентов с хроническим панкреатитом.

Методы

Методы. Поиск исследований проводился в электронных базах данных MEDLINE/PubMed, EMBASE, Cochrane, Google Scholar до октября 2020 года. В финальный анализ отбирались публикации, содержащие информацию по общему размеру выборки, количеству пациентов с хроническим панкреатитом, количеству человек в контрольных группах и числу больных с переломами в основной и контрольной группах.

Результаты

Результаты. В итоговый анализ было включено 6 исследований с участием 2 025 918 человек (18 844 пациента с хроническим панкреатитом, 2 007 074 человека – контроль). Обобщенная частота переломов у пациентов с хроническим панкреатитом составила 14,09% (95% ДИ: 5,877–25,098). Была выявлена значительная гетерогенность результатов (p<0,0001; I2=99,58%). Хронический панкреатит значительно повышал риск развития переломов в сравнении с контролем (отношение шансов (ОШ) 2,819; 95% ДИ: 1,855–4,282; I2=97,14%). При исключении из анализа двух исследований с широким 95% ДИ (менее 150 пациентов с хроническим панкреатитом в каждом) обобщенная частота переломов составила 9,25% (95% ДИ: 1,930–21,221; I2=99,74%).

Заключение

Заключение. Метаанализ продемонстрировал, что хронический панкреатит является фактором риска переломов. Учитывая данную ассоциацию, целесообразно включать денситометрию в рутинные алгоритмы обследования пациентов с хроническим панкреатитом, а также своевременно назначать таким больным лечение по поводу остеопороза.

Aim

Aim: to systematize data on the frequency and risk of bone fractures in patients with chronic pancreatitis.

Methods

Methods. MEDLINE/PubMed, EMBASE, Cochrane, Google Scholar through October 2020 were searched to identify studies evaluating the prevalence of bone fractures in chronic pancreatitis. For the final analysis, publications with detailed descriptive statistics (total sample size, number of patients with chronic pancreatitis, number of control persons, number of patients with fractures in groups) were selected, allowing the resulting data to be included in the meta-analysis.

Results

Results. The final analysis included 6 studies involving 2 025 918 people (18 844 patients with chronic pancreatitis; 2 007 074 – control subjects). The generalized incidence of fractures in patients with chronic pancreatitis was 14.09% (95% CI: 5.877–25.098). There was significant heterogeneity between the results (p<0.0001; I2=99.58%). Chronic pancreatitis significantly increases the risk of fractures in comparison with control subjects with OR 2.819 (95% CI: 1.855–4.282; I2=97.14%). With the exclusion from the analysis of 2 studies with a wide 95% CI (less than 150 patients with chronic pancreatitis in each), the pooled fracture frequency was 9.25% (95% CI: 1.930–21.221; I2=99.74%).

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The authors declare that there are no conflicts of interest present.