rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2022-45-51rsp-3115Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHСравнительная характеристика нелеченного раннего ревматоидного артрита у больных с ранним и поздним началом, по данным Общероссийского регистра больных артритом «ОРЕЛ»Comparative clinical characteristics of untreated early rheumatoid arthritis in patients with early and late onset according to the All-Russian Register of Patients with Arthritis “OREL”https://orcid.org/0000-0002-1508-0854СатыбалдыевА. М.SatybaldyevA. M.

Сатыбалдыев Азамат Махмудович

115522, Москва, Каширское шоссе, 34а

Azamat Satybaldyev

115522, Moscow, Kashirskoye Highway, 34A

azamatsat@yandex.ruhttps://orcid.org/0000-0003-3065-4235ДемидоваН. В.DemidovaN. V.

115522, Москва, Каширское шоссе, 34а

Natalia V. Demidova

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0002-0928-3911ГридневаГ. И.GridnevaG. I.

115522, Москва, Каширское шоссе, 34а

Galina I. Gridneva

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0002-4160-7218НикишинаН. Ю.NikishinaN. Yu.

115522, Москва, Каширское шоссе, 34а

Nina Yu. Nikishina

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0001-5815-561XГерасимоваЕ. В.GerasimovaE. V.

115522, Москва, Каширское шоссе, 34а

Elena V. Gerasimova

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0002-6852-6741КасумоваК. А.KasumovaK. A.

115522, Москва, Каширское шоссе, 34а

Kamalya A. Kasumova

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0002-5272-4735МисиюкА. С.MisiyukA. S.

115522, Москва, Каширское шоссе, 34а

Anna S. Misiyuk

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0002-7569-4110РумянцеваО. А.RumyantsevaO. A.

115522, Москва, Каширское шоссе, 34а

Oxana A. Rumyantseva

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0001-8130-5081СтребковаЕ. А.StrebkovaE. A.

115522, Москва, Каширское шоссе, 34а

Ekaterina A. Strebkova

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0003-3684-7310СороцкаяВ. Н.SorotskayaV. N.

300012,Тула, пр. Ленина, 92

Valentina N. Sorotskaya

300012, Tula, Lenina avenue, 92

https://orcid.org/0000-0001-8051-8659ЧичасоваН. В.ChichasovaN. V.

115522, Москва, Каширское шоссе, 34а

125993, Москва, ул. Баррикадная, 2/1, стр. 1

Natalia V. Chichasova

115522, Moscow, Kashirskoye Highway, 34A

125993, Moscow, Barrikadnaya str., 2/1, building 1

https://orcid.org/0000-0001-8051-8659НасоновЕ. Л.NasonovE. L.

115522, Москва, Каширское шоссе, 34а

119991, Москва, ул. Трубецкая, 8, стр. 2

Evgeny L. Nasonov

115522, Moscow, Kashirskoye Highway, 34A

119991, Moscow, Trubetskaya str., 8, building 2

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationФГБОУ ВО «Тульский государственный университет»РоссияTula State UniversityRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian FederationRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияV.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University)Russian Federation20222702202260145–51Copyright © Сатыбалдыев А.М., Демидова Н.В., Гриднева Г.И., Никишина Н.Ю., Герасимова Е.В., Касумова К.А., Мисиюк А.С., Румянцева О.А., Стребкова Е.А., Сороцкая В.Н., Чичасова Н.В., Насонов Е.Л., 20222022Сатыбалдыев А.М., Демидова Н.В., Гриднева Г.И., Никишина Н.Ю., Герасимова Е.В., Касумова К.А., Мисиюк А.С., Румянцева О.А., Стребкова Е.А., Сороцкая В.Н., Чичасова Н.В., Насонов Е.Л.Satybaldyev A.M., Demidova N.V., Gridneva G.I., Nikishina N.Y., Gerasimova E.V., Kasumova K.A., Misiyuk A.S., Rumyantseva O.A., Strebkova E.A., Sorotskaya V.N., Chichasova N.V., Nasonov E.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3115

Вопрос об особенностях течения ревматоидного артрита (РА) в разные возрастные периоды ставился в литературе неоднократно, и ответ на него зависел от периода развития ревматологии и не был однозначным. Также (хотя и реже) изучались возрастные особенности начальных этапов развития заболевания. В то же время вопросы возрастных особенностей еще не леченного раннего РА в изучаемой авторами литературе ранее представлены не были. В статье приводится краткий обзор проблемы и обсуждаются собственные данные.Цель настоящего исследования – сравнительное изучение раннего ревматоидного артрита с ранним (18– 49 лет) и поздним (50 лет и старше) началом заболевания у пациентов, не получавших базисных противовоспалительных препаратов.Материал и методы. Анализировались данные обследования 292 больных РА с длительностью заболевания от 1 до 12 месяцев, включенных в Общероссийский регистр больных артритом «ОРЕЛ» в период с 01 января 2012 г. по 31 декабря 2018 г. Все больные не получали ранее базисные противовоспалительные препараты (синтетические и генно-инженерные биологические) и системную терапию глюкокортикоидами. У 141 пациента заболевание началось в более молодом возрасте (18–49 лет) – 1-я группа, у 151 пациента – в более старшем (50 лет и старше) – 2-я группа. Активность заболевания оценивалась по индексу DAS-28, рентгенологическая стадия – по модифицированной классификации Штейнброкера, функциональные нарушения – в соответствии с функциональным классом, ревматоидный фактор, антитела к циклическому цитруллинированному пептиду и другие лабораторные показатели – в соответствии с требованиями действующей отечественной классификации РА.Результаты исследования свидетельствуют о том, что для заболевания, начавшегося в старшем возрасте,характерны более выраженные воспалительные и деструктивные изменения суставов, а также функциональные нарушения, чем для РА, начавшегося в молодом возрасте.

The question about the peculiarities of the course of rheumatoid arthritis in different age periods was raised in the literature repeatedly and the answer depended on the period of development of rheumatology and was not unambiguous. The course of age-specific features of the initial stages of disease development has also been studied (although less frequently). At the same time, the issues of age-related features of as yet untreated early rheumatoid arthritis have not been previously presented in the literature studied by the authors. This article gives a brief overview of the problem and discusses the findings.The aim of the present study was the comparative study of the characteristics of untreated early rheumatoid arthritis with early (18–49 years) and late (50 years and older) onset.The material was represented by 292 patients with rheumatoid arthritis with disease duration from 1 to 12 months from the disease onset, entered into the All-Russian Register of Patients with Inflammatory Arthritis “OREL” in the period from January 01, 2012 to December 31, 2018 with the results of examination at the time of the first examination. All patients were naïve to treatment with basal (synthetic, biological or other targeted) drugs and systemic glucocorticoid therapy. In 141 patients, the disease started at a younger age, group 1 (18–49 years), and in 151, at an older age (50 years or older), group 2.Methods. Disease activity (according to DAS-28 index), radiological stage – (according to Steinbroker, modified), functional disorders – according to functional class, immunological characteristic and additional immunological characteristic (rheumatoid factor, cyclic citrullinated peptide antibodies) and other parameters were estimated in accordance to requirements of current national rheumatoid arthritis classification. The results of the study indicate that the disease in older age is characterized by more pronounced inflammatory, destructive changes in relation to the joint apparatus and functional disorders than the onset of rheumatoid arthritis at a young age. 

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The authors declare that there are no conflicts of interest present.