rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2021-282-287rsp-3039Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHКомпозиционный состав тела и состояние минеральной плотности костной ткани у женщин в постменопаузе с ревматоидным артритомBody composition and bone mineral density in postmenopausal women with rheumatoid arthritishttps://orcid.org/0000-0003-4739-4302ТоропцоваН. В.ToroptsovaN. V.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

torop@irramn.ruhttps://orcid.org/0000-0002-2809-0197ДобровольскаяО. В.DobrovolskayaO. V.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0001-6759-8367НикитинскаяО. А.NikitinskayaO. A.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0002-8155-6101ЕфремоваА. О.EfremovaA. O.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0002-7661-3124ФеклистовА. Ю.FeklistovA. Yu.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0003-0961-9785ДеминН. В.DeminN. V.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation202114072021593282287Copyright © Торопцова Н.В., Добровольская О.В., Никитинская О.А., Ефремова А.О., Феклистов А.Ю., Демин Н.В., 20212021Торопцова Н.В., Добровольская О.В., Никитинская О.А., Ефремова А.О., Феклистов А.Ю., Демин Н.В.Toroptsova N.V., Dobrovolskaya O.V., Nikitinskaya O.A., Efremova A.O., Feklistov A.Y., Demin N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3039

Цель исследования – определить взаимосвязь компонентов состава тела и минеральной плотности кости (МПК) у женщин с ревматоидным артритом (РА) в постменопаузе.

Материал и методы

Материал и методы. В исследование включены 68 женщин (медиана возраста – 59 [54; 63] лет) в постменопаузе с РА. Всем пациенткам проводилась двуэнергетическая рентгеновская абсорбциометрия (Dual energy X-ray Absorptiometry, DXA) для определения МПК и состава тела.

Результаты

Результаты. У 33 (48,5%) женщин выявлена остеопения, у 17 (25,0%) – остеопороз (ОП). Низкая мышечная масса обнаружена у 10 (14,7%) пациенток. Установлены позитивные корреляционные связи между МПК различных отделов скелета и массой тела, жировой и мышечной массой туловища и общим содержанием мышечной массы. В ходе многофакторного линейного регрессионного анализа установлено влияние общего содержания мышечной массы на МПК поясничного отдела позвоночника (β=0,638; р=0,001) и проксимального отдела бедра в целом (β=0,473; р=0,008), мышечной массы конечностей, оцененной с помощью аппендикулярного мышечного индекса, – на МПК шейки бедра (β=0,360; р=0,014).

Заключение

Заключение. У 73,5% пациенток с РА выявлена сниженная МПК, у 14,7% – низкая мышечная масса. Обнаруженная значимая взаимосвязь между мышечным компонентом состава тела и МПК поясничного отдела позвоночника и проксимального отдела бедра указывает на важность выявления и коррекции низкой мышечной массы, а также профилактики ее снижения с целью предотвращения потерь МПК и остеопоротических переломов.

Aim – to study the relationship between body composition and bone mineral density (BMD) in postmenopausal women with rheumatoid arthritis (RA).

Material and methods

Material and methods. 68 postmenopausal women, median age 59 [54; 63] years, with RA were included in the study. Bone mineral density (BMD) and body composition were assessed with dual energy X-ray absorptiometry.

Results

Results. 33 (48.5%) women had osteopenia, and 17 (25.0%) – osteoporosis (OP). Low lean muscle mass was found in 10 (14.7%) patients. There were positive correlations between different areal BMD and body weight, trunk fat, trunk lean muscle mass and total lean muscle mass. In the multivariate linear regression analysis total lean muscle mass was associated with BMD of lumbar spine (β=0.638; p=0.001) and total hip (β=0.473; p=0.008), and appendicular lean muscle mass, estimated using the appendicular muscle index, with femoral neck BMD (β=0.360; p=0.014).

Conclusion

Conclusion. 73.5% of patients with RA had a reduced BMD, and 14.7% women – low muscle mass. The revealed significant association between the lean muscle mass and BMD of lumbar spine and proximal femur indicates the importance of detecting and correcting low lean muscle mass, as well as preventing its decline in order to prevent loss of BMD and osteoporotic fractures.

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The authors declare that there are no conflicts of interest present.