rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2021-608-614rsp-3082Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESМикроскопический полиангиит: современные представления и возможности терапииMicroscopic polyangiitis: Modern concepts and treatment optionshttps://orcid.org/0000-0001-8513-9279МуркамиловИ. Т.MurkamilovI. T.

Муркамилов Илхом Торобекович

720020, Кыргызстан, Бишкек, ул. Ахунбаева, 92

720020, Kyrgyzstan, Bishkek, Akhunbaev str., 92

murkamilov.i@mail.ruhttps://orcid.org/0000-0003-4973-039XАйтбаевК. А.AitbaevK. A.

720040, Кыргызстан, Бишкек, ул. Тоголок Молдо, 3

720040, Kyrgyzstan, Bishkek, Togolok Moldo str., 3

https://orcid.org/0000-0002-2682-4417ФоминВ. В.FominV. V.

119991, Российская Федерация, Москва, ул. Трубецкая, 8, стр. 2

119991, Russian Federation, Moscow, Trubetskaya str., 8, building 2

https://orcid.org/0000-0003-3007-8127КудайбергеноваИ. О.KudaibergenovaI. O.

720020, Кыргызстан, Бишкек, ул. Ахунбаева, 92

720020, Kyrgyzstan, Bishkek, Akhunbaev str., 92

https://orcid.org/0000-0003-0632-6653ЮсуповФ. А.YusupovF. A.

723500, Кыргызстан, Ош, ул. Ленина, 331

723500, Kyrgyzstan, Osh, Lenin str. 331

https://orcid.org/0000-0002-7653-0433МуркамиловаЖ. А.MurkamilovaZh. A.

720000, Кыргызстан, Бишкек, ул. Киевская, 44

720000, Kyrgyzstan, Bishkek, Kiev str. 44

https://orcid.org/0000-0003-2641-9785БекетоваТ. В.BeketovaT. V.

115522, Российская Федерация, Москва, Каширское шоссе, 34а

115522, Russian Federation, Moscow, Kashirskoye Highway, 34A

Кыргызская государственная медицинская академия имени И.К. АхунбаеваКыргызстанI.K. Akhunbaev Kyrgyz State Medical AcademyKyrgyzstanНаучно-исследовательский институт молекулярной биологии и медициныКыргызстанScientific and Research Institute of Molecular Biology and MedicineKyrgyzstanФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University)Russian FederationОшский государственный университетКыргызстанOsh State UniversityKyrgyzstanГОУ ВПО Кыргызско-Российский Славянский университет имени Б.Н. ЕльцинаКыргызстанB.N. Yeltsin Kyrgyz-Russian Slavic UniversityKyrgyzstanФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian Federation202131102021595608614Copyright © Муркамилов И.Т., Айтбаев К.А., Фомин В.В., Кудайбергенова И.О., Юсупов Ф.А., Муркамилова Ж.А., Бекетова Т.В., 20212021Муркамилов И.Т., Айтбаев К.А., Фомин В.В., Кудайбергенова И.О., Юсупов Ф.А., Муркамилова Ж.А., Бекетова Т.В.Murkamilov I.T., Aitbaev K.A., Fomin V.V., Kudaibergenova I.O., Yusupov F.A., Murkamilova Z.A., Beketova T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3082

В статье обобщены современные представления о микроскопическом полиангиите (МПА), заболевании из группы системных васкулитов, ассоциированных с антинейтрофильными цитоплазматическими антителами (АНЦА). В основе МПА лежит некротизирующий АНЦА-ассоциированный васкулит без иммунных депозитов, с преимущественным поражением мелких сосудов и без гранулематозного воспаления. Для МПА типичны развитие некротизирующего гломерулонефрита и частое присоединение геморрагического альвеолита, а также нередко отмечается быстропрогрессирующее течение. Обсуждаются современные возможности терапии МПА, прежде всего анти-В-клеточная терапия ритуксимабом.

The article summarizes the modern concepts of microscopic polyangiitis (MPA), a primary ANCA-associated systemic necrotizing vasculitis without immune globulin deposition (pauci-immune) that affects mainly small vessels, while granulomatous inflammation is absent. Necrotizing glomerulonephritis is very common and pulmonary capillaritis often occurs. MPA can cause rapidly progressive damage to organ systems. The modern possibilities of MPA treatment, primarily anti-B cell therapy with rituximab, are discussed.

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The authors declare that there are no conflicts of interest present.