rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2022-460-464rsp-3200Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHЗначение трабекулярного костного индекса у молодых мужчин с анкилозирующим спондилитомTrabecular bone score value in young men with ankylosing spondylitishttps://orcid.org/0000-0002-6834-2651КолпаковК. И.KolpakovK. I.

630060, Новосибирск, ул. Тимакова, 2

630060, Novosibirsk, Timakova str., 2

https://orcid.org/0000-0002-6275-2924ЛетягинаЕ. А.LetyaginaE. A.

630060, Новосибирск, ул. Тимакова, 2

630060, Novosibirsk, Timakova str., 2

https://orcid.org/0000-0001-6606-7185ОмельченкоВ. О.OmelchenkoV. O.

630060, Новосибирск, ул. Тимакова, 2

630060, Novosibirsk, Timakova str., 2

https://orcid.org/0000-0001-6330-1044УбшаеваЮ. Б.UbshaevaYu. B.

630060, Новосибирск, ул. Тимакова, 2

630060, Novosibirsk, Timakova str., 2

leobina@mail.ruhttps://orcid.org/0000-0002-4890-0847КоролевМ. А.KorolevM. A.

630060, Новосибирск, ул. Тимакова, 2

630060, Novosibirsk, Timakova str., 2

Научно-исследовательский институт клинической и экспериментальной лимфологии – филиал ФГБНУ «Федеральный исследовательский центр Институт цитологии и генетики СО РАН»РоссияResearch Institute of Clinical and Experimental Lymphology – Branch of the Federal Research Center Institute of Cytology and Genetics, Siberian Branch of Russian Academy of SciencesRussian Federation202207092022604460464Copyright © Колпаков К.И., Летягина Е.А., Омельченко В.О., Убшаева Ю.Б., Королев М.А., 20222022Колпаков К.И., Летягина Е.А., Омельченко В.О., Убшаева Ю.Б., Королев М.А.Kolpakov K.I., Letyagina E.A., Omelchenko V.O., Ubshaeva Y.B., Korolev M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3200

Цель исследования – изучить взаимосвязь трабекулярного костного индекса (ТКИ) с показателями активности и структурного прогрессирования анкилозирующего спондилита (АС) у мужчин моложе 50 лет без признаков остеопороза.

Материалы и методы

Материалы и методы. В исследовании приняли участие 26 мужчин с АС. Активность АС определялась по индексам BASDAI и ASDAS-СРБ, а также по уровню С-реактивного белка (СРБ). Структурное прогрессирование АС оценивалось по стадии сакроилиита (СИ). ТКИ определялся с помощью двухэнергетической рентгеновской абсорбциометрии. Связь клинических параметров с ТКИ оценивалась с помощью коэффициента корреляции Спирмена для количественных переменных и рангового коэффициента корреляции Кендалла (τ) для качественных показателей.

Результаты

Результаты. Корреляция ТКИ с активностью АС отсутствовала. Выявлена отрицательная корреляция между стадией СИ и ТКИ (τ=–0,313; p<0,05). Заключение. ТКИ коррелирует с выраженностью структурных изменений крестцово-подвздошных суставов у молодых мужчин с АС без остеопороза. Ключевые слова: анкилозирующий спондилит, трабекулярный костный индекс, структурное прогрессирование>˂ 0,05).

Заключение

Заключение. ТКИ коррелирует с выраженностью структурных изменений крестцово-подвздошных суставов у молодых мужчин с АС без остеопороза. 

Aim – to investigate relationship of trabecular bone score (TBS) with activity and structural progression of ankylosing spondylitis (AS) in males younger than 50 years old without osteoporosis.

Materials and methods

Materials and methods. 26 male AS patients took part in the investigation. AS activity was evaluated by BASDAI and ASDAS-CRP indices, and highly sensitive C-reactive protein level. Structural AS progression was evaluated by sacroiliitis (SI). TBS was evaluated using the double-energy X-ray absoptiometry. Correlation between clinical measures and TBS was obtained using the Spearman r-criterion for quantitative variables and Kendall’s τ coefficientfor qualitative variables.

Results

Results. There was obtained no correlation between AS activity and TBS. Among clinical characteristics, SI stage was negatively correlated with TBS (τ=–0.313; p<0.05). Conclusion. TBS is associated with the severity of sacroiliitis in young AS male patients. Key words: ankylosing spondylitis, trabecular bone score, structural progression>˂ 0.05).

Conclusion

Conclusion. TBS is associated with the severity of sacroiliitis in young AS male patients. 

анкилозирующий спондилиттрабекулярный костный индексструктурное прогрессированиеankylosing spondylitistrabecular bone scorestructural progressionИсследование выполнено при финансовой поддержке проектов базового бюджетного финансирования РФ № 0324- 2019-0046-C-02 (НИИКЭЛ – филиал ФИЦ ИЦИГ СО РАН).ReferencesГалушко ЕА, Насонов ЕЛ. Распространенность ревматиче - ских заболеваний в России. Альманах клинической медицины. 2018;46(1):32-39. doi: 10.18786/2072-0505-2018-46-1-32-39Galushko EA, Nasonov EL. Prevalence of rheumatic diseases in Russia. Almanac of Clinical Medicine. 2018; 46(1):32-39 (In Russ.). doi: 10.18786/2072-0505-2018-46-1-32-39Белая ЖЕ, Белова КЮ, Бирюкова ЕВ, Дедов ИИ, Дзеранова ЛК, Драпкина ОМ, и др. Федеральные клинические рекомендации по диагностике, лечению и профилактике остеопороза. Остеопороз и остеопатии.2021;24(2):4-47. doi: 10.14341/osteo12930Belaya ZE, Belova KYu, Biryukova EV, Dedov II, Dzeranova LK, Drapkina OM, et al. Federal clinical guidelines for diagnosis, treatment and prevention of osteoporosis. Osteoporosis and Bone Diseases. 2021;24(2):4-47 (In Russ.). doi: 10.14341/osteo12930Poddubnyy D, Gaydukova I, Hermann KG, Song IH, Haibel H, Braun J, et al. Magnetic resonance imaging compared to conventional radiographs for detection of chronic structural changes in sacroiliac joints in axial spondyloarthritis. J Rheumatol. 2013;40(9):1557-1565. doi: 10.3899/jrheum.130141Poddubnyy D, Gaydukova I, Hermann KG, Song IH, Haibel H, Braun J, et al. Magnetic resonance imaging compared to conventional radiographs for detection of chronic structural changes in sacroiliac joints in axial spondyloarthritis. J Rheumatol. 2013;40(9):1557-1565. doi: 10.3899/jrheum.130141Hebeisen M, Micheroli R, Scherer A, Baraliakos X, de Hooge M, van der Heijde D, et al. Spinal radiographic progression in axial spondyloarthritis and the impact of classification as nonradiographic versus radiographic disease: Data from the Swiss Clinical Quality Management cohort. PLoS One. 2020;15(3):e0230268. doi: 10.1371/journal.pone.0230268Hebeisen M, Micheroli R, Scherer A, Baraliakos X, de Hooge M, van der Heijde D, et al. Spinal radiographic progression in axial spondyloarthritis and the impact of classification as nonradiographic versus radiographic disease: Data from the Swiss Clinical Quality Management cohort. PLoS One. 2020;15(3):e0230268. doi: 10.1371/journal.pone.0230268Эрдес Ш, Смирнов АВ. Технология диагностики воспалительных изменений скелета при анкилозирующем спондилите по данным магнитно-резонансной томографии. Научнопрактическая ревматология. 2019;57(6):678-684. doi: 10.14412/1995-4484-2019-678-684Erdes S, Smirnov AV. Diagnostic technology for inflammatory changes in the skeleton with ankylosing spondylitis according to magnetic resonance imaging. Nauchno-PrakticheskayaRevmatologia = Rheumatology Science and Practice.2019;57(6):678-684 (In Russ.). doi: 10.14412/1995-4484-2019-678-684Muschitz C, Kocijan R, Haschka J, Pahr D, Kaider A, Pietschmann P, et al. TBS reflects trabecular microarchitecture in premenopausal women and men with idiopathic osteoporosis and low-traumatic fractures. Bone. 2015;79:259-266. doi: 10.1016/j.bone.2015.06.007Muschitz C, Kocijan R, Haschka J, Pahr D, Kaider A, Pietschmann P, et al. TBS reflects trabecular microarchitecture in premenopausal women and men with idiopathic osteoporosis and low-traumatic fractures. Bone. 2015;79:259-266. doi: 10.1016/j.bone.2015.06.007Expert Panel on Musculoskeletal Imaging; Ward RJ, Roberts CC, Bencardino JT, Arnold E, Baccei SJ, Cassidy RC, et al. ACR Appropriateness Criteria Osteoporosis and Bone Mineral Density. J Am Coll Radiol. 2017;14(5S):S189-S202. doi: 10.1016/j.jacr.2017.02.018Expert Panel on Musculoskeletal Imaging; Ward RJ, Roberts CC, Bencardino JT, Arnold E, Baccei SJ, Cassidy RC, et al. ACR Appropriateness Criteria Osteoporosis and Bone Mineral Density. J Am Coll Radiol. 2017;14(5S):S189-S202. doi: 10.1016/j.jacr.2017.02.018Kolta S, Briot K, Fechtenbaum J, Paternotte S, Armbrecht G, Felsenberg D, et al. TBS result is not affected by lumbar spine osteoarthritis. Osteoporos Int. 2014;25(6):1759-1764. doi: 10.1007/s00198-014-2685-6Kolta S, Briot K, Fechtenbaum J, Paternotte S, Armbrecht G, Felsenberg D, et al. TBS result is not affected by lumbar spine osteoarthritis. Osteoporos Int. 2014;25(6):1759-1764. doi: 10.1007/s00198-014-2685-6McCloskey EV, Odén A, Harvey NC, Leslie WD, Hans D, Johansson H, et al. A meta-analysis of trabecular bone score in fracture risk prediction and its relationship to FRAX. J Bone Miner Res. 2016;31(5):940-948. doi: 10.1002/jbmr.2734McCloskey EV, Odén A, Harvey NC, Leslie WD, Hans D, Johansson H, et al. A meta-analysis of trabecular bone score in fracture risk prediction and its relationship to FRAX. J Bone Miner Res. 2016;31(5):940-948. doi: 10.1002/jbmr.2734Kang KY, Goo HY, Park SH, Hong YS. Trabecular bone score as an assessment tool to identify the risk of osteoporosis in axial spondyloarthritis: A case-control study. Rheumatology (Oxford). 2018;57(3):462-469. doi: 10.1093/rheumatology/kex377Kang KY, Goo HY, Park SH, Hong YS. Trabecular bone score as an assessment tool to identify the risk of osteoporosis in axial spondyloarthritis: A case-control study. Rheumatology (Oxford). 2018;57(3):462-469. doi: 10.1093/rheumatology/kex377Kang KY, Chung MK, Kim HN, Hong YS, Ju JH, Park SH. Severity of sacroiliitis and erythrocyte sedimentation rate are associated with a low trabecular bone score in young male patients with ankylosing spondylitis. J Rheumatol. 2018;45(3):349-356. doi: 10.3899/jrheum.170079Kang KY, Chung MK, Kim HN, Hong YS, Ju JH, Park SH. Severity of sacroiliitis and erythrocyte sedimentation rate are associated with a low trabecular bone score in young male patients with ankylosing spondylitis. J Rheumatol. 2018;45(3):349-356. doi: 10.3899/jrheum.170079Kim JW, Chung MK, Lee J, Kwok SK, Kim WU, Park SH, et al. Low bone mineral density of vertebral lateral projections can predict spinal radiographic damage in patients with ankylosing spondylitis. Clin Rheumatol. 2019;38(12):3567-3574. doi: 10.1007/s10067-019-04743-7Kim JW, Chung MK, Lee J, Kwok SK, Kim WU, Park SH, et al. Low bone mineral density of vertebral lateral projections can predict spinal radiographic damage in patients with ankylosing spondylitis. Clin Rheumatol. 2019;38(12):3567-3574. doi: 10.1007/s10067-019-04743-7Wildberger L, Boyadzhieva V, Hans D, Stoilov N, Rashkov R, Aubry-Rozier B. Impact of lumbar syndesmophyte on bone health as assessed by bone density (BMD) and bone texture (TBS) in men with axial spondyloarthritis. Joint Bone Spine. 2017;84(4):463-466. doi: 10.1016/j.jbspin.2016.05.015Wildberger L, Boyadzhieva V, Hans D, Stoilov N, Rashkov R, Aubry-Rozier B. Impact of lumbar syndesmophyte on bone health as assessed by bone density (BMD) and bone texture (TBS) in men with axial spondyloarthritis. Joint Bone Spine. 2017;84(4):463-466. doi: 10.1016/j.jbspin.2016.05.015Kang KY, Ju JH, Park SH, Hong YS. Longitudinal association between trabecular bone loss and disease activity in axial spondyloarthritis: A 4-year prospective study. J Rheumatol. 2020;47(9):1330- 1337. doi: 10.3899/jrheum.190749Kang KY, Ju JH, Park SH, Hong YS. Longitudinal association between trabecular bone loss and disease activity in axial spondyloarthritis: A 4-year prospective study. J Rheumatol. 2020;47(9):1330- 1337. doi: 10.3899/jrheum.190749Jung JY, Han SH, Hong YS, Park SH, Ju JH, Kang KY. Inflammation on spinal magnetic resonance imaging is associated with poor bone quality in patients with ankylosing spondylitis. Mod Rheumatol. 2019;29(5):829-835. doi: 10.1080/14397595.2018.1510877Jung JY, Han SH, Hong YS, Park SH, Ju JH, Kang KY. Inflammation on spinal magnetic resonance imaging is associated with poor bone quality in patients with ankylosing spondylitis. Mod Rheumatol. 2019;29(5):829-835. doi: 10.1080/14397595.2018.1510877Kang KY, Jung JY, Lee SK, Min HK, Hong YS, Park SH, et al. Trabecular bone score value is associated with new bone formation independently of fat metaplasia on spinal magnetic resonance imaging in patients with ankylosing spondylitis. Scand J Rheumatol. 2020;49(4):292-300. doi: 10.1080/03009742.2019.1704053Kang KY, Jung JY, Lee SK, Min HK, Hong YS, Park SH, et al. Trabecular bone score value is associated with new bone formation independently of fat metaplasia on spinal magnetic resonance imaging in patients with ankylosing spondylitis. Scand J Rheumatol. 2020;49(4):292-300. doi: 10.1080/03009742.2019.1704053Martineau P, Leslie WD. Trabecular bone score (TBS): Method and applications. Bone. 2017;104:66-72. doi: 10.1016/j.bone.2017.01.035Martineau P, Leslie WD. Trabecular bone score (TBS): Method and applications. Bone. 2017;104:66-72. doi: 10.1016/j.bone.2017.01.035Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S, et al.; National Osteoporosis Foundation. Clinician’s guide to prevention and treatment of osteoporosis. Osteoporos Int. 2014;25(10):2359-2381. doi: 10.1007/s00198-014-2794-2Cosman F, de Beur SJ, LeBoff MS, Lewiecki EM, Tanner B, Randall S, et al.; National Osteoporosis Foundation. Clinician’s guide to prevention and treatment of osteoporosis. Osteoporos Int. 2014;25(10):2359-2381. doi: 10.1007/s00198-014-2794-2Krohn K, Schwartz EN, Chung YS, Lewiecki EM. Dual-energy X-ray absorptiometry monitoring with trabecular bone score: 2019 ISCD official position. J Clin Densitom. 2019;22(4):501-505. doi: 10.1016/j.jocd.2019.07.006Krohn K, Schwartz EN, Chung YS, Lewiecki EM. Dual-energy X-ray absorptiometry monitoring with trabecular bone score: 2019 ISCD official position. J Clin Densitom. 2019;22(4):501-505. doi: 10.1016/j.jocd.2019.07.006van der Heijde D, Ramiro S, Landewé R, Baraliakos X, Van den Bosch F, Sepriano A, et al. 2016 update of the ASASEULAR management recommendations for axial spondyloarthritis. Ann Rheum Dis. 2017;76(6):978-991. doi: 10.1136/annrheumdis-2016-210770van der Heijde D, Ramiro S, Landewé R, Baraliakos X, Van den Bosch F, Sepriano A, et al. 2016 update of the ASASEULAR management recommendations for axial spondyloarthritis. Ann Rheum Dis. 2017;76(6):978-991. doi: 10.1136/annrheumdis-2016-210770

The authors declare that there are no conflicts of interest present.