rspНаучно-практическая ревматологияRheumatology Science and Practice1995-44841995-4492IMA-PRESS, LLC10.47360/1995-4484-2023-106-111rsp-3286Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL RESEARCHПоражение экстракраниальных артерий при гигантоклеточном артериите по данным позитронно-эмиссионной и компьютерной томографииDamage to extracranial arteries in giant cell arteritis according to PET/CThttps://orcid.org/0000-0003-0853-8967ФилатоваЕ. Е.FilatovaE. E.

Филатова Екатерина Евгеньевна

119435, Российская Федерация, Москва, ул. Россолимо, 11/5

119435, Russian Federation, Moscow, Rossolimo str., 11/5

filatevichk@gmail.comhttps://orcid.org/0000-0002-3989-2590БулановН. М.BulanovN. M.

119435, Российская Федерация, Москва, ул. Россолимо, 11/5

119435, Russian Federation, Moscow, Rossolimo str., 11/5

https://orcid.org/0000-0002-5187-0108МешковА. Д.MeshkovA. D.

129226, Российская Федерация, Москва, ул. 1-я Леонова, 16

129226, Russian Federation, Moscow, 1ya Leonova str., 16

https://orcid.org/0000-0002-6866-188XБородинО. О.BorodinO. O.

119435, Российская Федерация, Москва, ул. Россолимо, 11/5

119435, Russian Federation, Moscow, Rossolimo str., 11/5

https://orcid.org/0000-0002-1508-3975СмитиенкоИ. О.SmitienkoI. O.

119415, Российская Федерация, Москва, ул. Лобачевского, 42, стр. 4

119415, Russian Federation, Moscow, Lobachevskogo str., 42, building 4

https://orcid.org/0000-0003-4268-2655ЧачилоЕ. В.ChachiloE. V.

119435, Russian Federation, Moscow, Rossolimo str., 11/5

https://orcid.org/0000-0003-0148-5655НовиковП. И.NovikovP. I.

119435, Российская Федерация, Москва, ул. Россолимо, 11/5

119435, Russian Federation, Moscow, Rossolimo str., 11/5

https://orcid.org/0000-0002-7232-4640МоисеевС. В.MoiseevS. V.

119435, Российская Федерация, Москва, ул. Россолимо, 11/5

119234, Российская Федерация, Москва, ул. Ленинские горы, 1

119435, Russian Federation, Moscow, Rossolimo str., 11/5

119234, Russian Federation, Moscow, Leninskie Gory str., 1

Клиника им. Е.М. Тареева, ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет)РоссияTareev Clinic of Internal Diseases, I.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University)Russian FederationРоссийский геронтологический научно-клинический центр, ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РоссииРоссияRussian Gerontological Research and Clinical Center, N.I. Pirogov Russian National Research Medical UniversityRussian FederationНОЧУ послевузовского и дополнительного профессионального образования «Международный институт постдипломного медицинского образования»РоссияInternational Institute of Postgraduate Medical EducationRussian FederationКлиника им. Е.М. Тареева, ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский Университет); ФГБОУ ВО «Московский государственный университет им. М.В. Ломоносова»РоссияTareev Clinic of Internal Diseases, I.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University); Lomonosov Moscow State UniversityRussian Federation202305032023611106111Copyright © Филатова Е.Е., Буланов Н.М., Мешков А.Д., Бородин О.О., Смитиенко И.О., Чачило Е.В., Новиков П.И., Моисеев С.В., 20232023Филатова Е.Е., Буланов Н.М., Мешков А.Д., Бородин О.О., Смитиенко И.О., Чачило Е.В., Новиков П.И., Моисеев С.В.Filatova E.E., Bulanov N.M., Meshkov A.D., Borodin O.O., Smitienko I.O., Chachilo E.V., Novikov P.I., Moiseev S.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsp.mediar-press.net/rsp/article/view/3286

Целью исследования была оценка частоты поражения артерий различной локализации у пациентов с гигантоклеточным артериитом (ГКА) по данным позитронно-эмиссионной и компьютерной томографии (ПЭТ/КТ) с 18F-фтордезоксиглюкозой (18F-ФДГ).Методы. В ретроспективное исследование включались пациенты в возрасте старше 50 лет с диагнозом ГКА (в сочетании с ревматической полимиалгией или без нее). Поражение экстракраниальных артерий оценивали на основании накопления 18F-ФДГ в стенках крупных сосудов по данным ПЭТ/КТ.Результаты. Включено 47 пациентов (14 (30%) мужчин и 33 (70%) женщины); медиана возраста составила 65 [57; 68] лет. У 32 (68%) из них ПЭТ/КТ с 18F-ФДГ проводилась до, у 15 (32%) – после начала терапии глюкокортикоидами. У 40 (91%) пациентов были выявлены признаки поражения экстракраниальных сосудов различной локализации, чаще всего грудного и брюшного отделов аорты (72% и 64% соответственно).Выводы. По данным ПЭТ/КТ с 18F-ФДГ, у большинства пациентов с ГКА в патологический процесс вовлекаются не только артерии головы и шеи, но и сосуды иной локализации.

The aim of the study was to assess the incidence of arterial lesions of various localizations in patients with giant cell arteritis (GCA) according to positron emission and computed tomography (PET/CT) with 18F-fluorodeoxyglucose (18F-FDG).Methods. Patients over 50 years of age diagnosed with GCA (with or without polymyalgia rheumatica) were included in a retrospective study. Damage to extracranial arteries was assessed based on the accumulation of 18F-FDG in the walls of large vessels according to PET/CT data.Results. The study included 47 patients, 14 (30%) men and 33 (70%) women, with a median age of 65 [57; 68] years. In 32 (68%) patients, 18F-FDG-PET/CT was performed before the start of therapy with glucocorticosteroids (GCS), in 15 (32%) after the start of treatment. In 40 (91%) patients, signs of damage to extracranial vessels of various localization were revealed, most often in the thoracic and abdominal aorta (72% and 64%, respectively).Conclusions. According to 18F-FDG-PET/CT data, in most patients with GCA, not only the arteries of the head and neck, but also vessels of other localization are involved in the pathological process.

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The authors declare that there are no conflicts of interest present.