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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsp</journal-id><journal-title-group><journal-title xml:lang="ru">Научно-практическая ревматология</journal-title><trans-title-group xml:lang="en"><trans-title>Rheumatology Science and Practice</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1995-4484</issn><issn pub-type="epub">1995-4492</issn><publisher><publisher-name>IMA-PRESS, LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.47360/1995-4484-2021-720-726</article-id><article-id custom-type="elpub" pub-id-type="custom">rsp-3100</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL RESEARCH</subject></subj-group></article-categories><title-group><article-title>Влияние поздней диагностики на выживаемость и риск развития сосудистых осложнений у пациентов с артериитом Такаясу</article-title><trans-title-group xml:lang="en"><trans-title>The effect of late diagnosis on survival and risk of vascular complications in Takayasu's arteritis patients</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5636-5928</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бородина</surname><given-names>И. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Borodina</surname><given-names>I. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бородина Ирина Эдуардовна.</p><p>620102, Екатеринбург, ул. Волгоградская, 185; 620014, Екатеринбург, ул. Репина, 3.</p></bio><bio xml:lang="en"><p>Irina E. Borodina.</p><p>620102, Yekaterinburg, Volgogradskaya str., 185; 620014, Yekaterinburg, Repina str., 3.</p></bio><email xlink:type="simple">borodysik@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6216-2468</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попов</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Popov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>620014, Екатеринбург, ул. Репина, 3.</p></bio><bio xml:lang="en"><p>Artem A. Popov.</p><p>620014, Yekaterinburg, Repina str., 3.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3720-9193</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шардина</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shardina</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>620014, Екатеринбург, ул. Репина, 3.</p></bio><bio xml:lang="en"><p>Lubov A. Shardina.</p><p>620014, Yekaterinburg, Repina str., 3.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Свердловская областная клиническая больница № 1; Уральский государственный медицинский университет Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Sverdlovsk Regional Clinical Hospital No. 1; Ural State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Уральский государственный медицинский университет Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ural State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>27</day><month>12</month><year>2021</year></pub-date><volume>59</volume><issue>6</issue><fpage>720</fpage><lpage>726</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бородина И.Э., Попов А.А., Шардина Л.А., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Бородина И.Э., Попов А.А., Шардина Л.А.</copyright-holder><copyright-holder xml:lang="en">Borodina I.E., Popov A.A., Shardina L.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsp.mediar-press.net/rsp/article/view/3100">https://rsp.mediar-press.net/rsp/article/view/3100</self-uri><abstract><p>Цель исследования - проанализировать влияние поздней диагностики на выживаемость и риск развития сосудистых осложнений у пациентов с артериитом Такаясу (АТ). </p><sec><title>Материал и методы</title><p>Материал и методы. Обследованы 183 больных АТ, проходивших лечение в Свердловской областной клинической больнице № 1 в период с 01.01.1979 по 31.04.2018. Среди них было 139 женщин и 44 мужчины с медианой возраста на момент установления диагноза 35 [24; 44] и 34 [26,5; 42] года и медианой промежутка от появления первых симптомов до установления диагноза 3 [1; 7] и 4 [1,5; 8] года соответственно. Диагноз АТ соответствовал критериям ACR (1990). </p></sec><sec><title>Результаты</title><p>Результаты. За период наблюдения отмечен 31 летальный исход (у 18 мужчин и 13 женщин). Медиана возраста смерти женщин составила 36 [32-44] лет, мужчин - 50 [40-57] лет. Сердечно сосудистые осложнения были зафиксированы у 72 пациентов (у 27 мужчин и 45 женщин). В структуре сосудистых осложнений преобладало острое нарушение мозгового кровообращения, наблюдавшееся у 31 (43%) больного, включая ишемический инсульт у 24 (35%), транзиторную ишемическую атаку у 3 (3%) и геморрагический инсульт у 4 (6%). Тромбозы артерий различного калибра зарегистрированы в 32 (44%) случаях. У 162 (88,5%) пациентов диагноз был установлен более чем через полгода от появления первых симптомов. При первичном обращении у 71 (39%) пациента первоначальный диагноз был ошибочен. Наиболее часто имевшаяся у них симптоматика расценивалась как проявление артериальной гипертензии (в 18% случаев). Промежуток от появления симптомов АТ до постановки диагноза, составлявший 4 года и более, ассоциировался со значительным повышением вероятности сердечно-сосудистых событий (отношение шансов (ОШ) — 1,8; 95%-й доверительный интервал (ДИ): 1,07-3,34) и преждевременной смерти к 5-му году наблюдения (ОШ=2,9; 95% ДИ: 1,27-6,55). </p></sec><sec><title>Заключение</title><p>Заключение. В анализируемой ретроспективной когорте поздняя верификация диагноза и позднее начало терапии АТ ассоциировались с повышенным риском преждевременной смерти и тяжелых сосудистых осложнений, описанным ранее в других выборках. Своевременная постановка диагноза и как можно более раннее назначение соответствующей терапии могут предотвратить прогрессирование заболевания и развитие инвалидизирующих осложнений.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To assess the effect of late diagnosis on survival and risk of vascular complications in Takayasu's arteritis (TA) patients.  Methods. 183 patients with TA who were treated at the Sverdlovsk Regional Clinical Hospital No. 1 during the period from 01.01.1979 to 31.04.2018 were examined. There were 139 women and 44 men included, median age at the time of diagnosis being 35 [24; 44] years in females and 34 [26.5; 42] years in males and a median interval from the first symptoms onset to the diagnosis of 3 [1; 7] and 4 [1.5; 8] years respectively. The diagnosis of TA met the ACR criteria (1990).</p></sec><sec><title>Results</title><p>Results. During the follow-up period, 31 deaths were observed (18 in males and 13 in females). The median age of death for women was 36 [32-44] years, for men - 50 [40-57] years. Cardiovascular complications were recorded in 72 patients (27 men and 45 women). Vascular complications and namely acute cerebrovascular accident observed in 31 (43%) patients, including ischemic stroke in 24 (35%), transient ischemic attack in 3 (3%) and hemorrhagic stroke in 4 (6%) were the most frequent. Arterial thromboses were registered in 32 (44%) cases. In 162 (88.5%) patients, the diagnosis was established more than six months after the appearance of the first symptoms.</p><p>At the primary physician visit in 71 (39%) patients, the initial diagnosis was erroneous. The most common symptoms they had were regarded as a manifestation of arterial hypertension (in 18% cases). 4 years or more interval from the onset of TA symptoms to diagnosis was associated with a significant cardiovascular events odds increase (OR=1.8; 95% CI: 1.07-3.34) and premature death by the 5th year of follow-up (OR=2.9; 95% CI: 1,27-6,55).</p></sec><sec><title>Conclusion</title><p>Conclusion. In the retrospective TA cohort setting, late diagnosis verification and delayed treatment initiation were associated with an increased risk of premature death and severe vascular complications, described earlier in other samplings. Timely diagnosis and as early as possible appropriate treatment administration can prevent the disease progression and disabling complications occurrence.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>поздняя диагностика</kwd><kwd>артериит Такаясу</kwd></kwd-group><kwd-group xml:lang="en"><kwd>late diagnosis</kwd><kwd>Takayasu's arteritis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Арабидзе ГГ, Абугова СП, Матвеева ЛС. Клинические аспекты болезни Такаясу (215 наблюдений). Терапевтический архив. 1980;5:124-129.</mixed-citation><mixed-citation xml:lang="en">Arabidze GG, Abugova SP, Matveeva LS. Clinical aspects of Takayasu's disease (215 observations). Terapevticheskii arkhiv. 1980;5:124-129 (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Aydin SZ, Yilmaz N, Akar S. 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