rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2021-367-383rsp-3053Research ArticleПЕРЕДОВАЯLEADING ARTICLEБелимумаб в лечении системной красной волчанки: 20 лет фундаментальных исследований, 10 лет клинической практикиBelimumab in the treatment of systemic lupus erythematosus: 20 years of basic research, 10 years of clinical practicehttps://orcid.org/0000-0002-1598-8360НасоновЕ. Л.NasonovE. L.

115522, Российская Федерация, Москва, Каширское шоссе, 34а

119991, Российская Федерация, Москва, ул. Трубецкая, 8, стр. 2

115522, Russian Federation, Moscow, Kashirskoye Highway, 34A

119991, Russian Federation, Moscow, Trubetskaya str., 8, building 2

https://orcid.org/0000-0001-5793-4689ПопковаТ. В.PopkovaT. V.

115522, Российская Федерация, Москва, Каширское шоссе, 34а

115522, Russian Federation, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0002-6068-3080ЛилаА. М.LilaA. M.

115522, Российская Федерация, Москва, Каширское шоссе, 34а

125993, Российская Федерация, Москва, ул. Баррикадная, 2/1, стр. 1

115522, Russian Federation, Moscow, Kashirskoye Highway, 34A

125993, Russian Federation, Moscow, Barrikadnaya str., 2/1, building 1

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияV.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University)Russian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian FederationRussian Federation202105092021594367383Copyright © Насонов Е.Л., Попкова Т.В., Лила А.М., 20212021Насонов Е.Л., Попкова Т.В., Лила А.М.Nasonov E.L., Popkova T.V., Lila A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3053

В настоящее время получены веские доказательства фундаментальной роли патологической активации В-клеток в патогенезе иммуновоспалительных (аутоиммунных) ревматических заболеваний (ИВРЗ), а препараты, специфически модулирующие функцию или вызывающие истощение (depletion) различных субпопуляций В-клеток и плазматических клеток, рассматриваются как перспективное направление фармакотерапии этих заболеваний. Особый интерес представляет белимумаб (БЛМ) – человеческие моноклональные антитела (мАТ) (IgG1λ) к BAFF (B cell activating factor belonging to the TNF family), – который является первым «таргетным» генно-инженерным биологическим препаратом, специально разработанным для лечения системной красной волчанки (СКВ). Эффективность и безопасность БЛМ при СКВ у взрослых и детей, включая волчаночный нефрит, в комбинированной терапии с ритуксимабом, стероид-сберегающее действие, способность предотвращать необратимое поражение внутренних органов диктуют необходимость более широкого его применения в клинической практике.

Currently, strong evidence has been obtained for the fundamental role of pathological activation of B cells in the pathogenesis of immunoinflammatory (autoimmune) rheumatic diseases (IMRD), and drugs that specifically modulate the function or cause depletion of various subpopulations of B cells and plasma cells are considered a promising direction. pharmacotherapy of these diseases. of particular interest is belimumab (BLM), a human monoclonal antibody (mAb) (IgG1λ) to BAFF (B cell-activating factor belonging to the TNF family), which is the first “targeted” biological drug specially developed for the treatment of systemic lupus erythematosus (SLE). The efficacy and safety of BLM in SLE in adults and children, including lupus nephritis, in combination therapy with rituximab, steroid-sparing effect, the ability to prevent irreversible damage to internal organs dictate the need for its wider application in clinical practice.

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The authors declare that there are no conflicts of interest present.