rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2022-535-545rsp-3243Research ArticleПРОБЛЕМЫ РЕВМАТОЛОГИИ В ПЕРИОД ПАНДЕМИИ КОРОНОВИРУСНОЙ БОЛЕЗНИ 2019PROBLEMS OF RHEUMATOLOGY DURING THE 2019 CORONAVIRUS PANDEMICАваскулярный некроз эпифизов костей у пациентов, перенесших инфекцию SARS-CoV-2Avascular necrosis of the epiphyses of bones in patients who have had SARS-CoV-2 infection: Clinical observations and a narrative review of literature datahttps://orcid.org/0000-0002-3745-0924БяликВ. Е.BialikV. E.

Бялик Валерий Евгеньевич

115522, Москва, Каширское шоссе, 34а

Valerii Bialik

115522, Moscow, Kashirskoye Highway, 34A

DoctorBjalik@yandex.ruhttps://orcid.org/0000-0002-1391-0711КаратеевА. Е.KarateevA. E.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0001-7938-1536БяликЕ. И.BialikE. I.

115522, Москва, Каширское шоссе, 34а

125993, Москва, ул. Баррикадная, 2/1, стр. 1

115522, Moscow, Kashirskoye Highway, 34A

125993, Moscow, Barrikadnaya str., 2/1, building 1

https://orcid.org/0000-0002-5626-7404МакаровМ. А.MakarovM. A.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0001-8563-0631МакаровС. А.MakarovS. A.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0003-4927-4291РоскидайлоА. А.RoskidailoA. A.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0002-7179-8174НестеренкоВ. А.NesterenkoV. A.

115522, Москва, Каширское шоссе, 34а

115522, Moscow, Kashirskoye Highway, 34A

https://orcid.org/0000-0002-6068-3080ЛилаА. М.LilaA. M.

115522, Москва, Каширское шоссе, 34а

125993, Москва, ул. Баррикадная, 2/1, стр. 1

115522, Moscow, Kashirskoye Highway, 34A

125993, Moscow, Barrikadnaya str., 2/1, building 1

https://orcid.org/0000-0002-2748-6931МалыгинаМ. А.MalyginaM. A.

129090, Москва, Большая Серпуховская пл., 3

129090, Moscow, Bolshaya Serpuhovskaya square, 3

ФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»РоссияV.A. Nasonova Research Institute of RheumatologyRussian FederationФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияV.A. Nasonova Research Institute of Rheumatology; Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian FederationRussian FederationГБУЗ г. Москвы «Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского Департамента здравоохранения г. Москвы»РоссияN.V. Sklifosovskiy Research Institute for Emergency MedicineRussian Federation202225122022606535–545Copyright © Бялик В.Е., Каратеев А.Е., Бялик Е.И., Макаров М.А., Макаров С.А., Роскидайло А.А., Нестеренко В.А., Лила А.М., Малыгина М.А., 20222022Бялик В.Е., Каратеев А.Е., Бялик Е.И., Макаров М.А., Макаров С.А., Роскидайло А.А., Нестеренко В.А., Лила А.М., Малыгина М.А.Bialik V.E., Karateev A.E., Bialik E.I., Makarov M.A., Makarov S.A., Roskidailo A.A., Nesterenko V.A., Lila A.M., Malygina M.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3243

Пандемия коронавирусной инфекции SARS-CoV-2 – ведущая медицинская проблема, находящаяся в центре внимания представителей всех медицинских специальностей. Помимо борьбы с самой инфекцией COVID-19, все более актуальной становится задача профилактики и лечения широкого спектра осложнений, возникающих после перенесенного заболевания. Одним из этих осложнений является аваскулярный некроз (АН) костной ткани – тяжелая патология, приводящая к серьезным страданиям, снижению качества жизни и инвалидизации пациентов. За период с 2020 по 2022 г. в мировой литературе появилось 9 обзоров, посвященных патогенезу, клиническим особенностям и возможностям терапии данного осложнения. В этот же период были опубликованы 5 статей с описанием клинических наблюдений АН после перенесенного COVID-19.Целью настоящей работы являются демонстрация собственных клинических наблюдений, а также обзор имеющихся литературных данных по проблеме АН после перенесенной инфекции COVID-19. На основании проведенного анализа можно сделать вывод, что АН после перенесенного COVID-19 наиболее часто развивается в головке бедренной кости (>50% случаев), возникает независимо от тяжести COVID-19 и кумулятивной дозы глюкокортикоидов, использованных в остром периоде болезни. Представляется целесообразным выполнять всем пациентам, переболевшим COVID-19 в тяжелой и среднетяжелой формах, магнитно-резонансную томографию тазобедренных суставов не реже 1 раза в 3 месяца в течение первого года после реконвалесценции.

The SARS-CoV-2 coronavirus pandemic is a leading medical problem that is in the focus of attention of representatives of all medical specialties. In addition to fighting the COVID-19 infection itself, the task of preventing and treating a wide range of complications arising after the disease is becoming increasingly urgent. One of these complications is avascular necrosis (AN) of bone tissue – a severe pathology that leads to serious suffering, a decrease in the quality of life and disability of patients. For the period from 2020 to 2022 there are 9 reviews in the world literature devoted to the pathogenesis, clinical features and treatment possibilities of this complication. During the same period, 5 articles were published describing clinical observations of AN after suffering COVID-19.The purpose of this work is to demonstrate our own clinical observations, as well as to review the available literature data on the problem of AN after COVID-19 infection. Based on the analysis, it can be concluded that AN after SARS-CoV-2 infection most often develops in the femoral head (>50% of cases), occurs regardless of the severity of the disease and the cumulative dose of glucocorticoids used in the acute period of the disease. It seems advisable to perform an MRI of the hip joints at least once every 3 months for all patients who have had COVID-19 in severe and moderate form during the first year after convalescence.

аваскулярный некрозCOVID-19вторичный остеоартриттазобедренный суставплечевой суставглюкокортикоидыavascular necrosisCOVID-19secondary osteoarthritiship jointshoulder jointglucocorticoidsReferencesCooper C, Steinbuch M, Stevenson R, Miday R, Watts NB. The epidemiology of osteonecrosis: Findings from the GPRD and THIN databases in the UK. Osteoporos Int. 2009;21(4):569-577. doi: 10.1007/s00198-009-1003-1Cooper C, Steinbuch M, Stevenson R, Miday R, Watts NB. The epidemiology of osteonecrosis: Findings from the GPRD and THIN databases in the UK. Osteoporos Int. 2009;21(4):569-577. doi: 10.1007/s00198-009-1003-1Sun W, Shi Z, Gao F, Wang B, Li Z. The pathogenesis of multifocal osteonecrosis. Sci Rep. 2016;6:29576. doi: 10.1038/srep29576Sun W, Shi Z, Gao F, Wang B, Li Z. The pathogenesis of multifocal osteonecrosis. Sci Rep. 2016;6:29576. doi: 10.1038/srep29576Lieberman JR, Berry DJ, Mont MA, Aaron RK, Callaghan JJ, Rajadhyaksha AD, et al. Osteonecrosis of the hip: Management in the 21st century. Instr Course Lect. 2003;52:337-355.Lieberman JR, Berry DJ, Mont MA, Aaron RK, Callaghan JJ, Rajadhyaksha AD, et al. Osteonecrosis of the hip: Management in the 21st century. Instr Course Lect. 2003;52:337-355.Petrigliano FA, Lieberman JR: Osteonecrosis of the hip: Novel approaches to evaluation and treatment. Clin Orthop Relat Res. 2007;465(465):53-62. doi: 10.1097/BLO.0b013e3181591c92Petrigliano FA, Lieberman JR: Osteonecrosis of the hip: Novel approaches to evaluation and treatment. Clin Orthop Relat Res. 2007;465(465):53-62. doi: 10.1097/BLO.0b013e3181591c92Bergman J, Nordström A, Nordström P. Epidemiology of osteonecrosis among older adults in Sweden. Osteoporos Int. 2019;30(5):965-973. doi: 10.1007/s00198-018-04826-2Bergman J, Nordström A, Nordström P. Epidemiology of osteonecrosis among older adults in Sweden. Osteoporos Int. 2019;30(5):965-973. doi: 10.1007/s00198-018-04826-2Dima A, Pedersen AB, Pedersen L, Baicus C, Thomsen RW. Association of common comorbidities with osteonecrosis: A nationwide population-based case–control study in Denmark. BMJ Open. 2018;8:1-6. doi: 10.1136/bmjopen-2017-020680Dima A, Pedersen AB, Pedersen L, Baicus C, Thomsen RW. Association of common comorbidities with osteonecrosis: A nationwide population-based case–control study in Denmark. BMJ Open. 2018;8:1-6. doi: 10.1136/bmjopen-2017-020680Gosling-Gardeniers AC, Rijnen WHC, Gardeniers JWM. The prevalence of osteonecrosis in different parts of the world osteonecrosis. Berlin,Heidelberg:Springer Berlin Heidelberg; 2014:35-37.Gosling-Gardeniers AC, Rijnen WHC, Gardeniers JWM. The prevalence of osteonecrosis in different parts of the world osteonecrosis. Berlin,Heidelberg:Springer Berlin Heidelberg; 2014:35-37.Zhao DW, Yu M, Hu K, Wang W, Yang L, Wang BJ, et al. Prevalence of nontraumatic osteonecrosis of the femoral head and its associated risk factors in the Chinese population: Results from a nationally representative survey. Chin Med J (Engl). 2015; 128(21):2843-2850. doi: 10.4103/0366-6999.168017Zhao DW, Yu M, Hu K, Wang W, Yang L, Wang BJ, et al. Prevalence of nontraumatic osteonecrosis of the femoral head and its associated risk factors in the Chinese population: Results from a nationally representative survey. Chin Med J (Engl). 2015; 128(21):2843-2850. doi: 10.4103/0366-6999.168017Kang JS, Park S, Song JH, Jung YY, Cho MR, Rhyu KH. Prevalence of osteonecrosis of the femoral head: A nationwide epidemiologic analysis in Korea. J Arthroplasty. 2009;24(8):1178-1183. doi: 10.1016/j.arth.2009.05.022Kang JS, Park S, Song JH, Jung YY, Cho MR, Rhyu KH. Prevalence of osteonecrosis of the femoral head: A nationwide epidemiologic analysis in Korea. J Arthroplasty. 2009;24(8):1178-1183. doi: 10.1016/j.arth.2009.05.022Мустафин РН. Аваскулярный некроз головки бедренной кости в Республике Башкортостан (клинико-эпидемиологическое исследование). Креативная хирургия и онкология. 2020;10(2):100-107. doi: 10.24060/2076-3093-2020-10-2-100-107Mustafin RN. Avascular necrosis of femoral head in the Republic of Bashkortostan: A clinical and epidemiological study. Creative Surgery and Oncology. 2020;10(2):100-107 (In Russ.)]. doi: 10.24060/2076-3093-2020-10-2-100-107Lespasio MJ, Sodhi N, Mont MA. Osteonecrosis of the hip: A primer. Perm J. 2019;23:18-100. doi: 10.7812/tpp/18-100Lespasio MJ, Sodhi N, Mont MA. Osteonecrosis of the hip: A primer. Perm J. 2019;23:18-100. doi: 10.7812/tpp/18-100Gladman DD, Dhillon N, Su J, Urowitz MB. Osteonecrosis in SLE: Prevalence, patterns, outcomes and predictors. Lupus. 2017;27(1):76-81. doi: 10.1177/0961203317711012Gladman DD, Dhillon N, Su J, Urowitz MB. Osteonecrosis in SLE: Prevalence, patterns, outcomes and predictors. Lupus. 2017;27(1):76-81. doi: 10.1177/0961203317711012Joo YB, Sung YK, Shim JS, Kim JH, Lee EK, Lee HS, et al. Prevalence, incidence, and associated factors of avascular necrosis in Korean patients with systemic lupus erythematosus: A nationwide epidemiologic study. Rheumatol Int. 2015;35(5):879-886. doi: 10.1007/s00296-014-3147-3Joo YB, Sung YK, Shim JS, Kim JH, Lee EK, Lee HS, et al. Prevalence, incidence, and associated factors of avascular necrosis in Korean patients with systemic lupus erythematosus: A nationwide epidemiologic study. Rheumatol Int. 2015;35(5):879-886. doi: 10.1007/s00296-014-3147-3Kunyakham W, Foocharoen C, Mahakkanukrauh A, Suwannaroj S, Nanagara R. Prevalence and risk factor for symptomatic avascular necrosis development in Thai systemic lupus erythematosus patients. Asian Pac J Allergy Immunol. 2012;30:152-157.Kunyakham W, Foocharoen C, Mahakkanukrauh A, Suwannaroj S, Nanagara R. Prevalence and risk factor for symptomatic avascular necrosis development in Thai systemic lupus erythematosus patients. Asian Pac J Allergy Immunol. 2012;30:152-157.Seamon J, Keller T, Saleh J, Cui Q. The pathogenesis of nontraumatic osteonecrosis. Arthritis. 2012;2012:601763. doi: 10.1155/2012/601763Seamon J, Keller T, Saleh J, Cui Q. The pathogenesis of nontraumatic osteonecrosis. Arthritis. 2012;2012:601763. doi: 10.1155/2012/601763Tektonidou MG, Moutsopoulos HM. Immunologic factors in the pathogenesis of osteonecrosis. Orthop Clin North Am. 2004;35(3):259-263. doi: 10.1016/j.ocl.2004.02.003Tektonidou MG, Moutsopoulos HM. Immunologic factors in the pathogenesis of osteonecrosis. Orthop Clin North Am. 2004;35(3):259-263. doi: 10.1016/j.ocl.2004.02.003Leung TYM, Chan AYL, Chan EW, Chan VKY, Chui CSL, Cowling BJ, et al. Short- and potential long-term adverse health outcomes of COVID-19: A rapid review. Emerg Microbes Infect. 2020;9(1):2190-2199. doi: 10.1080/22221751.2020.1825914Leung TYM, Chan AYL, Chan EW, Chan VKY, Chui CSL, Cowling BJ, et al. Short- and potential long-term adverse health outcomes of COVID-19: A rapid review. Emerg Microbes Infect. 2020;9(1):2190-2199. doi: 10.1080/22221751.2020.1825914Mahase E. COVID-19: What do we know about «long COVID»? BMJ. 2020;370:m2815. doi: 10.1136/bmj.m2815Mahase E. COVID-19: What do we know about «long COVID»? BMJ. 2020;370:m2815. doi: 10.1136/bmj.m2815Каратеев АЕ, Лила АМ, Алексеева ЛИ. Хроническая скелетно-мышечная боль, ассоциированная с перенесенной инфекцией SARS-CoV-2. Доктор.Ру. 2021;20(7):7-11. doi: 10.31550/1727-2378-2021-20-7-7-11Karateev AE, Lila AM, Alekseeva LI. Chronic musculoskeletal pain associated with a previous SARS-CoV-2 infection. Doctor.Ru. 2021;20(7):7-11 (In Russ.)]. doi: 10.31550/1727-2378-2021-20-7-7-11Bandeira IP, Schlindwein MAM, Breis LC, Peron JPS, Gonçalves MVM. Neurological Complications of the COVID-19 pandemic: What have we got so far? Adv Exp Med Biol. 2021;1321:21-31. doi: 10.1007/978-3-030-59261-5_2Bandeira IP, Schlindwein MAM, Breis LC, Peron JPS, Gonçalves MVM. Neurological Complications of the COVID-19 pandemic: What have we got so far? Adv Exp Med Biol. 2021;1321:21-31. doi: 10.1007/978-3-030-59261-5_2Shchendrygina A, Nagel E, Puntmann VO, Valbuena-Lopes S. COVID-19 myocarditis and prospective heart failure burden. Expert Rev Cardiovasc Ther. 2021;19(1):5-14. doi: 10.1080/14779072.2021.1844005Shchendrygina A, Nagel E, Puntmann VO, Valbuena-Lopes S. COVID-19 myocarditis and prospective heart failure burden. Expert Rev Cardiovasc Ther. 2021;19(1):5-14. doi: 10.1080/14779072.2021.1844005Ferrara F, Vitiello A. Scientific and pharmacological rationale for the treatment of cardiac damage caused by COVID-19. Discov Med. 2020;30(161):155-161.Ferrara F, Vitiello A. Scientific and pharmacological rationale for the treatment of cardiac damage caused by COVID-19. Discov Med. 2020;30(161):155-161.Zhang C, Wu Z, Li JW, Tan K, Yang W, Zhao H, et al. Discharge may not be the end of treatment: Pay attention to pulmonary fibrosis caused by severe COVID-19. J Med Virol. 2021;93(3):1378-1386. doi: 10.1002/jmv.26634Zhang C, Wu Z, Li JW, Tan K, Yang W, Zhao H, et al. Discharge may not be the end of treatment: Pay attention to pulmonary fibrosis caused by severe COVID-19. J Med Virol. 2021;93(3):1378-1386. doi: 10.1002/jmv.26634Somasundaram NP, Ranathunga I, Ratnasamy V, Wijewickrama PSA, Dissanayake HA, Yogendranathan N, et al. The impact of SARS-CoV-2 virus infection on the endocrine system. J Endocr Soc. 2020;4(8):bvaa082. doi: 10.1210/jendso/bvaa082Somasundaram NP, Ranathunga I, Ratnasamy V, Wijewickrama PSA, Dissanayake HA, Yogendranathan N, et al. The impact of SARS-CoV-2 virus infection on the endocrine system. J Endocr Soc. 2020;4(8):bvaa082. doi: 10.1210/jendso/bvaa082Amann K, Boor P, Wiech T, Singh J, Vonbrunn E, Knöll A, et al. COVID-19 effects on the kidney. Pathologe. 2021;42(Suppl 1):76-80. doi: 10.1007/s00292-020-00900-xAmann K, Boor P, Wiech T, Singh J, Vonbrunn E, Knöll A, et al. COVID-19 effects on the kidney. Pathologe. 2021;42(Suppl 1):76-80. doi: 10.1007/s00292-020-00900-xAskari H, Sanadgol N, Azarnezhad A, Tajbakhsh A, Rafiei H, Safarpour AR, et al. Kidney diseases and COVID-19 infection: Сauses and effect, supportive therapeutics and nutritional perspectives. Heliyon. 2021;7(1):e06008. doi: 10.1016/j.heliyon.2021.e06008Askari H, Sanadgol N, Azarnezhad A, Tajbakhsh A, Rafiei H, Safarpour AR, et al. Kidney diseases and COVID-19 infection: Сauses and effect, supportive therapeutics and nutritional perspectives. Heliyon. 2021;7(1):e06008. doi: 10.1016/j.heliyon.2021.e06008De Giorgio MR, Di Noia S, Morciano C, Conte D. The impact of SARS-CoV-2 on skeletal muscles. Acta Myol. 2020;39(4):307-312. doi: 10.36185/2532-1900-034De Giorgio MR, Di Noia S, Morciano C, Conte D. The impact of SARS-CoV-2 on skeletal muscles. Acta Myol. 2020;39(4):307-312. doi: 10.36185/2532-1900-034Agarwala SR, Vijayvargiya M, Pandey P. Avascular necrosis as a part of ‘long COVID-19’. BMJ Case Rep. 2021;14(7):e242101. doi: 10.1136/bcr-2021-242101Agarwala SR, Vijayvargiya M, Pandey P. Avascular necrosis as a part of ‘long COVID-19’. BMJ Case Rep. 2021;14(7):e242101. doi: 10.1136/bcr-2021-242101Sulewski A, Sieroń D, Szyluk K, Dąbrowski M, Kubaszewski Ł, Lukoszek D, et al. Avascular necrosis bone complication after active COVID-19 infection: Preliminary results. Medicina (Kaunas). 2021;57(12):1311. doi: 10.3390/medicina57121311Sulewski A, Sieroń D, Szyluk K, Dąbrowski M, Kubaszewski Ł, Lukoszek D, et al. Avascular necrosis bone complication after active COVID-19 infection: Preliminary results. Medicina (Kaunas). 2021;57(12):1311. doi: 10.3390/medicina57121311Angulo-Ardoy M, Ureña-Aguilera Á. Knee osteonecrosis after COVID-19. Fam Pract. 2021;38(1):45-47. doi: 10.1093/fampra/cmab063Angulo-Ardoy M, Ureña-Aguilera Á. Knee osteonecrosis after COVID-19. Fam Pract. 2021;38(1):45-47. doi: 10.1093/fampra/cmab063Панин МА, Петросян АС, Хаджихараламбус КХ, Бойко АВ. Остеонекроз головки бедренной кости после COVID-19: серия клинических наблюдений. Травматология и ортопедия России. 2022;28(1):110-117. doi: 10.17816/2311-2905-1687Panin MA, Petrosyan AS, Hadjicharalambous KK, Boiko AV. Avascular necrosis of the femoral head after COVID-19: A case series. Traumatology and Orthopedics of Russia. 2022;28(1):110-117 (In Russ.)]. doi: 10.17816/2311-2905-1687Баракат МФ, Мельцер РИ. Асептический некроз костей как осложнение ковидной инфекции. Sciences of Europe. 2022;89:23-25.Barakat MF, Meltzer RI. Aseptic bone necrosis as a complication of COVID infection. Sciences of Europe. 2022;89:23-25 (In Russ.)].Namiranian P, Razavi SZE, Karimi M, Ayati MH. Avascular necrosis in patients recovering from COVID-19. Am J Med Sci. 2021;362(3):331-332. doi: 10.1016/j.amjms.2021.05.018Namiranian P, Razavi SZE, Karimi M, Ayati MH. Avascular necrosis in patients recovering from COVID-19. Am J Med Sci. 2021;362(3):331-332. doi: 10.1016/j.amjms.2021.05.018Hajra A, Mathai SV, Ball S, Bandyopadhyay D, Veyseh M, Chakraborty S, et al. Management of thrombotic complications in COVID-19: An update. Drugs. 2020;80(15):1553-1562. doi: 10.1007/s40265-020-01377-xHajra A, Mathai SV, Ball S, Bandyopadhyay D, Veyseh M, Chakraborty S, et al. Management of thrombotic complications in COVID-19: An update. Drugs. 2020;80(15):1553-1562. doi: 10.1007/s40265-020-01377-xAnka AU, Tahir MI, Abubakar SD, Alsabbagh M, Zian Z, Hamedifar H, et al. Coronavirus disease 2019 (COVID-19): An overview of the immunopathology, serological diagnosis and management. Scand J Immunol. 2021;93(4):e12998. doi: 10.1111/sji.12998Anka AU, Tahir MI, Abubakar SD, Alsabbagh M, Zian Z, Hamedifar H, et al. Coronavirus disease 2019 (COVID-19): An overview of the immunopathology, serological diagnosis and management. Scand J Immunol. 2021;93(4):e12998. doi: 10.1111/sji.12998Dutch COVID & Thrombosis Coalition, Kaptein FHJ, Stals MAM, Grootenboers M, Braken SJE, Burggraaf JLI, et al. Incidence of thrombotic complications and overall survival in hospitalized patients with COVID-19 in the second and first wave. Thromb Res. 2021;199:143-148. doi: 10.1016/j.thromres.2020.12.019Dutch COVID & Thrombosis Coalition, Kaptein FHJ, Stals MAM, Grootenboers M, Braken SJE, Burggraaf JLI, et al. Incidence of thrombotic complications and overall survival in hospitalized patients with COVID-19 in the second and first wave. Thromb Res. 2021;199:143-148. doi: 10.1016/j.thromres.2020.12.019van Paassen J, Vos JS, Hoekstra EM, Neumann KMI, Boot PC, Arbous SM. Corticosteroid use in COVID-19 patients: A systematic review and meta-analysis on clinical outcomes. Crit Care. 2020; 24(1):696. doi: 10.1186/s13054-020-03400-9van Paassen J, Vos JS, Hoekstra EM, Neumann KMI, Boot PC, Arbous SM. Corticosteroid use in COVID-19 patients: A systematic review and meta-analysis on clinical outcomes. Crit Care. 2020; 24(1):696. doi: 10.1186/s13054-020-03400-9Cano EJ, Fonseca Fuentes X, Corsini Campioli C, O’Horo JC, Abu Saleh O, Odeyemi Y, et al. Impact of corticosteroids in coronavirus disease 2019 outcomes: Systematic review and meta-analysis. Chest. 2021;159(3):1019-1040. doi: 10.1016/j.chest.2020.10.054Cano EJ, Fonseca Fuentes X, Corsini Campioli C, O’Horo JC, Abu Saleh O, Odeyemi Y, et al. Impact of corticosteroids in coronavirus disease 2019 outcomes: Systematic review and meta-analysis. Chest. 2021;159(3):1019-1040. doi: 10.1016/j.chest.2020.10.054Shetty GM. Double trouble – COVID-19 and the widespread use of corticosteroids: Are we staring at an osteonecrosis epidemic? Indian J Orthop. 2022;56(2):226-236. doi: 10.1007/s43465-021-00546-8Shetty GM. Double trouble – COVID-19 and the widespread use of corticosteroids: Are we staring at an osteonecrosis epidemic? Indian J Orthop. 2022;56(2):226-236. doi: 10.1007/s43465-021-00546-8Sung JJ, Wu A, Joynt GM, Yuen KY, Lee N, Chan PK, et al. Severe acute respiratory syndrome: Report of treatment and outcome after a major outbreak. Thorax. 2004;59(5):414-420. doi: 10.1136/thx.2003.014076Sung JJ, Wu A, Joynt GM, Yuen KY, Lee N, Chan PK, et al. Severe acute respiratory syndrome: Report of treatment and outcome after a major outbreak. Thorax. 2004;59(5):414-420. doi: 10.1136/thx.2003.014076World Health Organization. Summary table of SARS cases by country, November 1, 2002 – August 7, 2003. URL: http://www.who.int/csr/sars/country/2003_08_15/en/ (accessed: 12 October 2022)World Health Organization. Summary table of SARS cases by country, November 1, 2002 – August 7, 2003. URL: http://www.who.int/csr/sars/country/2003_08_15/en/ (accessed: 12 October 2022)Wang Z, Liu T, Wang J. The clinical research of the SARS patients diagnosed with femur head necrosis. TianJin Medical Journal. 2006;34(1):50.Wang Z, Liu T, Wang J. The clinical research of the SARS patients diagnosed with femur head necrosis. TianJin Medical Journal. 2006;34(1):50.Cheng X, Qu H, Liu W, Liu X, Cheng K, Zhao T, et al. The prevalence of osteonecrosis in severe acute respiratory syndrome patients: An MRI screening study. Chinese Journal of Radiology. 2005;39(8):791-797 [In Chinese].Cheng X, Qu H, Liu W, Liu X, Cheng K, Zhao T, et al. The prevalence of osteonecrosis in severe acute respiratory syndrome patients: An MRI screening study. Chinese Journal of Radiology. 2005;39(8):791-797 [In Chinese].Cheng X, Qu H, Liu W, Sun J, Cheng K, Feng S, et al. MRI screening on bone ischemia of hip and knee in recovered SARS patients. Chinese Journal of Radiology. 2004;38(3):230-235 [In Chinese].Cheng X, Qu H, Liu W, Sun J, Cheng K, Feng S, et al. MRI screening on bone ischemia of hip and knee in recovered SARS patients. Chinese Journal of Radiology. 2004;38(3):230-235 [In Chinese].Chen W, Zhang Q, Liu D, Zhang H, Zhang L, Gu L, et al. Analyses of attacking characteristics and clinical significance about osteonecrosis of the femoral head secondary to SARS. Zhongguo Gu Shang. 2004;17(7):388-390 [In Chinese].Chen W, Zhang Q, Liu D, Zhang H, Zhang L, Gu L, et al. Analyses of attacking characteristics and clinical significance about osteonecrosis of the femoral head secondary to SARS. Zhongguo Gu Shang. 2004;17(7):388-390 [In Chinese].Wang Y. The investigation of the SARS patients with ANFH in Beijing Ditan Hospital. Taishan Medical Institute;2011.Wang Y. The investigation of the SARS patients with ANFH in Beijing Ditan Hospital. Taishan Medical Institute;2011.Han Y, Zhou X, Zeng Z, Zhang H-l, Geng H, et al. Osteonecrosis in post-SARS patients: A clinical study. Chinese Journal of Nosoconmiology. 2005;15(5):481-484 [In Chinese].Han Y, Zhou X, Zeng Z, Zhang H-l, Geng H, et al. Osteonecrosis in post-SARS patients: A clinical study. Chinese Journal of Nosoconmiology. 2005;15(5):481-484 [In Chinese].Liu B, Li Z. The relationship of the range and location of osteonecrosis of the femoral head with the dose of steroid in SARS patients. Chinese Journal of Orthopaedics. 2009;29(6):554-557.Liu B, Li Z. The relationship of the range and location of osteonecrosis of the femoral head with the dose of steroid in SARS patients. Chinese Journal of Orthopaedics. 2009;29(6):554-557.Dong W, Bai B, Lin Y, Zeng Q. Case control study of avascular necrosis of femoral head during SARS patients’convalescence. Chinese Journal Postgraduates of Medicine. 2007;30(6):1-3.Dong W, Bai B, Lin Y, Zeng Q. Case control study of avascular necrosis of femoral head during SARS patients’convalescence. Chinese Journal Postgraduates of Medicine. 2007;30(6):1-3.Hong N, Du XK. Avascular necrosis of bone in severe acute respiratory syndrome. Clin Radiol. 2004;59(7):602-608. doi: 10.1016/j.crad.2003.12.008Hong N, Du XK. Avascular necrosis of bone in severe acute respiratory syndrome. Clin Radiol. 2004;59(7):602-608. doi: 10.1016/j.crad.2003.12.008Griffith JF, Antonio GE, Kumta SM, Hui DS, Wong JK, Joynt GM, et al. Osteonecrosis of hip and knee in patients with severe acute respiratory syndrome treated with steroids. Radiology. 2005;235(1):168-175. doi: 10.1148/radiol.2351040100Griffith JF, Antonio GE, Kumta SM, Hui DS, Wong JK, Joynt GM, et al. Osteonecrosis of hip and knee in patients with severe acute respiratory syndrome treated with steroids. Radiology. 2005;235(1):168-175. doi: 10.1148/radiol.2351040100Zhang NF, Li ZR, Wei HY, Liu Z-H, Hernigou P. Steroid-induced osteonecrosis: The number of lesions is related to the dosage. J Bone Joint Surg Br. 2008;90(9):1239-1243. doi: 10.1302/0301-620X.90B9.20056Zhang NF, Li ZR, Wei HY, Liu Z-H, Hernigou P. Steroid-induced osteonecrosis: The number of lesions is related to the dosage. J Bone Joint Surg Br. 2008;90(9):1239-1243. doi: 10.1302/0301-620X.90B9.20056Lv H, de Vlas SJ, Liu W, Wang TB, Cao ZY, Li CP, et al. Avascular osteonecrosis after treatment of SARS: A 3-year longitudinal study. Trop Med Int Health. 2009;14(Suppl 1):79-84. doi: 10.1111/j.1365-3156.2008.02187.xLv H, de Vlas SJ, Liu W, Wang TB, Cao ZY, Li CP, et al. Avascular osteonecrosis after treatment of SARS: A 3-year longitudinal study. Trop Med Int Health. 2009;14(Suppl 1):79-84. doi: 10.1111/j.1365-3156.2008.02187.xGuo KJ, Zhao FC, Guo Y, Li FL, Zhu L, Zheng W. The influence of age, gender and treatment with steroids on the incidence of osteonecrosis of the femoral head during the management of severe acute respiratory syndrome: A retrospective study. Bone Joint J. 2014;96-B(2):259-262. doi: 10.1302/0301-620X.96B2.31935Guo KJ, Zhao FC, Guo Y, Li FL, Zhu L, Zheng W. The influence of age, gender and treatment with steroids on the incidence of osteonecrosis of the femoral head during the management of severe acute respiratory syndrome: A retrospective study. Bone Joint J. 2014;96-B(2):259-262. doi: 10.1302/0301-620X.96B2.31935Li W, Huang Z, Tan B, Chen G, Li X, Xiong K, et al. General recommendation for assessment and management on the risk of glucocorticoid-induced osteonecrosis in patients with COVID-19. J Orthop Translat. 2021;31:1-9. doi: 10.1016/j.jot.2021.09.005Li W, Huang Z, Tan B, Chen G, Li X, Xiong K, et al. General recommendation for assessment and management on the risk of glucocorticoid-induced osteonecrosis in patients with COVID-19. J Orthop Translat. 2021;31:1-9. doi: 10.1016/j.jot.2021.09.005Patel MS, Gutman MJ, Abboud JA. Orthopaedic considerations following COVID-19 lessons from the 2003 SARS outbreak. JBJS Rev. 2020;8(7):e20.00052 doi: 10.2106/JBJS.RVW.20.00052Patel MS, Gutman MJ, Abboud JA. Orthopaedic considerations following COVID-19 lessons from the 2003 SARS outbreak. JBJS Rev. 2020;8(7):e20.00052 doi: 10.2106/JBJS.RVW.20.00052Zhang B, Zhang S. Corticosteroid-induced osteonecrosis in COVID-19: A call for caution. J Bone Min Res. 2020;25(9): 1828-1829. doi: 10.1002/JBMR.4136Zhang B, Zhang S. Corticosteroid-induced osteonecrosis in COVID-19: A call for caution. J Bone Min Res. 2020;25(9): 1828-1829. doi: 10.1002/JBMR.4136Daltro G, Silva ICF, Daltro PB, Silva ICF, Botelho VL. SARSCoV-2/COVID-19 and its implications in the development of osteonecrosis. J Regen Biol Med. 2020;2(4):1-19.Daltro G, Silva ICF, Daltro PB, Silva ICF, Botelho VL. SARSCoV-2/COVID-19 and its implications in the development of osteonecrosis. J Regen Biol Med. 2020;2(4):1-19.Zhang S, Wang C, Shi L, Xue Q. Beware of steroid-induced avascular necrosis of the femoral head in the treatment of COVID19 – Experience and lessons from the SARS epidemic. Drug Des Devel Ther. 2021;15:983-995. doi: 10.2147/DDDT.S298691Zhang S, Wang C, Shi L, Xue Q. Beware of steroid-induced avascular necrosis of the femoral head in the treatment of COVID19 – Experience and lessons from the SARS epidemic. Drug Des Devel Ther. 2021;15:983-995. doi: 10.2147/DDDT.S298691Snowden GT, Clement ND, Zhang S, Xue Q, Simpson AHRW. Orthopaedic long COVID – The unknown unknowns: Are we facing a pandemic of avascular necrosis following COVID-19? Bone Joint Res. 2022;11(1):10-11. doi: 10.1302/2046-3758.111.BJR-2021-0505Snowden GT, Clement ND, Zhang S, Xue Q, Simpson AHRW. Orthopaedic long COVID – The unknown unknowns: Are we facing a pandemic of avascular necrosis following COVID-19? Bone Joint Res. 2022;11(1):10-11. doi: 10.1302/2046-3758.111.BJR-2021-0505Торгашин АН, Родионова СС. Остеонекроз у пациентов, перенесших COVID-19: механизмы развития, диагностика, лечение на ранних стадиях (обзор литературы). Травматология и ортопедия России. 2022;28(1):128-137. doi: 10.17816/2311-2905-1707Torgashin AN, Rodionova SS. Osteonecrosis in patients recovering from COVID19: Mechanisms, diagnosis, and treatment at early-stage disease (review). Traumatology and Orthopedics of Russia. 2022;28(1):128-137 (In Russ.)]. doi: 10.17816/2311-2905-1707Hu L, Zhang X, Kourkoumelis N, Shang X. The mysteries of rapidly destructive arthrosis of the hip joint: A systemic literature review. Ann Palliat Med. 2020;9(3):1220-1229. doi: 10.21037/apm.2020.03.17Hu L, Zhang X, Kourkoumelis N, Shang X. The mysteries of rapidly destructive arthrosis of the hip joint: A systemic literature review. Ann Palliat Med. 2020;9(3):1220-1229. doi: 10.21037/apm.2020.03.17Arai R, Takahashi D, Inoue M, Irie T, Asano T, Konno T, et al. Efficacy of teriparatide in the treatment of nontraumatic osteonecrosis of the femoral head: A retrospective comparative study with alendronate. BMC Musculoskelet Disord. 2017;18(1):24. doi: 10.1186/s12891-016-1379-yArai R, Takahashi D, Inoue M, Irie T, Asano T, Konno T, et al. Efficacy of teriparatide in the treatment of nontraumatic osteonecrosis of the femoral head: A retrospective comparative study with alendronate. BMC Musculoskelet Disord. 2017;18(1):24. doi: 10.1186/s12891-016-1379-yGalluccio F, Matucci-Cerinic M. Efficacy of short-term teriparatide for hip osteonecrosis. J Rheum. 2016;43(11):2084-2085. doi: 10.3899/jrheum.160190Galluccio F, Matucci-Cerinic M. Efficacy of short-term teriparatide for hip osteonecrosis. J Rheum. 2016;43(11):2084-2085. doi: 10.3899/jrheum.160190Claßen T, Becker A, Landgraeber S, Haversath M, Li X, Zilkens C, et al. Long-term clinical results after iloprost treatment for bone marrow edema and avascular necrosis. Orthop Rev (Pavia). 2016;8(1):6150. doi: 10.4081/or.2016.6150Claßen T, Becker A, Landgraeber S, Haversath M, Li X, Zilkens C, et al. Long-term clinical results after iloprost treatment for bone marrow edema and avascular necrosis. Orthop Rev (Pavia). 2016;8(1):6150. doi: 10.4081/or.2016.6150Guo P, Gao F, Wang Y, Zhang Z, Sun W, Jiang B, et al. The use of anticoagulants for prevention and treatment of osteonecrosis of the femoral head: A systematic review. Medicine (Baltimore). 2017;96(16):e6646. doi: 10.1097/MD.0000000000006646Guo P, Gao F, Wang Y, Zhang Z, Sun W, Jiang B, et al. The use of anticoagulants for prevention and treatment of osteonecrosis of the femoral head: A systematic review. Medicine (Baltimore). 2017;96(16):e6646. doi: 10.1097/MD.0000000000006646Luan S, Wang S, Lin C, Fan S, Liu C, Ma C, et al. Comparisons of ultrasound-guided platelet-rich plasma intra-articular injection and extracorporeal shock wave therapy in treating ARCO I–III symptomatic non-traumatic femoral head necrosis: A randomized controlled clinical trial. J Pain Res. 2022;15:341-354. doi: 10.2147/JPR.S347961Luan S, Wang S, Lin C, Fan S, Liu C, Ma C, et al. Comparisons of ultrasound-guided platelet-rich plasma intra-articular injection and extracorporeal shock wave therapy in treating ARCO I–III symptomatic non-traumatic femoral head necrosis: A randomized controlled clinical trial. J Pain Res. 2022;15:341-354. doi: 10.2147/JPR.S347961

The authors declare that there are no conflicts of interest present.